Publications

1. Shi BY, Sriram V, Wu SY, Huang D, Cheney A, Metzger MF, Sundberg O, Lyons KM, McKenna CE, Nishimura I, Kremen TJ. Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing.. Frontiers in bioengineering and biotechnology, 2024.
2. Lyons KM, Rosen V. Strengthening the case for BMP inhibition as a point of intervention for osteoarthritis.. Osteoarthritis and cartilage, 2023.
3. Azadeh Ranjbar P, Maxwell PJ, Barna A, Balouch B, Hawkshaw M, Al Omari AI, Lyons K, Alnouri G, Sataloff RT. An Exploration of the Risk Factors, Severity, and Sequelae of Vocal Fold Hemorrhage in a Population of Voice Patients Before and After Diagnosis.. Journal of voice : official journal of the Voice Foundation, 2023.
4. Qiao X, Wu X, Zhao Y, Yang Y, Zhang L, Cai X, Ma JA, Ji J, Lyons K, Boström KI, Yao Y. Cell Transitions Contribute to Glucocorticoid-Induced Bone Loss.. Cells, 2023.
5. Kremen TJ, Shi BY, Wu SY, Sundberg O, Sriram V, Kim W, Sheyn D, Lyons KM, Wang W, McKenna CE, Nishimura I. Biologically-coupled bisphosphonate chaperones effectively deliver molecules to the site of soft tissue-bone healing.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2023.
6. Maxwell PJ, Ranjbar PA, Mishra V, Yam C, Alnouri G, Lyons K, Paknezhad H, Sataloff RT. Assessing the Prevalence and Associated Risk Factors for Presbylarynx in the Elderly Laryngology Population.. Journal of voice : official journal of the Voice Foundation, 2023.
7. Sarkar A, Liu NQ, Magallanes J, Tassey J, Lee S, Shkhyan R, Lee Y, Lu J, Ouyang Y, Tang H, Bian F, Tao L, Segil N, Ernst J, Lyons K, Horvath S, Evseenko D. STAT3 promotes a youthful epigenetic state in articular chondrocytes.. Aging cell, 2023.
8. Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. Author Correction: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.. Communications biology, 2022.
9. Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.. Communications biology, 2022.
10. Vance D, Park J, Alnouri G, Turner RR, Daggumati S, Ferster APO, Ahmad A, Lyons K, Ross J, Russell K, Wu W, Sataloff RT. Diagnosing Laryngopharyngeal Reflux: A Comparison between 24-hour pH-Impedance Testing and Pharyngeal Probe (Restech) Testing, with Introduction of the Sataloff Score.. Journal of voice : official journal of the Voice Foundation, 2021.
11. Deng P, Yuan Q, Cheng Y, Li J, Liu Z, Liu Y, Li Y, Su T, Wang J, Salvo ME, Wang W, Fan G, Lyons K, Yu B, Wang CY. Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging.. Cell stem cell, 2021.
12. James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. Author Correction: NELL-1 in the treatment of osteoporotic bone loss.. Nature communications, 2021.
13. Vance D, Alnouri G, Shah P, O'Connell Ferster AP, Lyons K, Ross J, Sataloff RT. The Validity and Reliability of the Reflux Finding Score.. Journal of voice : official journal of the Voice Foundation, 2020.
14. Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM. CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020.
15. Hsu GC, Marini S, Negri S, Wang Y, Xu J, Pagani C, Hwang C, Stepien D, Meyers CA, Miller S, McCarthy E, Lyons KM, Levi B, James AW. Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.. JCI insight, 2020.
16. Ohkawara B, Kobayakawa A, Kanbara S, Hattori T, Kubota S, Ito M, Masuda A, Takigawa M, Lyons KM, Ishiguro N, Ohno K. CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction.. EMBO reports, 2020.
17. Wang W, Rigueur D, Lyons KM. TGFβ as a gatekeeper of BMP action in the developing growth plate.. Bone, 2020.
18. Falke LL, He N, Chuva de Sousa Lopes SM, Broekhuizen R, Lyons K, Nguyen TQ, Goldschmeding R. Correction to: FoxD1-driven CCN2 deletion causes axial skeletal deformities, pulmonary hypoplasia, and neonatal asphyctic death.. Journal of cell communication and signaling, 2020.
19. Falke LL, He N, Chuva de Sousa Lopes SM, Broekhuizen R, Lyons K, Nguyen TQ, Goldschmeding R. FoxD1-driven CCN2 deletion causes axial skeletal deformities, pulmonary hypoplasia, and neonatal asphyctic death.. Journal of cell communication and signaling, 2020.
20. Russell BE, Rigueur D, Weaver KN, Sund K, Basil JS, Hufnagel RB, Prows CA, Oestreich A, Al-Gazali L, Hopkin RJ, Saal HM, Lyons K, Dauber A. Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features.. Molecular genetics & genomic medicine, 2019.
21. Wang W, Chun H, Baek J, Sadik JE, Shirazyan A, Razavi P, Lopez N, Lyons KM. The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
22. Lyons KM, Rosen V. BMPs, TGFβ, and border security at the interzone.. Current topics in developmental biology, 2019.
23. Jaworek AJ, Earasi K, Lyons KM, Daggumati S, Hu A, Sataloff RT. Acute infectious laryngitis: A case series.. Ear, nose, & throat journal, 2018.
24. Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM. CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018.
25. Jiang J, Zhao G, Lyons KM. Correction to: Characterization of bone morphology in CCN5/WISP2 knockout mice.. Journal of cell communication and signaling, 2018.
26. Jiang J, Zhao G, Lyons KM. Characterization of bone morphology in CCN5/WISP5 knockout mice.. Journal of cell communication and signaling, 2018.
27. Pan H, Zhang H, Abraham P, Komatsu Y, Lyons K, Kaartinen V, Mishina Y. BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.. Developmental biology, 2017.
28. Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. A genetic signature of the evolution of loss of flight in the Galapagos cormorant.. Science (New York, N.Y.), 2017.
29. Zhang Y, Huang H, Zhao G, Yokoyama T, Vega H, Huang Y, Sood R, Bishop K, Maduro V, Accardi J, Toro C, Boerkoel CF, Lyons K, Gahl WA, Duan X, Malicdan MC, Lin S. Correction: ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13.. PLoS genetics, 2017.
30. Zhang Y, Huang H, Zhao G, Yokoyama T, Vega H, Huang Y, Sood R, Bishop K, Maduro V, Accardi J, Toro C, Boerkoel CF, Lyons K, Gahl WA, Duan X, Malicdan MC, Lin S. ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13.. PLoS genetics, 2017.
31. Jiang J, Hu Z, Lyons KM. Design and Analysis of CCN Gene Activity Using CCN Knockout Mice Containing LacZ Reporters.. Methods in molecular biology (Clifton, N.J.), 2017.
32. Falke LL, Leeuwis JW, Lyons KM, Mummery CL, Nguyen TQ, Goldschmeding R. CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy.. Journal of cell communication and signaling, 2016.
33. Wang W, Song B, Anbarchian T, Shirazyan A, Sadik JE, Lyons KM. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.. PLoS genetics, 2016.
34. Rojas Y, Jaramillo S, Lyons K, Mahmood N, Wu MF, Liu H, Vasudevan SA, Guillerman RP, Louis CU, Russell HV, Nuchtern JG, Kim ES. The optimal timing of surgical resection in high-risk neuroblastoma.. Journal of pediatric surgery, 2016.
35. Krishnamurthy R, Malone L, Lyons K, Ketwaroo P, Dodd N, Ashton D. Body MR angiography in children: how we do it.. Pediatric radiology, 2016.
36. Shi C, Iura A, Terajima M, Liu F, Lyons K, Pan H, Zhang H, Yamauchi M, Mishina Y, Sun H. Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.. Scientific reports, 2016.
37. Zieba J, Forlenza KN, Khatra JS, Sarukhanov A, Duran I, Rigueur D, Lyons KM, Cohn DH, Merrill AE, Krakow D. TGFβ and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions.. PLoS genetics, 2016.
38. Perbal B, Lau L, Lyons K, Kubota S, Yeger H, Fisher G. Report on the 8th international workshop on the CCN family of genes - Nice November 3-8, 2015.. Journal of cell communication and signaling, 2016.
39. Lyons K, Seghers V, Sorensen JI, Zhang W, Paldino MJ, Krishnamurthy R, Rohren EM. Comparison of Standardized Uptake Values in Normal Structures Between PET/CT and PET/MRI in a Tertiary Pediatric Hospital: A Prospective Study.. AJR. American journal of roentgenology, 2015.
40. Murase Y, Hattori T, Aoyama E, Nishida T, Maeda-Uematsu A, Kawaki H, Lyons KM, Sasaki A, Takigawa M, Kubota S. Role of CCN2 in Amino Acid Metabolism of Chondrocytes.. Journal of cellular biochemistry, 2015.
41. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors.. The American journal of pathology, 2015.
42. Lyons K, Seghers V, Williams JL, Sorensen JI, Paldino MJ, Krishnamurthy R, Rohren EM. Qualitative FDG PET Image Assessment Using Automated Three-Segment MR Attenuation Correction Versus CT Attenuation Correction in a Tertiary Pediatric Hospital: A Prospective Study.. AJR. American journal of roentgenology, 2015.
43. James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. NELL-1 in the treatment of osteoporotic bone loss.. Nature communications, 2015.
44. Lyons K, Cassady C, Mehollin-Ray A, Krishnamurthy R. Current Role of Fetal Magnetic Resonance Imaging in Body Anomalies.. Seminars in ultrasound, CT, and MR, 2015.
45. Lyons K, Cassady C, Jones J, Paldino M, Mehollin-Ray A, Guimaraes C, Krishnamurthy R. Current Role of Fetal Magnetic Resonance Imaging in Neurologic Anomalies.. Seminars in ultrasound, CT, and MR, 2015.
46. Maeda A, Ono M, Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny EM, Tantillo MA, Kohn DH, Lyons KM, Robey PG, Young MF. WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.. The Journal of biological chemistry, 2015.
47. Rigueur D, Brugger S, Anbarchian T, Kim JK, Lee Y, Lyons KM. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015.
48. Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.. Developmental cell, 2014.
49. Güemes M, Garcia AJ, Rigueur D, Runke S, Wang W, Zhao G, Mayorga VH, Atti E, Tetradis S, Péault B, Lyons K, Miranda-Carboni GA, Krum SA. GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014.
50. Ascenzi M, Du X, Harding JI, Beylerian EN, de Silva BM, Gross BJ, Kastein HK, Wang W, Lyons KM, Schaeffer H. Automated Cell Detection and Morphometry on Growth Plate Images of Mouse Bone.. Applied mathematics, 2014.
51. Nishida T, Kubota S, Aoyama E, Janune D, Lyons KM, Takigawa M. CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts.. Journal of biochemistry, 2014.
52. Heman-Ackah YD, Sataloff RT, Laureyns G, Lurie D, Michael DD, Heuer R, Rubin A, Eller R, Chandran S, Abaza M, Lyons K, Divi V, Lott J, Johnson J, Hillenbrand J. Quantifying the cepstral peak prominence, a measure of dysphonia.. Journal of voice : official journal of the Voice Foundation, 2014.
53. Maeda-Uematsu A, Kubota S, Kawaki H, Kawata K, Miyake Y, Hattori T, Nishida T, Moritani N, Lyons KM, Iida S, Takigawa M. CCN2 as a novel molecule supporting energy metabolism of chondrocytes.. Journal of cellular biochemistry, 2014.
54. Cheung LC, Strickland DH, Howlett M, Ford J, Charles AK, Lyons KM, Brigstock DR, Goldschmeding R, Cole CH, Alexander WS, Kees UR. Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis.. Haematologica, 2014.
55. Wang W, Rigueur D, Lyons KM. TGFβ signaling in cartilage development and maintenance.. Birth defects research. Part C, Embryo today : reviews, 2014.
56. Rigueur D, Lyons KM. Whole-mount skeletal staining.. Methods in molecular biology (Clifton, N.J.), 2014.
57. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells.. Stem cell reports, 2013.
58. Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM. Smad7 regulates terminal maturation of chondrocytes in the growth plate.. Developmental biology, 2013.
59. Battula VL, Chen Y, Cabreira Mda G, Ruvolo V, Wang Z, Ma W, Konoplev S, Shpall E, Lyons K, Strunk D, Bueso-Ramos C, Davis RE, Konopleva M, Andreeff M. Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment.. Blood, 2013.
60. Hall-Glenn F, Aivazi A, Akopyan L, Ong JR, Baxter RR, Benya PD, Goldschmeding R, van Nieuwenhoven FA, Hunziker EB, Lyons KM. CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress.. Journal of cell communication and signaling, 2013.
61. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.. The Journal of biological chemistry, 2013.
62. Falke LL, Dendooven A, Leeuwis JW, Nguyen TQ, van Geest RJ, van der Giezen DM, Broekhuizen R, Lyons K, Stoop R, Kemperman H, Schlingemann R, Joles JA, Goldschmeding R. Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney.. Matrix biology : journal of the International Society for Matrix Biology, 2012.
63. Merrill AE, Sarukhanov A, Krejci P, Idoni B, Camacho N, Estrada KD, Lyons KM, Deixler H, Robinson H, Chitayat D, Curry CJ, Lachman RS, Wilcox WR, Krakow D. Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling.. American journal of human genetics, 2012.
64. Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM. CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis.. PloS one, 2012.
65. Heman-Ackah YD, Hawkshaw MJ, Lyons KM. Laryngeal thrush from asthma inhalers.. Ear, nose, & throat journal, 2012.
66. Estrada KD, Retting KN, Chin AM, Lyons KM. Smad6 is essential to limit BMP signaling during cartilage development.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011.
67. Nagashima T, Kim J, Li Q, Lydon JP, DeMayo FJ, Lyons KM, Matzuk MM. Connective tissue growth factor is required for normal follicle development and ovulation.. Molecular endocrinology (Baltimore, Md.), 2011.
68. Hall-Glenn F, Lyons KM. Roles for CCN2 in normal physiological processes.. Cellular and molecular life sciences : CMLS, 2011.
69. Ascenzi MG, Blanco C, Drayer I, Kim H, Wilson R, Retting KN, Lyons KM, Mohler G. Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization.. Journal of theoretical biology, 2011.
70. Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ. Systems genetics analysis of mouse chondrocyte differentiation.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011.
71. Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP. Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis.. International journal of oncology, 2011.
72. Nishida T, Emura K, Kubota S, Lyons KM, Takigawa M. CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011.
73. Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010.
74. Stevens JR, Miranda-Carboni GA, Singer MA, Brugger SM, Lyons KM, Lane TF. Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010.
75. Huang BL, Brugger SM, Lyons KM. Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.. The Journal of biological chemistry, 2010.
76. Edson MA, Nalam RL, Clementi C, Franco HL, Demayo FJ, Lyons KM, Pangas SA, Matzuk MM. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development.. Molecular endocrinology (Baltimore, Md.), 2010.
77. Song B, Estrada KD, Lyons KM. Smad signaling in skeletal development and regeneration.. Cytokine & growth factor reviews, 2009.
78. Chandran SK, Lyons KM, Divi V, Geyer M, Sataloff RT. Fungal laryngitis.. Ear, nose, & throat journal, 2009.
79. Lyons K, Ezaki M. Molecular regulation of limb growth.. The Journal of bone and joint surgery. American volume, 2009.
80. Turk T, Leeuwis JW, Gray J, Torti SV, Lyons KM, Nguyen TQ, Goldschmeding R. BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009.
81. Retting KN, Song B, Yoon BS, Lyons KM. BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation.. Development (Cambridge, England), 2009.
82. Eller R, Ginsburg M, Lurie D, Heman-Ackah Y, Lyons K, Sataloff R. Flexible laryngoscopy: a comparison of fiber optic and distal chip technologies-part 2: laryngopharyngeal reflux.. Journal of voice : official journal of the Voice Foundation, 2009.
83. Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M. Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.. Molecular endocrinology (Baltimore, Md.), 2009.
84. Maeda A, Nishida T, Aoyama E, Kubota S, Lyons KM, Kuboki T, Takigawa M. CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.. Journal of biochemistry, 2008.
85. Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M. Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008.
86. Nishida T, Kondo S, Maeda A, Kubota S, Lyons KM, Takigawa M. CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition.. Bone, 2008.
87. Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles JA, Vial C, Brandan E, Lyons KM, Goldschmeding R. CTGF inhibits BMP-7 signaling in diabetic nephropathy.. Journal of the American Society of Nephrology : JASN, 2008.
88. Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.. Journal of molecular biology, 2008.
89. Kuiper EJ, van Zijderveld R, Roestenberg P, Lyons KM, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2008.
90. Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A. Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.. The Journal of biological chemistry, 2008.
91. Einhorn TA, Laurencin CT, Lyons K. An AAOS-NIH symposium. Fracture repair: challenges, opportunities, and directions for future research.. The Journal of bone and joint surgery. American volume, 2008.
92. Laurencin CT, Einhorn TA, Lyons K. Fracture repair: challenges and opportunities.. The Journal of bone and joint surgery. American volume, 2008.
93. Eller R, Ginsburg M, Lurie D, Heman-Ackah Y, Lyons K, Sataloff R. Flexible laryngoscopy: a comparison of fiber optic and distal chip technologies. Part 1: vocal fold masses.. Journal of voice : official journal of the Voice Foundation, 2008.
94. Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG. Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development.. Cells, tissues, organs, 2007.
95. Kawaki H, Kubota S, Suzuki A, Yamada T, Matsumura T, Mandai T, Yao M, Maeda T, Lyons KM, Takigawa M. Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.. Biochemical and biophysical research communications, 2007.
96. Kuiper EJ, Roestenberg P, Ehlken C, Lambert V, van Treslong-de Groot HB, Lyons KM, Agostini HJ, Rakic JM, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO. Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2007.
97. Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM. CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.. Journal of cell communication and signaling, 2007.
98. Huang BL, Dornbach LM, Lyons KM. The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.. Journal of cell communication and signaling, 2007.
99. Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for the function of mouse embryonic fibroblasts.. Experimental cell research, 2006.
100. Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.. Development (Cambridge, England), 2006.
101. Gamradt SC, Abe N, Bahamonde ME, Lee YP, Nelson SD, Lyons KM, Lieberman JR. Tracking expression of virally mediated BMP-2 in gene therapy for bone repair.. Clinical orthopaedics and related research, 2006.
102. Wan DC, Shi YY, Nacamuli RP, Quarto N, Lyons KM, Longaker MT. Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
103. Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE. Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis.. Human molecular genetics, 2006.
104. Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.. The Journal of biological chemistry, 2006.
105. Pogue R, Lyons K. BMP signaling in the cartilage growth plate.. Current topics in developmental biology, 2006.
106. Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
107. Lee NV, Rodriguez-Manzaneque JC, Thai SN, Twal WO, Luque A, Lyons KM, Argraves WS, Iruela-Arispe ML. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.. The Journal of biological chemistry, 2005.
108. Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. GDF11 controls the timing of progenitor cell competence in developing retina.. Science (New York, N.Y.), 2005.
109. Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM. Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm.. Development (Cambridge, England), 2005.
110. Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
111. Murali D, Yoshikawa S, Corrigan RR, Plas DJ, Crair MC, Oliver G, Lyons KM, Mishina Y, Furuta Y. Distinct developmental programs require different levels of Bmp signaling during mouse retinal development.. Development (Cambridge, England), 2005.
112. Chuva de Sousa Lopes SM, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P, Mummery CL. Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.. Developmental dynamics : an official publication of the American Association of Anatomists, 2004.
113. Wine-Lee L, Ahn KJ, Richardson RD, Mishina Y, Lyons KM, Crenshaw EB. Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord.. Development (Cambridge, England), 2004.
114. Brugger SM, Merrill AE, Torres-Vazquez J, Wu N, Ting MC, Cho JY, Dobias SL, Yi SE, Lyons K, Bell JR, Arora K, Warrior R, Maxson R. A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos.. Development (Cambridge, England), 2004.
115. Chen Y, Abraham DJ, Shi-Wen X, Pearson JD, Black CM, Lyons KM, Leask A. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.. Molecular biology of the cell, 2004.
116. Yoon BS, Lyons KM. Multiple functions of BMPs in chondrogenesis.. Journal of cellular biochemistry, 2004.
117. Nakamura K, Kennedy MA, Baldán A, Bojanic DD, Lyons K, Edwards PA. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein.. The Journal of biological chemistry, 2004.
118. Andl T, Ahn K, Kairo A, Chu EY, Wine-Lee L, Reddy ST, Croft NJ, Cebra-Thomas JA, Metzger D, Chambon P, Lyons KM, Mishina Y, Seykora JT, Crenshaw EB, Millar SE. Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.. Development (Cambridge, England), 2004.
119. Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development.. Development (Cambridge, England), 2003.
120. Schneider MD, Gaussin V, Lyons KM. Tempting fate: BMP signals for cardiac morphogenesis.. Cytokine & growth factor reviews, 2003.
121. Wu HH, Ivkovic S, Murray RC, Jaramillo S, Lyons KM, Johnson JE, Calof AL. Autoregulation of neurogenesis by GDF11.. Neuron, 2003.
122. Nishimura I, Drake TA, Lusis AJ, Lyons KM, Nadeau JH, Zernik J. ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities.. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 2003.