Publications

1. Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C. Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.. Nature, 2024.
2. Parthasarathy D, Pothula KR, Dam KA, Ratnapriya S, Benet HC, Parsons R, Huang X, Sammour S, Janowska K, Harris M, Sacco S, Sodroski J, Bridges MD, Hubbell WL, Acharya P, Herschhorn A. Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies.. bioRxiv : the preprint server for biology, 2023.
3. Khan F, Elgeti M, Grandfield S, Paz A, Naughton FB, Marcoline FV, Althoff T, Ermolova N, Wright EM, Hubbell WL, Grabe M, Abramson J. Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.. Nature communications, 2023.
4. Chen M, Kálai T, Cascio D, Bridges MD, Whitelegge JP, Elgeti M, Hubbell WL. A Highly Ordered Nitroxide Side Chain for Distance Mapping and Monitoring Slow Structural Fluctuations in Proteins.. Applied magnetic resonance, 2023.
5. Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, Che T, Hubbell WL, Kobilka BK, Chen C. Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy.. bioRxiv : the preprint server for biology, 2023.
6. Yang Z, Dam KA, Bridges MD, Hoffmann MAG, DeLaitsch AT, Gristick HB, Escolano A, Gautam R, Martin MA, Nussenzweig MC, Hubbell WL, Bjorkman PJ. Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.. Nature communications, 2022.
7. Gaffney KA, Guo R, Bridges MD, Muhammednazaar S, Chen D, Kim M, Yang Z, Schilmiller AL, Faruk NF, Peng X, Jones AD, Kim KH, Sun L, Hubbell WL, Sosnick TR, Hong H. Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
8. Elgeti M, Hubbell WL. DEER Analysis of GPCR Conformational Heterogeneity.. Biomolecules, 2021.
9. Chen Q, Zhuo Y, Sharma P, Perez I, Francis DJ, Chakravarthy S, Vishnivetskiy SA, Berndt S, Hanson SM, Zhan X, Brooks EK, Altenbach C, Hubbell WL, Klug CS, Iverson TM, Gurevich VV. An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins.. Journal of molecular biology, 2020.
10. Lerch MT, Matt RA, Masureel M, Elgeti M, Kumar KK, Hilger D, Foys B, Kobilka BK, Hubbell WL. Viewing rare conformations of the β2 adrenergic receptor with pressure-resolved DEER spectroscopy.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
11. McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
12. Sanabria H, Rodnin D, Hemmen K, Peulen TO, Felekyan S, Fleissner MR, Dimura M, Koberling F, Kühnemuth R, Hubbell W, Gohlke H, Seidel CAM. Resolving dynamics and function of transient states in single enzyme molecules.. Nature communications, 2020.
13. Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.. Cell, 2019.
14. Gu X, Bridges MD, Yan Y, de Waal PW, Zhou XE, Suino-Powell KM, Xu HE, Hubbell WL, Melcher K. Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).. The Journal of biological chemistry, 2018.
15. Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. Structural basis for activation of voltage sensor domains in an ion channel TPC1.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
16. Stadtmueller BM, Bridges MD, Dam KM, Lerch MT, Huey-Tubman KE, Hubbell WL, Bjorkman PJ. DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions.. Immunity, 2018.
17. Van Eps N, Altenbach C, Caro LN, Latorraca NR, Hollingsworth SA, Dror RO, Ernst OP, Hubbell WL. Gi- and Gs-coupled GPCRs show different modes of G-protein binding.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
18. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
19. Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.. Cell, 2017.
20. Van Eps N, Caro LN, Morizumi T, Kusnetzow AK, Szczepek M, Hofmann KP, Bayburt TH, Sligar SG, Ernst OP, Hubbell WL. Conformational equilibria of light-activated rhodopsin in nanodiscs.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
21. Wheatley NM, Eden KD, Ngo J, Rosinski JS, Sawaya MR, Cascio D, Collazo M, Hoveida H, Hubbell WL, Yeates TO. A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein.. Journal of molecular biology, 2016.
22. Stadtmueller BM, Yang Z, Huey-Tubman KE, Roberts-Mataric H, Hubbell WL, Bjorkman PJ. Biophysical and Biochemical Characterization of Avian Secretory Component Provides Structural Insights into the Evolution of the Polymeric Ig Receptor.. Journal of immunology (Baltimore, Md. : 1950), 2016.
23. Yang Z, Bridges MD, López CJ, Rogozhnikova OY, Trukhin DV, Brooks EK, Tormyshev V, Halpern HJ, Hubbell WL. A triarylmethyl spin label for long-range distance measurement at physiological temperatures using T1 relaxation enhancement.. Journal of magnetic resonance (San Diego, Calif. : 1997), 2016.
24. Davydov DR, Yang Z, Davydova N, Halpert JR, Hubbell WL. Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy.. Biophysical journal, 2016.
25. Guo R, Gaffney K, Yang Z, Kim M, Sungsuwan S, Huang X, Hubbell WL, Hong H. Steric trapping reveals a cooperativity network in the intramembrane protease GlpG.. Nature chemical biology, 2016.
26. Stadtmueller BM, Huey-Tubman KE, López CJ, Yang Z, Hubbell WL, Bjorkman PJ. The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins.. eLife, 2016.
27. Lerch MT, Yang Z, Altenbach C, Hubbell WL. High-Pressure EPR and Site-Directed Spin Labeling for Mapping Molecular Flexibility in Proteins.. Methods in enzymology, 2015.
28. Altenbach C, López CJ, Hideg K, Hubbell WL. Exploring Structure, Dynamics, and Topology of Nitroxide Spin-Labeled Proteins Using Continuous-Wave Electron Paramagnetic Resonance Spectroscopy.. Methods in enzymology, 2015.
29. Yang Z, Bridges M, Lerch MT, Altenbach C, Hubbell WL. Saturation Recovery EPR and Nitroxide Spin Labeling for Exploring Structure and Dynamics in Proteins.. Methods in enzymology, 2015.
30. Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.. Nature, 2015.
31. Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.. Science (New York, N.Y.), 2015.
32. Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.. Cell, 2015.
33. Lerch MT, López CJ, Yang Z, Kreitman MJ, Horwitz J, Hubbell WL. Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
34. Van Eps N, Thomas CJ, Hubbell WL, Sprang SR. The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
35. Dutta A, Altenbach C, Mangahas S, Yanamala N, Gardner E, Hubbell WL, Klein-Seetharaman J. Differential dynamics of extracellular and cytoplasmic domains in denatured States of rhodopsin.. Biochemistry, 2014.
36. López CJ, Fleissner MR, Brooks EK, Hubbell WL. Stationary-phase EPR for exploring protein structure, conformation, and dynamics in spin-labeled proteins.. Biochemistry, 2014.
37. Yang Z, Jiménez-Osés G, López CJ, Bridges MD, Houk KN, Hubbell WL. Long-range distance measurements in proteins at physiological temperatures using saturation recovery EPR spectroscopy.. Journal of the American Chemical Society, 2014.
38. Vendome J, Felsovalyi K, Song H, Yang Z, Jin X, Brasch J, Harrison OJ, Ahlsen G, Bahna F, Kaczynska A, Katsamba PS, Edmond D, Hubbell WL, Shapiro L, Honig B. Structural and energetic determinants of adhesive binding specificity in type I cadherins.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
39. Lerch MT, Yang Z, Brooks EK, Hubbell WL. Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron-electron resonance.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
40. Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J. High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population.. The Journal of biological chemistry, 2014.
41. Chen Q, Zhuo Y, Kim M, Hanson SM, Francis DJ, Vishnivetskiy SA, Altenbach C, Klug CS, Hubbell WL, Gurevich VV. Self-association of arrestin family members.. Handbook of experimental pharmacology, 2014.
42. Lerch MT, Horwitz J, McCoy J, Hubbell WL. Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
43. López CJ, Yang Z, Altenbach C, Hubbell WL. Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
44. Song X, Seo J, Baameur F, Vishnivetskiy SA, Chen Q, Kook S, Kim M, Brooks EK, Altenbach C, Hong Y, Hanson SM, Palazzo MC, Chen J, Hubbell WL, Gurevich EV, Gurevich VV. Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.. Cellular signalling, 2013.
45. Hubbell WL, López CJ, Altenbach C, Yang Z. Technological advances in site-directed spin labeling of proteins.. Current opinion in structural biology, 2013.
46. Razzaghi S, Brooks EK, Bordignon E, Hubbell WL, Yulikov M, Jeschke G. EPR relaxation-enhancement-based distance measurements on orthogonally spin-labeled T4-lysozyme.. Chembiochem : a European journal of chemical biology, 2013.
47. Toledo Warshaviak D, Khramtsov VV, Cascio D, Altenbach C, Hubbell WL. Structure and dynamics of an imidazoline nitroxide side chain with strongly hindered internal motion in proteins.. Journal of magnetic resonance (San Diego, Calif. : 1997), 2013.
48. Garbuio L, Bordignon E, Brooks EK, Hubbell WL, Jeschke G, Yulikov M. Orthogonal spin labeling and Gd(III)-nitroxide distance measurements on bacteriophage T4-lysozyme.. The journal of physical chemistry. B, 2013.
49. Vishnivetskiy SA, Chen Q, Palazzo MC, Brooks EK, Altenbach C, Iverson TM, Hubbell WL, Gurevich VV. Engineering visual arrestin-1 with special functional characteristics.. The Journal of biological chemistry, 2012.
50. Kim M, Vishnivetskiy SA, Van Eps N, Alexander NS, Cleghorn WM, Zhan X, Hanson SM, Morizumi T, Ernst OP, Meiler J, Gurevich VV, Hubbell WL. Conformation of receptor-bound visual arrestin.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
51. Francis DJ, Hubbell WL, Klug CS. Probing Protein Secondary Structure using EPR: Investigating a Dynamic Region of Visual Arrestin.. Applied magnetic resonance, 2012.
52. Durer ZA, Kudryashov DS, Sawaya MR, Altenbach C, Hubbell W, Reisler E. Structural states and dynamics of the D-loop in actin.. Biophysical journal, 2012.
53. López CJ, Oga S, Hubbell WL. Mapping molecular flexibility of proteins with site-directed spin labeling: a case study of myoglobin.. Biochemistry, 2012.
54. Yang Z, Liu Y, Borbat P, Zweier JL, Freed JH, Hubbell WL. Pulsed ESR dipolar spectroscopy for distance measurements in immobilized spin labeled proteins in liquid solution.. Journal of the American Chemical Society, 2012.
55. Fawzi NL, Fleissner MR, Anthis NJ, Kálai T, Hideg K, Hubbell WL, Clore GM. A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data.. Journal of biomolecular NMR, 2011.
56. Fleissner MR, Bridges MD, Brooks EK, Cascio D, Kálai T, Hideg K, Hubbell WL. Structure and dynamics of a conformationally constrained nitroxide side chain and applications in EPR spectroscopy.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
57. Januszyk K, Fleissner MR, Atchabahian L, Shieh FK, Altenbach C, Martin SL, Guo F, Hubbell WL, Clubb RT. Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon.. Protein science : a publication of the Protein Society, 2011.
58. Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL. Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
59. Vishnivetskiy SA, Gimenez LE, Francis DJ, Hanson SM, Hubbell WL, Klug CS, Gurevich VV. Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins.. The Journal of biological chemistry, 2011.
60. Armstrong BD, Choi J, López C, Wesener DA, Hubbell W, Cavagnero S, Han S. Site-specific hydration dynamics in the nonpolar core of a molten globule by dynamic nuclear polarization of water.. Journal of the American Chemical Society, 2011.
61. Kim M, Hanson SM, Vishnivetskiy SA, Song X, Cleghorn WM, Hubbell WL, Gurevich VV. Robust self-association is a common feature of mammalian visual arrestin-1.. Biochemistry, 2011.
62. McCoy J, Hubbell WL. High-pressure EPR reveals conformational equilibria and volumetric properties of spin-labeled proteins.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
63. Warshaviak DT, Serbulea L, Houk KN, Hubbell WL. Conformational analysis of a nitroxide side chain in an α-helix with density functional theory.. The journal of physical chemistry. B, 2010.
64. Van Eps N, Anderson LL, Kisselev OG, Baranski TJ, Hubbell WL, Marshall GR. Electron paramagnetic resonance studies of functionally active, nitroxide spin-labeled peptide analogues of the C-terminus of a G-protein alpha subunit.. Biochemistry, 2010.
65. Zhang Z, Fleissner MR, Tipikin DS, Liang Z, Moscicki JK, Earle KA, Hubbell WL, Freed JH. Multifrequency electron spin resonance study of the dynamics of spin labeled T4 lysozyme.. The journal of physical chemistry. B, 2010.
66. Bridges MD, Hideg K, Hubbell WL. Resolving Conformational and Rotameric Exchange in Spin-Labeled Proteins Using Saturation Recovery EPR.. Applied magnetic resonance, 2010.
67. Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL. Site-directed spin labeling of a genetically encoded unnatural amino acid.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
68. Vishnivetskiy SA, Francis D, Van Eps N, Kim M, Hanson SM, Klug CS, Hubbell WL, Gurevich VV. The role of arrestin alpha-helix I in receptor binding.. Journal of molecular biology, 2009.
69. López CJ, Fleissner MR, Guo Z, Kusnetzow AK, Hubbell WL. Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins.. Protein science : a publication of the Protein Society, 2009.
70. Fleissner MR, Cascio D, Hubbell WL. Structural origin of weakly ordered nitroxide motion in spin-labeled proteins.. Protein science : a publication of the Protein Society, 2009.
71. Scoville D, Stamm JD, Altenbach C, Shvetsov A, Kokabi K, Rubenstein PA, Hubbell WL, Reisler E. Effects of binding factors on structural elements in F-actin.. Biochemistry, 2009.
72. Schwartz TW, Hubbell WL. Structural biology: A moving story of receptors.. Nature, 2008.
73. Hanson SM, Dawson ES, Francis DJ, Van Eps N, Klug CS, Hubbell WL, Meiler J, Gurevich VV. A model for the solution structure of the rod arrestin tetramer.. Structure (London, England : 1993), 2008.
74. Altenbach C, Kusnetzow AK, Ernst OP, Hofmann KP, Hubbell WL. High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
75. Vamvouka M, Cieslak J, Van Eps N, Hubbell W, Gross A. The structure of the lipid-embedded potassium channel voltage sensor determined by double-electron-electron resonance spectroscopy.. Protein science : a publication of the Protein Society, 2008.
76. Hanson SM, Vishnivetskiy SA, Hubbell WL, Gurevich VV. Opposing effects of inositol hexakisphosphate on rod arrestin and arrestin2 self-association.. Biochemistry, 2007.
77. Guo Z, Cascio D, Hideg K, Hubbell WL. Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme.. Protein science : a publication of the Protein Society, 2007.
78. Knierim B, Hofmann KP, Ernst OP, Hubbell WL. Sequence of late molecular events in the activation of rhodopsin.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
79. Knierim B, Hofmann KP, Gärtner W, Hubbell WL, Ernst OP. Rhodopsin and 9-demethyl-retinal analog: effect of a partial agonist on displacement of transmembrane helix 6 in class A G protein-coupled receptors.. The Journal of biological chemistry, 2007.
80. Epand RF, Zhang YL, Mirzabekov T, Kagan B, Silberstein A, Hubbell WL, Epand RM, Chakraborti S, Dimitrov DS, Anderson WF, Rozenberg-Adler Y. Membrane activity of an amphiphilic alpha-helical membrane-proximal cytoplasmic domain of the MoMuLV envelope glycoprotein.. Experimental and molecular pathology, 2007.
81. Smirnova I, Kasho V, Choe JY, Altenbach C, Hubbell WL, Kaback HR. Sugar binding induces an outward facing conformation of LacY.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
82. Guo Z, Cascio D, Hideg K, Kálái T, Hubbell WL. Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme.. Protein science : a publication of the Protein Society, 2007.
83. Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE. Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
84. Sasaki J, Phillips BJ, Chen X, Van Eps N, Tsai AL, Hubbell WL, Spudich JL. Different dark conformations function in color-sensitive photosignaling by the sensory rhodopsin I-HtrI complex.. Biophysical journal, 2007.
85. Hanson SM, Van Eps N, Francis DJ, Altenbach C, Vishnivetskiy SA, Arshavsky VY, Klug CS, Hubbell WL, Gurevich VV. Structure and function of the visual arrestin oligomer.. The EMBO journal, 2007.
86. Scoville D, Stamm JD, Toledo-Warshaviak D, Altenbach C, Phillips M, Shvetsov A, Rubenstein PA, Hubbell WL, Reisler E. Hydrophobic loop dynamics and actin filament stability.. Biochemistry, 2006.
87. Van Eps N, Oldham WM, Hamm HE, Hubbell WL. Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
88. Cai Q, Kusnetzow AK, Hubbell WL, Haworth IS, Gacho GP, Van Eps N, Hideg K, Chambers EJ, Qin PZ. Site-directed spin labeling measurements of nanometer distances in nucleic acids using a sequence-independent nitroxide probe.. Nucleic acids research, 2006.
89. Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.. Nature structural & molecular biology, 2006.
90. Crane JM, Suo Y, Lilly AA, Mao C, Hubbell WL, Randall LL. Sites of interaction of a precursor polypeptide on the export chaperone SecB mapped by site-directed spin labeling.. Journal of molecular biology, 2006.
91. Jacobsen K, Hubbell WL, Ernst OP, Risse T. Details of the partial unfolding of T4 lysozyme on quartz using site-directed spin labeling.. Angewandte Chemie (International ed. in English), 2006.
92. Shvetsov A, Stamm JD, Phillips M, Warshaviak D, Altenbach C, Rubenstein PA, Hideg K, Hubbell WL, Reisler E. Conformational dynamics of loop 262-274 in G- and F-actin.. Biochemistry, 2006.
93. Kusnetzow AK, Altenbach C, Hubbell WL. Conformational states and dynamics of rhodopsin in micelles and bilayers.. Biochemistry, 2006.
94. Hanson SM, Francis DJ, Vishnivetskiy SA, Kolobova EA, Hubbell WL, Klug CS, Gurevich VV. Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
95. Crane JM, Mao C, Lilly AA, Smith VF, Suo Y, Hubbell WL, Randall LL. Mapping of the docking of SecA onto the chaperone SecB by site-directed spin labeling: insight into the mechanism of ligand transfer during protein export.. Journal of molecular biology, 2005.
96. Qin PZ, Feigon J, Hubbell WL. Site-directed spin labeling studies reveal solution conformational changes in a GAAA tetraloop receptor upon Mg(2+)-dependent docking of a GAAA tetraloop.. Journal of molecular biology, 2005.
97. Pyka J, Ilnicki J, Altenbach C, Hubbell WL, Froncisz W. Accessibility and dynamics of nitroxide side chains in T4 lysozyme measured by saturation recovery EPR.. Biophysical journal, 2005.
98. Altenbach C, Froncisz W, Hemker R, McHaourab H, Hubbell WL. Accessibility of nitroxide side chains: absolute Heisenberg exchange rates from power saturation EPR.. Biophysical journal, 2005.
99. Jacobsen K, Oga S, Hubbell WL, Risse T. Determination of the orientation of T4 lysozyme vectorially bound to a planar-supported lipid bilayer using site-directed spin labeling.. Biophysical journal, 2005.
100. Klug CS, Camenisch TG, Hubbell WL, Hyde JS. Multiquantum EPR spectroscopy of spin-labeled arrestin K267C at 35 GHz.. Biophysical journal, 2005.
101. Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG. Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge.. Proceedings of the National Academy of Sciences of the United States of America, 2004.
102. Columbus L, Hubbell WL. Mapping backbone dynamics in solution with site-directed spin labeling: GCN4-58 bZip free and bound to DNA.. Biochemistry, 2004.
103. Isas JM, Langen R, Hubbell WL, Haigler HT. Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12.. The Journal of biological chemistry, 2004.
104. Lietzow MA, Hubbell WL. Motion of spin label side chains in cellular retinol-binding protein: correlation with structure and nearest-neighbor interactions in an antiparallel beta-sheet.. Biochemistry, 2004.
105. Risse T, Hubbell WL, Isas JM, Haigler HT. Structure and dynamics of annexin 12 bound to a planar lipid bilayer.. Physical review letters, 2003.
106. Preininger AM, Van Eps N, Yu NJ, Medkova M, Hubbell WL, Hamm HE. The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution.. Biochemistry, 2003.
107. Qin PZ, Hideg K, Feigon J, Hubbell WL. Monitoring RNA base structure and dynamics using site-directed spin labeling.. Biochemistry, 2003.
108. Zhang JH, Xiao G, Gunsalus RP, Hubbell WL. Phosphorylation triggers domain separation in the DNA binding response regulator NarL.. Biochemistry, 2003.
109. Hubbell WL, Altenbach C, Hubbell CM, Khorana HG. Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking.. Advances in protein chemistry, 2003.
110. Serag AA, Altenbach C, Gingery M, Hubbell WL, Yeates TO. Arrangement of subunits and ordering of beta-strands in an amyloid sheet.. Nature structural biology, 2002.
111. Medkova M, Preininger AM, Yu NJ, Hubbell WL, Hamm HE. Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation.. Biochemistry, 2002.
112. Barnakov A, Altenbach C, Barnakova L, Hubbell WL, Hazelbauer GL. Site-directed spin labeling of a bacterial chemoreceptor reveals a dynamic, loosely packed transmembrane domain.. Protein science : a publication of the Protein Society, 2002.
113. Isas JM, Langen R, Haigler HT, Hubbell WL. Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study.. Biochemistry, 2002.
114. Gross A, Hubbell WL. Identification of protein side chains near the membrane-aqueous interface: a site-directed spin labeling study of KcsA.. Biochemistry, 2002.
115. Sutton MD, Guzzo A, Narumi I, Costanzo M, Altenbach C, Ferentz AE, Hubbell WL, Walker GC. A model for the structure of the Escherichia coli SOS-regulated UmuD2 protein.. DNA repair, 2002.
116. Altenbach C, Oh KJ, Trabanino RJ, Hideg K, Hubbell WL. Estimation of inter-residue distances in spin labeled proteins at physiological temperatures: experimental strategies and practical limitations.. Biochemistry, 2001.
117. Altenbach C, Klein-Seetharaman J, Cai K, Khorana HG, Hubbell WL. Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1.. Biochemistry, 2001.
118. Altenbach C, Cai K, Klein-Seetharaman J, Khorana HG, Hubbell WL. Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 65 in helix TM1 and residues in the sequence 306-319 at the cytoplasmic end of helix TM7 and in helix H8.. Biochemistry, 2001.
119. Klein-Seetharaman J, Hwa J, Cai K, Altenbach C, Hubbell WL, Khorana HG. Probing the dark state tertiary structure in the cytoplasmic domain of rhodopsin: proximities between amino acids deduced from spontaneous disulfide bond formation between Cys316 and engineered cysteines in cytoplasmic loop 1.. Biochemistry, 2001.
120. Cai K, Klein-Seetharaman J, Altenbach C, Hubbell WL, Khorana HG. Probing the dark state tertiary structure in the cytoplasmic domain of rhodopsin: proximities between amino acids deduced from spontaneous disulfide bond formation between cysteine pairs engineered in cytoplasmic loops 1, 3, and 4.. Biochemistry, 2001.
121. Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K. Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies.. The Journal of biological chemistry, 2001.
122. Columbus L, Kálai T, Jekö J, Hideg K, Hubbell WL. Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure.. Biochemistry, 2001.
123. Voss J, Wu J, Hubbell WL, Jacques V, Meares CF, Kaback HR. Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide.. Biochemistry, 2001.
124. Zhao M, Kálai T, Hideg K, Altenbach C, Hubbell WL, Kaback HR. Binding of spin-labeled galactosides to the lactose permease of Escherichia coli.. Biochemistry, 2000.
125. Hubbell WL, Cafiso DS, Altenbach C. Identifying conformational changes with site-directed spin labeling.. Nature structural biology, 2000.
126. Langen R, Oh KJ, Cascio D, Hubbell WL. Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure.. Biochemistry, 2000.
127. Mollaaghababa R, Steinhoff HJ, Hubbell WL, Khorana HG. Time-resolved site-directed spin-labeling studies of bacteriorhodopsin: loop-specific conformational changes in M.. Biochemistry, 2000.
128. Gaponenko V, Howarth JW, Columbus L, Gasmi-Seabrook G, Yuan J, Hubbell WL, Rosevear PR. Protein global fold determination using site-directed spin and isotope labeling.. Protein science : a publication of the Protein Society, 2000.
129. Oh KJ, Altenbach C, Collier RJ, Hubbell WL. Site-directed spin labeling of proteins. Applications to diphtheria toxin.. Methods in molecular biology (Clifton, N.J.), 2000.
130. Zhao M, Zen KC, Hernandez-Borrell J, Altenbach C, Hubbell WL, Kaback HR. Nitroxide scanning electron paramagnetic resonance of helices IV and V and the intervening loop in the lactose permease of Escherichia coli.. Biochemistry, 1999.
131. Glasgow BJ, Gasymov OK, Abduragimov AR, Yusifov TN, Altenbach C, Hubbell WL. Side chain mobility and ligand interactions of the G strand of tear lipocalins by site-directed spin labeling.. Biochemistry, 1999.
132. Cai K, Klein-Seetharaman J, Hwa J, Hubbell WL, Khorana HG. Structure and function in rhodopsin: effects of disulfide cross-links in the cytoplasmic face of rhodopsin on transducin activation and phosphorylation by rhodopsin kinase.. Biochemistry, 1999.
133. Oh KJ, Zhan H, Cui C, Altenbach C, Hubbell WL, Collier RJ. Conformation of the diphtheria toxin T domain in membranes: a site-directed spin-labeling study of the TH8 helix and TL5 loop.. Biochemistry, 1999.
134. Gross A, Columbus L, Hideg K, Altenbach C, Hubbell WL. Structure of the KcsA potassium channel from Streptomyces lividans: a site-directed spin labeling study of the second transmembrane segment.. Biochemistry, 1999.
135. Cai K, Klein-Seetharaman J, Farrens D, Zhang C, Altenbach C, Hubbell WL, Khorana HG. Single-cysteine substitution mutants at amino acid positions 306-321 in rhodopsin, the sequence between the cytoplasmic end of helix VII and the palmitoylation sites: sulfhydryl reactivity and transducin activation reveal a tertiary structure.. Biochemistry, 1999.
136. Klein-Seetharaman J, Hwa J, Cai K, Altenbach C, Hubbell WL, Khorana HG. Single-cysteine substitution mutants at amino acid positions 55-75, the sequence connecting the cytoplasmic ends of helices I and II in rhodopsin: reactivity of the sulfhydryl groups and their derivatives identifies a tertiary structure that changes upon light-activation.. Biochemistry, 1999.
137. Altenbach C, Cai K, Khorana HG, Hubbell WL. Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: a site-directed spin-labeling study.. Biochemistry, 1999.
138. Altenbach C, Klein-Seetharaman J, Hwa J, Khorana HG, Hubbell WL. Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: a site-directed spin-labeling study.. Biochemistry, 1999.
139. Langen R, Cai K, Altenbach C, Khorana HG, Hubbell WL. Structural features of the C-terminal domain of bovine rhodopsin: a site-directed spin-labeling study.. Biochemistry, 1999.
140. Zhao M, Zen KC, Hubbell WL, Kaback HR. Proximity between Glu126 and Arg144 in the lactose permease of Escherichia coli.. Biochemistry, 1999.
141. Barnes JP, Liang Z, Mchaourab HS, Freed JH, Hubbell WL. A multifrequency electron spin resonance study of T4 lysozyme dynamics.. Biophysical journal, 1999.
142. Mchaourab HS, Kálai T, Hideg K, Hubbell WL. Motion of spin-labeled side chains in T4 lysozyme: effect of side chain structure.. Biochemistry, 1999.
143. Sun J, Voss J, Hubbell WL, Kaback HR. Proximity between periplasmic loops in the lactose permease of Escherichia coli as determined by site-directed spin labeling.. Biochemistry, 1999.
144. Salwinski L, Hubbell WL. Structure in the channel forming domain of colicin E1 bound to membranes: the 402-424 sequence.. Protein science : a publication of the Protein Society, 1999.
145. Langen R, Isas JM, Hubbell WL, Haigler HT. A transmembrane form of annexin XII detected by site-directed spin labeling.. Proceedings of the National Academy of Sciences of the United States of America, 1998.
146. Hubbell WL, Gross A, Langen R, Lietzow MA. Recent advances in site-directed spin labeling of proteins.. Current opinion in structural biology, 1998.
147. Piasecki W, Froncisz W, Hubbell WL. A rectangular loop-gap resonator for EPR studies of aqueous samples.. Journal of magnetic resonance (San Diego, Calif. : 1997), 1998.
148. Langen R, Isas JM, Luecke H, Haigler HT, Hubbell WL. Membrane-mediated assembly of annexins studied by site-directed spin labeling.. The Journal of biological chemistry, 1998.
149. Wang Q, Voss J, Hubbell WL, Kaback HR. Proximity of helices VIII (Ala273) and IX (Met299) in the lactose permease of Escherichia coli.. Biochemistry, 1998.
150. Lin Y, Nielsen R, Murray D, Hubbell WL, Mailer C, Robinson BH, Gelb MH. Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance.. Science (New York, N.Y.), 1998.
151. Glasgow BJ, Abduragimov AR, Yusifov TN, Gasymov OK, Horwitz J, Hubbell WL, Faull KF. A conserved disulfide motif in human tear lipocalins influences ligand binding.. Biochemistry, 1998.
152. Voss J, Hubbell WL, Kaback HR. Helix packing in the lactose permease determined by metal-nitroxide interaction.. Biochemistry, 1998.
153. Kim JM, Altenbach C, Thurmond RL, Khorana HG, Hubbell WL. Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state.. Proceedings of the National Academy of Sciences of the United States of America, 1997.
154. Cai K, Langen R, Hubbell WL, Khorana HG. Structure and function in rhodopsin: topology of the C-terminal polypeptide chain in relation to the cytoplasmic loops.. Proceedings of the National Academy of Sciences of the United States of America, 1997.
155. Voss J, Hubbell WL, Hernandez-Borrell J, Kaback HR. Site-directed spin-labeling of transmembrane domain VII and the 4B1 antibody epitope in the lactose permease of Escherichia coli.. Biochemistry, 1997.
156. He MM, Voss J, Hubbell WL, Kaback HR. Arginine 302 (helix IX) in the lactose permease of Escherichia coli is in close proximity to glutamate 269 (helix VIII) as well as glutamate 325.. Biochemistry, 1997.
157. Mchaourab HS, Oh KJ, Fang CJ, Hubbell WL. Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling.. Biochemistry, 1997.
158. Yang K, Farrens DL, Altenbach C, Farahbakhsh ZT, Hubbell WL, Khorana HG. Structure and function in rhodopsin. Cysteines 65 and 316 are in proximity in a rhodopsin mutant as indicated by disulfide formation and interactions between attached spin labels.. Biochemistry, 1996.
159. Farrens DL, Altenbach C, Yang K, Hubbell WL, Khorana HG. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin.. Science (New York, N.Y.), 1996.
160. Steinhoff HJ, Hubbell WL. Calculation of electron paramagnetic resonance spectra from Brownian dynamics trajectories: application to nitroxide side chains in proteins.. Biophysical journal, 1996.
161. Voss J, He MM, Hubbell WL, Kaback HR. Site-directed spin labeling demonstrates that transmembrane domain XII in the lactose permease of Escherichia coli is an alpha-helix.. Biochemistry, 1996.
162. Altenbach C, Yang K, Farrens DL, Farahbakhsh ZT, Khorana HG, Hubbell WL. Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study.. Biochemistry, 1996.
163. Yang K, Farrens DL, Hubbell WL, Khorana HG. Structure and function in rhodopsin. Single cysteine substitution mutants in the cytoplasmic interhelical E-F loop region show position-specific effects in transducin activation.. Biochemistry, 1996.
164. Wu J, Voss J, Hubbell WL, Kaback HR. Site-directed spin labeling and chemical crosslinking demonstrate that helix V is close to helices VII and VIII in the lactose permease of Escherichia coli.. Proceedings of the National Academy of Sciences of the United States of America, 1996.
165. Oh KJ, Zhan H, Cui C, Hideg K, Collier RJ, Hubbell WL. Organization of diphtheria toxin T domain in bilayers: a site-directed spin labeling study.. Science (New York, N.Y.), 1996.
166. Hubbell WL, Mchaourab HS, Altenbach C, Lietzow MA. Watching proteins move using site-directed spin labeling.. Structure (London, England : 1993), 1996.
167. Mchaourab HS, Lietzow MA, Hideg K, Hubbell WL. Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics.. Biochemistry, 1996.
168. Wiedau-Pazos M, Trudell JR, Altenbach C, Kane DJ, Hubbell WL, Bredesen DE. Expression of bcl-2 inhibits cellular radical generation.. Free radical research, 1996.
169. Voss J, Salwinski L, Kaback HR, Hubbell WL. A method for distance determination in proteins using a designed metal ion binding site and site-directed spin labeling: evaluation with T4 lysozyme.. Proceedings of the National Academy of Sciences of the United States of America, 1995.
170. Voss J, Hubbell WL, Kaback HR. Distance determination in proteins using designed metal ion binding sites and site-directed spin labeling: application to the lactose permease of Escherichia coli.. Proceedings of the National Academy of Sciences of the United States of America, 1995.
171. He MM, Voss J, Hubbell WL, Kaback HR. Use of designed metal-binding sites to study helix proximity in the lactose permease of Escherichia coli. 1. Proximity of helix VII (Asp237 and Asp240) with helices X (Lys319) and XI (Lys358).. Biochemistry, 1995.
172. He MM, Voss J, Hubbell WL, Kaback HR. Use of designed metal-binding sites to study helix proximity in the lactose permease of Escherichia coli. 2. Proximity of helix IX (Arg302) with helix X (His322 and Glu325).. Biochemistry, 1995.
173. Ujwal ML, Jung H, Bibi E, Manoil C, Altenbach C, Hubbell WL, Kaback HR. Membrane topology of helices VII and XI in the lactose permease of Escherichia coli studied by lacY-phoA fusion analysis and site-directed spectroscopy.. Biochemistry, 1995.
174. Steinhoff HJ, Mollaaghababa R, Altenbach C, Khorana HG, Hubbell WL. Site directed spin labeling studies of structure and dynamics in bacteriorhodopsin.. Biophysical chemistry, 1995.
175. Farahbakhsh ZT, Ridge KD, Khorana HG, Hubbell WL. Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: a site-directed spin labeling study.. Biochemistry, 1995.
176. Jung K, Voss J, He M, Hubbell WL, Kaback HR. Engineering a metal binding site within a polytopic membrane protein, the lactose permease of Escherichia coli.. Biochemistry, 1995.
177. Glasgow BJ, Abduragimov AR, Farahbakhsh ZT, Faull KF, Hubbell WL. Tear lipocalins bind a broad array of lipid ligands.. Current eye research, 1995.
178. Zhan H, Oh KJ, Shin YK, Hubbell WL, Collier RJ. Interaction of the isolated transmembrane domain of diphtheria toxin with membranes.. Biochemistry, 1995.
179. Farahbakhsh ZT, Huang QL, Ding LL, Altenbach C, Steinhoff HJ, Horwitz J, Hubbell WL. Interaction of alpha-crystallin with spin-labeled peptides.. Biochemistry, 1995.
180. Steinhoff HJ, Mollaaghababa R, Altenbach C, Hideg K, Krebs M, Khorana HG, Hubbell WL. Time-resolved detection of structural changes during the photocycle of spin-labeled bacteriorhodopsin.. Science (New York, N.Y.), 1994.
181. Cornish VW, Benson DR, Altenbach CA, Hideg K, Hubbell WL, Schultz PG. Site-specific incorporation of biophysical probes into proteins.. Proceedings of the National Academy of Sciences of the United States of America, 1994.
182. Altenbach C, Greenhalgh DA, Khorana HG, Hubbell WL. A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin.. Proceedings of the National Academy of Sciences of the United States of America, 1994.
183. Farahbakhsh ZT, Hideg K, Hubbell WL. Photoactivated conformational changes in rhodopsin: a time-resolved spin label study.. Science (New York, N.Y.), 1993.
184. Resek JF, Farahbakhsh ZT, Hubbell WL, Khorana HG. Formation of the meta II photointermediate is accompanied by conformational changes in the cytoplasmic surface of rhodopsin.. Biochemistry, 1993.
185. Perozo E, Hubbell WL. Voltage activation of reconstituted sodium channels: use of bacteriorhodopsin as a light-driven current source.. Biochemistry, 1993.
186. Franklin JC, Cafiso DS, Flewelling RF, Hubbell WL. Probes of membrane electrostatics: synthesis and voltage-dependent partitioning of negative hydrophobic ion spin labels in lipid vesicles.. Biophysical journal, 1993.
187. Shin YK, Levinthal C, Levinthal F, Hubbell WL. Colicin E1 binding to membranes: time-resolved studies of spin-labeled mutants.. Science (New York, N.Y.), 1993.
188. Wu G, Hubbell WL. Phospholipid asymmetry and transmembrane diffusion in photoreceptor disc membranes.. Biochemistry, 1993.
189. Farahbakhsh ZT, Altenbach C, Hubbell WL. Spin labeled cysteines as sensors for protein-lipid interaction and conformation in rhodopsin.. Photochemistry and photobiology, 1992.
190. Shin YK, Hubbell WL. Determination of electrostatic potentials at biological interfaces using electron-electron double resonance.. Biophysical journal, 1992.
191. Anthony-Cahill SJ, Benfield PA, Fairman R, Wasserman ZR, Brenner SL, Stafford WF, Altenbach C, Hubbell WL, DeGrado WF. Molecular characterization of helix-loop-helix peptides.. Science (New York, N.Y.), 1992.
192. Greenhalgh DA, Altenbach C, Hubbell WL, Khorana HG. Locations of Arg-82, Asp-85, and Asp-96 in helix C of bacteriorhodopsin relative to the aqueous boundaries.. Proceedings of the National Academy of Sciences of the United States of America, 1991.
193. Levinthal F, Todd AP, Hubbell WL, Levinthal C. A single tryptic fragment of colicin E1 can form an ion channel: stoichiometry confirms kinetics.. Proteins, 1991.
194. Trudell JR, Costa AK, Hubbell WL. Inhibition of protein kinase C by local anesthetics.. Annals of the New York Academy of Sciences, 1991.
195. Tosteson MT, Alvarez O, Hubbell W, Bieganski RM, Attenbach C, Caporales LH, Levy JJ, Nutt RF, Rosenblatt M, Tosteson DC. Primary structure of peptides and ion channels. Role of amino acid side chains in voltage gating of melittin channels.. Biophysical journal, 1990.
196. Oldenburg KR, Hubbell WL. Invertebrate rhodopsin cleavage by an endogenous calcium activated protease.. Experimental eye research, 1990.
197. Altenbach C, Marti T, Khorana HG, Hubbell WL. Transmembrane protein structure: spin labeling of bacteriorhodopsin mutants.. Science (New York, N.Y.), 1990.
198. Tsui FC, Sundberg SA, Hubbell WL. Distribution of charge on photoreceptor disc membranes and implications for charged lipid asymmetry.. Biophysical journal, 1990.
199. Hubbell WL. Transbilayer coupling mechanism for the formation of lipid asymmetry in biological membranes. Application to the photoreceptor disc membrane.. Biophysical journal, 1990.
200. Altenbach C, Froncisz W, Hyde JS, Hubbell WL. Conformation of spin-labeled melittin at membrane surfaces investigated by pulse saturation recovery and continuous wave power saturation electron paramagnetic resonance.. Biophysical journal, 1989.
201. Altenbach C, Flitsch SL, Khorana HG, Hubbell WL. Structural studies on transmembrane proteins. 2. Spin labeling of bacteriorhodopsin mutants at unique cysteines.. Biochemistry, 1989.
202. Todd AP, Cong J, Levinthal F, Levinthal C, Hubbell WL. Site-directed mutagenesis of colicin E1 provides specific attachment sites for spin labels whose spectra are sensitive to local conformation.. Proteins, 1989.
203. Altenbach C, Hubbell WL. The aggregation state of spin-labeled melittin in solution and bound to phospholipid membranes: evidence that membrane-bound melittin is monomeric.. Proteins, 1988.
204. Flewelling RF, Hubbell WL. Hydrophobic ion interactions with membranes. Thermodynamic analysis of tetraphenylphosphonium binding to vesicles.. Biophysical journal, 1986.
205. Sundberg SA, Hubbell WL. Investigation of surface potential asymmetry in phospholipid vesicles by a spin label relaxation method.. Biophysical journal, 1986.
206. Tsui FC, Ojcius DM, Hubbell WL. The intrinsic pKa values for phosphatidylserine and phosphatidylethanolamine in phosphatidylcholine host bilayers.. Biophysical journal, 1986.
207. Flewelling RF, Hubbell WL. The membrane dipole potential in a total membrane potential model. Applications to hydrophobic ion interactions with membranes.. Biophysical journal, 1986.
208. Honig BH, Hubbell WL, Flewelling RF. Electrostatic interactions in membranes and proteins.. Annual review of biophysics and biophysical chemistry, 1986.
209. Baldwin PA, Hubbell WL. Effects of lipid environment on the light-induced conformational changes of rhodopsin. 1. Absence of metarhodopsin II production in dimyristoylphosphatidylcholine recombinant membranes.. Biochemistry, 1985.
210. Baldwin PA, Hubbell WL. Effects of lipid environment on the light-induced conformational changes of rhodopsin. 2. Roles of lipid chain length, unsaturation, and phase state.. Biochemistry, 1985.
211. Honig BH, Hubbell WL. Stability of "salt bridges" in membrane proteins.. Proceedings of the National Academy of Sciences of the United States of America, 1984.
212. Cafiso DS, Hubbell WL. Electrogenic H+/OH- movement across phospholipid vesicles measured by spin-labeled hydrophobic ions.. Biophysical journal, 1983.
213. Cafiso DS, Hubbell WL. Transmembrane electrical currents of spin-labeled hydrophobic ions.. Biophysical journal, 1982.
214. Fung BK, Hubbell WL. Iodination of rhodopsin and transmembrane topology.. Methods in enzymology, 1982.
215. Hong K, Knudsen PJ, Hubbell WL. Purification of rhodopsin on hydroxyapatite columns, detergent exchange, and recombination with phospholipids.. Methods in enzymology, 1982.
216. Martin FJ, Hubbell WL, Papahadjopoulos D. Immunospecific targeting of liposomes to cells: a novel and efficient method for covalent attachment of Fab' fragments via disulfide bonds.. Biochemistry, 1981.
217. Cafiso DS, Hubbell WL. EPR determination of membrane potentials.. Annual review of biophysics and bioengineering, 1981.
218. Cafiso DS, Hubbell WL. Interfacial charge separation in photoreceptor memebranes.. Photochemistry and photobiology, 1980.
219. Cafiso DS, Hubbell WL. Light-induced interfacial potentials in photoreceptor membranes.. Biophysical journal, 1980.
220. Shinozawa T, Uchida S, Martin E, Cafiso D, Hubbell W, Bitensky M. Additional component required for activity and reconstitution of light-activated vertebrate photoreceptor GTPase.. Proceedings of the National Academy of Sciences of the United States of America, 1980.
221. Hubbell WL, Fung BK. The structure and chemistry of rhodopsin: relationship to models of function.. Society of General Physiologists series, 1979.
222. Hubbell WL, Bownds MD. Visual transduction in vertebrate photoreceptors.. Annual review of neuroscience, 1979.
223. Fung BK, Hubbell WL. Organization of rhodopsin in photoreceptor membranes. 1. Proteolysis of bovine rhodopsin in native membranes and the distribution of sulfhydryl groups in the fragments.. Biochemistry, 1978.
224. Fung BK, Hubbell WL. Organization of rhodopsin in photoreceptor membranes. 2. Transmembrane organization of bovine rhodopsin: evidence from proteolysis and lactoperoxidase-catalyzed iodination of native and reconstituted membranes.. Biochemistry, 1978.
225. Cafiso DS, Hubbell WL. Estimation of transmembrane potentials from phase equilibria of hydrophobic paramagnetic ions.. Biochemistry, 1978.
226. Chen YS, Hubbell WL. Reactions of the sulfhydryl groups of membrane-bound bovine rhodopsin.. Membrane biochemistry, 1978.
227. Knudsen P, Hubbell WL. Stability of rhodopsin in detergent solutions.. Membrane biochemistry, 1978.
228. Lotan R, Beattie G, Hubbell W, Nicolson GL. Activities of lectins and their immobilized derivatives in detergent solutions. Implications on the use of lectin affinity chromatography for the purification of membrane glycoproteins.. Biochemistry, 1977.
229. Castle JD, Hubbell WL. Estimation of membrane surface potential and charge density from the phase equilibrium of a paramagnetic amphiphile.. Biochemistry, 1976.
230. Trudell JR, Hubbell WL. Localization of molecular halothane in phospholipid bilayer model nerve membranes.. Anesthesiology, 1976.
231. Trudell JR, Hubbell WL, Cohen EN. Electron spin resonance studies with the volatile anesthetics on phospholipid model membranes.. Annals of the New York Academy of Sciences, 1973.
232. Hong K, Chen YS, Hubbell WL. The noncovalent coupling of rhodopsin and phosphatidylcholines.. Annals of the New York Academy of Sciences, 1973.
233. Chen YS, Hubbell WL. Temperature- and light-dependent structural changes in rhodopsin-lipid membranes.. Experimental eye research, 1973.
234. Hong K, Hubbell WL. Lipid requirements for Rhodopsin regenerability.. Biochemistry, 1973.
235. Trudell JR, Hubbell WL, Cohen EN, Kendig JJ. Pressure reversal of anesthesia: the extent of small-molecule exclusion from spin-labeled phospholipid model membranes.. Anesthesiology, 1973.
236. Trudell JR, Hubbell WL, Cohen EN. Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles.. Biochimica et biophysica acta, 1973.
237. Trudell JR, Hubbell WL, Cohen EN. The effect of two inhalation anesthetics on the order of spin-labeled phospholipid vesicles.. Biochimica et biophysica acta, 1973.
238. Shimshick EJ, Kleemann W, Hubbell WL, McConnell HM. Lateral phase separations in membranes.. Journal of supramolecular structure, 1973.
239. Hong K, Chen YS, Hubbell WL. Rhodopsin-lipid interactions.. Journal of supramolecular structure, 1973.
240. Hong K, Hubbell WL. Preparation and properties of phospholipid bilayers containing rhodopsin.. Proceedings of the National Academy of Sciences of the United States of America, 1972.
241. Hubbell WL. Carriers and specificity in membranes. 3. Carrier-facilitated transport. Molecular motion in phospholipid bilayers and biomembranes.. Neurosciences Research Program bulletin, 1971.
242. Hubbell WL, McConnell HM. Molecular motion in spin-labeled phospholipids and membranes.. Journal of the American Chemical Society, 1971.
243. Hubbell WL, Metcalfe JC, Metcalfe SM, McConnell HM. The interaction of small molecules with spin-labelled erythrocyte membranes.. Biochimica et biophysica acta, 1970.
244. Rottem S, Hubbell WL, Hayflick L, McConnell HM. Motion of fatty acid spin labels in the plasma membrane of mycoplasma.. Biochimica et biophysica acta, 1970.
245. Hubbell WL, McConnell HM. Orientation and motion of amphiphilic spin labels in membranes.. Proceedings of the National Academy of Sciences of the United States of America, 1969.
246. Hubbell WL, McConnell HM. Motion of steroid spin labels in membranes.. Proceedings of the National Academy of Sciences of the United States of America, 1969.
247. Hubbell WL, McConnell HM, Metcalfe JC. Magnetic resonance studies of anaesthetics in cyto-membranes.. British journal of pharmacology, 1969.
248. Hubbell WL, McConnell HM. Spin-label studies of the excitable membranes of nerve and muscle.. Proceedings of the National Academy of Sciences of the United States of America, 1968.