Bioinformatics can be defined broadly as the study of the inherent structure of biological information. Some of this inherent structure is very obvious (e.g., statistical patterns that reveal crucial functional regions such as genes), while others are less obvious but still immediately fruitful (e.g., how regulatory sequences give rise to “programs” of gene expression), while others are profound long-term challenges (e.g., how the genome encodes the capabilities of the human mind). Bioinformatics is the marriage of biology and the information sciences. The Bioinformatics Home Area offers integrated doctoral training for students interested in working at the interface of computer science, biology, and mathematics to address the fundamental challenges of contemporary genomic-scale research. Our program features faculty mentors spanning biology, mathematics, engineering, and medicine.