Publications

1. Zhong X, Wu H, Ouyang C, Zhang W, Shi Y, Wang YC, Ann DK, Gwack Y, Shang W, Sun Z. Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function.. Cancer immunology research, 2023.
2. Howard E, Hurrell BP, Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models.. Nature communications, 2023.
3. Nguyen A, Sung Y, Lee SH, Martin CE, Srikanth S, Chen W, Kang MK, Kim RH, Park NH, Gwack Y, Kim Y, Shin KH. Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression.. Cells, 2023.
4. Zhang W, Cao X, Zhong X, Wu H, Shi Y, Feng M, Wang YC, Ann D, Gwack Y, Yuan YC, Shang W, Sun Z. SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.. Proceedings of the National Academy of Sciences of the United States of America, 2023.
5. Zhong X, Wu H, Zhang W, Gwack Y, Shang W, Lee KO, Isakov N, He Z, Sun Z. Decoupling the role of RORγt in the differentiation and effector function of TH17 cells.. Science advances, 2022.
6. Zhang W, Cao X, Zhong X, Wu H, Feng M, Gwack Y, Isakov N, Sun Z. Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via up-regulating Nr4a2.. Science advances, 2022.
7. Williams DW, Ho K, Lenon A, Kim S, Kim T, Gwack Y, Kim RH. Long-Term Ligature-Induced Periodontitis Exacerbates Development of Bisphosphonate-Related Osteonecrosis of the Jaw in Mice.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022.
8. Wu B, Woo JS, Sun Z, Srikanth S, Gwack Y. Ca2+ Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells.. Journal of immunology (Baltimore, Md. : 1950), 2022.
9. Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, McKeown L, Anwar R, Doody GM, Srikanth S, Gwack Y, Savic S. Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder.. eLife, 2021.
10. Kim JH, Hwang KH, Dang BTN, Eom M, Kong ID, Gwack Y, Yu S, Gee HY, Birnbaumer L, Park KS, Cha SK. Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria.. Nature communications, 2021.
11. Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells.. Cell reports, 2021.
12. Wu B, Ramaiah A, Garcia G, Gwack Y, Arumugaswami V, Srikanth S. ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling.. bioRxiv : the preprint server for biology, 2021.
13. Srikanth S, Gwack Y. Blue light opens the ORAI1 LOC(K).. Cell calcium, 2021.
14. Hasiakos S, Gwack Y, Kang M, Nishimura I. Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity.. Journal of dental research, 2021.
15. Woo JS, Sun Z, Srikanth S, Gwack Y. The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1.. Scientific reports, 2020.
16. Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019.
17. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.. Journal of immunology (Baltimore, Md. : 1950), 2019.
18. Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype.. Journal of clinical immunology, 2019.
19. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.. Nature immunology, 2019.
20. He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z. SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development.. Journal of immunology (Baltimore, Md. : 1950), 2018.
21. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.. Journal of immunology (Baltimore, Md. : 1950), 2018.
22. Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells.. Bone reports, 2018.
23. Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ-dependent manner.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
24. He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z. Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt.. Journal of immunology (Baltimore, Md. : 1950), 2017.
25. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. Laminar flow downregulates Notch activity to promote lymphatic sprouting.. The Journal of clinical investigation, 2017.
26. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.. Circulation research, 2017.
27. Srikanth S, Woo JS, Sun Z, Gwack Y. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes.. Advances in experimental medicine and biology, 2017.
28. He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z. Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment.. Journal of immunology (Baltimore, Md. : 1950), 2016.
29. Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma.. Oncotarget, 2016.
30. Srikanth S, Woo JS, Gwack Y. A large Rab GTPase family in a small GTPase world.. Small GTPases, 2016.
31. Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.. Biochemical and biophysical research communications, 2016.
32. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.. Science signaling, 2016.
33. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
34. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. Dental enamel cells express functional SOCE channels.. Scientific reports, 2015.
35. Sohn S, Park Y, Srikanth S, Arai A, Song M, Yu B, Shin KH, Kang MK, Wang C, Gwack Y, Park NH, Kim RH. The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells.. Journal of dental research, 2015.
36. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.. Nature immunology, 2014.
37. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.. Science signaling, 2014.
38. Srikanth S, Kim KD, Gwack Y. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes.. Methods in enzymology, 2014.
39. Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.. Journal of immunology (Baltimore, Md. : 1950), 2013.
40. Srikanth S, Gwack Y. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation.. Molecules and cells, 2013.
41. Srikanth S, Ribalet B, Gwack Y. Regulation of CRAC channels by protein interactions and post-translational modification.. Channels (Austin, Tex.), 2013.
42. Srikanth S, Gwack Y. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes.. Methods in molecular biology (Clifton, N.J.), 2013.
43. Srikanth S, Gwack Y. Molecular regulation of the pore component of CRAC channels, Orai1.. Current topics in membranes, 2013.
44. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).. Proceedings of the National Academy of Sciences of the United States of America, 2012.
45. Srikanth S, Gwack Y. Orai1, STIM1, and their associating partners.. The Journal of physiology, 2012.
46. Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. ORAI1 deficiency impairs activated T cell death and enhances T cell survival.. Journal of immunology (Baltimore, Md. : 1950), 2011.
47. Srikanth S, Yee MK, Gwack Y, Ribalet B. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties.. The Journal of biological chemistry, 2011.
48. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.. Journal of immunology (Baltimore, Md. : 1950), 2010.
49. Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.. Nature cell biology, 2010.
50. Srikanth S, Jung HJ, Ribalet B, Gwack Y. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels.. The Journal of biological chemistry, 2009.
51. E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68.. PLoS pathogens, 2009.
52. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. Hair loss and defective T- and B-cell function in mice lacking ORAI1.. Molecular and cellular biology, 2008.
53. Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.. Molecular biology of the cell, 2008.
54. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.. Cell calcium, 2007.
55. Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Biochemical and functional characterization of Orai proteins.. The Journal of biological chemistry, 2007.
56. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.. The Journal of biological chemistry, 2007.
57. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel.. Nature, 2006.
58. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.. Nature, 2006.
59. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.. Nature, 2006.
60. Chang H, Gwack Y, Kingston D, Souvlis J, Liang X, Means RE, Cesarman E, Hutt-Fletcher L, Jung JU. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA.. Journal of virology, 2005.
61. Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU. Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein.. Molecular and cellular biology, 2004.
62. Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication.. Molecular and cellular biology, 2003.
63. Nakamura H, Lu M, Gwack Y, Souvlis J, Zeichner SL, Jung JU. Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator.. Journal of virology, 2003.
64. Hwang S, Lee D, Gwack Y, Min H, Choe J. Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5.. The Journal of general virology, 2003.
65. Gwack Y, Baek HJ, Nakamura H, Lee SH, Meisterernst M, Roeder RG, Jung JU. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation.. Molecular and cellular biology, 2003.
66. Lim C, Sohn H, Lee D, Gwack Y, Choe J. Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome.. Journal of virology, 2002.
67. Gwack Y, Hwang S, Lim C, Won YS, Lee CH, Choe J. Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3.. The Journal of biological chemistry, 2001.
68. Lim C, Gwack Y, Hwang S, Kim S, Choe J. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus.. The Journal of biological chemistry, 2001.
69. Gwack Y, Byun H, Hwang S, Lim C, Choe J. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50.. Journal of virology, 2001.
70. Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.. Journal of virology, 2000.
71. Lim C, Sohn H, Gwack Y, Choe J. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity.. The Journal of general virology, 2000.
72. Gwack Y, Yoo H, Song I, Choe J, Han JH. RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3.. Journal of virology, 1999.
73. Kim DW, Kim J, Gwack Y, Han JH, Choe J. Mutational analysis of the hepatitis C virus RNA helicase.. Journal of virology, 1997.
74. Gwack Y, Kim DW, Han JH, Choe J. DNA helicase activity of the hepatitis C virus nonstructural protein 3.. European journal of biochemistry, 1997.
75. Kim DW, Gwack Y, Han JH, Choe J. Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein.. Virus research, 1997.
76. Gwack Y, Kim DW, Han JH, Choe J. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein.. Biochemical and biophysical research communications, 1996.
77. Kim DW, Gwack Y, Han JH, Choe J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity.. Biochemical and biophysical research communications, 1995.