Publications

1. Siekhaus DE, Stanley-Ahmed JA. Discovering mechanisms of macrophage tissue infiltration with Drosophila.. Current opinion in immunology, 2024.
2. Lopez Espinoza A, Christopher T, Tait Wojno ED. Epithelial-immune interactions govern type 2 immunity at barrier surfaces.. Current opinion in immunology, 2024.
3. Boytsov D, Madej GM, Horn G, Blaha N, Köcher T, Sitte HH, Siekhaus D, Ziegler C, Sandtner W, Roblek M. Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport.. Proceedings of the National Academy of Sciences of the United States of America, 2024.
4. Nagano M, Aoshima K, Shimamura H, Siekhaus DE, Toshima JY, Toshima J. Distinct role of TGN-resident clathrin adaptors for Vps21p activation in the TGN-endosome trafficking pathway.. Journal of cell science, 2023.
5. Toshima JY, Tsukahara A, Nagano M, Tojima T, Siekhaus DE, Nakano A, Toshima J. The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network.. eLife, 2023.
6. Enshoji M, Miyano Y, Yoshida N, Nagano M, Watanabe M, Kunihiro M, Siekhaus DE, Toshima JY, Toshima J. Eps15/Pan1p is a master regulator of the late stages of the endocytic pathway.. The Journal of cell biology, 2022.
7. Akhmanova M, Emtenani S, Krueger D, Gyoergy A, Guarda M, Vlasov M, Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. Cell division in tissues enables macrophage infiltration.. Science (New York, N.Y.), 2022.
8. Martin ET, Blatt P, Nguyen E, Lahr R, Selvam S, Yoon HAM, Pocchiari T, Emtenani S, Siekhaus DE, Berman A, Fuchs G, Rangan P. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis.. Developmental cell, 2022.
9. Emtenani S, Martin ET, Gyoergy A, Bicher J, Genger JW, Köcher T, Akhmanova M, Guarda M, Roblek M, Bergthaler A, Hurd TR, Rangan P, Siekhaus DE. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila.. The EMBO journal, 2022.
10. Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE. The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis.. Frontiers in oncology, 2022.
11. Belyaeva V, Wachner S, Gyoergy A, Emtenani S, Gridchyn I, Akhmanova M, Linder M, Roblek M, Sibilia M, Siekhaus D. Fos regulates macrophage infiltration against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila.. PLoS biology, 2022.
12. Ingles-Prieto A, Furthmann N, Crossman SH, Tichy AM, Hoyer N, Petersen M, Zheden V, Biebl J, Reichhart E, Gyoergy A, Siekhaus DE, Soba P, Winklhofer KF, Janovjak H. Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease.. PLoS genetics, 2021.
13. Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, Gyoergy A, Groß O, Siekhaus DE, Dionne MS. Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila.. eLife, 2020.
14. Nagano M, Toshima JY, Siekhaus DE, Toshima J. Rab5-mediated endosome formation is regulated at the trans-Golgi network.. Communications biology, 2019.
15. Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, Ratheesh A, Reis-Rodrigues P, Shkarina K, Larsen ISB, Vakhrushev SY, Clausen H, Siekhaus DE. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion.. eLife, 2019.
16. Trébuchet G, Cattenoz PB, Zsámboki J, Mazaud D, Siekhaus DE, Fanto M, Giangrande A. The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018.
17. Ratheesh A, Biebl J, Vesela J, Smutny M, Papusheva E, Krens SFG, Kaufmann W, Gyoergy A, Casano AM, Siekhaus DE. Drosophila TNF Modulates Tissue Tension in the Embryo to Facilitate Macrophage Invasive Migration.. Developmental cell, 2018.
18. Gyoergy A, Roblek M, Ratheesh A, Valoskova K, Belyaeva V, Wachner S, Matsubayashi Y, Sánchez-Sánchez BJ, Stramer B, Siekhaus DE. Tools Allowing Independent Visualization and Genetic Manipulation of Drosophila melanogaster Macrophages and Surrounding Tissues.. G3 (Bethesda, Md.), 2018.
19. Yamamoto W, Wada S, Nagano M, Aoshima K, Siekhaus DE, Toshima JY, Toshima J. Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis in yeast.. Journal of cell science, 2018.
20. Matsubayashi Y, Louani A, Dragu A, Sánchez-Sánchez BJ, Serna-Morales E, Yolland L, Gyoergy A, Vizcay G, Fleck RA, Heddleston JM, Chew TL, Siekhaus DE, Stramer BM. A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation.. Current biology : CB, 2017.
21. Toshima JY, Furuya E, Nagano M, Kanno C, Sakamoto Y, Ebihara M, Siekhaus DE, Toshima J. Yeast Eps15-like endocytic protein Pan1p regulates the interaction between endocytic vesicles, endosomes and the actin cytoskeleton.. eLife, 2016.
22. Toshima JY, Horikomi C, Okada A, Hatori MN, Nagano M, Masuda A, Yamamoto W, Siekhaus DE, Toshima J. Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis.. Journal of cell science, 2015.
23. Ratheesh A, Belyaeva V, Siekhaus DE. Drosophila immune cell migration and adhesion during embryonic development and larval immune responses.. Current opinion in cell biology, 2015.
24. Kawada D, Kobayashi H, Tomita T, Nakata E, Nagano M, Siekhaus DE, Toshima JY, Toshima J. The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins.. Biochimica et biophysica acta, 2014.
25. Toshima JY, Nishinoaki S, Sato Y, Yamamoto W, Furukawa D, Siekhaus DE, Sawaguchi A, Toshima J. Bifurcation of the endocytic pathway into Rab5-dependent and -independent transport to the vacuole.. Nature communications, 2014.
26. DeGennaro M, Hurd TR, Siekhaus DE, Biteau B, Jasper H, Lehmann R. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion.. Developmental cell, 2011.
27. Siekhaus D, Haesemeyer M, Moffitt O, Lehmann R. RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila.. Nature cell biology, 2010.
28. Kunwar PS, Siekhaus DE, Lehmann R. In vivo migration: a germ cell perspective.. Annual review of cell and developmental biology, 2006.
29. Siekhaus DE, Drubin DG. Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant.. Nature cell biology, 2003.
30. Rayburn LY, Gooding HC, Choksi SP, Maloney D, Kidd AR, Siekhaus DE, Bender M. amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development.. Genetics, 2003.
31. Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion.. The Journal of biological chemistry, 2000.
32. Siekhaus DE, Fuller RS. A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999.