Esteban C Dell'angelica
Department Vice Chair, Human Genetics, Human Genetics, University of California Los Angeles
Professor, Human Genetics, University of California Los Angeles
Los Angeles, CA 90095
Los Angeles, CA 90095
Member, Genetics & Genomics GPB Home Area, Human Genetics
Esteban C. Dell’Angelica got his Ph.D. degree at the University of Buenos Aires (Argentina) for his isolation and biochemical characterization of a hitherto unknown calcium-binding protein from neutrophils. During his postdoctoral training in the laboratory of Juan S. Bonifacino, Ph.D., at the National Institutes of Health (Bethesda, Maryland), he identified and characterized several components of the molecular machinery for protein trafficking within the so-called late secretory and endocytic intracellular pathways, and he described the first example of human disease due to mutations in a known component of such molecular machinery (Hermansky-Pudlak syndrome type 2). As a junior faculty at UCLA, he identified and characterized three multi-subunit protein complexes, named BLOC-1 through -3, which are required for the biogenesis of lysosome-related organelles such as melanosomes and platelet dense granules. He is an active member of a multidisciplinary team at UCLA that collaborates with other teams of the nation-wide Undiagnosed Diseases Network (UDN) to tackle very rare and poorly understood human diseases.
For a complete list of publications, please see:
For a list of publications of the UDN, please see:
- Dell'Angelica EC. Melanosomes made from recycling (endosomes): A tubule-stabilizing function revealed for Biogenesis of Lysosome-related Organelles Complex-1.. Pigment cell & melanoma research, 2016.
- Dell'Angelica EC. AP-3-dependent trafficking and disease: the first decade.. Current opinion in cell biology, 2009.
- Dell'Angelica EC. The building BLOC(k)s of lysosomes and related organelles.. Current opinion in cell biology, 2004.
- Dell'Angelica EC. Melanosome biogenesis: shedding light on the origin of an obscure organelle.. Trends in cell biology, 2003.
- Vesa J, Chin MH, Oelgeschläger K, Isosomppi J, DellAngelica EC, Jalanko A, Peltonen L. Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3.. Molecular biology of the cell, 2002.
- Dell'Angelica EC, Payne GS. Intracellular cycling of lysosomal enzyme receptors: cytoplasmic tails' tales.. Cell, 2001.
- Dell'Angelica EC. Clathrin-binding proteins: got a motif? Join the network!. Trends in cell biology, 2001.