Heather R Christofk
Professor, Biological Chemistry, University of California Los Angeles
hchristofk@mednet.ucla.edu
310-794-4248
Mailing Address:
390A BSRB
CA
Office Address:
390A BSRB
615 Charles E. Young Drive South
Los Angeles, CA 90095
Affiliations
Associate Director, Basic/Translational Research, Jonsson Comprehensive Cancer Center
Research Interests
We are studying the interconnection of growth factor signaling and cell metabolism. In particular, we are interested in how signaling pathways control metabolic fluxes and the impact this may have on diseases such as cancer. It has long been appreciated that cancer cells exhibit an altered metabolism compared to their normal cell counterparts. We have discovered one mechanism by which cancer cells achieve this altered metabolism, and our findings support the idea that this is required to support cell growth. We are now exploring additional mechanisms of metabolic regulation with the goals of identifying novel drug targets for cancer and other proliferative disorders and better defining the role of metabolism in cell growth.
Biography
Heather Christofk is an Associate Professor of Biological Chemistry at UCLA. She earned a B.S. in Molecular, Cell and Developmental Biology at UCLA in 2001, and a PhD in Cell and Developmental Biology at Harvard in 2007. The goal of Dr. Christofk’s research is to understand the regulation and role of metabolic transitions in cellular transformation, virus infection, and differentiation. She is a Searle Scholar and recipient of the Damon Runyon-Rachleff Innovation Award, the NIH Director’s New Innovator Award, and an American Cancer Society Research Scholar Award.
Publications
A selected list of publications:
- Thaker Shivani K, Chapa Travis, Garcia Gustavo, Gong Danyang, Schmid Ernst W, Arumugaswami Vaithilingaraja, Sun Ren, Christofk Heather R Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells Cell metabolism, 2019; 29(5): 1206-1216.e4.
- Thaker Shivani K, Ch’ng James, Christofk Heather R Viral hijacking of cellular metabolism BMC biology, 2019; 17(1): 59.
- Sullivan William J, Mullen Peter J, Schmid Ernst W, Flores Aimee, Momcilovic Milica, Sharpley Mark S, Jelinek David, Whiteley Andrew E, Maxwell Matthew B, Wilde Blake R, Banerjee Utpal, Coller Hilary A, Shackelford David B, Braas Daniel, Ayer Donald E, de Aguiar Vallim Thomas Q, Lowry William E, Christofk Heather R Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization Cell, 2018; 175(1): 117-132.e21.
- Flores Aimee, Schell John, Krall Abigail S, Jelinek David, Miranda Matilde, Grigorian Melina, Braas Daniel, White Andrew C, Zhou Jessica L, Graham Nicholas A, Graeber Thomas, Seth Pankaj, Evseenko Denis, Coller Hilary A, Rutter Jared, Christofk Heather R, Lowry William E Lactate dehydrogenase activity drives hair follicle stem cell activation Nature cell biology, 2017; 19(9): 1017-1026.
- Krall Abigail S, Christofk Heather R Cell cycle: Division enzyme regulates metabolism Nature, 2017; 546(7658): 357-358.
- Momcilovic Milica, Bailey Sean T, Lee Jason T, Fishbein Michael C, Magyar Clara, Braas Daniel, Graeber Thomas, Jackson Nicholas J, Czernin Johannes, Emberley Ethan, Gross Matthew, Janes Julie, Mackinnon Andy, Pan Alison, Rodriguez Mirna, Works Melissa, Zhang Winter, Parlati Francesco, Demo Susan, Garon Edward, Krysan Kostyantyn, Walser Tonya C, Dubinett Steven M, Sadeghi Saman, Christofk Heather R, Shackelford David B Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer Cell reports, 2017; 18(3): 601-610.
- Krall Abigail S, Xu Shili, Graeber Thomas G, Braas Daniel, Christofk Heather R Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor Nature communications, 2016; 7(1): 11457.
- Gu Wen, Gaeta Xavier, Sahakyan Anna, Chan Alanna B, Hong Candice S, Kim Rachel, Braas Daniel, Plath Kathrin, Lowry William E, Christofk Heather R Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State Cell stem cell, 2016; 19(4): 476-490.
- Hong Candice Sun, Graham Nicholas A, Gu Wen, Espindola Camacho Carolina, Mah Vei, Maresh Erin L, Alavi Mohammed, Bagryanova Lora, Krotee Pascal A L, Gardner Brian K, Behbahan Iman Saramipoor, Horvath Steve, Chia David, Mellinghoff Ingo K, Hurvitz Sara A, Dubinett Steven M, Critchlow Susan E, Kurdistani Siavash K, Goodglick Lee, Braas Daniel, Graeber Thomas G, Christofk Heather R MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4 Cell reports, 2016; 14(7): 1590-601.
- Fu Xudong, Chin Randall M, Vergnes Laurent, Hwang Heejun, Deng Gang, Xing Yanpeng, Pai Melody Y, Li Sichen, Ta Lisa, Fazlollahi Farbod, Chen Chuo, Prins Robert M, Teitell Michael A, Nathanson David A, Lai Albert, Faull Kym F, Jiang Meisheng, Clarke Steven G, Cloughesy Timothy F, Graeber Thomas G, Braas Daniel, Christofk Heather R, Jung Michael E, Reue Karen, Huang Jing 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling Cell metabolism, 2015; 22(3): 508-15.
- Thai Minh, Thaker Shivani K, Feng Jun, Du Yushen, Hu Hailiang, Ting Wu Ting, Graeber Thomas G, Braas Daniel, Christofk Heather R MYC-induced reprogramming of glutamine catabolism supports optimal virus replication Nature communications, 2015; 6(12): 8873.
- Krall Abigail S, Christofk Heather R Rethinking glutamine addiction Nature cell biology, 2015; 17(12): 1515-7.
- Sullivan William J, Christofk Heather R The metabolic milieu of metastases Cell, 2015; 160(3): 363-4.
- Thai Minh, Graham Nicholas A, Braas Daniel, Nehil Michael, Komisopoulou Evangelia, Kurdistani Siavash K, McCormick Frank, Graeber Thomas G, Christofk Heather R Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication Cell metabolism, 2014; 19(4): 694-701.
- Garon Edward B, Christofk Heather R, Hosmer Wylie, Britten Carolyn D, Bahng Agnes, Crabtree Matthew J, Hong Candice Sun, Kamranpour Naeimeh, Pitts Sharon, Kabbinavar Fairooz, Patel Cecil, von Euw Erika, Black Alexander, Michelakis Evangelos D, Dubinett Steven M, Slamon Dennis J Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer Journal of cancer research and clinical oncology, 2014; 140(3): 443-52.
- Chin Randall M, Fu Xudong, Pai Melody Y, Vergnes Laurent, Hwang Heejun, Deng Gang, Diep Simon, Lomenick Brett, Meli Vijaykumar S, Monsalve Gabriela C, Hu Eileen, Whelan Stephen A, Wang Jennifer X, Jung Gwanghyun, Solis Gregory M, Fazlollahi Farbod, Kaweeteerawat Chitrada, Quach Austin, Nili Mahta, Krall Abby S, Godwin Hilary A, Chang Helena R, Faull Kym F, Guo Feng, Jiang Meisheng, Trauger Sunia A, Saghatelian Alan, Braas Daniel, Christofk Heather R, Clarke Catherine F, Teitell Michael A, Petrascheck Michael, Reue Karen, Jung Michael E, Frand Alison R, Huang Jing The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR Nature, 2014; 510(7505): 397-401.
- Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity Cancer research, 2013; 73(9): 2850-2862.
- Krall Abigail S, Christofk Heather R Cancer: A metabolic metamorphosis Nature, 2013; 496(7443): 38-40.
- Ahler Ethan, Sullivan William J, Cass Ashley, Braas Daniel, York Autumn G, Bensinger Steven J, Graeber Thomas G, Christofk Heather R Doxycycline alters metabolism and proliferation of human cell lines PloS one, 2013; 8(5): e64561.
- Babic Ivan, Anderson Erik S, Tanaka Kazuhiro, Guo Deliang, Masui Kenta, Li Bing, Zhu Shaojun, Gu Yuchao, Villa Genaro R, Akhavan David, Nathanson David, Gini Beatrice, Mareninov Sergey, Li Rui, Camacho Carolina Espindola, Kurdistani Siavash K, Eskin Ascia, Nelson Stanley F, Yong William H, Cavenee Webster K, Cloughesy Timothy F, Christofk Heather R, Black Douglas L, Mischel Paul S EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer Cell metabolism, 2013; 17(6): 1000-8.
- Wang Jun, Hwang Kiwook, Braas Daniel, Dooraghi Alex, Nathanson David, Campbell Dean O, Gu Yuchao, Sandberg Troy, Mischel Paul, Radu Caius, Chatziioannou Arion F, Phelps Michael E, Christofk Heather, Heath James R Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013; 54(10): 1820-4.
- McBrian Matthew A, Behbahan Iman Saramipoor, Ferrari Roberto, Su Trent, Huang Ta-Wei, Li Kunwu, Hong Candice S, Christofk Heather R, Vogelauer Maria, Seligson David B, Kurdistani Siavash K Histone acetylation regulates intracellular pH Molecular cell, 2013; 49(2): 310-21.
- Smith Kathleen B, Tran Linh M, Tam Brenna M, Shurell Elizabeth M, Li Yunfeng, Braas Daniel, Tap William D, Christofk Heather R, Dry Sarah M, Eilber Fritz C, Wu Hong Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition The American journal of pathology, 2013; 182(4): 1400-11.
- Nagaraj Raghavendra, Gururaja-Rao Shubha, Jones Kevin T, Slattery Matthew, Negre Nicolas, Braas Daniel, Christofk Heather, White Kevin P, Mann Richard, Banerjee Utpal Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway Genes & development, 2012; 26(18): 2027-37.
- Braas Daniel, Ahler Ethan, Tam Brenna, Nathanson David, Riedinger Mirielle, Benz Matthias R, Smith Kathleen B, Eilber Fritz C, Witte Owen N, Tap William D, Wu Hong, Christofk Heather R Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment Cancer discovery, 2012; 2(12): 1109-17.
- Bensinger Steven J, Christofk Heather R New aspects of the Warburg effect in cancer cell biology Seminars in cell & developmental biology, 2012; .
- Anastasiou Dimitrios, Yu Yimin, Israelsen William J, Jiang Jian-Kang, Boxer Matthew B, Hong Bum Soo, Tempel Wolfram, Dimov Svetoslav, Shen Min, Jha Abhishek, Yang Hua, Mattaini Katherine R, Metallo Christian M, Fiske Brian P, Courtney Kevin D, Malstrom Scott, Khan Tahsin M, Kung Charles, Skoumbourdis Amanda P, Veith Henrike, Southall Noel, Walsh Martin J, Brimacombe Kyle R, Leister William, Lunt Sophia Y, Johnson Zachary R, Yen Katharine E, Kunii Kaiko, Davidson Shawn M, Christofk Heather R, Austin Christopher P, Inglese James, Harris Marian H, Asara John M, Stephanopoulos Gregory, Salituro Francesco G, Jin Shengfang, Dang Lenny, Auld Douglas S, Park Hee-Won, Cantley Lewis C, Thomas Craig J, Vander Heiden Matthew G Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Nature chemical biology, 2012; 8(10): 839-47.
- Vlashi Erina, Lagadec Chann, Vergnes Laurent, Matsutani Tomoo, Masui Kenta, Poulou Maria, Popescu Ruxandra, Della Donna Lorenza, Evers Patrick, Dekmezian Carmen, Reue Karen, Christofk Heather, Mischel Paul S, Pajonk Frank Metabolic state of glioma stem cells and nontumorigenic cells Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(38): 16062-7.
- Christofk Heather R, Wu Ning, Cantley Lewis C, Asara John M Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries Journal of proteome research, 2011; 10(9): 4158-64.
- Vander Heiden Matthew G, Locasale Jason W, Swanson Kenneth D, Sharfi Hadar, Heffron Greg J, Amador-Noguez Daniel, Christofk Heather R, Wagner Gerhard, Rabinowitz Joshua D, Asara John M, Cantley Lewis C Evidence for an alternative glycolytic pathway in rapidly proliferating cells Science (New York, N.Y.), 2010; 329(5998): 1492-9.
- Vander Heiden Matthew G, Christofk Heather R, Schuman Eli, Subtelny Alexander O, Sharfi Hadar, Harlow Edward E, Xian Jun, Cantley Lewis C Identification of small molecule inhibitors of pyruvate kinase M2 Biochemical pharmacology, 2009; .
- Christofk Heather R, Vander Heiden Matthew G, Wu Ning, Asara John M, Cantley Lewis C Pyruvate kinase M2 is a phosphotyrosine-binding protein Nature, 2008; 452(7184): 181-6.
- Christofk Heather R, Vander Heiden Matthew G, Harris Marian H, Ramanathan Arvind, Gerszten Robert E, Wei Ru, Fleming Mark D, Schreiber Stuart L, Cantley Lewis C The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth Nature, 2008; 452(7184): 230-3.
Publications
- Campos OA, Attar N, Cheng C, Vogelauer M, Mallipeddi NV, Schmollinger S, Matulionis N, Christofk HR, Merchant SS, Kurdistani SK. A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's ataxia.. Science advances, 2021.
- Lu E, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Zavoshi S, Li S, Zhang L, Wilde BR, Christofk HR, Boutros PC, Shuch B. Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing.. Cancer, 2021.
- Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K. More Metabolism!. Molecular cell, 2021.
- Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H. Metabolic decisions in development and disease-a Keystone Symposia report.. Annals of the New York Academy of Sciences, 2021.
- Bonglack EN, Messinger JE, Cable JM, Ch'ng J, Parnell KM, Reinoso-Vizcaíno NM, Barry AP, Russell VS, Dave SS, Christofk HR, Luftig MA. Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
- Ariav Y, Ch'ng JH, Christofk HR, Ron-Harel N, Erez A. Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response.. Science advances, 2021.
- Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration.. Scientific reports, 2021.
- Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.. Nature communications, 2021.
- Perez-Ramirez CA, Christofk HR. Challenges in Studying Stem Cell Metabolism.. Cell stem cell, 2021.
- Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.. Cell metabolism, 2021.
- Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss.. Journal of medicinal chemistry, 2021.
- Wilde BR, Christofk HR. O-Mg! Lactate Drives Mg2+ Mobilization.. Molecular cell, 2020.
- Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy.. iScience, 2020.
- Albrecht LV, Tejeda-Mu?oz N, Bui MH, Cicchetto AC, Di Biagio D, Colozza G, Schmid E, Piccolo S, Christofk HR, De Robertis EM. GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery.. Cell reports, 2020.
- Shapira SN, Christofk HR. Metabolic Regulation of Tissue Stem Cells.. Trends in cell biology, 2020.
- Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.. Nature, 2020.
- Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.. Nature, 2019.
- Thaker SK, Ch'ng J, Christofk HR. Viral hijacking of cellular metabolism.. BMC biology, 2019.
- Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. Author Correction: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin.. Nature communications, 2019.
- Thaker SK, Chapa T, Garcia G, Gong D, Schmid EW, Arumugaswami V, Sun R, Christofk HR. Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells.. Cell metabolism, 2019.
- Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin.. Nature communications, 2019.
- Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M. The next decade of metabolism.. Nature metabolism, 2019.
- Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.. Cell, 2018.
- Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue.. Journal of visualized experiments : JoVE, 2018.
- Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.. Cancer cell, 2018.
- Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.. Cancer & metabolism, 2018.
- Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.. eLife, 2017.
- Miranda M, Christofk H, Jones DL, Lowry WE. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle.. The Journal of investigative dermatology, 2017.
- Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.. Nature cell biology, 2017.
- Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. Lactate dehydrogenase activity drives hair follicle stem cell activation.. Nature cell biology, 2017.
- Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.. Molecular cell, 2017.
- Krall AS, Christofk HR. Cell cycle: Division enzyme regulates metabolism.. Nature, 2017.
- Graham NA, Minasyan A, Lomova A, Cass A, Balanis NG, Friedman M, Chan S, Zhao S, Delgado A, Go J, Beck L, Hurtz C, Ng C, Qiao R, Ten Hoeve J, Palaskas N, Wu H, M?schen M, Multani AS, Port E, Larson SM, Schultz N, Braas D, Christofk HR, Mellinghoff IK, Graeber TG. Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.. Molecular systems biology, 2017.
- Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.. Cell reports, 2017.
- Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR. Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State.. Cell stem cell, 2016.
- Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M. Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma.. Genome medicine, 2016.
- Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.. Nature communications, 2016.
- Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR. MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.. Cell reports, 2016.
- Krall AS, Christofk HR. Rethinking glutamine addiction.. Nature cell biology, 2015.
- Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR. MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.. Nature communications, 2015.
- Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.. Cell metabolism, 2015.
- Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML. Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.. Journal of cell science, 2015.
- Sullivan WJ, Christofk HR. The metabolic milieu of metastases.. Cell, 2015.
- Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. Estrogen receptor (ER)a-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.. The Journal of biological chemistry, 2014.
- Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. The metabolite a-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.. Nature, 2014.
- Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.. Cell metabolism, 2014.
- Garon EB, Christofk HR, Hosmer W, Britten CD, Bahng A, Crabtree MJ, Hong CS, Kamranpour N, Pitts S, Kabbinavar F, Patel C, von Euw E, Black A, Michelakis ED, Dubinett SM, Slamon DJ. Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer.. Journal of cancer research and clinical oncology, 2014.
- Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013.
- Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR. Doxycycline alters metabolism and proliferation of human cell lines.. PloS one, 2013.
- Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer.. Cell metabolism, 2013.
- Krall AS, Christofk HR. Cancer: A metabolic metamorphosis.. Nature, 2013.
- Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.. Cancer research, 2013.
- Smith KB, Tran LM, Tam BM, Shurell EM, Li Y, Braas D, Tap WD, Christofk HR, Dry SM, Eilber FC, Wu H. Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition.. The American journal of pathology, 2013.
- Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment.. Cancer discovery, 2012.
- McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK. Histone acetylation regulates intracellular pH.. Molecular cell, 2012.
- Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.. Nature chemical biology, 2012.
- Nagaraj R, Gururaja-Rao S, Jones KT, Slattery M, Negre N, Braas D, Christofk H, White KP, Mann R, Banerjee U. Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway.. Genes & development, 2012.
- Bensinger SJ, Christofk HR. New aspects of the Warburg effect in cancer cell biology.. Seminars in cell & developmental biology, 2012.
- Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Metabolic state of glioma stem cells and nontumorigenic cells.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
- Christofk HR, Wu N, Cantley LC, Asara JM. Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries.. Journal of proteome research, 2011.
- Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells.. Science (New York, N.Y.), 2010.
- Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2.. Biochemical pharmacology, 2009.
- Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein.. Nature, 2008.
- Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.. Nature, 2008.
- Asara JM, Christofk HR, Freimark LM, Cantley LC. A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.. Proteomics, 2008.
- Asara JM, Zhang X, Zheng B, Maroney LA, Christofk HR, Wu N, Cantley LC. In-gel stable isotope labeling for relative quantification using mass spectrometry.. Nature protocols, 2006.
- Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H. Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life.. Molecular and cellular biology, 2004.