Publications

1. Aguirre CG, Woo JH, Romero-Sosa JL, Rivera ZM, Tejada AN, Munier JJ, Perez J, Goldfarb M, Das K, Gomez M, Ye T, Pannu J, Evans K, O'Neill PR, Spigelman I, Soltani A, Izquierdo A. Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024.
2. Aguirre CG, Woo JH, Romero-Sosa JL, Rivera ZM, Tejada AN, Munier JJ, Perez J, Goldfarb M, Das K, Gomez M, Ye T, Pannu J, Evans K, O'Neill PR, Spigelman I, Soltani A, Izquierdo A. Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty.. bioRxiv : the preprint server for biology, 2023.
3. Munier JJ, Shen S, Rahal D, Hanna A, Marty VN, O'Neill PR, Fanselow MS, Spigelman I. Chronic intermittent ethanol exposure disrupts stress-related tripartite communication to impact affect-related behavioral selection in male rats.. Neurobiology of stress, 2023.
4. Munier JJ, Marty VN, Spigelman I. Sex differences in α-adrenergic receptor function contribute to impaired hypothalamic metaplasticity following chronic intermittent ethanol exposure.. Alcoholism, clinical and experimental research, 2022.
5. Mulpuri Y, Yamamoto T, Nishimura I, Spigelman I. Role of voltage-gated sodium channels in axonal signal propagation of trigeminal ganglion neurons after infraorbital nerve entrapment.. Neurobiology of pain (Cambridge, Mass.), 2022.
6. Wiese BM, Liktor-Busa E, Couture SA, Nikas SP, Ji L, Liu Y, Makriyannis A, Spigelman I, Vanderah TW, Largent-Milnes TM. Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression.. Cannabis and cannabinoid research, 2021.
7. Yamamoto T, Mulpuri Y, Izraylev M, Li Q, Simonian M, Kramme C, Schmidt BL, Seltzman HH, Spigelman I. Selective targeting of peripheral cannabinoid receptors prevents behavioral symptoms and sensitization of trigeminal neurons in mouse models of migraine and medication overuse headache.. Pain, 2021.
8. Gonzalez ST, Marty V, Spigelman I, Reise SP, Fanselow MS. Impact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake.. Neurobiology of stress, 2021.
9. Marty VN, Farokhnia M, Munier JJ, Mulpuri Y, Leggio L, Spigelman I. Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Suppress Voluntary Alcohol Intake in Male Wistar Rats.. Frontiers in neuroscience, 2020.
10. Tavanasefat H, Li F, Koyano K, Gourtani BK, Marty V, Mulpuri Y, Lee SH, Shin KH, Wong DTW, Xiao X, Spigelman I, Kim Y. Molecular consequences of fetal alcohol exposure on amniotic exosomal miRNAs with functional implications for stem cell potency and differentiation.. PloS one, 2020.
11. Aguirre CG, Stolyarova A, Das K, Kolli S, Marty V, Ray L, Spigelman I, Izquierdo A. Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal.. PloS one, 2020.
12. Marty VN, Mulpuri Y, Munier JJ, Spigelman I. Chronic alcohol disrupts hypothalamic responses to stress by modifying CRF and NMDA receptor function.. Neuropharmacology, 2020.
13. Carvalho GB, Mulpuri Y, Damasio A, Spigelman I. A Role for The P2Y1 Receptor in Nonsynaptic Cross-depolarization in the Rat Dorsal Root Ganglia.. Neuroscience, 2019.
14. Seki S, Yamamoto T, Quinn K, Spigelman I, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH, Venugopal S. Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1G93A Mouse Model for ALS.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019.
15. Zhang H, Lund DM, Ciccone HA, Staatz WD, Ibrahim MM, Largent-Milnes TM, Seltzman HH, Spigelman I, Vanderah TW. Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain.. Pain, 2018.
16. Mulpuri Y, Marty VN, Munier JJ, Mackie K, Schmidt BL, Seltzman HH, Spigelman I. Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation.. Neuropharmacology, 2018.
17. Hirai T, Mulpuri Y, Cheng Y, Xia Z, Li W, Ruangsri S, Spigelman I, Nishimura I. Aberrant plasticity of peripheral sensory axons in a painful neuropathy.. Scientific reports, 2017.
18. Lindemeyer AK, Shen Y, Yazdani F, Shao XM, Spigelman I, Davies DL, Olsen RW, Liang J. α2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus.. Molecular pharmacology, 2017.
19. Seltzman HH, Shiner C, Hirt EE, Gilliam AF, Thomas BF, Maitra R, Snyder R, Black SL, Patel PR, Mulpuri Y, Spigelman I. Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain.. Journal of medicinal chemistry, 2016.
20. Suryanarayanan A, Carter JM, Landin JD, Morrow AL, Werner DF, Spigelman I. Role of interleukin-10 (IL-10) in regulation of GABAergic transmission and acute response to ethanol.. Neuropharmacology, 2016.
21. Perusini JN, Meyer EM, Long VA, Rau V, Nocera N, Avershal J, Maksymetz J, Spigelman I, Fanselow MS. Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015.
22. Marty VN, Vlkolinsky R, Minassian N, Cohen T, Nelson GA, Spigelman I. Radiation-induced alterations in synaptic neurotransmission of dentate granule cells depend on the dose and species of charged particles.. Radiation research, 2014.
23. Li A, Hokugo A, Yalom A, Berns EJ, Stephanopoulos N, McClendon MT, Segovia LA, Spigelman I, Stupp SI, Jarrahy R. A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers.. Biomaterials, 2014.
24. Khalid O, Kim JJ, Kim HS, Hoang M, Tu TG, Elie O, Lee C, Vu C, Horvath S, Spigelman I, Kim Y. Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells.. Stem cell research, 2014.
25. Liang J, Marty VN, Mulpuri Y, Olsen RW, Spigelman I. Selective modulation of GABAergic tonic current by dopamine in the nucleus accumbens of alcohol-dependent rats.. Journal of neurophysiology, 2014.
26. Lindemeyer AK, Liang J, Marty VN, Meyer EM, Suryanarayanan A, Olsen RW, Spigelman I. Ethanol-induced plasticity of GABAA receptors in the basolateral amygdala.. Neurochemical research, 2014.
27. Liang J, Lindemeyer AK, Suryanarayanan A, Meyer EM, Marty VN, Ahmad SO, Shao XM, Olsen RW, Spigelman I. Plasticity of GABA(A) receptor-mediated neurotransmission in the nucleus accumbens of alcohol-dependent rats.. Journal of neurophysiology, 2014.
28. Liang J, Shen Y, Shao XM, Scott MB, Ly E, Wong S, Nguyen A, Tan K, Kwon B, Olsen RW, Spigelman I. Dihydromyricetin prevents fetal alcohol exposure-induced behavioral and physiological deficits: the roles of GABAA receptors in adolescence.. Neurochemical research, 2014.
29. Meyer EM, Long V, Fanselow MS, Spigelman I. Stress increases voluntary alcohol intake, but does not alter established drinking habits in a rat model of posttraumatic stress disorder.. Alcoholism, clinical and experimental research, 2012.
30. Marty VN, Spigelman I. Long-lasting alterations in membrane properties, k(+) currents, and glutamatergic synaptic currents of nucleus accumbens medium spiny neurons in a rat model of alcohol dependence.. Frontiers in neuroscience, 2012.
31. Marty VN, Spigelman I. Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens.. Alcohol (Fayetteville, N.Y.), 2012.
32. Shen Y, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J. Dihydromyricetin as a novel anti-alcohol intoxication medication.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
33. Ruangsri S, Lin A, Mulpuri Y, Lee K, Spigelman I, Nishimura I. Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats.. The Journal of biological chemistry, 2011.
34. Suryanarayanan A, Liang J, Meyer EM, Lindemeyer AK, Chandra D, Homanics GE, Sieghart W, Olsen RW, Spigelman I. Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice.. Frontiers in neuroscience, 2011.
35. Kumada A, Matsuka Y, Spigelman I, Maruhama K, Yamamoto Y, Neubert JK, Nolan TA, Watanabe K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K. Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay.. Journal of oral rehabilitation, 2011.
36. Shen Y, Lindemeyer AK, Spigelman I, Sieghart W, Olsen RW, Liang J. Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons.. Molecular pharmacology, 2010.
37. Ribak CE, Shapiro LA, Perez ZD, Spigelman I. Microglia-associated granule cell death in the normal adult dentate gyrus.. Brain structure & function, 2009.
38. Díaz-Cintra S, Xue B, Spigelman I, Van K, Wong AM, Obenaus A, Ribak CE. Dentate granule cells form hilar basal dendrites in a rat model of hypoxia-ischemia.. Brain research, 2009.
39. Liang J, Spigelman I, Olsen RW. Tolerance to sedative/hypnotic actions of GABAergic drugs correlates with tolerance to potentiation of extrasynaptic tonic currents of alcohol-dependent rats.. Journal of neurophysiology, 2009.
40. Thakor DK, Lin A, Matsuka Y, Meyer EM, Ruangsri S, Nishimura I, Spigelman I. Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy.. Molecular pain, 2009.
41. Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K. Botulinum toxin type a (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction.. Neuroscience, 2009.
42. Matsuka Y, Ono T, Iwase H, Mitrirattanakul S, Omoto KS, Cho T, Lam YY, Snyder B, Spigelman I. Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats.. Molecular pain, 2008.
43. Jain NK, Ishikawa TO, Spigelman I, Herschman HR. COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.. Prostaglandins, leukotrienes, and essential fatty acids, 2008.
44. Chandra D, Werner DF, Liang J, Suryanarayanan A, Harrison NL, Spigelman I, Olsen RW, Homanics GE. Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.. Alcoholism, clinical and experimental research, 2007.
45. Liang J, Suryanarayanan A, Chandra D, Homanics GE, Olsen RW, Spigelman I. Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells.. Alcoholism, clinical and experimental research, 2007.
46. Liang J, Suryanarayanan A, Abriam A, Snyder B, Olsen RW, Spigelman I. Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
47. Thakor D, Spigelman I, Tabata Y, Nishimura I. Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons.. Molecular therapy : the journal of the American Society of Gene Therapy, 2007.
48. Mitrirattanakul S, López-Valdés HE, Liang J, Matsuka Y, Mackie K, Faull KF, Spigelman I. Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence.. Alcoholism, clinical and experimental research, 2007.
49. Matsuka Y, Edmonds B, Mitrirattanakul S, Schweizer FE, Spigelman I. Two types of neurotransmitter release patterns in isolectin B4-positive and negative trigeminal ganglion neurons.. Neuroscience, 2006.
50. Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE. GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
51. Mitrirattanakul S, Ramakul N, Guerrero AV, Matsuka Y, Ono T, Iwase H, Mackie K, Faull KF, Spigelman I. Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain.. Pain, 2006.
52. Liang J, Zhang N, Cagetti E, Houser CR, Olsen RW, Spigelman I. Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006.
53. Walwyn WM, Matsuka Y, Arai D, Bloom DC, Lam H, Tran C, Spigelman I, Maidment NT. HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.. Experimental neurology, 2006.
54. Olsen RW, Liang J, Cagetti E, Spigelman I. Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol.. Neurochemical research, 2005.
55. Bartnik BL, Spigelman I, Obenaus A. Cell-permeant calcium buffer induced neuroprotection after cortical devascularization.. Experimental neurology, 2005.
56. Liang J, Cagetti E, Olsen RW, Spigelman I. Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.. The Journal of pharmacology and experimental therapeutics, 2004.
57. Matsuka Y, Spigelman I. Hyperosmolar solutions selectively block action potentials in rat myelinated sensory fibers: implications for diabetic neuropathy.. Journal of neurophysiology, 2003.
58. Dashtipour K, Wong AM, Obenaus A, Spigelman I, Ribak CE. Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus.. Epilepsy research, 2003.
59. Spigelman I, Li Z, Liang J, Cagetti E, Samzadeh S, Mihalek RM, Homanics GE, Olsen RW. Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit.. Journal of neurophysiology, 2003.
60. Marvizón JC, Wang X, Matsuka Y, Neubert JK, Spigelman I. Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.. Neuroscience, 2003.
61. Cagetti E, Liang J, Spigelman I, Olsen RW. Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors.. Molecular pharmacology, 2003.
62. Neubert JK, Matsuka Y, Maidment NT, Spigelman I. Microdialysis in trigeminal ganglia.. Brain research. Brain research protocols, 2002.
63. Spigelman I, Li Z, Banerjee PK, Mihalek RM, Homanics GE, Olsen RW. Behavior and physiology of mice lacking the GABAA-receptor delta subunit.. Epilepsia, 2002.
64. Matsuka Y, Neubert JK, Maidment NT, Spigelman I. Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo.. Brain research, 2001.
65. Yan XX, Spigelman I, Tran PH, Ribak CE. Atypical features of rat dentate granule cells: recurrent basal dendrites and apical axons.. Anatomy and embryology, 2001.
66. Ribak CE, Tran PH, Spigelman I, Okazaki MM, Nadler JV. Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry.. The Journal of comparative neurology, 2000.
67. Neubert JK, Maidment NT, Matsuka Y, Adelson DW, Kruger L, Spigelman I. Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo.. Brain research, 2000.
68. Mihalek RM, Banerjee PK, Korpi ER, Quinlan JJ, Firestone LL, Mi ZP, Lagenaur C, Tretter V, Sieghart W, Anagnostaras SG, Sage JR, Fanselow MS, Guidotti A, Spigelman I, Li Z, DeLorey TM, Olsen RW, Homanics GE. Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.. Proceedings of the National Academy of Sciences of the United States of America, 1999.
69. Szucs P, Polgar E, Spigelman I, Porszasz R, Nagy I. Neurokinin-1 receptor expression in dorsal root ganglion neurons of young rats.. Journal of the peripheral nervous system : JPNS, 1999.
70. Kang MH, Spigelman I, Olsen RW. Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment.. Alcoholism, clinical and experimental research, 1998.
71. Spigelman I, Obenaus A, Mazarati A, Wasterlain CG. Intravenously administered cell-permeant calcium buffer decreases evoked synaptic potentials in rat dentate gyrus in vivo.. Brain research, 1998.
72. Spigelman I, Yan XX, Obenaus A, Lee EY, Wasterlain CG, Ribak CE. Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy.. Neuroscience, 1998.
73. Wasterlain CG, Shirasaka Y, Mazarati AM, Spigelman I. Chronic epilepsy with damage restricted to the hippocampus: possible mechanisms.. Epilepsy research, 1996.
74. Spigelman I, Tymianski M, Wallace CM, Carlen PL, Velumian AA. Modulation of hippocampal synaptic transmission by low concentrations of cell-permeant Ca2+ chelators: effects of Ca2+ affinity, chelator structure and binding kinetics.. Neuroscience, 1996.
75. Kang M, Spigelman I, Sapp DW, Olsen RW. Persistent reduction of GABA(A) receptor-mediated inhibition in rat hippocampus after chronic intermittent ethanol treatment.. Brain research, 1996.
76. Gordey M, Kang M, Olsen RW, Spigelman I. Zinc modulation of GABAA receptor-mediated chloride flux in rat hippocampal slices.. Brain research, 1995.
77. Tymianski M, Spigelman I, Zhang L, Carlen PL, Tator CH, Charlton MP, Wallace MC. Mechanism of action and persistence of neuroprotection by cell-permeant Ca2+ chelators.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994.
78. Mills LR, Niesen CE, So AP, Carlen PL, Spigelman I, Jones OT. N-type Ca2+ channels are located on somata, dendrites, and a subpopulation of dendritic spines on live hippocampal pyramidal neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994.
79. Tymianski M, Wallace MC, Spigelman I, Uno M, Carlen PL, Tator CH, Charlton MP. Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo.. Neuron, 1993.
80. Hutcheon B, Puil E, Spigelman I. Histamine actions and comparison with substance P effects in trigeminal neurons.. Neuroscience, 1993.
81. Spigelman I, Zhang L, Carlen PL. Patch-clamp study of postnatal development of CA1 neurons in rat hippocampal slices: membrane excitability and K+ currents.. Journal of neurophysiology, 1992.
82. Zhang L, Spigelman I, Carlen PL. Development of GABA-mediated, chloride-dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices.. The Journal of physiology, 1991.
83. Zhang L, Spigelman I, Carlen PL. Whole-cell patch study of GABAergic inhibition in CA1 neurons of immature rat hippocampal slices.. Brain research. Developmental brain research, 1990.
84. Spigelman I, Puil E. Ionic mechanism of substance P actions on neurons in trigeminal root ganglia.. Journal of neurophysiology, 1990.
85. Puil E, Miura RM, Spigelman I. Consequences of 4-aminopyridine applications to trigeminal root ganglion neurons.. Journal of neurophysiology, 1989.
86. Spigelman I, Puil E. K+-channel blockade in trigeminal root ganglion neurons: effects on membrane outward currents.. Journal of neurophysiology, 1989.
87. Kim SU, Osborne DN, Kim MW, Spigelman I, Puil E, Shin DH, Eisen A. Long-term culture of human fetal spinal cord neurons: morphological, immunocytochemical and electrophysiological characteristics.. Neuroscience, 1988.
88. Puil E, Spigelman I. Electrophysiological responses of trigeminal root ganglion neurons in vitro.. Neuroscience, 1988.
89. Puil E, Gimbarzevsky B, Spigelman I. Primary involvement of K+ conductance in membrane resonance of trigeminal root ganglion neurons.. Journal of neurophysiology, 1988.