Jonathan David Herman

Assistant Professor-in-residence, Medicine, University of California Los Angeles

UC Profile

Interests

host-pathogen interactions, complement biology, phage-display immunoprecipitation, therapeutic development, novel technology development, interplay of innate and adaptive immunity, systems serology, malaria immunology, organoid models of disease and immunity, systems biology, machine learning, human immunology, IgM biology, fc-driven antibody immunology, Antibody immunology, vaccine development

Education and Training

Massachusetts General Hospital | Brigham and Women's HospitalFellowship2022Infectious Disease
NewYork Presbyterian | Weill Cornell Medical CenterResidency2018Internal Medicine
Harvard Medical SchoolM.D.2016
Harvard Medical SchoolPh.D.2016
Brown UniversitySc.B.2007

Awards and Honors

  • Young Physician-Scientist Award, The American Society for Clinical Investigation, 2025.
  • Physician Scientist Fellowship Award, Doris Duke Charitable Foundation, 2021.
  • Henry Asbury Christian Award, Harvard Medical School, 2016.
  • Fulbright Fellowship, U.S. Department of State, 2007.

Publications

  1. Kisalu, N.K., Pereira, L.D.S., Herman, J.D., Asokan, M., Ernste, K., Merriam, J., Liu, C., Demouth, M.E., Pegu, A., Lofgren, M., Dillon, M., Bonilla, B., Macvicar, R., Zur, Y., Kiyuka, P., Flores-Garcia, Y., Chakraborty, S., Nikolaeva, D., Ogwang, R., Flynn, B., Francica, J., Pierson, T.C., Koup, R.A., Zavala, F., Wang, T.T., Alter, G., Idris, A.H., Seder, R.A.. FcγR binding differentially contributes to protection by two human monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein. Science Translational Medicine, 2025.
  2. Jongo S, Church LWP, Milando F, Qassim M, Schindler T, Rashid M, Tumbo A, Nyaulingo G, Bakari BM, Athuman Mbaga T, Mohamed L, Kassimu K, Simon BS, Mpina M, Zaidi I, Duffy PE, Swanson PA, Seder R, Herman JD, Mendu M, Zur Y, Alter G, Kc N, Riyahi P, Abebe Y, Murshedkar T, James ER, Billingsley PF, Sim BKL, Richie TL, Daubenberger C, Abdulla S, Hoffman SL. Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults.. The Journal of clinical investigation, 2024.
  3. Andrews HS, Herman JD, Gandhi RT. Treatments for COVID-19.. Annual review of medicine, 2023.
  4. Nziza N, Tran TM, DeRiso EA, Dolatshahi S, Herman JD, de Lacerda L, Junqueira C, Lieberman J, Ongoiba A, Doumbo S, Kayentao K, Traore B, Crompton PD, Alter G. Accumulation of Neutrophil Phagocytic Antibody Features Tracks With Naturally Acquired Immunity Against Malaria in Children.. The Journal of infectious diseases, 2023.
  5. Herman JD, Atyeo C, Zur Y, Cook CE, Patel NJ, Vanni KM, Kowalski EN, Qian G, Srivatsan S, Shadick NA, Rao DA, Kellman B, Mann CJ, Lauffenburger D, Wallace ZS, Sparks JA, Alter G. Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases.. Science translational medicine, 2023.
  6. Herman JD, Wang C, Burke JS, Zur Y, Compere H, Kang J, Macvicar R, Taylor S, Shin S, Frank I, Siegel D, Tebas P, Choi GH, Shaw PA, Yoon H, Pirofski LA, Julg BD, Bar KJ, Lauffenburger D, Alter G. Nucleocapsid-specific antibody function is associated with therapeutic benefits from COVID-19 convalescent plasma therapy.. Cell reports. Medicine, 2022.
  7. Herman JD, Wang C, Loos C, Yoon H, Rivera J, Eugenia Dieterle M, Haslwanter D, Jangra RK, Bortz RH, Bar KJ, Julg B, Chandran K, Lauffenburger D, Pirofski LA, Alter G. Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response.. Nature communications, 2021.
  8. Queen J, Karaba S, Albin J, Karaba A, Howard-Anderson J, Skinner N, Herman JD, Paras ML, Melia MT. The Time is Now: A Call for Renewed Support of Infectious Diseases Physician-Scientist Trainees in the Era of Coronavirus Disease 2019.. The Journal of infectious diseases, 2021.
  9. Fagbami, L., Deik, A. A., Singh, K., Santos, S. A., Herman, J. D., Bopp, S. E., Lukens, A. K., Clish, C. B., Wirth, D. F., and Mazitschek, R. . The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling. ACS Infect Dis, 2019.
  10. Volkman, S. K., Herman, J. D., Lukens, A. K., Hartl, D. L. . Genome Wide Association Studies of Drug-Resistance Determinants. Trends in Parasitology , 2017.
  11. Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.. Science translational medicine, 2015.
  12. Herman JD, Rice DP, Ribacke U, Silterra J, Deik AA, Moss EL, Broadbent KM, Neafsey DE, Desai MM, Clish CB, Mazitschek R, Wirth DF. A genomic and evolutionary approach reveals non-genetic drug resistance in malaria.. Genome biology, 2014.
  13. Hanson, K. K., Ressurreição, A. S., Buchholz, K., Prudêncio, M., Herman-Ornelas, J. D., Rebelo, M., Rebelo, M., Beatty, W. L., Wirth, D. F., Hänscheid, T., Moreira, R., Marti, M., Mota, M. M. . Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci USA, 2013.
  14. Herman JD, Appelbaum H. Hereditary breast and ovarian cancer syndrome and issues in pediatric and adolescent practice.. Journal of pediatric and adolescent gynecology, 2010.