Lena Pernas

Assistant Professor, MIMG, University of California Los Angeles

Publications

  1. Kreimendahl S, Pernas L. Metabolic immunity against microbes.. Trends in cell biology, 2023.
  2. Mehra C, Pernas L. Contact sites between host organelles and pathogens: boon or bane?. mSphere, 2023.
  3. Beros S, Pernas L. Sleeping monsters: chronic infections in COVID-19 pathogenesis.. Trends in microbiology, 2023.
  4. Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L. Author Correction: The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites.. Nature metabolism, 2022.
  5. Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF. Mitochondria shed their outer membrane in response to infection-induced stress.. Science (New York, N.Y.), 2022.
  6. Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L. The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites.. Nature metabolism, 2021.
  7. Medeiros TC, Mehra C, Pernas L. Contact and competition between mitochondria and microbes.. Current opinion in microbiology, 2021.
  8. Mehra C, Pernas L. Move it to lose it: Mitocytosis expels damaged mitochondria.. Developmental cell, 2021.
  9. Pernas L. Cellular metabolism in the defense against microbes.. Journal of cell science, 2021.
  10. Carvalho KF, Machado TS, Garcia BM, Zangirolamo AF, Macabelli CH, Sugiyama FHC, Grejo MP, Augusto Neto JD, Tostes K, Ribeiro FKS, Sarapião FD, Pandey AK, Nociti RP, Tizioto P, Coutinho LL, Meirelles FV, Guimarães FEG, Pernas L, Seneda MM, Chiaratti MR. Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020.
  11. Pernas L. mSphere of Influence: Finding a Direction-How Do Mitochondria Know Where To Go?. mSphere, 2019.
  12. Blank ML, Parker ML, Ramaswamy R, Powell CJ, English ED, Adomako-Ankomah Y, Pernas LF, Workman SD, Boothroyd JC, Boulanger MJ, Boyle JP. A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions.. Molecular microbiology, 2018.
  13. Pernas L, Bean C, Boothroyd JC, Scorrano L. Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids.. Cell metabolism, 2018.
  14. Pernas L, Scorrano L. RevAMPing Mitochondrial Shape to Live Longer.. Cell metabolism, 2017.
  15. Adomako-Ankomah Y, English ED, Danielson JJ, Pernas LF, Parker ML, Boulanger MJ, Dubey JP, Boyle JP. Host Mitochondrial Association Evolved in the Human Parasite Toxoplasma gondii via Neofunctionalization of a Gene Duplicate.. Genetics, 2016.
  16. Pernas L, Scorrano L. Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function.. Annual review of physiology, 2015.
  17. Pernas L, Adomako-Ankomah Y, Shastri AJ, Ewald SE, Treeck M, Boyle JP, Boothroyd JC. Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response.. PLoS biology, 2014.
  18. Pernas L, Ramirez R, Holmes TH, Montoya JG, Boothroyd JC. Immune profiling of pregnant Toxoplasma-infected US and Colombia patients reveals surprising impacts of infection on peripheral blood cytokines.. The Journal of infectious diseases, 2014.
  19. Pernas L, Boothroyd JC. Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8.. International journal for parasitology, 2010.