Leonid Kruglyak *

Leonid Kruglyak

Department Chair, Human Genetics, University of California Los Angeles

Professor, Human Genetics, University of California Los Angeles

Professor, Biological Chemistry, University of California Los Angeles

Leonid Kruglyak, Ph.D., holds The Diller-von Furstenberg Family Endowed Chair in Human Genetics.

Publications

  1. Boocock J, Alexander N, Tapia LA, Walter-McNeill L, Munugala C, Bloom JS, Kruglyak L. Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction.. bioRxiv : the preprint server for biology, 2023.
  2. Guo L, Kruglyak L. Genetics and biology of coloration in reptiles: the curious case of the Lemon Frost geckos.. Physiological genomics, 2023.
  3. Kruglyak L, Beyer A, Bloom JS, Grossbach J, Lieberman TD, Mancuso CP, Rich MS, Sherlock G, Kaplan CD. Insufficient evidence for non-neutrality of synonymous mutations.. Nature, 2023.
  4. Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. Heritable Cas9-induced nonhomologous recombination in C. elegans.. microPublication biology, 2023.
  5. Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. Cas9-induced nonhomologous recombination in C. elegans.. bioRxiv : the preprint server for biology, 2023.
  6. Swichkow CR, Bloom JS, Kruglyak L. Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications.. PLoS biology, 2022.
  7. Dhindsa RS, Wang Q, Vitsios D, Burren OS, Hu F, DiCarlo JE, Kruglyak L, MacArthur DG, Hurles ME, Petrovski S. A minimal role for synonymous variation in human disease.. American journal of human genetics, 2022.
  8. Schubert OT, Bloom JS, Sadhu MJ, Kruglyak L. Genome-wide base editor screen identifies regulators of protein abundance in yeast.. eLife, 2022.
  9. Brandenberg OF, Schubert OT, Kruglyak L. Towards synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression.. Microbial cell factories, 2022.
  10. Guo L, Bloom JS, Dols-Serrate D, Boocock J, Ben-David E, Schubert OT, Kozuma K, Ho K, Warda E, Chui C, Wei Y, Leighton D, Lemus Vergara T, Riutort M, Sánchez Alvarado A, Kruglyak L. Island-specific evolution of a sex-primed autosome in a sexual planarian.. Nature, 2022.
  11. Guo L, Boocock J, Hilt EE, Chandrasekaran S, Zhang Y, Munugala C, Sathe L, Alexander N, Arboleda VA, Flint J, Eskin E, Luo C, Yang S, Garner OB, Yin Y, Bloom JS, Kruglyak L. Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA.. BMC genomics, 2022.
  12. Hilt EE, Boocock J, Trejo M, Le CQ, Guo L, Zhang Y, Sathe L, Arboleda VA, Yin Y, Bloom JS, Wang PC, Elmore JG, Kruglyak L, Shrestha L, Bakhash SAM, Lin M, Xie H, Huang ML, Roychoudhury P, Greninger A, Chandrasekaran S, Yang S, Garner OB. Retrospective Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Symptomatic Patients Prior to Widespread Diagnostic Testing in Southern California.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022.
  13. Adamson PC, Pfeffer MA, Arboleda VA, Garner OB, de St Maurice A, von Bredow B, Flint J, Kruglyak L, Currier JS. Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California.. Open forum infectious diseases, 2021.
  14. Guo F, McClain M, Zhao X, Yi K, Parmely T, Unruh J, Slaughter B, Kruglyak L, Guo L, Sánchez Alvarado A. Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining.. Journal of visualized experiments : JoVE, 2021.
  15. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples.. Nature biomedical engineering, 2021.
  16. Guo L, Bloom J, Sykes S, Huang E, Kashif Z, Pham E, Ho K, Alcaraz A, Xiao XG, Duarte-Vogel S, Kruglyak L. Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos.. PLoS genetics, 2021.
  17. Ben-David E, Boocock J, Guo L, Zdraljevic S, Bloom JS, Kruglyak L. Whole-organism eQTL mapping at cellular resolution with single-cell sequencing.. eLife, 2021.
  18. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing.. medRxiv : the preprint server for health sciences, 2021.
  19. Boocock J, Sadhu MJ, Durvasula A, Bloom JS, Kruglyak L. Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast.. Science (New York, N.Y.), 2021.
  20. Ben-David E, Pliota P, Widen SA, Koreshova A, Lemus-Vergara T, Verpukhovskiy P, Mandali S, Braendle C, Burga A, Kruglyak L. Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species.. Current biology : CB, 2021.
  21. Renganaath K, Chong R, Day L, Kosuri S, Kruglyak L, Albert FW. Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross.. eLife, 2020.
  22. Burga A, Ben-David E, Kruglyak L. Toxin-Antidote Elements Across the Tree of Life.. Annual review of genetics, 2020.
  23. Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S. Screening Human Embryos for Polygenic Traits Has Limited Utility.. Cell, 2019.
  24. Bloom JS, Boocock J, Treusch S, Sadhu MJ, Day L, Oates-Barker H, Kruglyak L. Rare variants contribute disproportionately to quantitative trait variation in yeast.. eLife, 2019.
  25. Zeevi D, Bloom JS, Sadhu MJ, Ben Yehuda A, Zangen D, Levy-Lahad E, Kruglyak L. Analysis of the genetic basis of height in large Jewish nuclear families.. PLoS genetics, 2019.
  26. Burga A, Ben-David E, Lemus Vergara T, Boocock J, Kruglyak L. Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk.. Nature communications, 2019.
  27. Gou L, Bloom JS, Kruglyak L. The Genetic Basis of Mutation Rate Variation in Yeast.. Genetics, 2018.
  28. Sadhu MJ, Kruglyak L. How Low Can You Go?. The CRISPR journal, 2018.
  29. Albert FW, Bloom JS, Siegel J, Day L, Kruglyak L. Genetics of trans-regulatory variation in gene expression.. eLife, 2018.
  30. Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L. Highly parallel genome variant engineering with CRISPR-Cas9.. Nature genetics, 2018.
  31. Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. Genetic variation in adaptability and pleiotropy in budding yeast.. eLife, 2017.
  32. Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J. The genetic basis of natural variation in a phoretic behavior.. Nature communications, 2017.
  33. Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. A genetic signature of the evolution of loss of flight in the Galapagos cormorant.. Science (New York, N.Y.), 2017.
  34. Ben-David E, Burga A, Kruglyak L. A maternal-effect selfish genetic element in Caenorhabditis elegans.. Science (New York, N.Y.), 2017.
  35. Forsberg SK, Bloom JS, Sadhu MJ, Kruglyak L, Carlborg Ö. Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast.. Nature genetics, 2017.
  36. Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.. Genetics, 2016.
  37. Kruglyak L. Complex Traits and Simple Systems: An Interview with Leonid Kruglyak.. Genetics, 2016.
  38. Sadhu MJ, Bloom JS, Day L, Kruglyak L. CRISPR-directed mitotic recombination enables genetic mapping without crosses.. Science (New York, N.Y.), 2016.
  39. Kruglyak L. 2015 Curt Stern Award.. American journal of human genetics, 2016.
  40. Bloom JS, Kotenko I, Sadhu MJ, Treusch S, Albert FW, Kruglyak L. Genetic interactions contribute less than additive effects to quantitative trait variation in yeast.. Nature communications, 2015.
  41. Ghosh R, Bloom JS, Mohammadi A, Schumer ME, Andolfatto P, Ryu W, Kruglyak L. Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans.. Genetics, 2015.
  42. Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJ, Brenchley R, Van't Hof A, Bevers RP, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, Andersen EC, Moerman DG, Hillier LW, Kammenga JE, Waterston RH. Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856.. Genetics, 2015.
  43. Thomas CG, Wang W, Jovelin R, Ghosh R, Lomasko T, Trinh Q, Kruglyak L, Stein LD, Cutter AD. Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis.. Genome research, 2015.
  44. Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, Kruglyak L. A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains.. G3 (Bethesda, Md.), 2015.
  45. Albert FW, Kruglyak L. The role of regulatory variation in complex traits and disease.. Nature reviews. Genetics, 2015.
  46. Balla KM, Andersen EC, Kruglyak L, Troemel ER. A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite.. PLoS pathogens, 2015.
  47. Treusch S, Albert FW, Bloom JS, Kotenko IE, Kruglyak L. Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae.. PLoS genetics, 2015.
  48. Wang X, Kruglyak L. Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent.. PLoS genetics, 2014.
  49. Albert FW, Muzzey D, Weissman JS, Kruglyak L. Genetic influences on translation in yeast.. PLoS genetics, 2014.
  50. Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW. Genetic influences on brain gene expression in rats selected for tameness and aggression.. Genetics, 2014.
  51. Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L. Genetic basis of metabolome variation in yeast.. PLoS genetics, 2014.
  52. Andersen EC, Bloom JS, Gerke JP, Kruglyak L. A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology.. PLoS genetics, 2014.
  53. Albert FW, Treusch S, Shockley AH, Bloom JS, Kruglyak L. Genetics of single-cell protein abundance variation in large yeast populations.. Nature, 2014.
  54. Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess DC. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case.. G3 (Bethesda, Md.), 2013.
  55. Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.. PLoS genetics, 2013.
  56. Bloom JS, Ehrenreich IM, Loo WT, Lite TL, Kruglyak L. Finding the sources of missing heritability in a yeast cross.. Nature, 2013.
  57. Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans.. PLoS genetics, 2012.
  58. Ghosh R, Mohammadi A, Kruglyak L, Ryu WS. Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans.. BMC biology, 2012.
  59. Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans.. Genetics, 2012.
  60. Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells.. Science (New York, N.Y.), 2012.
  61. Ehrenreich IM, Bloom J, Torabi N, Wang X, Jia Y, Kruglyak L. Genetic architecture of highly complex chemical resistance traits across four yeast strains.. PLoS genetics, 2012.
  62. Torabi N, Kruglyak L. Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast.. PLoS genetics, 2012.
  63. Ghosh R, Andersen EC, Shapiro JA, Gerke JP, Kruglyak L. Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.. Science (New York, N.Y.), 2012.
  64. Andersen EC, Gerke JP, Shapiro JA, Crissman JR, Ghosh R, Bloom JS, Félix MA, Kruglyak L. Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity.. Nature genetics, 2012.
  65. Khan Z, Bloom JS, Amini S, Singh M, Perlman DH, Caudy AA, Kruglyak L. Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS.. Molecular systems biology, 2012.
  66. Khan Z, Amini S, Bloom JS, Ruse C, Caudy AA, Kruglyak L, Singh M, Perlman DH, Tavazoie S. Accurate proteome-wide protein quantification from high-resolution 15N mass spectra.. Genome biology, 2011.
  67. Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms.. PLoS biology, 2011.
  68. Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.. PLoS genetics, 2011.
  69. Torabi N, Kruglyak L. Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae.. PLoS genetics, 2011.
  70. Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L. A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans.. PLoS biology, 2011.
  71. Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, Bargmann CI. Catecholamine receptor polymorphisms affect decision-making in C. elegans.. Nature, 2011.
  72. Rockman MV, Skrovanek SS, Kruglyak L. Selection at linked sites shapes heritable phenotypic variation in C. elegans.. Science (New York, N.Y.), 2010.
  73. Ehrenreich IM, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, Gresham D, Caudy AA, Kruglyak L. Dissection of genetically complex traits with extremely large pools of yeast segregants.. Nature, 2010.
  74. Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D. Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
  75. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases.. Nature, 2009.
  76. Ehrenreich IM, Gerke JP, Kruglyak L. Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross.. Cold Spring Harbor symposia on quantitative biology, 2009.
  77. Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. Using expression and genotype to predict drug response in yeast.. PloS one, 2009.
  78. Khan Z, Bloom JS, Garcia BA, Singh M, Kruglyak L. Protein quantification across hundreds of experimental conditions.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
  79. Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE. Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains.. Genetics, 2009.
  80. Kruglyak L, Storey JD. Cause and express.. Nature biotechnology, 2009.
  81. Bloom JS, Khan Z, Kruglyak L, Singh M, Caudy AA. Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays.. BMC genomics, 2009.
  82. Khan Z, Bloom JS, Kruglyak L, Singh M. A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays.. Bioinformatics (Oxford, England), 2009.
  83. Rockman MV, Kruglyak L. Recombinational landscape and population genomics of Caenorhabditis elegans.. PLoS genetics, 2009.
  84. McGrath PT, Rockman MV, Zimmer M, Jang H, Macosko EZ, Kruglyak L, Bargmann CI. Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors.. Neuron, 2009.
  85. Schacherer J, Shapiro JA, Ruderfer DM, Kruglyak L. Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae.. Nature, 2009.
  86. Reddy KC, Andersen EC, Kruglyak L, Kim DH. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans.. Science (New York, N.Y.), 2009.
  87. Capra EJ, Skrovanek SM, Kruglyak L. Comparative developmental expression profiling of two C. elegans isolates.. PloS one, 2008.
  88. Coller HA, Kruglyak L. Genetics. It's the sequence, stupid!. Science (New York, N.Y.), 2008.
  89. Gresham D, Kruglyak L. Rise of the machines.. PLoS genetics, 2008.
  90. Palopoli MF, Rockman MV, TinMaung A, Ramsay C, Curwen S, Aduna A, Laurita J, Kruglyak L. Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.. Nature, 2008.
  91. Demogines A, Smith E, Kruglyak L, Alani E. Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast.. PLoS genetics, 2008.
  92. Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L, Bumgarner RE, Schadt EE. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks.. Nature genetics, 2008.
  93. Rockman MV, Kruglyak L. Breeding designs for recombinant inbred advanced intercross lines.. Genetics, 2008.
  94. Smith EN, Kruglyak L. Gene-environment interaction in yeast gene expression.. PLoS biology, 2008.
  95. Kruglyak L. The road to genome-wide association studies.. Nature reviews. Genetics, 2008.
  96. Seidel HS, Rockman MV, Kruglyak L. Widespread genetic incompatibility in C. elegans maintained by balancing selection.. Science (New York, N.Y.), 2008.
  97. Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast.. Nature genetics, 2007.
  98. Kruglyak L, Stern DL. Evolution. An embarrassment of switches.. Science (New York, N.Y.), 2007.
  99. Schacherer J, Ruderfer DM, Gresham D, Dolinski K, Botstein D, Kruglyak L. Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains.. PloS one, 2007.
  100. Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast.. Nature genetics, 2007.
  101. Rockman MV, Kruglyak L. Genetics of global gene expression.. Nature reviews. Genetics, 2006.
  102. Ruderfer DM, Pratt SC, Seidel HS, Kruglyak L. Population genomic analysis of outcrossing and recombination in yeast.. Nature genetics, 2006.
  103. Eberle MA, Rieder MJ, Kruglyak L, Nickerson DA. Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome.. PLoS genetics, 2006.
  104. Riehle MM, Markianos K, Niaré O, Xu J, Li J, Touré AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traoré SF, Vernick KD. Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region.. Science (New York, N.Y.), 2006.
  105. Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.. PLoS genetics, 2006.
  106. Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham MJ, Botstein D, Kruglyak L. Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray.. Science (New York, N.Y.), 2006.
  107. Parker HG, Kruglyak L, Ostrander EA. Molecular genetics: DNA analysis of a putative dog clone.. Nature, 2006.
  108. Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. Revealing complex traits with small molecules and naturally recombinant yeast strains.. Chemistry & biology, 2006.
  109. Kruglyak L. Power tools for human genetics.. Nature genetics, 2005.
  110. Ronald J, Brem RB, Whittle J, Kruglyak L. Local regulatory variation in Saccharomyces cerevisiae.. PLoS genetics, 2005.
  111. Brem RB, Storey JD, Whittle J, Kruglyak L. Genetic interactions between polymorphisms that affect gene expression in yeast.. Nature, 2005.
  112. Storey JD, Akey JM, Kruglyak L. Multiple locus linkage analysis of genomewide expression in yeast.. PLoS biology, 2005.
  113. Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays.. Genome research, 2005.
  114. Brem RB, Kruglyak L. The landscape of genetic complexity across 5,700 gene expression traits in yeast.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  115. Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, Ostrander EA. Extensive and breed-specific linkage disequilibrium in Canis familiaris.. Genome research, 2004.
  116. Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K, Patterson N. No bias in linkage analysis.. American journal of human genetics, 2004.
  117. Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. Population history and natural selection shape patterns of genetic variation in 132 genes.. PLoS biology, 2004.
  118. Carlson CS, Reider MJ, Nickerson DA, Eberle MA, Kruglyak L. Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'.. Bioinformatics (Oxford, England), 2004.
  119. Furman I, Rieder MJ, Da Ponte S, Carrington DP, Nickerson DA, Kruglyak L, Markianos K. Sequence-based linkage analysis.. American journal of human genetics, 2004.
  120. Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies.. Nature, 2004.
  121. Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. Genetic structure of the purebred domestic dog.. Science (New York, N.Y.), 2004.
  122. Crawford DC, Carlson CS, Rieder MJ, Carrington DP, Yi Q, Smith JD, Eberle MA, Kruglyak L, Nickerson DA. Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations.. American journal of human genetics, 2004.
  123. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.. American journal of human genetics, 2003.
  124. Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.. Nature genetics, 2003.
  125. Matise TC, Sachidanandam R, Clark AG, Kruglyak L, Wijsman E, Kakol J, Buyske S, Chui B, Cohen P, de Toma C, Ehm M, Glanowski S, He C, Heil J, Markianos K, McMullen I, Pericak-Vance MA, Silbergleit A, Stein L, Wagner M, Wilson AF, Winick JD, Winn-Deen ES, Yamashiro CT, Cann HM, Lai E, Holden AL. A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set.. American journal of human genetics, 2003.
  126. Carlson CS, Eberle MA, Rieder MJ, Smith JD, Kruglyak L, Nickerson DA. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans.. Nature genetics, 2003.
  127. Niaré O, Markianos K, Volz J, Oduol F, Touré A, Bagayoko M, Sangaré D, Traoré SF, Wang R, Blass C, Dolo G, Bouaré M, Kafatos FC, Kruglyak L, Touré YT, Vernick KD. Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population.. Science (New York, N.Y.), 2002.
  128. Ardlie KG, Kruglyak L, Seielstad M. Patterns of linkage disequilibrium in the human genome.. Nature reviews. Genetics, 2002.
  129. Brem RB, Yvert G, Clinton R, Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast.. Science (New York, N.Y.), 2002.
  130. Eberle MA, Pfützer R, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, Duerr RH, Kruglyak L, Whitcomb DC, Brentnall TA. A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34.. American journal of human genetics, 2002.
  131. Lindgren CM, Mahtani MM, Widén E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, Lander ES. Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.. American journal of human genetics, 2002.
  132. Ardlie K, Liu-Cordero SN, Eberle MA, Daly M, Barrett J, Winchester E, Lander ES, Kruglyak L. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion.. American journal of human genetics, 2001.
  133. Subrahmanyan L, Eberle MA, Clark AG, Kruglyak L, Nickerson DA. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus.. American journal of human genetics, 2001.
  134. Markianos K, Daly MJ, Kruglyak L. Efficient multipoint linkage analysis through reduction of inheritance space.. American journal of human genetics, 2001.
  135. Kruglyak L, Nickerson DA. Variation is the spice of life.. Nature genetics, 2001.
  136. Markianos K, Carlson S, Gibbs M, Kruglyak L. A joint analysis of asthma affection status and IgE levels in multiple data sets collected for asthma.. Genetic epidemiology, 2001.
  137. Altshuler D, Daly M, Kruglyak L. Guilt by association.. Nature genetics, 2000.
  138. Yang Z, Wong GK, Eberle MA, Kibukawa M, Passey DA, Hughes WR, Kruglyak L, Yu J. Sampling SNPs.. Nature genetics, 2000.
  139. Ostrander EA, Kruglyak L. Unleashing the canine genome.. Genome research, 2000.
  140. Rasko JE, Battini JL, Kruglyak L, Cox DR, Miller AD. Precise gene localization by phenotypic assay of radiation hybrid cells.. Proceedings of the National Academy of Sciences of the United States of America, 2000.
  141. Nancarrow DJ, Levinson DF, Taylor JM, Hayward NK, Walters MK, Lennon DP, Nertney DA, Jones HL, Mahtani MM, Kirby A, Kruglyak L, Brown DM, Crowe RR, Andreasen NC, Black DW, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, Mowry BJ. No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees.. American journal of medical genetics, 2000.
  142. Pratt SC, Daly MJ, Kruglyak L. Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components.. American journal of human genetics, 2000.
  143. Eberle MA, Kruglyak L. An analysis of strategies for discovery of single-nucleotide polymorphisms.. Genetic epidemiology, 2000.
  144. Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD, McInnis M, Simpson S, McMahon F, Stine OC, Meyers D, Xu J, MacKinnon D, Swift-Scanlan T, Jamison K, Folstein S, Daly M, Kruglyak L, Marr T, DePaulo JR, Botstein D. Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.. American journal of human genetics, 2000.
  145. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes.. Nature genetics, 1999.
  146. Kruglyak L. Genetic isolates: separate but equal?. Proceedings of the National Academy of Sciences of the United States of America, 1999.
  147. Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kirby A, Hayward NK, Crowe RR, Andreasen NC, Black DW, Silverman JM, Endicott J, Sharpe L, Mohs RC, Siever LJ, Walters MK, Lennon DP, Jones HL, Nertney DA, Daly MJ, Gladis M, Mowry BJ. Genome scan of schizophrenia.. The American journal of psychiatry, 1998.
  148. Altshuler D, Kruglyak L, Lander E. Genetic polymorphisms and disease.. The New England journal of medicine, 1998.
  149. Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. Siblings of centenarians live longer.. Lancet (London, England), 1998.
  150. Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, Robinson E, Mittmann M, Morris MS, Shen N, Kilburn D, Rioux J, Nusbaum C, Rozen S, Hudson TJ, Lipshutz R, Chee M, Lander ES. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome.. Science (New York, N.Y.), 1998.
  151. Kruglyak L, Daly MJ. Linkage thresholds for two-stage genome scans.. American journal of human genetics, 1998.
  152. Kruglyak L, McAllister L. Who needs genetic markers?. Nature genetics, 1998.
  153. Kruglyak L, Lander ES. Faster multipoint linkage analysis using Fourier transforms.. Journal of computational biology : a journal of computational molecular cell biology, 1998.
  154. McCarthy MI, Kruglyak L, Lander ES. Sib-pair collection strategies for complex diseases.. Genetic epidemiology, 1998.
  155. Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kääriäinen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES, Laitinen LA, Kere J. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population.. Human molecular genetics, 1997.
  156. Kruglyak L. What is significant in whole-genome linkage disequilibrium studies?. American journal of human genetics, 1997.
  157. Kruglyak L. The use of a genetic map of biallelic markers in linkage studies.. Nature genetics, 1997.
  158. Kruglyak L. Nonparametric linkage tests are model free.. American journal of human genetics, 1997.
  159. Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression.. Neuron, 1997.
  160. Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonard S, Byerley W. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus.. Proceedings of the National Academy of Sciences of the United States of America, 1997.
  161. Slonim D, Kruglyak L, Stein L, Lander E. Building human genome maps with radiation hybrids.. Journal of computational biology : a journal of computational molecular cell biology, 1997.
  162. Daly M, Kirby A, Kruglyak L. Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18?. Genetic epidemiology, 1997.
  163. Kruglyak L. Thresholds and sample sizes.. Nature genetics, 1996.
  164. Mahtani MM, Widén E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families.. Nature genetics, 1996.
  165. Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faure S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D. A locus for Fanconi anemia on 16q determined by homozygosity mapping.. American journal of human genetics, 1996.
  166. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach.. American journal of human genetics, 1996.
  167. Kruglyak L, Lander ES. Limits on fine mapping of complex traits.. American journal of human genetics, 1996.
  168. Levy EN, Shen Y, Kupelian A, Kruglyak L, Aksentijevich I, Pras E, Balow JE, Linzer B, Chen X, Shelton DA, Gumucio D, Pras M, Shohat M, Rotter JI, Fischel-Ghodsian N, Richards RI, Kastner DL. Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246.. American journal of human genetics, 1996.
  169. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. Disruption of the nuclear hormone receptor RORalpha in staggerer mice.. Nature, 1996.
  170. Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson KM, Bae JS, Maitra S, Ganiatsas S, Evans CA, DeAngelis MM, Ingalls KA, Nahf RW, Horton LT, Anderson MO, Collymore AJ, Ye W, Kouyoumjian V, Zemsteva IS, Tam J, Devine R, Courtney DF, Renaud MT, Nguyen H, O'Connor TJ, Fizames C, Fauré S, Gyapay G, Dib C, Morissette J, Orlin JB, Birren BW, Goodman N, Weissenbach J, Hawkins TL, Foote S, Page DC, Lander ES. An STS-based map of the human genome.. Science (New York, N.Y.), 1995.
  171. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.. Nature genetics, 1995.
  172. Hu S, Pattatucci AM, Patterson C, Li L, Fulker DW, Cherny SS, Kruglyak L, Hamer DH. Linkage between sexual orientation and chromosome Xq28 in males but not in females.. Nature genetics, 1995.
  173. Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits.. American journal of human genetics, 1995.
  174. Kruglyak L, Lander ES. High-resolution genetic mapping of complex traits.. American journal of human genetics, 1995.
  175. Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci.. Genetics, 1995.
  176. Kruglyak L, Daly MJ, Lander ES. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping.. American journal of human genetics, 1995.
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