Lin Jiang
Associate Professor-in-Residence, Neurology, University of California Los Angeles
linjiang@mednet.ucla.edu
(310) 206-0908
Neuroscience Research Building, Room 475B
635 Charles E Young Drive South
Los Angeles, CA 90095
Affiliations
Member, Biochemistry, Biochemistry, Biophysics & Structural Biology GPB Home Area, Brain Research Institute, Molecular Biology Institute
Biography:
Jiang lab focuses on computational structural biology and drug design for Alzheimer’s, Parkinson’s, Lou Gehrig’s disease and other degenerative disorders. Current research is driven by two key questions: How do unfolded or misfolded proteins self-associate into abnormal aggregates? How do these aggregates propagate and lead to disease? Ongoing research is to develop new thereupetic approach for neurodegenerative and other brain diseases, which includes: 1) design allosteric BACE inhibitor that specifically blocks the APP cleavage and Abeta production; 2) design protein inhibitor that blocks the prion-like transmission of protein aggregates in neurodegenerative diseases; 3) design and test new protein that crosses the blood-brain barrier via carrier-mediated transport. The findings of the research will identify new drug targets, develop new therapeutics and design new therapeutic compounds or peptides for the treatment of neurodegenerative disorders. All of these will strengthen our ability of designing biological systems with desired properties, provide an alternative perspective for us to ultimately understand our living world, and promise solutions to some of the most pressing problems in human health.
Publications
A selected list of publications:
- Gu Lei, Tran Joyce, Jiang Lin, Guo Zhefeng A new structural model of Alzheimer’s Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling Journal of structural biology, 2016; 194(1): 61-7.
- Yang Guang, Zhang Xiang, Kochovski Zdravko, Zhang Yufei, Dai Bin, Sakai Fuji, Jiang Lin, Lu Yan, Ballauff Matthias, Li Xueming, Liu Cong, Chen Guosong, Jiang Ming Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions Journal of the American Chemical Society, 2016; 138(6): 1932-7.
- Soragni Alice, Janzen Deanna M, Johnson Lisa M, Lindgren Anne G, Thai-Quynh Nguyen Anh, Tiourin Ekaterina, Soriaga Angela B, Lu Jing, Jiang Lin, Faull Kym F, Pellegrini Matteo, Memarzadeh Sanaz, Eisenberg David S A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas Cancer cell, 2016; 29(1): 90-103.
- Lai Yen-Ting, Jiang Lin, Chen Wuyang, Yeates Todd O On the predictability of the orientation of protein domains joined by a spanning alpha-helical linker Protein engineering, design & selection : PEDS, 2015; 28(11): 491-500.
- Saelices Lorena, Johnson Lisa M, Liang Wilson Y, Sawaya Michael R, Cascio Duilio, Ruchala Piotr, Whitelegge Julian, Jiang Lin, Riek Roland, Eisenberg David S Uncovering the Mechanism of Aggregation of Human Transthyretin The Journal of biological chemistry, 2015; 290(48): 28932-43.
- Hayden Eric Y, Yamin Ghiam, Beroukhim Shiela, Chen Benson, Kibalchenko Mikhail, Jiang Lin, Ho Lap, Wang Jun, Pasinetti Giulio M, Teplow David B Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols Journal of neurochemistry, 2015; 135(2): 416-30.
- Rodriguez Jose A, Ivanova Magdalena I, Sawaya Michael R, Cascio Duilio, Reyes Francis E, Shi Dan, Sangwan Smriti, Guenther Elizabeth L, Johnson Lisa M, Zhang Meng, Jiang Lin, Arbing Mark A, Nannenga Brent L, Hattne Johan, Whitelegge Julian, Brewster Aaron S, Messerschmidt Marc, Boutet Sébastien, Sauter Nicholas K, Gonen Tamir, Eisenberg David S Structure of the toxic core of α-synuclein from invisible crystals Nature, 2015; 525(7570): 486-90.
- Kurt Timothy D, Jiang Lin, Fernández-Borges Natalia, Bett Cyrus, Liu Jun, Yang Tom, Spraker Terry R, Castilla JoaquÃn, Eisenberg David, Kong Qingzhong, Sigurdson Christina J Human prion protein sequence elements impede cross-species chronic wasting disease transmission The Journal of clinical investigation, 2015; 125(6): 2548.
- James Aaron W, Shen Jia, Zhang Xinli, Asatrian Greg, Goyal Raghav, Kwak Jin H, Jiang Lin, Bengs Benjamin, Culiat Cymbeline T, Turner A Simon, Seim Iii Howard B, Wu Benjamin M, Lyons Karen, Adams John S, Ting Kang, Soo Chia NELL-1 in the treatment of osteoporotic bone loss Nature communications, 2015; 6(23): 7362.
- Gu Lei, Liu Cong, Stroud James C, Ngo Sam, Jiang Lin, Guo Zhefeng Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers The Journal of biological chemistry, 2014; 289(39): 27300-13.
- Jiang Lin, Liu Cong, Leibly David, Landau Meytal, Zhao Minglei, Hughes Michael P, Eisenberg David S Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta eLife, 2013; 2(48): e00857.
- Liu Cong, Zhao Minglei, Jiang Lin, Cheng Pin-Nan, Park Jiyong, Sawaya Michael R, Pensalfini Anna, Gou Dawei, Berk Arnold J, Glabe Charles G, Nowick James, Eisenberg David Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(51): 20913-8.
- Sievers Stuart A, Karanicolas John, Chang Howard W, Zhao Anni, Jiang Lin, Zirafi Onofrio, Stevens Jason T, Münch Jan, Baker David, Eisenberg David Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation Nature, 2011; 475(7354): 96-100.
- Landau Meytal, Sawaya Michael R, Faull Kym F, Laganowsky Arthur, Jiang Lin, Sievers Stuart A, Liu Jie, Barrio Jorge R, Eisenberg David Towards a pharmacophore for amyloid PLoS biology, 2011; 9(6): e1001080.
- Röthlisberger Daniela, Khersonsky Olga, Wollacott Andrew M, Jiang Lin, DeChancie Jason, Betker Jamie, Gallaher Jasmine L, Althoff Eric A, Zanghellini Alexandre, Dym Orly, Albeck Shira, Houk Kendall N, Tawfik Dan S, Baker David Kemp elimination catalysts by computational enzyme design Nature, 2008; 453(7192): 190-5.
- Jiang Lin, Althoff Eric A, Clemente Fernando R, Doyle Lindsey, Röthlisberger Daniela, Zanghellini Alexandre, Gallaher Jasmine L, Betker Jamie L, Tanaka Fujie, Barbas Carlos F, Hilvert Donald, Houk Kendall N, Stoddard Barry L, Baker David De novo computational design of retro-aldol enzymes Science (New York, N.Y.), 2008; 319(5868): 1387-91.
- Zanghellini Alexandre, Jiang Lin, Wollacott Andrew M, Cheng Gong, Meiler Jens, Althoff Eric A, Röthlisberger Daniela, Baker David New algorithms and an in silico benchmark for computational enzyme design Protein science : a publication of the Protein Society, 2006; 15(12): 2785-94.
- Jiang Lin, Kuhlman Brian, Kortemme Tanja, Baker David A “solvated rotamer” approach to modeling water-mediated hydrogen bonds at protein-protein interfaces Proteins, 2005; 58(4): 893-904.
- Jiang Lin, Lai Luhua CH…O hydrogen bonds at protein-protein interfaces The Journal of biological chemistry, 2002; 277(40): 37732-40.
- Jiang Lin, Gao Ying, Mao Fenglou, Liu Zhijie, Lai Luhua Potential of mean force for protein-protein interaction studies Proteins, 2002; 46(2): 190-6.