Simon Beaven

Simon W Beaven

HS Associate Clinical Professor, Medicine, University of California Los Angeles


200 UCLA Medical Plaza
Los Angeles, CA 90095

UCLA Vatche and Tamar Manoukian Division of Digestive Diseases

UCLA Center for Obesity and METabolic Health (COMET)


Member, CTSI, Hepatology, I3T Theme, Molecular, Cellular & Integrative Physiology GPB Home Area, Pfleger Liver Institute


Dr. Beaven attended Stanford University where he majored in mathematics with honors in humanities. He went on to receive his MD from the University of California, San Francisco, and received the Dean’s Research Prize for work he performed in the laboratory of Dr. Scott Friedman under a Howard Hughes Medical Student Research Fellowship. Dr. Beaven completed internal medicine residency training at the Brigham & Women’s Hospital and Harvard Medical School in Boston. He came to UCLA in 2003 as a fellow in digestive diseases where he completed his gastroenterology fellowship. During this period, Dr. Beaven continued his research training and received a PhD with Dr. Peter Tontonoz in the Howard Hughes Medical Institute and Department of Pathology. His doctoral work focused on cholesterol and lipid metabolism as it pertains to an important clinical problem: the metabolic syndrome. His major research interests include the genetics of liver fibrosis, especially in relation to fatty liver and the metabolic syndrome, the study of rare GI diseases (porphyrias and familial Mediterranean fever), and quality improvement projects in gastroenterology and liver disease at Olive View – UCLA Medical Center.

Dr. Beaven joined the digestive diseases faculty at UCLA as an assistant professor in 2010. He is a research director for the Center for Obesity and Metabolic Health (COMET), which studies how metabolic pathways influence liver and gastrointestinal diseases. He has been studying the biology of the hepatic stellate cell, the key scar-forming cell in all forms of liver disease (e.g. fatty liver, viral hepatitis, alcoholic liver disease). This work is aimed at better understanding the genetics of liver fibrosis and the development of better tools to detect and predict outcomes from liver disease. He is a member of the American Porphyria Foundation and has joined the NIH-funded Porphyria Research Consortium. More recently, he is spearheading an effort to focus on rare liver and GI diseases such as the porphyrias and familial Mediterranean fever (FMF).  Dr. Beaven and his trainees have received awards from the UCLA Department of Medicine Research Day, UCLA CURE, and the American Association for the Study of Liver Diseases (AASLD). He is an active peer reviewer for several scientific journals, including DiabetesMolecular & Cellular BiologyHepatologyGastroenterology, and the Journal of Lipid Research. Dr. Beaven teaches in the medical school at all levels and lectures to medical residents and fellows on issues related to liver and gastrointestinal disease. He primarily sees patients with liver diseases at the Pfleger Liver Institute (UCLA) and patients with liver disease and general GI conditions at Olive View – UCLA Medical Center.