Simon W Beaven
HS Associate Clinical Professor, Medicine, University of California Los Angeles
200 UCLA Medical Plaza
Los Angeles, CA 90095
Dr. Beaven attended Stanford University where he majored in mathematics with honors in humanities. He went on to receive his MD from the University of California, San Francisco, and received the Dean’s Research Prize for work he performed in the laboratory of Dr. Scott Friedman under a Howard Hughes Medical Student Research Fellowship. Dr. Beaven completed internal medicine residency training at the Brigham & Women’s Hospital and Harvard Medical School in Boston. He came to UCLA in 2003 as a fellow in digestive diseases where he completed his gastroenterology fellowship. During this period, Dr. Beaven continued his research training and received a PhD with Dr. Peter Tontonoz in the Howard Hughes Medical Institute and Department of Pathology. His doctoral work focused on cholesterol and lipid metabolism as it pertains to an important clinical problem: the metabolic syndrome. His major research interests include the genetics of liver fibrosis, especially in relation to fatty liver and the metabolic syndrome, the study of rare GI diseases (porphyrias and familial Mediterranean fever), and quality improvement projects in gastroenterology and liver disease at Olive View – UCLA Medical Center.
Dr. Beaven joined the digestive diseases faculty at UCLA as an assistant professor in 2010. He is a research director for the Center for Obesity and Metabolic Health (COMET), which studies how metabolic pathways influence liver and gastrointestinal diseases. He has been studying the biology of the hepatic stellate cell, the key scar-forming cell in all forms of liver disease (e.g. fatty liver, viral hepatitis, alcoholic liver disease). This work is aimed at better understanding the genetics of liver fibrosis and the development of better tools to detect and predict outcomes from liver disease. He is a member of the American Porphyria Foundation and has joined the NIH-funded Porphyria Research Consortium. More recently, he is spearheading an effort to focus on rare liver and GI diseases such as the porphyrias and familial Mediterranean fever (FMF). Dr. Beaven and his trainees have received awards from the UCLA Department of Medicine Research Day, UCLA CURE, and the American Association for the Study of Liver Diseases (AASLD). He is an active peer reviewer for several scientific journals, including Diabetes, Molecular & Cellular Biology, Hepatology, Gastroenterology, and the Journal of Lipid Research. Dr. Beaven teaches in the medical school at all levels and lectures to medical residents and fellows on issues related to liver and gastrointestinal disease. He primarily sees patients with liver diseases at the Pfleger Liver Institute (UCLA) and patients with liver disease and general GI conditions at Olive View – UCLA Medical Center.
- Law J, Rajan A, Trieu H, Azizian J, Berry R, Beaven SW, Tabibian JH. Predictive Modeling of Colonoscopic Findings in a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program.. Digestive diseases and sciences, 2021.
- Tuominen I, Fuqua BK, Pan C, Renaud N, Wroblewski K, Civelek M, Clerkin K, Asaryan A, Haroutunian SG, Loureiro J, Borawski J, Roma G, Knehr J, Carbone W, French S, Parks BW, Hui ST, Mehrabian M, Magyar C, Cantor RM, Ukomadu C, Lusis AJ, Beaven SW. The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.. Cellular and molecular gastroenterology and hepatology, 2020.
- Myint A, Tong MJ, Beaven SW. Reactivation of Hepatitis B Virus: A Review of Clinical Guidelines.. Clinical liver disease, 2020.
- Dalai C, Beaven SW. Hymenolepis nana Causing Chronic Diarrhea in an Immunosuppressed Patient.. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020.
- Yin F, Gupta R, Vergnes L, Driscoll WS, Ricks J, Ramanathan G, Stewart JA, Shih DM, Faull KF, Beaven SW, Lusis AJ, Reue K, Rosenfeld ME, Araujo JA. Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis.. Arteriosclerosis, thrombosis, and vascular biology, 2019.
- Hui ST, Kurt Z, Tuominen I, Norheim F, C Davis R, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ. The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice.. Hepatology (Baltimore, Md.), 2018.
- Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.. Science translational medicine, 2016.
- Lu NT, Crespi CM, Liu NM, Vu JQ, Ahmadieh Y, Wu S, Lin S, McClune A, Durazo F, Saab S, Han S, Neiman DC, Beaven S, French SW. A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C.. Phytotherapy research : PTR, 2015.
- Tuominen I, Beaven SW. Intestinal farnesoid X receptor puts a fresh coat of wax on fatty liver.. Hepatology (Baltimore, Md.), 2015.
- O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW. Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein.. Hepatology (Baltimore, Md.), 2015.
- Beaven SW. La mort de la lipogenèse: RNF20 lashes ubiquitin to SREBP-1c.. Hepatology (Baltimore, Md.), 2014.
- Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
- Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.. Cell metabolism, 2013.
- Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.. Mammalian genome : official journal of the International Mammalian Genome Society, 2012.
- Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. The number of x chromosomes causes sex differences in adiposity in mice.. PLoS genetics, 2012.
- Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.. The Journal of clinical investigation, 2011.
- Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.. Gastroenterology, 2010.
- Ribas V, Nguyen MT, Henstridge DC, Nguyen AK, Beaven SW, Watt MJ, Hevener AL. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice.. American journal of physiology. Endocrinology and metabolism, 2009.
- Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt.. Cell metabolism, 2009.
- Bansal MB, Beaven SW, Rockey DC. Scott L. Friedman, 59th President, AASLD.. Hepatology (Baltimore, Md.), 2008.
- Banck MS, Beaven SW, Narla G, Walsh MJ, Friedman SL, Beutler AS. KLF6 degradation after apoptotic DNA damage.. FEBS letters, 2006.
- Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors.. FEBS letters, 2006.
- Beaven SW, Tontonoz P. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia.. Annual review of medicine, 2006.
- Chen M, Beaven S, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.. Journal of lipid research, 2005.
- Beaven SW, Martín MG. Tales from the crypt: beta-catenin in the development of juvenile polyps: commentary on the article by Iwamoto et al. on page 4.. Pediatric research, 2004.
- Beaven SW, Abreu MT. Biomarkers in inflammatory bowel disease.. Current opinion in gastroenterology, 2004.