Publications

• Wu B, Woo JS, Sun Z, Srikanth S, Gwack Y. Ca2+ Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells.. Journal of immunology (Baltimore, Md. : 1950), 2022.
• Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, McKeown L, Anwar R, Doody GM, Srikanth S, Gwack Y, Savic S. Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder.. eLife, 2021.
• Wu B, Ramaiah A, Garcia G, Hasiakos S, Arumugaswami V, Srikanth S. ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling.. Journal of immunology (Baltimore, Md. : 1950), 2021.
• Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells.. Cell reports, 2021.
• Wu B, Ramaiah A, Garcia G, Gwack Y, Arumugaswami V, Srikanth S. ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling.. bioRxiv : the preprint server for biology, 2021.
• Srikanth S, Gwack Y. Blue light opens the ORAI1 LOC(K).. Cell calcium, 2021.
• Woo JS, Sun Z, Srikanth S, Gwack Y. The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1.. Scientific reports, 2020.
• Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.. Journal of immunology (Baltimore, Md. : 1950), 2019.
• Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype.. Journal of clinical immunology, 2019.
• Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.. Nature immunology, 2019.
• Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.. Journal of immunology (Baltimore, Md. : 1950), 2018.
• Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells.. Bone reports, 2018.
• Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. Laminar flow downregulates Notch activity to promote lymphatic sprouting.. The Journal of clinical investigation, 2017.
• Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.. Circulation research, 2017.
• Srikanth S, Woo JS, Sun Z, Gwack Y. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes.. Advances in experimental medicine and biology, 2017.
• Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma.. Oncotarget, 2016.
• Srikanth S, Woo JS, Gwack Y. A large Rab GTPase family in a small GTPase world.. Small GTPases, 2016.
• Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.. Biochemical and biophysical research communications, 2016.
• Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.. Science signaling, 2016.
• Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
• Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. Dental enamel cells express functional SOCE channels.. Scientific reports, 2015.
• Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.. Nature immunology, 2014.
• Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.. Science signaling, 2014.
• Srikanth S, Kim KD, Gwack Y. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes.. Methods in enzymology, 2014.
• Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.. Journal of immunology (Baltimore, Md. : 1950), 2013.
• Srikanth S, Gwack Y. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation.. Molecules and cells, 2013.
• Srikanth S, Ribalet B, Gwack Y. Regulation of CRAC channels by protein interactions and post-translational modification.. Channels (Austin, Tex.), 2013.
• Srikanth S, Gwack Y. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes.. Methods in molecular biology (Clifton, N.J.), 2013.
• Srikanth S, Gwack Y. Molecular regulation of the pore component of CRAC channels, Orai1.. Current topics in membranes, 2013.
• Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).. Proceedings of the National Academy of Sciences of the United States of America, 2012.
• Srikanth S, Gwack Y. Orai1, STIM1, and their associating partners.. The Journal of physiology, 2012.
• Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. ORAI1 deficiency impairs activated T cell death and enhances T cell survival.. Journal of immunology (Baltimore, Md. : 1950), 2011.
• Srikanth S, Yee MK, Gwack Y, Ribalet B. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties.. The Journal of biological chemistry, 2011.
• Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.. Journal of immunology (Baltimore, Md. : 1950), 2010.
• Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.. Nature cell biology, 2010.
• Srikanth S, Jung HJ, Ribalet B, Gwack Y. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels.. The Journal of biological chemistry, 2009.
• Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. Hair loss and defective T- and B-cell function in mice lacking ORAI1.. Molecular and cellular biology, 2008.
• Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.. Molecular biology of the cell, 2008.
• Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.. Cell calcium, 2007.
• Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Biochemical and functional characterization of Orai proteins.. The Journal of biological chemistry, 2007.
• Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.. The Journal of biological chemistry, 2007.
• Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel.. Nature, 2006.
• Banerjee S, Joshi R, Venkiteswaran G, Agrawal N, Srikanth S, Alam F, Hasan G. Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006.
• Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.. Nature, 2006.
• Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.. Nature, 2006.
• Srikanth S, Banerjee S, Hasan G. Ectopic expression of a Drosophila InsP(3)R channel mutant has dominant-negative effects in vivo.. Cell calcium, 2005.
• Srikanth S, Wang Z, Hasan G, Bezprozvanny I. Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor.. FEBS letters, 2004.
• Srikanth S, Wang Z, Tu H, Nair S, Mathew MK, Hasan G, Bezprozvanny I. Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants.. Biophysical journal, 2004.