Xingxing Kong
Affiliations
Assistant Professor, Pediatrics
Member, Medical Informatics GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area
Member, Medical Informatics GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area
Research Interests
Many studies have demonstrated that muscle plays a very important role during exercise, as the benefits of exercise are thought to result from improve tissue metabolism in a cell-autonomous and tissue-autonomous fashion with tissue crosstalk. However, there a paucity of research on other tissue involvement during exercise. As fat and muscle are two of the most abundant organs in the body, Dr. Kong’s research investigates the crosstalk between muscle and fat. Does fat tissue secrete any adipokines to regulate muscle? Do metabolites build up a bridge to link the two? Are there any other tissues involved in this metabolic activity, such as the liver, brain, or other tissues? Dr. Kong’s exciting lab research is focusing on uncovering the molecular mechanisms of exercise-induced health benefits.
Biography:
Dr. Xinxing Kong is an Assistant Professor of Pediatrics at the David Geffen School of Medicine at UCLA. After completing her PhD from Peking Union Medical College, the top medical school in China, she completed a postdoctoral fellowship at Beth Israel Deaconess Medical Center and Harvard Medical School. Her research is focused on the transcriptional pathways that underlie metabolic diseases such as obesity and type 2 diabetes, with a specific investigation of the role of IRF4 in thermogenesis.
Publications
A selected list of publications:
- Kong Xingxing, Yao Ting, Zhou Peng, Kazak Lawrence, Tenen Danielle, Lyubetskaya Anna, Dawes Brian A, Tsai Linus, Kahn Barbara B, Spiegelman Bruce M, Liu Tiemin, Rosen Evan D Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin Cell metabolism, 2018; 28(4): 631-643.e3.
- Williams Kevin W, Liu Tiemin, Kong Xingxing, Fukuda Makoto, Deng Yingfeng, Berglund Eric D, Deng Zhuo, Gao Yong, Liu Tianya, Sohn Jong-Woo, Jia Lin, Fujikawa Teppei, Kohno Daisuke, Scott Michael M, Lee Syann, Lee Charlotte E, Sun Kai, Chang Yongsheng, Scherer Philipp E, Elmquist Joel K Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis Cell metabolism, 2014; 20(3): 471-82.
- Kong Xingxing, Banks Alexander, Liu Tiemin, Kazak Lawrence, Rao Rajesh R, Cohen Paul, Wang Xun, Yu Songtao, Lo James C, Tseng Yu-Hua, Cypess Aaron M, Xue Ruidan, Kleiner Sandra, Kang Sona, Spiegelman Bruce M, Rosen Evan D IRF4 is a key thermogenic transcriptional partner of PGC-1α Cell, 2014; 158(1): 69-83.
- Berglund Eric D, Liu Tiemin, Kong Xingxing, Sohn Jong-Woo, Vong Linh, Deng Zhuo, Lee Charlotte E, Lee Syann, Williams Kevin W, Olson David P, Scherer Philipp E, Lowell Bradford B, Elmquist Joel K Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia Nature neuroscience, 2014; 17(7): 911-3.
- Eguchi Jun, Kong Xingxing, Tenta Masafumi, Wang Xun, Kang Sona, Rosen Evan D Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization Diabetes, 2013; 62(10): 3394-403.