Amander Therese Clark

Professor, Molecular, Cell and Developmental Biology, University of California Los Angeles

794 4201

Amander Clark PhD is the Founding Director of the UCLA Center for Reproductive Science, Health and Education and Professor of Molecular Cell and Developmental Biology. Professor Clark is an award-winning scientist and internationally recognized expert on topics in stem cell biology and reproductive science authoring more than 100 scientific articles with >17,000 citations of her lab's reserach. Results from the Clark Lab provide the basis for engineering models of the ovary in order to understand ovarian development as well as ovarian disease and dysfunction which affect millions of women and girls around the world. Professor Clark is regularly invited to appear as a subject matter expert for media outlets including the New York Times, the Economist, the New Yorker and Public Radio. She also serves on the National Academies of Science Engineering and Medicine Board of Health Sciences Policy. In 2023 Professor Clark began her elected role as President of the International Society for Stem Cell Research, a global non-profit that promotes excellence in stem cell science and applications to human health.

Interests

Stem Cell Biology, Reproductive biology, Genetics, Development, Cell Biology, Epigenetics

Education and Training

Baylor College of MedicinePostdoc08/2022Genetics
University of California, San FranciscoAssistant Researcher06/2006Stem Cell Biology
University of MelbournePhD03/1999Cell and Developmental Biology
University of MelbourneBSc04/1995Cell and Developmental Biology

Awards and Honors

  • Founders Medal, Australian and New Zealand Society for Reproductive Biology, 2022.
  • Young Investigator Prize, Lance Armstrong Foundation, 2007.
  • Young Investigator Award, International Society for Stem Cell Research, 2003.
  • Young Investigator Prize, Concern Foundation, 2015.

Publications

  1. Esfahani SN, Zheng Y, Arabpour A, Irizarry AMR, Kobayashi N, Xue X, Shao Y, Zhao C, Agranonik NL, Sparrow M, Hunt TJ, Faith J, Lara MJ, Wu QY, Silber S, Petropoulos S, Yang R, Chien KR, Clark AT, Fu J. Derivation of human primordial germ cell-like cells in an embryonic-like culture.. Nature communications, 2024.
  2. Verdikt R, Armstrong AA, Cheng J, Hwang YS, Clark AT, Yang X, Allard P. Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells.. eLife, 2023.
  3. Lara MJD, Wamaitha SE, Arabpour A, Hennebold JD, Clark AT, Sosa E. Generation of a rhesus macaque induced pluripotent stem cell line (riPSC05) under feeder-free conditions.. Stem cell research, 2023.
  4. Sosa E, Mumu SK, Alvarado CC, Wu QY, Roberson I, Espinoza A, Hsu FM, Saito K, Hunt TJ, Faith JE, Lowe MG, DiRusso JA, Clark AT. Reconstituted ovaries self-assemble without an ovarian surface epithelium.. Stem cell reports, 2023.
  5. Landecker HL, Clark AT. Human embryo models made from pluripotent stem cells are not synthetic; they aren't embryos, either.. Cell stem cell, 2023.
  6. Verdikt R, Armstrong AA, Cheng J, Hwang YS, Clark AT, Yang X, Allard P. Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells.. bioRxiv : the preprint server for biology, 2023.
  7. Wamaitha SE, Nie X, Pandolfi EC, Wang X, Yang Y, Stukenborg JB, Cairns BR, Guo J, Clark AT. Single-cell analysis of the developing human ovary defines distinct insights into ovarian somatic and germline progenitors.. Developmental cell, 2023.
  8. DiRusso JA, Clark AT. Transposable elements in early human embryo development and embryo models.. Current opinion in genetics & development, 2023.
  9. Hsu FM, Wu QY, Fabyanic EB, Wei A, Wu H, Clark AT. TET1 facilitates specification of early human lineages including germ cells.. iScience, 2023.
  10. Pandolfi EC, Hsu FM, Duhon M, Zheng Y, Goldsmith S, Fu J, Silber SJ, Clark AT. In vitro germ cell induction from fertile and infertile monozygotic twin research participants.. Cell reports. Medicine, 2022.
  11. Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids.. Stem cell reports, 2022.
  12. Lowe MG, Yen MR, Hsu FM, Hosohama L, Hu Z, Chitiashvili T, Hunt TJ, Gorgy I, Bernard M, Wamaitha SE, Chen PY, Clark AT. EED is required for mouse primordial germ cell differentiation in the embryonic gonad.. Developmental cell, 2022.
  13. Chitiashvili T, Hsu FM, Dror I, Plath K, Clark A. FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes.. Stem cell reports, 2022.
  14. Xiang X, Tao Y, DiRusso J, Hsu FM, Zhang J, Xue Z, Pontis J, Trono D, Liu W, Clark AT. Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections.. Nature communications, 2022.
  15. Desai VP, Chouaref J, Wu H, Pastor WA, Kan RL, Oey HM, Li Z, Ho J, Vonk KKD, San Leon Granado D, Christopher MA, Clark AT, Jacobsen SE, Daxinger L. The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.. Epigenetics & chromatin, 2021.
  16. Shetty G, Mitchell JM, Lam TNA, Phan TT, Zhang J, Tailor RC, Peters KA, Penedo MC, Hanna CB, Clark AT, Orwig KE, Meistrich ML. Postpubertal spermatogonial stem cell transplantation restores functional sperm production in rhesus monkeys irradiated before and after puberty.. Andrology, 2021.
  17. Pandolfi EC, Hunt TJ, Goldsmith S, Hurlbut K, Silber SJ, Clark AT. Generation of three human induced pluripotent stem cell sublines (UCLAi004-A, UCLAi004-B, and UCLAi004-C) for reproductive science research.. Stem cell research, 2021.
  18. Pandolfi EC, Hunt TJ, Goldsmith S, Hurlbut K, Silber SJ, Clark AT. Generation of three human induced pluripotent stem cell sublines (UCLAi005-A, UCLAi005-B and UCLAi005-C) for reproductive science research.. Stem cell research, 2021.
  19. Clark AT, Brivanlou A, Fu J, Kato K, Mathews D, Niakan KK, Rivron N, Saitou M, Surani A, Tang F, Rossant J. Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines.. Stem cell reports, 2021.
  20. Liu X, Tan JP, Schröder J, Aberkane A, Ouyang JF, Mohenska M, Lim SM, Sun YBY, Chen J, Sun G, Zhou Y, Poppe D, Lister R, Clark AT, Rackham OJL, Zenker J, Polo JM. Modelling human blastocysts by reprogramming fibroblasts into iBlastoids.. Nature, 2021.
  21. Hancock GV, Wamaitha SE, Peretz L, Clark AT. Mammalian primordial germ cell specification.. Development (Cambridge, England), 2021.
  22. Pandolfi EC, Sosa E, Hunt TJ, Goldsmith S, Hurlbut K, Silber SJ, Clark AT. Generation of six human induced pluripotent stem cell sublines (MZT01E, MZT01F, MZT01N and MZT02D, MZT02G and MZT02H) for reproductive science research.. Stem cell research, 2021.
  23. Guo J, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E, DonorConnect, Plath K, Hotaling JM, Stukenborg JB, Clark AT, Cairns BR. Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment.. Cell stem cell, 2021.
  24. Chitiashvili T, Dror I, Kim R, Hsu FM, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke-Layland K, Plath K, Clark A. Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation.. Nature cell biology, 2020.
  25. Liu X, Ouyang JF, Rossello FJ, Tan JP, Davidson KC, Valdes DS, Schröder J, Sun YBY, Chen J, Knaupp AS, Sun G, Chy HS, Huang Z, Pflueger J, Firas J, Tano V, Buckberry S, Paynter JM, Larcombe MR, Poppe D, Choo XY, O'Brien CM, Pastor WA, Chen D, Leichter AL, Naeem H, Tripathi P, Das PP, Grubman A, Powell DR, Laslett AL, David L, Nilsson SK, Clark AT, Lister R, Nefzger CM, Martelotto LG, Rackham OJL, Polo JM. Reprogramming roadmap reveals route to human induced trophoblast stem cells.. Nature, 2020.
  26. Gell JJ, Liu W, Sosa E, Chialastri A, Hancock G, Tao Y, Wamaitha SE, Bower G, Dey SS, Clark AT. An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure.. Stem cell reports, 2020.
  27. Chen D, Sun N, Hou L, Kim R, Faith J, Aslanyan M, Tao Y, Zheng Y, Fu J, Liu W, Kellis M, Clark A. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors.. Cell reports, 2019.
  28. Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule.. Cell reports, 2019.
  29. Clark AT. Standing on the shoulders of giants: The changing landscape of pluripotent stem cells in research.. Anatomical record (Hoboken, N.J. : 2007), 2019.
  30. Pandolfi EC, Rojas EJ, Sosa E, Gell JJ, Hunt TJ, Goldsmith S, Fan Y, Silber SJ, Clark AT. Generation of three human induced pluripotent stem cell sublines (MZT04D, MZT04J, MZT04C) for reproductive science research.. Stem cell research, 2019.
  31. Clark AT. Human embryo implantation modelled in microfluidic channels.. Nature, 2019.
  32. Chen D, Liu W, Zimmerman J, Pastor WA, Kim R, Hosohama L, Ho J, Aslanyan M, Gell JJ, Jacobsen SE, Clark AT. The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation.. Cell reports, 2018.
  33. Sosa E, Chen D, Rojas EJ, Hennebold JD, Peters KA, Wu Z, Lam TN, Mitchell JM, Sukhwani M, Tailor RC, Meistrich ML, Orwig KE, Shetty G, Clark AT. Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche.. Nature communications, 2018.
  34. Gell JJ, Clark AT. Restoring Fertility with Human Induced Pluripotent Stem Cells: Are We There Yet?. Cell stem cell, 2018.
  35. Pastor WA, Liu W, Chen D, Ho J, Kim R, Hunt TJ, Lukianchikov A, Liu X, Polo JM, Jacobsen SE, Clark AT. TFAP2C regulates transcription in human naive pluripotency by opening enhancers.. Nature cell biology, 2018.
  36. Clark AT, Orwig KE. Editorial.. Stem cell research, 2018.
  37. Chen D, Clark AT. Mitochondrial DNA selection in human germ cells.. Nature cell biology, 2018.
  38. Gupta S, Sivalingam D, Hain S, Makkar C, Sosa E, Clark A, Butler SJ. Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells.. Stem cell reports, 2018.
  39. Gell JJ, Zhao J, Chen D, Hunt TJ, Clark AT. PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.. Stem cell research, 2018.
  40. Tao Y, Yen MR, Chitiashvili T, Nakano H, Kim R, Hosohama L, Tan YC, Nakano A, Chen PY, Clark AT. TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency.. Stem cell reports, 2017.
  41. Morselli M, Pastor WA, Montanini B, Nee K, Ferrari R, Fu K, Bonora G, Rubbi L, Clark AT, Ottonello S, Jacobsen SE, Pellegrini M. Correction: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse.. eLife, 2017.
  42. Clark AT, Gkountela S, Chen D, Liu W, Sosa E, Sukhwani M, Hennebold JD, Orwig KE. Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23.. Stem cell reports, 2017.
  43. Chen D, Gell JJ, Tao Y, Sosa E, Clark AT. Modeling human infertility with pluripotent stem cells.. Stem cell research, 2017.
  44. Sosa E, Kim R, Rojas EJ, Hosohama L, Hennebold JD, Orwig KE, Clark AT. An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC90) from embryonic fibroblasts.. Stem cell research, 2017.
  45. O'Brien CM, Chy HS, Zhou Q, Blumenfeld S, Lambshead JW, Liu X, Kie J, Capaldo BD, Chung TL, Adams TE, Phan T, Bentley JD, McKinstry WJ, Oliva K, McMurrick PJ, Wang YC, Rossello FJ, Lindeman GJ, Chen D, Jarde T, Clark AT, Abud HE, Visvader JE, Nefzger CM, Polo JM, Loring JF, Laslett AL. New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells.. Stem cells (Dayton, Ohio), 2017.
  46. Nagaraj R, Sharpley MS, Chi F, Braas D, Zhou Y, Kim R, Clark AT, Banerjee U. Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation.. Cell, 2017.
  47. Chen D, Liu W, Lukianchikov A, Hancock GV, Zimmerman J, Lowe MG, Kim R, Galic Z, Irie N, Surani MA, Jacobsen SE, Clark AT. Germline competency of human embryonic stem cells depends on eomesodermin.. Biology of reproduction, 2017.
  48. Patel S, Bonora G, Sahakyan A, Kim R, Chronis C, Langerman J, Fitz-Gibbon S, Rubbi L, Skelton RJP, Ardehali R, Pellegrini M, Lowry WE, Clark AT, Plath K. Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation.. Cell reports, 2016.
  49. Sahakyan A, Kim R, Chronis C, Sabri S, Bonora G, Theunissen TW, Kuoy E, Langerman J, Clark AT, Jaenisch R, Plath K. Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation.. Cell stem cell, 2016.
  50. Masaeli M, Gupta D, O'Byrne S, Tse HT, Gossett DR, Tseng P, Utada AS, Jung HJ, Young S, Clark AT, Di Carlo D. Multiparameter mechanical and morphometric screening of cells.. Scientific reports, 2016.
  51. Sosa E, Kim R, Rojas EJ, Hosohama L, Hennebold JD, Orwig KE, Clark AT. An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC89) from embryonic fibroblasts.. Stem cell research, 2016.
  52. Hargan-Calvopina J, Taylor S, Cook H, Hu Z, Lee SA, Yen MR, Chiang YS, Chen PY, Clark AT. Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation.. Developmental cell, 2016.
  53. Li S, Yen L, Pastor WA, Johnston JB, Du J, Shew CJ, Liu W, Ho J, Stender B, Clark AT, Burlingame AL, Daxinger L, Patel DJ, Jacobsen SE. Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
  54. Pastor WA, Chen D, Liu W, Kim R, Sahakyan A, Lukianchikov A, Plath K, Jacobsen SE, Clark AT. Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory.. Cell stem cell, 2016.
  55. Clark AT. DNA methylation remodeling in vitro and in vivo.. Current opinion in genetics & development, 2015.
  56. Clark AT, Zwaka TP. Editorial overview: Cell reprogramming, regeneration and repair: Reprogramming: the eternal circle.. Current opinion in genetics & development, 2015.
  57. Oliveros-Etter M, Li Z, Nee K, Hosohama L, Hargan-Calvopina J, Lee SA, Joti P, Yu J, Clark AT. PGC Reversion to Pluripotency Involves Erasure of DNA Methylation from Imprinting Control Centers followed by Locus-Specific Re-methylation.. Stem cell reports, 2015.
  58. Pastor WA, Stroud H, Nee K, Liu W, Pezic D, Manakov S, Lee SA, Moissiard G, Zamudio N, Bourc'his D, Aravin AA, Clark AT, Jacobsen SE. Erratum: MORC1 represses transposable elements in the mouse male germline.. Nature communications, 2015.
  59. Gkountela S, Zhang KX, Shafiq TA, Liao WW, Hargan-Calvopiña J, Chen PY, Clark AT. DNA Demethylation Dynamics in the Human Prenatal Germline.. Cell, 2015.
  60. Calvopina JH, Cook H, Vincent JJ, Nee K, Clark AT. The Aorta-Gonad-Mesonephros Organ Culture Recapitulates 5hmC Reorganization and Replication-Dependent and Independent Loss of DNA Methylation in the Germline.. Stem cells and development, 2015.
  61. Morselli M, Pastor WA, Montanini B, Nee K, Ferrari R, Fu K, Bonora G, Rubbi L, Clark AT, Ottonello S, Jacobsen SE, Pellegrini M. In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse.. eLife, 2015.
  62. Chen D, Clark AT. Human germline differentiation charts a new course.. The EMBO journal, 2015.
  63. Li Z, Yu J, Hosohama L, Nee K, Gkountela S, Chaudhari S, Cass AA, Xiao X, Clark AT. The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice.. The EMBO journal, 2014.
  64. Pastor WA, Stroud H, Nee K, Liu W, Pezic D, Manakov S, Lee SA, Moissiard G, Zamudio N, Bourc'his D, Aravin AA, Clark AT, Jacobsen SE. MORC1 represses transposable elements in the mouse male germline.. Nature communications, 2014.
  65. Gkountela S, Clark AT. A big surprise in the little zygote: the curious business of losing methylated cytosines.. Cell stem cell, 2014.
  66. Ben-David U, Arad G, Weissbein U, Mandefro B, Maimon A, Golan-Lev T, Narwani K, Clark AT, Andrews PW, Benvenisty N, Carlos Biancotti J. Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.. Nature communications, 2014.
  67. Gkountela S, Li Z, Chin CJ, Lee SA, Clark AT. PRMT5 is required for human embryonic stem cell proliferation but not pluripotency.. Stem cell reviews and reports, 2014.
  68. Valli H, Phillips BT, Shetty G, Byrne JA, Clark AT, Meistrich ML, Orwig KE. Germline stem cells: toward the regeneration of spermatogenesis.. Fertility and sterility, 2013.
  69. Feng Y, Maity R, Whitelegge JP, Hadjikyriacou A, Li Z, Zurita-Lopez C, Al-Hadid Q, Clark AT, Bedford MT, Masson JY, Clarke SG. Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.. The Journal of biological chemistry, 2013.
  70. Clark A. Human somatic cell nuclear transfer: a scientist's perspective.. Molecular reproduction and development, 2013.
  71. Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status.. Stem cell research & therapy, 2013.
  72. Gkountela S, Clark AT. RNA-Seq Library Generation from Rare Human Cells Isolated by FACS.. Bio-protocol, 2013.
  73. Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.. Cell stem cell, 2013.
  74. Gkountela S, Li Z, Vincent JJ, Zhang KX, Chen A, Pellegrini M, Clark AT. The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation.. Nature cell biology, 2012.
  75. Clark AT. Pluripotency takes off without Blimp1.. Cell stem cell, 2012.
  76. Deshpande AM, Khalid O, Kim JJ, Kim Y, Lindgren A, Clark AT, Wong DT. Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells.. Stem cells and development, 2012.
  77. Gossett DR, Tse HT, Lee SA, Ying Y, Lindgren AG, Yang OO, Rao J, Clark AT, Di Carlo D. Hydrodynamic stretching of single cells for large population mechanical phenotyping.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
  78. Vincent JJ, Li Z, Lee SA, Liu X, Etter MO, Diaz-Perez SV, Taylor SK, Gkountela S, Lindgren AG, Clark AT. Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells.. PloS one, 2011.
  79. Clark AT, Phillips BT, Orwig KE. Fruitful progress to fertility: male fertility in the test tube.. Nature medicine, 2011.
  80. Diaz Perez SV, Kim R, Li Z, Marquez VE, Patel S, Plath K, Clark AT. Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin.. Human molecular genetics, 2011.
  81. Azghadi S, Clark AT. Epigenetically reprogramming of human embryonic stem cells by 3-deazaneplanocin a and sodium butyrate.. International journal of preventive medicine, 2011.
  82. Mandal S, Lindgren AG, Srivastava AS, Clark AT, Banerjee U. Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells.. Stem cells (Dayton, Ohio), 2011.
  83. Lindgren AG, Natsuhara K, Tian E, Vincent JJ, Li X, Jiao J, Wu H, Banerjee U, Clark AT. Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog.. PloS one, 2011.
  84. Mayshar Y, Ben-David U, Lavon N, Biancotti JC, Yakir B, Clark AT, Plath K, Lowry WE, Benvenisty N. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.. Cell stem cell, 2010.
  85. Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. Female human iPSCs retain an inactive X chromosome.. Cell stem cell, 2010.
  86. Ambartsumyan G, Gill RK, Perez SD, Conway D, Vincent J, Dalal Y, Clark AT. Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage.. Human molecular genetics, 2010.
  87. Chodavarapu RK, Feng S, Bernatavichute YV, Chen PY, Stroud H, Yu Y, Hetzel JA, Kuo F, Kim J, Cokus SJ, Casero D, Bernal M, Huijser P, Clark AT, Krämer U, Merchant SS, Zhang X, Jacobsen SE, Pellegrini M. Relationship between nucleosome positioning and DNA methylation.. Nature, 2010.
  88. Kamei K, Ohashi M, Gschweng E, Ho Q, Suh J, Tang J, For Yu ZT, Clark AT, Pyle AD, Teitell MA, Lee KB, Witte ON, Tseng HR. Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions.. Lab on a chip, 2010.
  89. Clark AT. Egg-citing advances in generating primordial germ cells in the laboratory.. Biology of reproduction, 2009.
  90. Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, Ambartsumyan G, Aimiuwu O, Richter L, Zhang J, Khvorostov I, Ott V, Grunstein M, Lavon N, Benvenisty N, Croce CM, Clark AT, Baxter T, Pyle AD, Teitell MA, Pelegrini M, Plath K, Lowry WE. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.. Cell stem cell, 2009.
  91. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation.. The Journal of biological chemistry, 2009.
  92. Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, Richter L, Teitell MA, Mikkola HK, Lowry WE, Plath K, Clark AT. Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells.. Stem cells (Dayton, Ohio), 2009.
  93. Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.. Stem cells (Dayton, Ohio), 2009.
  94. Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M. Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.. Molecular cell, 2009.
  95. Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, Pelligrini M, Teitell MA, Clark AT. A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors.. Stem cells (Dayton, Ohio), 2009.
  96. Ambartsumyan G, Clark AT. Aneuploidy and early human embryo development.. Human molecular genetics, 2008.
  97. Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. Copy number variant analysis of human embryonic stem cells.. Stem cells (Dayton, Ohio), 2008.
  98. Bostick M, Kim JK, Estève PO, Clark A, Pradhan S, Jacobsen SE. UHRF1 plays a role in maintaining DNA methylation in mammalian cells.. Science (New York, N.Y.), 2007.
  99. Clark AT. Establishment and differentiation of human embryonic stem cell derived germ cells.. Society of Reproduction and Fertility supplement, 2007.
  100. Clark AT. The stem cell identity of testicular cancer.. Stem cell reviews, 2007.
  101. Kee K, Gonsalves JM, Clark AT, Pera RA. Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells.. Stem cells and development, 2006.
  102. Fox MS, Clark AT, El Majdoubi M, Vigne JL, Urano J, Hostetler CE, Griswold MD, Weiner RI, Reijo Pera RA. Intermolecular interactions of homologs of germ plasm components in mammalian germ cells.. Developmental biology, 2006.
  103. Clark AT, Reijo Pera RA. Modeling human germ cell development with embryonic stem cells.. Regenerative medicine, 2006.
  104. Ezeh UI, Turek PJ, Reijo RA, Clark AT. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma.. Cancer, 2005.
  105. Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ. Implementing large-scale ENU mutagenesis screens in North America.. Genetica, 2004.
  106. Clark AT, Bodnar MS, Fox M, Rodriquez RT, Abeyta MJ, Firpo MT, Pera RA. Spontaneous differentiation of germ cells from human embryonic stem cells in vitro.. Human molecular genetics, 2004.
  107. Abeyta MJ, Clark AT, Rodriguez RT, Bodnar MS, Pera RA, Firpo MT. Unique gene expression signatures of independently-derived human embryonic stem cell lines.. Human molecular genetics, 2004.
  108. Clark AT, Firozi K, Justice MJ. Mutations in a novel locus on mouse chromosome 11 resulting in male infertility associated with defects in microtubule assembly and sperm tail function.. Biology of reproduction, 2004.
  109. Clark AT, Rodriguez RT, Bodnar MS, Abeyta MJ, Cedars MI, Turek PJ, Firpo MT, Reijo Pera RA. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma.. Stem cells (Dayton, Ohio), 2004.
  110. Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ. Functional genetic analysis of mouse chromosome 11.. Nature, 2003.