Publications

1. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.. The Journal of biological chemistry, 2024.
2. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.. bioRxiv : the preprint server for biology, 2023.
3. Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, Lishko PV. Mitochondrial uncouplers impair human sperm motility without altering ATP content†.. Biology of reproduction, 2023.
4. Chang CF, Gunawan AL, Liparulo I, Zushin PH, Bertholet AM, Kirichok Y, Stahl A. CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression.. Antioxidants (Basel, Switzerland), 2022.
5. Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.. Nature, 2022.
6. Bertholet AM, Kirichok Y. Mitochondrial H+ Leak and Thermogenesis.. Annual review of physiology, 2021.
7. Bertholet AM. The Use of the Patch-Clamp Technique to Study the Thermogenic Capacity of Mitochondria.. Journal of visualized experiments : JoVE, 2021.
8. Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D. Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.. The Journal of biological chemistry, 2021.
9. Bertholet AM, Kirichok Y. Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat.. Frontiers in physiology, 2020.
10. Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. H+ transport is an integral function of the mitochondrial ADP/ATP carrier.. Nature, 2019.
11. Bertholet AM, Kirichok Y. The Mechanism FA-Dependent H+ Transport by UCP1.. Handbook of experimental pharmacology, 2019.
12. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2.. Cell, 2017.
13. Bertholet AM, Kazak L, Chouchani ET, Bogaczynska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling.. Cell metabolism, 2017.
14. Bertholet AM, Kirichok Y. UCP1: A transporter for H+ and fatty acid anions.. Biochimie, 2016.
15. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2.. Cell, 2016.
16. Millet AM, Bertholet AM, Daloyau M, Reynier P, Galinier A, Devin A, Wissinguer B, Belenguer P, Davezac N. Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis.. Annals of clinical and translational neurology, 2016.
17. Bertholet AM, Millet AM, Guillermin O, Daloyau M, Davezac N, Miquel MC, Belenguer P. OPA1 loss of function affects in vitro neuronal maturation.. Brain : a journal of neurology, 2013.
18. Landes T, Leroy I, Bertholet A, Diot A, Khosrobakhsh F, Daloyau M, Davezac N, Miquel MC, Courilleau D, Guillou E, Olichon A, Lenaers G, Arnauné-Pelloquin L, Emorine LJ, Belenguer P. OPA1 (dys)functions.. Seminars in cell & developmental biology, 2010.
19. Betourne A, Bertholet AM, Labroue E, Halley H, Sun HS, Lorsignol A, Feng ZP, French RJ, Penicaud L, Lassalle JM, Frances B. Involvement of hippocampal CA3 K(ATP) channels in contextual memory.. Neuropharmacology, 2008.