Amy Rowat

Amy Catherine Rowat

Professor, Integrative Biology And Physiology, University of California Los Angeles


  1. Kawecki NS, Norris SCP, Xu Y, Wu Y, Davis AR, Fridman E, Chen KK, Crosbie RH, Garmyn AJ, Li S, Mason TG, Rowat AC. Engineering multicomponent tissue by spontaneous adhesion of myogenic and adipogenic microtissues cultured with customized scaffolds.. Food research international (Ottawa, Ont.), 2023.
  2. Soto J, Song Y, Wu Y, Chen B, Park H, Akhtar N, Wang PY, Hoffman T, Ly C, Sia J, Wong S, Kelkhoff DO, Chu J, Poo MM, Downing TL, Rowat AC, Li S. Reduction of Intracellular Tension and Cell Adhesion Promotes Open Chromatin Structure and Enhances Cell Reprogramming.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023.
  3. Ly C, Ogana H, Kim HN, Hurwitz S, Deeds EJ, Kim YM, Rowat AC. Altered physical phenotypes of leukemia cells that survive chemotherapy treatment.. Integrative biology : quantitative biosciences from nano to macro, 2023.
  4. Song Y, Soto J, Chen B, Hoffman T, Zhao W, Zhu N, Peng Q, Liu L, Ly C, Wong PK, Wang Y, Rowat AC, Kurdistani SK, Li S. Transient nuclear deformation primes epigenetic state and promotes cell reprogramming.. Nature materials, 2022.
  5. Fu T, Chan TW, Bahn JH, Kim TH, Rowat AC, Xiao X. Multifaceted role of RNA editing in promoting loss-of-function of PODXL in cancer.. iScience, 2022.
  6. Norris SCP, Kawecki NS, Davis AR, Chen KK, Rowat AC. Emulsion-templated microparticles with tunable stiffness and topology: Applications as edible microcarriers for cultured meat.. Biomaterials, 2022.
  7. Zhang X, Kim TH, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S. Corrigendum to "Unraveling the mechanobiology of immune cells" [Curr Opin Biotechnol 66 (2020) 236-245].. Current opinion in biotechnology, 2021.
  8. Yuen JSK, Stout AJ, Kawecki NS, Letcher SM, Theodossiou SK, Cohen JM, Barrick BM, Saad MK, Rubio NR, Pietropinto JA, DiCindio H, Zhang SW, Rowat AC, Kaplan DL. Perspectives on scaling production of adipose tissue for food applications.. Biomaterials, 2021.
  9. Kim PH, Chen NY, Heizer PJ, Tu Y, Weston TA, Fong JL, Gill NK, Rowat AC, Young SG, Fong LG. Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome.. JCI insight, 2021.
  10. Yu W, Lu QY, Sharma S, Ly C, Di Carlo D, Rowat AC, LeClaire M, Kim D, Chow C, Gimzewski JK, Rao J. Single Cell Mechanotype and Associated Molecular Changes in Urothelial Cell Transformation and Progression.. Frontiers in cell and developmental biology, 2020.
  11. Zhang X, Kim TH, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S. Unraveling the mechanobiology of immune cells.. Current opinion in biotechnology, 2020.
  12. Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.. Cell, 2020.
  13. Moose DL, Krog BL, Kim TH, Zhao L, Williams-Perez S, Burke G, Rhodes L, Vanneste M, Breheny P, Milhem M, Stipp CS, Rowat AC, Henry MD. Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation.. Cell reports, 2020.
  14. Lawrenson K, Fonseca MAS, Liu AY, Segato Dezem F, Lee JM, Lin X, Corona RI, Abbasi F, Vavra KC, Dinh HQ, Gill NK, Seo JH, Coetzee S, Lin YG, Pejovic T, Mhawech-Fauceglia P, Rowat AC, Drapkin R, Karlan BY, Hazelett DJ, Freedman ML, Gayther SA, Noushmehr H. A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development.. Cell reports, 2019.
  15. Rowat AC, Soh M, Malan H, Jensen L, Schmidt L, Slusser W. Promoting an interdisciplinary food literacy framework to cultivate critical citizenship.. Journal of American college health : J of ACH, 2019.
  16. Nguyen AV, Trompetto B, Tan XHM, Scott MB, Hu KH, Deeds E, Butte MJ, Chiou PY, Rowat AC. Differential Contributions of Actin and Myosin to the Physical Phenotypes and Invasion of Pancreatic Cancer Cells.. Cellular and molecular bioengineering, 2019.
  17. Malan H, Watson TD, Slusser W, Glik D, Rowat AC, Prelip M. Challenges, Opportunities, and Motivators for Developing and Applying Food Literacy in a University Setting: A Qualitative Study.. Journal of the Academy of Nutrition and Dietetics, 2019.
  18. Sano M, Kaji N, Rowat AC, Yasaki H, Shao L, Odaka H, Yasui T, Higashiyama T, Baba Y. Microfluidic Mechanotyping of a Single Cell with Two Consecutive Constrictions of Different Sizes and an Electrical Detection System.. Analytical chemistry, 2019.
  19. Gill NK, Ly C, Kim PH, Saunders CA, Fong LG, Young SG, Luxton GWG, Rowat AC. DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces.. Frontiers in cell and developmental biology, 2019.
  20. Gunaratne PH, Pan Y, Rao AK, Lin C, Hernandez-Herrera A, Liang K, Rait AS, Venkatanarayan A, Benham AL, Rubab F, Kim SS, Rajapakshe K, Chan CK, Mangala LS, Lopez-Berestein G, Sood AK, Rowat AC, Coarfa C, Pirollo KF, Flores ER, Chang EH. Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.. Cancer, 2019.
  21. Gill NK, Ly C, Nyberg KD, Lee L, Qi D, Tofig B, Reis-Sobreiro M, Dorigo O, Rao J, Wiedemeyer R, Karlan B, Lawrenson K, Freeman MR, Damoiseaux R, Rowat AC. A scalable filtration method for high throughput screening based on cell deformability.. Lab on a chip, 2019.
  22. Kim TH, Ly C, Christodoulides A, Nowell CJ, Gunning PW, Sloan EK, Rowat AC. Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018.
  23. Reis-Sobreiro M, Chen JF, Novitskaya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR. Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential.. Cancer research, 2018.
  24. Nyberg KD, Bruce SL, Nguyen AV, Chan CK, Gill NK, Kim TH, Sloan EK, Rowat AC. Predicting cancer cell invasion by single-cell physical phenotyping.. Integrative biology : quantitative biosciences from nano to macro, 2018.
  25. Nyberg KD, Hu KH, Kleinman SH, Khismatullin DB, Butte MJ, Rowat AC. Quantitative Deformability Cytometry: Rapid, Calibrated Measurements of Cell Mechanical Properties.. Biophysical journal, 2017.
  26. Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, Basu-Roy U, Mansukhani A, Chu A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Coarfa C, Ma Y, Moore RA, Schein JE, Mungall AJ, Liu J, Pecot CV, Sood AK, Jones SJ, Marra MA, Gunaratne PH. Correction: miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.. Oncotarget, 2017.
  27. Evans AA, Cheung E, Nyberg KD, Rowat AC. Wrinkling of milk skin is mediated by evaporation.. Soft matter, 2017.
  28. Nguyen AV, Nyberg KD, Scott MB, Welsh AM, Nguyen AH, Wu N, Hohlbauch SV, Geisse NA, Gibb EA, Robertson AG, Donahue TR, Rowat AC. Stiffness of pancreatic cancer cells is associated with increased invasive potential.. Integrative biology : quantitative biosciences from nano to macro, 2016.
  29. Kim TH, Gill NK, Nyberg KD, Nguyen AV, Hohlbauch SV, Geisse NA, Nowell CJ, Sloan EK, Rowat AC. Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.. Journal of cell science, 2016.
  30. Chan CK, Pan Y, Nyberg K, Marra MA, Lim EL, Jones SJ, Maar D, Gibb EA, Gunaratne PH, Robertson AG, Rowat AC. Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour.. Open biology, 2016.
  31. Nyberg KD, Scott MB, Bruce SL, Gopinath AB, Bikos D, Mason TG, Kim JW, Choi HS, Rowat AC. The physical origins of transit time measurements for rapid, single cell mechanotyping.. Lab on a chip, 2016.
  32. Kim TH, Rowat AC, Sloan EK. Neural regulation of cancer: from mechanobiology to inflammation.. Clinical & translational immunology, 2016.
  33. Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, Basu-Roy U, Mansukhani A, Chu A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Coarfa C, Ma Y, Moore RA, Schein JE, Mungall AJ, Liu J, Pecot CV, Sood AK, Jones SJ, Marra MA, Gunaratne PH. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.. Oncotarget, 2016.
  34. Qi D, Kaur Gill N, Santiskulvong C, Sifuentes J, Dorigo O, Rao J, Taylor-Harding B, Ruprecht Wiedemeyer W, Rowat AC. Screening cell mechanotype by parallel microfiltration.. Scientific reports, 2015.
  35. Lautscham LA, Kämmerer C, Lange JR, Kolb T, Mark C, Schilling A, Strissel PL, Strick R, Gluth C, Rowat AC, Metzner C, Fabry B. Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness.. Biophysical journal, 2015.
  36. Zhou L, Nyberg K, Rowat AC. Understanding diffusion theory and Fick's law through food and cooking.. Advances in physiology education, 2015.
  37. Hoelzle DJ, Varghese BA, Chan CK, Rowat AC. A microfluidic technique to probe cell deformability.. Journal of visualized experiments : JoVE, 2014.
  38. Clarke CF, Rowat AC, Gober JW. Osmotic stress: Is CoQ a membrane stabilizer?. Nature chemical biology, 2014.
  39. Fogle C, Rowat AC, Levine AJ, Rudnick J. Shape transitions in soft spheres regulated by elasticity.. Physical review. E, Statistical, nonlinear, and soft matter physics, 2013.
  40. Rowat AC, Jaalouk DE, Zwerger M, Ung WL, Eydelnant IA, Olins DE, Olins AL, Herrmann H, Weitz DA, Lammerding J. Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions.. The Journal of biological chemistry, 2013.
  41. Martinez CJ, Kim JW, Ye C, Ortiz I, Rowat AC, Marquez M, Weitz D. A microfluidic approach to encapsulate living cells in uniform alginate hydrogel microparticles.. Macromolecular bioscience, 2012.
  42. Lin YC, Broedersz CP, Rowat AC, Wedig T, Herrmann H, Mackintosh FC, Weitz DA. Divalent cations crosslink vimentin intermediate filament tail domains to regulate network mechanics.. Journal of molecular biology, 2010.
  43. Agresti JJ, Antipov E, Abate AR, Ahn K, Rowat AC, Baret JC, Marquez M, Klibanov AM, Griffiths AD, Weitz DA. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
  44. Rowat AC, Bird JC, Agresti JJ, Rando OJ, Weitz DA. Tracking lineages of single cells in lines using a microfluidic device.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
  45. Ebina W, Rowat AC, Weitz DA. Electrodes on a budget: Micropatterned electrode fabrication by wet chemical deposition.. Biomicrofluidics, 2009.
  46. Rafat M, Raad DR, Rowat AC, Auguste DT. Fabrication of reversibly adhesive fluidic devices using magnetism.. Lab on a chip, 2009.
  47. Rowat AC. Physical properties of the nucleus studied by micropipette aspiration.. Methods in molecular biology (Clifton, N.J.), 2009.
  48. Schmitz CH, Rowat AC, Köster S, Weitz DA. Dropspots: a picoliter array in a microfluidic device.. Lab on a chip, 2008.
  49. Holtze C, Rowat AC, Agresti JJ, Hutchison JB, Angilè FE, Schmitz CH, Köster S, Duan H, Humphry KJ, Scanga RA, Johnson JS, Pisignano D, Weitz DA. Biocompatible surfactants for water-in-fluorocarbon emulsions.. Lab on a chip, 2008.
  50. Köster S, Angilè FE, Duan H, Agresti JJ, Wintner A, Schmitz C, Rowat AC, Merten CA, Pisignano D, Griffiths AD, Weitz DA. Drop-based microfluidic devices for encapsulation of single cells.. Lab on a chip, 2008.
  51. Terama E, Ollila OH, Salonen E, Rowat AC, Trandum C, Westh P, Patra M, Karttunen M, Vattulainen I. Influence of ethanol on lipid membranes: from lateral pressure profiles to dynamics and partitioning.. The journal of physical chemistry. B, 2008.
  52. Rowat AC, Lammerding J, Herrmann H, Aebi U. Towards an integrated understanding of the structure and mechanics of the cell nucleus.. BioEssays : news and reviews in molecular, cellular and developmental biology, 2008.
  53. Kasza KE, Rowat AC, Liu J, Angelini TE, Brangwynne CP, Koenderink GH, Weitz DA. The cell as a material.. Current opinion in cell biology, 2006.
  54. Rowat AC, Lammerding J, Ipsen JH. Mechanical properties of the cell nucleus and the effect of emerin deficiency.. Biophysical journal, 2006.
  55. Henriksen J, Rowat AC, Brief E, Hsueh YW, Thewalt JL, Zuckermann MJ, Ipsen JH. Universal behavior of membranes with sterols.. Biophysical journal, 2005.
  56. Rowat AC, Kitson N, Thewalt JL. Interactions of oleic acid and model stratum corneum membranes as seen by 2H NMR.. International journal of pharmaceutics, 2005.
  57. Rowat AC, Keller D, Ipsen JH. Effects of farnesol on the physical properties of DMPC membranes.. Biochimica et biophysica acta, 2005.
  58. Rowat AC, Foster LJ, Nielsen MM, Weiss M, Ipsen JH. Characterization of the elastic properties of the nuclear envelope.. Journal of the Royal Society, Interface, 2005.
  59. Henriksen J, Rowat AC, Ipsen JH. Vesicle fluctuation analysis of the effects of sterols on membrane bending rigidity.. European biophysics journal : EBJ, 2004.
  60. Rowat AC, Davis JH. Farnesol-DMPC phase behaviour: a (2)H-NMR study.. Biochimica et biophysica acta, 2004.
  61. Rowat AC, Brask J, Sparrman T, Jensen KJ, Lindblom G, Ipsen JH. Farnesylated peptides in model membranes: a biophysical investigation.. European biophysics journal : EBJ, 2003.