Andrew Goldstein

Associate Professor, Molecular, Cell and Developmental Biology, University of California Los Angeles

Associate Professor, Urology, University of California Los Angeles


The research in the Goldstein laboratory is focused on understanding the role of prostate epithelial cells in development, reproduction, aging and tumorigenesis. Dr. Goldstein described the isolation of epithelial progenitor cells from mouse and human prostate tissue and demonstrated the capacity of progenitor cells to initiate prostate cancer in response to oncogenic transformation. Following up on this work, Dr. Goldstein and colleagues determined that prostate cancer can evolve from a basal cell of origin to a luminal-like tumor-propagating cell population. The Goldstein lab has demonstrated that chronic inflammation in the human prostate is associated with an expansion of rare progenitor-like luminal cells marked by low CD38 expression that can initiate aggressive prostate cancer. These findings help to explain why chronic inflammation increases prostate cancer risk. The lab has determined that luminal progenitor cells are increased in the aging mouse and human prostate and that aging signatures indicate age-related metabolic reprogramming of prostate epithelial cells. More recently, the Goldstein laboratory has been investigating the role of metabolism in prostate lineage identity and prostate cancer treatment-resistance.


Benign Prostatic Hyperplasia, Cancer, Prostate Cancer, Metabolism, Tumor immunology, Aging, Reproduction, Fertility, Prostate epithelium, Stem cells and progenitor cells

Education and Training

University of California, Los AngelesPhD06/11Molecular Biology
Dartmouth CollegeBA06/05Biochemistry and Molecular Biology

Awards and Honors

  • Research Scholar Grant, American Cancer Society, 2017-2021.
  • Innovator Award, Rose Hills Foundation, 2019-2020.
  • Rheos Medicine Short Talk Award, Metabolism in Health and Disease Conference, 2022.
  • Research Award, Margaret E Early Medical Research Trust, 2017-2019.
  • Kidney Cancer Research Program Concept Award, Department of Defense, 2021-2022.
  • Young Investigator Award, Society for Basic Urologic Research, 2019.
  • Prostate Cancer Research Program Idea Development Award, Department of Defense, 2013-2016.
  • R01, NIH/NCI, 2019-2024.
  • Young Investigator Award, Prostate Cancer Foundation, 2011-2014.
  • Faculty Seed Grant, University of California Cancer Research Coordinating Committee, 2022-2023.
  • Prostate Cancer Research Program Idea Development Award, Department of Defense, 2023-2026.
  • Research Career Development Award, STOP CANCER, 2017-2019.
  • Giants of Science Hope Award, American Cancer Society, 2018.
  • Ablon Scholars Award, UCLA Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, 2021-2024.
  • Innovation Award, UCLA Broad Stem Cell Research Center, 2022-2023.


  1. Bernard MJ, Goldstein AS. A metabolic-epigenetic mechanism directs cell fate and therapeutic sensitivity in breast cancer.. Cancer research, 2024.
  2. Giafaglione JM, Crowell PD, Delcourt AML, Hashimoto T, Ha SM, Atmakuri A, Nunley NM, Dang RMA, Tian M, Diaz JA, Tika E, Payne MC, Burkhart DL, Li D, Navone NM, Corey E, Nelson PS, Lin NYC, Blanpain C, Ellis L, Boutros PC, Goldstein AS. Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment.. Nature cell biology, 2023.
  3. Wang CW, Clémot M, Hashimoto T, Diaz JA, Goins LM, Goldstein AS, Nagaraj R, Banerjee U. A conserved mechanism for JNK-mediated loss of Notch function in advanced prostate cancer.. Science signaling, 2023.
  4. Crowell PD, Giafaglione JM, Jones AE, Nunley NM, Hashimoto T, Delcourt AML, Petcherski A, Agrawal R, Bernard MJ, Diaz JA, Heering KY, Huang RR, Low JY, Matulionis N, Navone NM, Ye H, Zoubeidi A, Christofk HR, Rettig MB, Reiter RE, Haffner MC, Boutros PC, Shirihai OS, Divakaruni AS, Goldstein AS. MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer.. Cell reports, 2023.
  5. Bernard MJ, Smith CM, Goldstein AS. Prostatic proliferative inflammatory atrophy: welcome to the club†.. The Journal of pathology, 2023.
  6. Fox JJ, Hashimoto T, Navarro HI, Garcia AJ, Shou BL, Goldstein AS. Highly multiplexed immune profiling throughout adulthood reveals kinetics of lymphocyte infiltration in the aging mouse prostate.. Aging, 2023.
  7. Payne MC, Ho S, Hashimoto T, Imboden S, Diaz JA, Lee BS, Rupert MJ, Cai NY, Goldstein AS, Lin NYC. Microwell-based flow culture increases viability and restores drug response in prostate cancer spheroids.. Biotechnology journal, 2023.
  8. Freeland J, Crowell PD, Giafaglione JM, Boutros PC, Goldstein AS. Aging of the progenitor cells that initiate prostate cancer.. Cancer letters, 2021.
  9. Crowell PD, Giafaglione JM, Hashimoto T, Goldstein AS. Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming.. American journal of clinical and experimental urology, 2020.
  10. Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer.. Science translational medicine, 2019.
  11. Crowell PD, Giafaglione JM, Hashimoto T, Diaz JA, Goldstein AS. Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture.. Journal of visualized experiments : JoVE, 2019.
  12. Fox JJ, Navarro HI, Hashimoto T, Garcia AJ, Goldstein AS. Mass cytometry reveals species-specific differences and a new level of complexity for immune cells in the prostate.. American journal of clinical and experimental urology, 2019.
  13. Crowell PD, Fox JJ, Hashimoto T, Diaz JA, Navarro HI, Henry GH, Feldmar BA, Lowe MG, Garcia AJ, Wu YE, Sajed DP, Strand DW, Goldstein AS. Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate.. Cell reports, 2019.
  14. Mottahedeh J, Haffner MC, Grogan TR, Hashimoto T, Crowell PD, Beltran H, Sboner A, Bareja R, Esopi D, Isaacs WB, Yegnasubramanian S, Rettig MB, Elashoff DA, Platz EA, De Marzo AM, Teitell MA, Goldstein AS. CD38 is methylated in prostate cancer and regulates extracellular NAD.. Cancer & metabolism, 2018.
  15. Navarro HI, Goldstein AS. HoxB13 mediates AR-V7 activity in prostate cancer.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
  16. Crowell PD, Goldstein AS. Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer.. Molecular & cellular oncology, 2017.
  17. Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.. Cell reports, 2016.
  18. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
  19. Zong Y, Goldstein AS, Witte ON. Tissue Recombination Models for the Study of Epithelial Cancer.. Cold Spring Harbor protocols, 2015.
  20. Zong Y, Goldstein AS, Witte ON. Dissociated Prostate Regeneration under the Renal Capsule.. Cold Spring Harbor protocols, 2015.
  21. Zong Y, Goldstein AS, Witte ON. Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models.. Cold Spring Harbor protocols, 2015.
  22. Strand DW, Goldstein AS. The many ways to make a luminal cell and a prostate cancer cell.. Endocrine-related cancer, 2015.
  23. Liu X, Goldstein AS. Inflammation promotes prostate differentiation.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
  24. Stoyanova T, Goldstein AS. Distinct phases of human prostate cancer initiation and progression can be driven by different cell-types.. Cancer cell & microenvironment, 2014.
  25. Goldstein AS. A symbiotic relationship between epithelial and stromal stem cells.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
  26. Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
  27. Goldstein AS, Witte ON. Does the microenvironment influence the cell types of origin for prostate cancer?. Genes & development, 2013.
  28. Zong Y, Goldstein AS, Huang J. The molecular basis for ethnic variation and histological subtype differences in prostate cancer.. Science China. Life sciences, 2013.
  29. Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.. Stem cells (Dayton, Ohio), 2013.
  30. Zong Y, Goldstein AS. Adaptation or selection--mechanisms of castration-resistant prostate cancer.. Nature reviews. Urology, 2012.
  31. Stoyanova TI, Goldstein AS. Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells.. Asian journal of andrology, 2012.
  32. Goldstein AS, Witte ON. A plethora of progenitors in the post-natal prostate.. EMBO reports, 2012.
  33. Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling.. Genes & development, 2012.
  34. Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells.. PloS one, 2012.
  35. Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
  36. Goldstein AS, Drake JM, Burnes DL, Finley DS, Zhang H, Reiter RE, Huang J, Witte ON. Purification and direct transformation of epithelial progenitor cells from primary human prostate.. Nature protocols, 2011.
  37. Goldstein AS, Zong Y, Witte ON. A two-step toward personalized therapies for prostate cancer.. Science translational medicine, 2011.
  38. Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
  39. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. Identification of a cell of origin for human prostate cancer.. Science (New York, N.Y.), 2010.
  40. Goldstein AS, Stoyanova T, Witte ON. Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells.. Molecular oncology, 2010.
  41. Derogatis LR, Laan E, Brauer M, Van Lunsen RHW, Jannini EA, Davis SR, Fabre L, Smith LC, Basson R, Guay AT, Rubio-Aurioles E, Goldstein A, Pukall C, Kellogg S, Burrows L, Morrison P, Krychman M, Goldstein SW, Goldstein I. Responses to the proposed DSM-V changes.. The journal of sexual medicine, 2010.
  42. Garraway IP, Sun W, Tran CP, Perner S, Zhang B, Goldstein AS, Hahm SA, Haider M, Head CS, Reiter RE, Rubin MA, Witte ON. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo.. The Prostate, 2010.
  43. Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. Isolation, cultivation and characterization of adult murine prostate stem cells.. Nature protocols, 2010.
  44. Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
  45. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
  46. Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. Epithelial stem cells of the prostate and their role in cancer progression.. Cold Spring Harbor symposia on quantitative biology, 2008.