Dr. Goldstein is an Assistant Professor in the departments of Molecular, Cell & Developmental Biology and Urology, and a member of the Broad Stem Cell Research Center and Jonsson Comprehensive Cancer Center at UCLA. Dr. Goldstein attended Dartmouth College in Hanover, New Hampshire where he majored in Biochemistry and Molecular Biology and was a two-time NCAA Division 1 All-American lacrosse player. Dr. Goldstein moved to UCLA where he completed his Ph.D. in the laboratory of Dr. Owen Witte, isolating epithelial progenitor cells from mouse and human prostate tissue and demonstrating the capacity of progenitor cells to respond to oncogenic transformation. This work included the first demonstration of a cell of origin for human prostate cancer reported in Science Magazine. In 2011, Dr. Goldstein became the Inaugural fellow of the Broad Stem Cell Research Center and received a Prostate Cancer Foundation Young Investigator Award and a Department of Defense Prostate Cancer Research Program Idea Development Award to elucidate the cellular and molecular mechanisms promoting epithelial cancer initiation, progression and resistance to treatment.

His laboratory is interested in functionally defining mechanisms that drive the initiation and progression of human prostate cancer. Recent advances in sequencing technology have enabled the identification of numerous mutations, amplifications and deletions that may contribute to the pathogenesis of prostate cancer. However, few of these alterations have been functionally characterized to distinguish drivers from passengers. Dr. Goldstein’s group utilizes an innovative approach to engineer over-expression of known and candidate oncogenic drivers and determine which alterations can directly convert benign human prostate epithelium into cancer in mice. Dr. Goldstein has published his group’s results in PNAS (2013) and Cell Reports (2016), demonstrating the capacity of distinct genetic alterations to drive cancer from distinct cells of origin. Most recently, his group discovered that luminal progenitor cells are expanded in the aging mouse and human prostate, providing a potential explanation for the age-related increased risk of disease in the prostate. In addition to support from the Prostate Cancer Foundation, Department of Defense and American Cancer Society, Dr. Goldstein has recently received funding from an NIH/NCI R01 award.

Publications

A selected list of publications:

• Preston D. Crowell, Jonathan J. Fox, Takao Hashimoto, Johnny A. Diaz, Héctor I. Navarro, Gervaise H. Henry, Blake A. Feldman, Matthew G. Lowe, Alejandro J. Garcia, Ye E. Wu, Dipti P. Sajed, Douglas W. Strand & Andrew S. Goldstein   Expansion of luminal progenitor cells in the aging mouse and human prostate Cell Reports, 2019; 28(6): 1499-1510.
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• Jonathan J Fox, Héctor I Navarro, Takao Hashimoto, Alejandro J Garcia, Andrew S Goldstein   Mass cytometry reveals species-specific differences and a new level of complexity for immune cells in the prostate Am J Clin Exp Urol, 2019; 7(4): 281-296.
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• Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan, Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja, David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell and Andrew S. Goldstein   CD38 is methylated in prostate cancer and regulates extracellular NAD+ Cancer & Metabolism, 2018; 6: 13.
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• Navarro Héctor I, Goldstein Andrew S   HoxB13 mediates AR-V7 activity in prostate cancer Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(26): 6528-6529.
• Crowell Preston D, Goldstein Andrew S   Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer Molecular & cellular oncology, 2017; 4(2): e1279723.
• Remacle Francoise, Goldstein Andrew S, Levine Raphael D   Multivariate Surprisal Analysis of Gene Expression Levels Entropy, 2016; 18(12): 445.
• Liu Xian, Grogan Tristan R, Hieronymus Haley, Hashimoto Takao, Mottahedeh Jack, Cheng Donghui, Zhang Lijun, Huang Kevin, Stoyanova Tanya, Park Jung Wook, Shkhyan Ruzanna O, Nowroozizadeh Behdokht, Rettig Matthew B, Sawyers Charles L, Elashoff David, Horvath Steve, Huang Jiaoti, Witte Owen N, Goldstein Andrew S   Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome Cell reports, 2016; 17(10): 2596-2606.
• Stoyanova Tanya, Riedinger Mireille, Lin Shu, Faltermeier Claire M, Smith Bryan A, Zhang Kelvin X, Going Catherine C, Goldstein Andrew S, Lee John K, Drake Justin M, Rice Meghan A, Hsu En-Chi, Nowroozizadeh Behdokht, Castor Brandon, Orellana Sandra Y, Blum Steven M, Cheng Donghui, Pienta Kenneth J, Reiter Robert E, Pitteri Sharon J, Huang Jiaoti, Witte Owen N   Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer Proceedings of the National Academy of Sciences of the United States of America, 2016; 63: 325-336.
• Lawson Devon A, Werb Zena, Zong Yang, Goldstein Andrew S   The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis Cold Spring Harbor protocols, 2015; 2015(12): pdb.prot078071.
• Strand Douglas W, Goldstein Andrew S   The many ways to make a luminal cell and a prostate cancer cell Endocrine-related cancer, 2015; 22(6): T187-97.
• Zong Yang, Goldstein Andrew S, Witte Owen N   Tissue Recombination Models for the Study of Epithelial Cancer Cold Spring Harbor protocols, 2015; 2015(12): pdb.top069880.
• Zong Yang, Goldstein Andrew S, Witte Owen N   Dissociated Prostate Regeneration under the Renal Capsule Cold Spring Harbor protocols, 2015; 2015(11): 991-4.
• Zong Yang, Goldstein Andrew S, Witte Owen N   Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models Cold Spring Harbor protocols, 2015; 2015(11): 988-90.
• Liu Xian, Goldstein Andrew S   Inflammation promotes prostate differentiation Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(5): 1666-7.
• Goldstein Andrew S   A symbiotic relationship between epithelial and stromal stem cells Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(51): 20356-7.
• Stoyanova Tanya, Cooper Aaron R, Drake Justin M, Liu Xian, Armstrong Andrew J, Pienta Kenneth J, Zhang Hong, Kohn Donald B, Huang Jiaoti, Witte Owen N, Goldstein Andrew S   Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(50): 20111-6.
• Goldstein Andrew S, Witte Owen N   Does the microenvironment influence the cell types of origin for prostate cancer? Genes & development, 2013; 27(14): 1539-44.
• Janzen Deanna M, Cheng Donghui, Schafenacker Amanda M, Paik Daniel Y, Goldstein Andrew S, Witte Owen N, Jaroszewicz Artur, Pellegrini Matteo, Memarzadeh Sanaz   Estrogen and progesterone together expand murine endometrial epithelial progenitor cells Stem cells (Dayton, Ohio), 2013; 31(4): 808-22.
• Stoyanova Tanya I, Goldstein Andrew S   Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells Asian journal of andrology, 2013; 15(1): 83-4.
• Goldstein Andrew S, Witte Owen N   A plethora of progenitors in the post-natal prostate EMBO reports, 2012; 13(12): 1036-7.
• Stoyanova Tanya, Goldstein Andrew S, Cai Houjian, Drake Justin M, Huang Jiaoti, Witte Owen N   Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling Genes & development, 2012; 26(20): 2271-85.
• Miller Jeffrey P, Yeh Nancy, Hofstetter Christoph P, Keskin Doruk, Goldstein Andrew S, Koff Andrew   p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation The Journal of biological chemistry, 2012; 287(24): 19775-85.
• Kravchenko-Balasha Nataly, Levitzki Alexander, Goldstein Andrew, Rotter Varda, Gross A, Remacle F, Levine R D   On a fundamental structure of gene networks in living cells Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(12): 4702-7.
• Jiao Jing, Hindoyan Antreas, Wang Shunyou, Tran Linh M, Goldstein Andrew S, Lawson Devon, Chen Donghui, Li Yunfeng, Guo Changyong, Zhang Baohui, Fazli Ladan, Gleave Martin, Witte Owen N, Garraway Isla P, Wu Hong   Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells PloS one, 2012; 7(8): e42564.
• Drake Justin M, Graham Nicholas A, Stoyanova Tanya, Sedghi Amir, Goldstein Andrew S, Cai Houjian, Smith Daniel A, Zhang Hong, Komisopoulou Evangelia, Huang Jiaoti, Graeber Thomas G, Witte Owen N   Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(5): 1643-8.
• Goldstein Andrew S, Huang Jiaoti   Do neuroendocrine cells come up large in small cell lung cancer? Cell cycle (Georgetown, Tex.), 2011; 10(21): 3627.
• Goldstein Andrew S, Drake Justin M, Burnes Daina L, Finley David S, Zhang Hong, Reiter Robert E, Huang Jiaoti, Witte Owen N   Purification and direct transformation of epithelial progenitor cells from primary human prostate Nature protocols, 2011; 6(5): 656-67.
• Goldstein Andrew S, Zong Yang, Witte Owen N   A two-step toward personalized therapies for prostate cancer Science translational medicine, 2011; 3(72): 72ps7.
• Memarzadeh Sanaz, Zong Yang, Janzen Deanna M, Goldstein Andrew S, Cheng Donghui, Kurita Takeshi, Schafenacker Amanda M, Huang Jiaoti, Witte Owen N   Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(40): 17298-303.
• Goldstein Andrew S, Stoyanova Tanya, Witte Owen N   Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells Molecular oncology, 2010; 4(5): 385-96.
• Goldstein Andrew S, Huang Jiaoti, Guo Changyong, Garraway Isla P, Witte Owen N   Identification of a cell of origin for human prostate cancer Science (New York, N.Y.), 2010; 329(5991): 568-71.
• Garraway Isla P, Sun Wenyi, Tran Chau P, Perner Sven, Zhang Bao, Goldstein Andrew S, Hahm Scott A, Haider Maahum, Head Christian S, Reiter Robert E, Rubin Mark A, Witte Owen N   Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo The Prostate, 2010; 70(5): 491-501.
• Lukacs Rita U, Goldstein Andrew S, Lawson Devon A, Cheng Donghui, Witte Owen N   Isolation, cultivation and characterization of adult murine prostate stem cells Nature protocols, 2010; 5(4): 702-13.
• Zong Yang, Xin Li, Goldstein Andrew S, Lawson Devon A, Teitell Michael A, Witte Owen N   ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(30): 12465-70.
• Goldstein Andrew S, Lawson Devon A, Cheng Donghui, Sun Wenyi, Garraway Isla P, Witte Owen N   Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(52): 20882-7.