Publications

1. Baba S, Shinjo S, Seya D, Bochimoto H, Akaike T, Nakano A, Minamisawa S. Transgenic mice overexpressing Pitx2 in the atria develop tachycardia-bradycardia syndrome.. PloS one, 2025.
2. Liu N, Nakano H, Nakano A. Fetal heart as a new local site for hematopoiesis and macrophage formation.. Experimental hematology, 2025.
3. Ihara K, Iwamiya S, Ikuta M, Soejima Y, Hiraoka Y, Nakano A, Minamisawa S, Furukawa T, Kuroyanagi H, Sasano T. Cytoplasmic mutant RBM20 causes arrhythmogenicity in murine atria.. Journal of molecular and cellular cardiology, 2025.
4. Valencia DA, Koeberlein AN, Nakano H, Rudas A, Patel AA, Harui A, Spencer C, Nakano A, Quinlan ME. Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes.. bioRxiv : the preprint server for biology, 2025.
5. Liu N, Nakano H, Nakano A. Mutual Regulation of Cardiovascular and Hematopoietic Development.. Current cardiology reports, 2025.
6. Liu N, Nakano A. A crucial new aspect of cardiac morphogenesis: endocardial hematopoiesis.. Frontiers in physiology, 2024.
7. Etezadi F, Ito S, Yasui K, Kado Abdalkader R, Minami I, Uesugi M, Ganesh Pandian N, Nakano H, Nakano A, Packwood DM. Molecular Design for Cardiac Cell Differentiation Using a Small Data Set and Decorated Shape Features.. Journal of chemical information and modeling, 2024.
8. Otani K, Zeniya T, Kawashima H, Moriguchi T, Nakano A, Han C, Murata S, Nishimura K, Koshino K, Yamahara K, Inubushi M, Iida H. Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction.. European journal of nuclear medicine and molecular imaging, 2024.
9. Nakano H, Nakano A. The role of metabolism in cardiac development.. Current topics in developmental biology, 2024.
10. Perez-Ramirez CA, Nakano H, Law RC, Matulionis N, Thompson J, Pfeiffer A, Park JO, Nakano A, Christofk HR. Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy.. Cell, 2023.
11. Langenbacher AD, Lu F, Tsang L, Huang ZYS, Keer B, Tian Z, Eide A, Pellegrini M, Nakano H, Nakano A, Chen JN. Rtf1-dependent transcriptional pausing regulates cardiogenesis.. bioRxiv : the preprint server for biology, 2023.
12. Liu N, Kawahira N, Nakashima Y, Nakano H, Iwase A, Uchijima Y, Wang M, Wu SM, Minamisawa S, Kurihara H, Nakano A. Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5.. Nature communications, 2023.
13. Nakano A, Liu N. Response to Matters Arising: Intercellular genetic tracing of cardiac endothelium in the developing heart.. Developmental cell, 2023.
14. Liu N, Butcher JT, Nakano A, Del Campo A. Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan.. Aging, 2023.
15. Hosomi K, Kawashima H, Nakano A, Kakino A, Okamatsu-Ogura Y, Yamashita Y, Sasaoka M, Masuda D, Yamashita S, Chen CH, Yuzuriha S, Hosoda H, Iida H, Sawamura T. NanoSPECT imaging reveals the uptake of 123I-labelled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.. Cardiovascular research, 2023.
16. Trieu T, Mach P, Bunn K, Huang V, Huang J, Chow C, Nakano H, Fajardo VM, Touma M, Ren S, Wang Y, Nakano A. A novel murine model of atrial fibrillation by diphtheria toxin-induced injury.. Frontiers in physiology, 2022.
17. Shibata H, Terabe M, Shibano Y, Saitoh S, Takasugi T, Hayashi Y, Okabe S, Yamaguchi Y, Yasukawa H, Suetomo H, Miyanabe K, Ohbayashi N, Akimaru M, Saito S, Ito D, Nakano A, Kojima S, Miyahara Y, Sasaki K, Maruno T, Noda M, Kiyoshi M, Harazono A, Torisu T, Uchiyama S, Ishii-Watabe A. A Collaborative Study on the Classification of Silicone Oil Droplets and Protein Particles Using Flow Imaging Method.. Journal of pharmaceutical sciences, 2022.
18. Dunham CS, Mackenzie ME, Nakano H, Kim AR, Nakano A, Stieg AZ, Gimzewski JK. Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis.. PloS one, 2022.
19. Dunham CS, Mackenzie ME, Nakano H, Kim AR, Juda MB, Nakano A, Stieg AZ, Gimzewski JK. Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures.. PloS one, 2022.
20. Zhao Y, Wang LK, Eskin A, Kang X, Fajardo VM, Mehta Z, Pineles S, Schmidt RJ, Nagiel A, Satou G, Garg M, Federman M, Reardon LC, Lee SL, Biniwale R, Grody WW, Halnon N, Khanlou N, Quintero-Rivera F, Alejos JC, Nakano A, Fishbein GA, Van Arsdell GS, Nelson SF, Touma M. Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome.. Journal of molecular medicine (Berlin, Germany), 2021.
21. Harada Y, Tanaka T, Arai Y, Isomoto Y, Nakano A, Nakao S, Urasaki A, Watanabe Y, Kawamura T, Nakagawa O. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development.. Genes to cells : devoted to molecular & cellular mechanisms, 2021.
22. Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration.. Scientific reports, 2021.
23. Nakano H, Fajardo VM, Nakano A. The role of glucose in physiological and pathological heart formation.. Developmental biology, 2021.
24. Watanabe Y, Seya D, Ihara D, Ishii S, Uemoto T, Kubo A, Arai Y, Isomoto Y, Nakano A, Abe T, Shigeta M, Kawamura T, Saito Y, Ogura T, Nakagawa O. Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription.. The Journal of biological chemistry, 2020.
25. Anderson A, Masuho I, Marron Fernandez de Velasco E, Nakano A, Birnbaumer L, Martemyanov KA, Wickman K. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
26. Ihara D, Watanabe Y, Seya D, Arai Y, Isomoto Y, Nakano A, Kubo A, Ogura T, Kawamura T, Nakagawa O. Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors.. Developmental biology, 2020.
27. Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A. Endocardially Derived Macrophages Are Essential for Valvular Remodeling.. Developmental cell, 2019.
28. Lee SW, Anderson A, Guzman PA, Nakano A, Tolkacheva EG, Wickman K. Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation on Heart Rate Dynamics and Arrhythmogenesis.. Frontiers in physiology, 2018.
29. Anderson A, Kulkarni K, Marron Fernandez de Velasco E, Carlblom N, Xia Z, Nakano A, Martemyanov KA, Tolkacheva EG, Wickman K. Expression and relevance of the G protein-gated K+ channel in the mouse ventricle.. Scientific reports, 2018.
30. Tao Y, Yen MR, Chitiashvili T, Nakano H, Kim R, Hosohama L, Tan YC, Nakano A, Chen PY, Clark AT. TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency.. Stem cell reports, 2017.
31. Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.. eLife, 2017.
32. Asanuma H, Sanada S, Yoshitomi T, Sasaki H, Takahama H, Ihara M, Takahama H, Shinozaki Y, Mori H, Asakura M, Nakano A, Sugimachi M, Asano Y, Minamino T, Takashima S, Nagasaki Y, Kitakaze M. Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts.. Cardiovascular drugs and therapy, 2017.
33. Zhu H, Scharnhorst KS, Stieg AZ, Gimzewski JK, Minami I, Nakatsuji N, Nakano H, Nakano A. Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system.. Scientific reports, 2017.
34. Ding Y, Lee J, Ma J, Sung K, Yokota T, Singh N, Dooraghi M, Abiri P, Wang Y, Kulkarni RP, Nakano A, Nguyen TP, Fei P, Hsiai TK. Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution.. Scientific reports, 2017.
35. Fukuda H, Suwa H, Nakano A, Sakamoto M, Imazu M, Hasegawa T, Takahama H, Amaki M, Kanzaki H, Anzai T, Mochizuki N, Ishii A, Asanuma H, Asakura M, Washio T, Kitakaze M. Non-linear Equation using Plasma Brain Natriuretic Peptide Levels to Predict Cardiovascular Outcomes in Patients with Heart Failure.. Scientific reports, 2016.
36. Sung K, Ding Y, Ma J, Chen H, Huang V, Cheng M, Yang CF, Kim JT, Eguchi D, Di Carlo D, Hsiai TK, Nakano A, Kulkarni RP. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping.. Scientific reports, 2016.
37. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells.. Cell stem cell, 2016.
38. Nakano A, Nakano H, Smith KA, Palpant NJ. The developmental origins and lineage contributions of endocardial endothelium.. Biochimica et biophysica acta, 2016.
39. Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S. Heterozygous deletion of sarcolipin maintains normal cardiac function.. American journal of physiology. Heart and circulatory physiology, 2015.
40. Lluri G, Huang V, Touma M, Liu X, Harmon AW, Nakano A. Hematopoietic progenitors are required for proper development of coronary vasculature.. Journal of molecular and cellular cardiology, 2015.
41. Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H. Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015.
42. Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.. The Journal of experimental medicine, 2015.
43. Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S. Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.. Nature communications, 2015.
44. Hayashi T, Asano Y, Shintani Y, Aoyama H, Kioka H, Tsukamoto O, Hikita M, Shinzawa-Itoh K, Takafuji K, Higo S, Kato H, Yamazaki S, Matsuoka K, Nakano A, Asanuma H, Asakura M, Minamino T, Goto Y, Ogura T, Kitakaze M, Komuro I, Sakata Y, Tsukihara T, Yoshikawa S, Takashima S. Higd1a is a positive regulator of cytochrome c oxidase.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
45. Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen JN. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity.. eLife, 2015.
46. Nakashima Y, Yanez DA, Touma M, Nakano H, Jaroszewicz A, Jordan MC, Pellegrini M, Roos KP, Nakano A. Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system.. Circulation research, 2014.
47. Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Takafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y, Takashima S. Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
48. Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.. PloS one, 2013.
49. Harmon AW, Nakano A. Nkx2-5 lineage tracing visualizes the distribution of second heart field-derived aortic smooth muscle.. Genesis (New York, N.Y. : 2000), 2013.
50. Arshi A, Nakashima Y, Nakano H, Eaimkhong S, Evseenko D, Reed J, Stieg AZ, Gimzewski JK, Nakano A. Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells.. Science and technology of advanced materials, 2013.
51. Chen PY, Ganguly A, Rubbi L, Orozco LD, Morselli M, Ashraf D, Jaroszewicz A, Feng S, Jacobsen SE, Nakano A, Devaskar SU, Pellegrini M. Intrauterine calorie restriction affects placental DNA methylation and gene expression.. Physiological genomics, 2013.
52. Nakano H, Liu X, Arshi A, Nakashima Y, van Handel B, Sasidharan R, Harmon AW, Shin JH, Schwartz RJ, Conway SJ, Harvey RP, Pashmforoush M, Mikkola HK, Nakano A. Haemogenic endocardium contributes to transient definitive haematopoiesis.. Nature communications, 2013.
53. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.. Cell, 2012.
54. Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. Cardiac origin of smooth muscle cells in the inflow tract.. Journal of molecular and cellular cardiology, 2010.
55. Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M. Identification of genes related to heart failure using global gene expression profiling of human failing myocardium.. Biochemical and biophysical research communications, 2010.
56. Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. Islet1 cardiovascular progenitors: a single source for heart lineages?. Development (Cambridge, England), 2008.
57. Kato H, Takashima S, Asano Y, Shintani Y, Yamazaki S, Seguchi O, Yamamoto H, Nakano A, Higo S, Ogai A, Minamino T, Kitakaze M, Hori M. Identification of p32 as a novel substrate for ATM in heart.. Biochemical and biophysical research communications, 2007.
58. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.. Cell, 2006.
59. Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T. The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.. Developmental biology, 2006.