Brent Linden Fogel

Professor-in-Residence, Neurology, University of California Los Angeles

Professor-in-Residence, Human Genetics, University of California Los Angeles

695 Charles E. Young Drive South, Gonda Room 6554A
Los Angeles, CA 90095

Websites

Laboratory

Clinic

UC Profile

Brent L. Fogel MD, PhD is a Professor in the Departments of Neurology and Human Genetics at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Dr. Fogel’s research uses genomics, bioinformatics, and systems biology to understand how genetic mutations and associated impairment of genetic pathways leads to neurodegenerative disorders such as spinocerebellar ataxia or neurodevelopmental conditions. Dr. Fogel also specifically studies the molecular pathogenesis of ataxia with oculomotor apraxia (AOA) and the development of gene therapy approaches to treatment of this disorder. Clinically, Dr. Fogel directs the UCLA Clinical Neurogenomics Research Center, a department-wide program in Neurology designed to promote and facilitate access to genomic and other cellular and molecular research studies for all UCLA Neurology patients. He also directs the UCLA Neurogenetics Clinic where his work focuses on the use of genomic sequencing to identify rare and novel causes of neurological disease. Dr. Fogel also runs a clinic devoted to patients with AOA and diagnoses and treats various disorders of balance and coordination in the UCLA Ataxia Center. He has authored multiple research and clinical articles, reviews, and book chapters on spinocerebellar ataxia, clinical neurogenetics, and neurodevelopmental disease. Dr. Fogel’s work has been funded, in part, by the American Academy of Neurology / American Brain Foundation, the National Institutes of Health, and the National Ataxia Foundation. Lab Website: https://fogellab.neurology.ucla.edu/ Twitter: @fogellab

Research Interests

  • Neurogenetics
  • Genomics of Neurological Disease
  • Genetic Diagnostics
  • Neurodevelopment
  • Regulation of gene expression
  • Gene therapy
  • Bioinformatics
  • Systems biology
  • Molecular genetics

Biography

Dr. Brent Fogel obtained a Ph.D. in Microbiology and Molecular Genetics from the Medical College of Wisconsin as well as an M.D. degree. He completed his residency training in Neurology at UCLA as well as a research fellowship in Neurogenetics. He is currently an Associate Professor in the Departments of Neurology and Human Genetics at the David Geffen School of Medicine at UCLA. Dr. Fogel’s research studies genomic methods to improve diagnosis of neurological disease, basic molecular mechanisms of neuronal function to understand how impairment can lead to neurodegenerative disorders such as cerebellar ataxia and develop new methods of treatment such as gene therapy, and the genetics of neurodevelopment to investigate conditions such as autism spectrum disorder and other neurological disorders. Clinically, Dr. Fogel directs the UCLA Neurogenetics Clinic where he is using genome-wide methods to identify rare and novel causes of neurodegenerative disease, particularly cerebellar ataxia, as well as other disorders including various forms of leukodystrophy and spastic paraparesis. Dr. Fogel is a member of the UCLA Ataxia Center and directs the Ataxia and Neurogenetics Biobank Program. Dr. Fogel also directs the Clinical Neurogenomics Research Center (CNRC) within the UCLA Department of Neurology. The CNRC facilitates incorporation of genomic data into clinical care and links patient populations with precision health-based research studies into the genetic and molecular basis of disease to improve diagnosis and treatment. He has authored many research and clinical articles, reviews, and book chapters on spinocerebellar ataxia, clinical neurogenetics, and neurodevelopmental disease. Dr. Fogel’s work has been funded by the American Academy of Neurology, the American Brain Foundation, the National Institutes of Health, and the National Ataxia Foundation.

Publications

A selected list of publications:

Publications