Publications

1. Rose DA, Treacy JW, Seth K, Tanzillo AF, Li A, Tamshen K, Sloan LK, Boehnke N, Evans CJ, Cahill CM, Maynard HD. An Orally Administered Misuse Deterrent Opioid Prodrug for Treatment of Acute Pain.. JACS Au, 2025.
2. Alderete J, Tanzillo A, Miller J, Barrall L, Nasef H, Ellis E, Sigal G, Silva FD'D, Dagher M, Evans CJ, Cahill CM. Opposing effects of mu opioid receptors on dopamine D1 and D2 receptor expressing neurons in opioid mediated antinociception.. The journal of pain, 2025.
3. Lueptow L, Shashkova L, Twombly E, Greenhill H, Yang H, Taylor AMW, Cameron CM, Evans CJ, Andrews AM, Cahill CM. Chronic pain selectively reduces the motivation to work for remifentanil but not food reward.. Pain, 2025.
4. Dagher M, Cahill CM, Evans CJ. Opioid Systems and Depression: The Relationship Is Strengthening.. Biological psychiatry, 2022.
5. Barry J, Oikonomou KD, Peng A, Yu D, Yang C, Golshani P, Evans CJ, Levine MS, Cepeda C. Dissociable effects of oxycodone on behavior, calcium transient activity, and excitability of dorsolateral striatal neurons.. Frontiers in neural circuits, 2022.
6. Grodin EN, Nieto SJ, Meredith LR, Burnette E, O'Neill J, Alger J, London ED, Miotto K, Evans CJ, Irwin MR, Ray LA. Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial.. Addiction biology, 2022.
7. Cahill CM, Lueptow L, Kim H, Shusharla R, Bishop A, Evans CJ. Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction.. Handbook of experimental pharmacology, 2022.
8. Kibaly C, Alderete JA, Liu SH, Nasef HS, Law PY, Evans CJ, Cahill CM. Oxycodone in the Opioid Epidemic: High 'Liking', 'Wanting', and Abuse Liability.. Cellular and molecular neurobiology, 2020.
9. Lichtenberg NT, Thompson AB, Iguchi MY, Evans CJ, Romero-Calderón R. An Undergraduate Student-Led Neuroscience Outreach Program Shows Promise in Shifting Teen Attitudes About Drugs.. Mind, brain and education : the official journal of the International Mind, Brain, and Education Society, 2020.
10. Lueptow LM, Shashkova EC, Miller MG, Evans CJ, Cahill CM. Insights into the Neurobiology of Craving in Opioid Use Disorder.. Current anesthesiology reports, 2020.
11. Severino AL, Mittal N, Hakimian JK, Velarde N, Minasyan A, Albert R, Torres C, Romaneschi N, Johnston C, Tiwari S, Lee AS, Taylor AM, Gavériaux-Ruff C, Kieffer BL, Evans CJ, Cahill CM, Walwyn WM. μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors.. eNeuro, 2020.
12. Huang AY, Taylor AMW, Ghogha A, Pribadi M, Wang Q, Kim TSJ, Cahill CM, Coppola G, Evans CJ. Genetic and functional analysis of a Pacific hagfish opioid system.. Journal of neuroscience research, 2020.
13. Taylor AMW, Chadwick CI, Mehrabani S, Hrncir H, Arnold AP, Evans CJ. Sex differences in kappa opioid receptor antinociception is influenced by the number of X chromosomes in mouse.. Journal of neuroscience research, 2020.
14. Pennington ZT, Trott JM, Rajbhandari AK, Li K, Walwyn WM, Evans CJ, Fanselow MS. Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019.
15. Severino AL, Evans CJ. Digging through the roots of addiction: Understanding the causes that underlie the insidious problem of substance use disorders (SUDs).. Neuroscience and biobehavioral reviews, 2019.
16. Saravanapandian V, Sparck EM, Cheng KY, Yu F, Yaeger C, Hu T, Suthana N, Romero-Calderón R, Ghiani CA, Evans CJ, Carpenter EM, Ge W. Quantitative assessments reveal improved neuroscience engagement and learning through outreach.. Journal of neuroscience research, 2019.
17. Liu SS, Pickens S, Burma NE, Ibarra-Lecue I, Yang H, Xue L, Cook C, Hakimian JK, Severino AL, Lueptow L, Komarek K, Taylor AMW, Olmstead MC, Carroll FI, Bass CE, Andrews AM, Walwyn W, Trang T, Evans CJ, Leslie FM, Cahill CM. Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019.
18. Kibaly C, Xu C, Cahill CM, Evans CJ, Law PY. Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect.. Nature reviews. Neuroscience, 2019.
19. Lee K, Vuong HE, Nusbaum DJ, Hsiao EY, Evans CJ, Taylor AMW. The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018.
20. Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.. Neuron, 2018.
21. Cahill CM, Walwyn W, Taylor AMW, Pradhan AAA, Evans CJ. Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation.. Trends in pharmacological sciences, 2016.
22. Evans CJ, Cahill CM. Neurobiology of opioid dependence in creating addiction vulnerability.. F1000Research, 2016.
23. Smith WC, Rosenberg MH, Claar LD, Chang V, Shah SN, Walwyn WM, Evans CJ, Masmanidis SC. Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence.. eNeuro, 2016.
24. Pradhan AA, Perroy J, Walwyn WM, Smith ML, Vicente-Sanchez A, Segura L, Bana A, Kieffer BL, Evans CJ. Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016.
25. Taylor AM, Castonguay A, Ghogha A, Vayssiere P, Pradhan AA, Xue L, Mehrabani S, Wu J, Levitt P, Olmstead MC, De Koninck Y, Evans CJ, Cahill CM. Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015.
26. Taylor AM, Castonguay A, Taylor AJ, Murphy NP, Ghogha A, Cook C, Xue L, Olmstead MC, De Koninck Y, Evans CJ, Cahill CM. Microglia disrupt mesolimbic reward circuitry in chronic pain.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015.
27. Cahill CM, Taylor AM, Cook C, Ong E, Morón JA, Evans CJ. Does the kappa opioid receptor system contribute to pain aversion?. Frontiers in pharmacology, 2014.
28. Taylor AM, Murphy NP, Evans CJ, Cahill CM. Correlation between ventral striatal catecholamine content and nociceptive thresholds in neuropathic mice.. The journal of pain, 2014.
29. Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW. Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.. Nature neuroscience, 2014.
30. Pradhan AA, Smith ML, McGuire B, Tarash I, Evans CJ, Charles A. Characterization of a novel model of chronic migraine.. Pain, 2013.
31. Ma YY, Henley SM, Toll J, Jentsch JD, Evans CJ, Levine MS, Cepeda C. Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens.. ASN neuro, 2013.
32. James AS, Chen JY, Cepeda C, Mittal N, Jentsch JD, Levine MS, Evans CJ, Walwyn W. Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons.. Behavioural brain research, 2013.
33. Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.. Pharmacological reviews, 2013.
34. Pradhan AA, Smith ML, Kieffer BL, Evans CJ. Ligand-directed signalling within the opioid receptor family.. British journal of pharmacology, 2012.
35. Ma YY, Cepeda C, Chatta P, Franklin L, Evans CJ, Levine MS. Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons.. ASN neuro, 2012.
36. Poole DP, Pelayo JC, Scherrer G, Evans CJ, Kieffer BL, Bunnett NW. Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice.. Gastroenterology, 2011.
37. Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W. Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2.. Molecular pain, 2011.
38. Walwyn WM, Miotto KA, Evans CJ. Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions.. Drug and alcohol dependence, 2010.
39. Walwyn W, John S, Maga M, Evans CJ, Hales TG. Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons.. Molecular pharmacology, 2009.
40. Tan M, Walwyn WM, Evans CJ, Xie CW. p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.. The Journal of biological chemistry, 2009.
41. Wassum KM, Evans CJ. International Narcotics Research Conference - 39th Annual Meeting.. IDrugs : the investigational drugs journal, 2008.
42. Gioiosa L, Chen X, Watkins R, Klanfer N, Bryant CD, Evans CJ, Arnold AP. Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice.. Hormones and behavior, 2007.
43. Walwyn W, Evans CJ, Hales TG. Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
44. Bryant CD, Roberts KW, Byun JS, Fanselow MS, Evans CJ. Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice.. Pharmacology, biochemistry, and behavior, 2006.
45. Bryant CD, Eitan S, Sinchak K, Fanselow MS, Evans CJ. NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice.. American journal of physiology. Regulatory, integrative and comparative physiology, 2006.
46. Walwyn W, Maidment NT, Sanders M, Evans CJ, Kieffer BL, Hales TG. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons.. Molecular pharmacology, 2005.
47. Evans CJ. Secrets of the opium poppy revealed.. Neuropharmacology, 2004.
48. Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
49. Eitan S, Bryant CD, Saliminejad N, Yang YC, Vojdani E, Keith D, Polakiewicz R, Evans CJ. Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
50. Li Y, Eitan S, Wu J, Evans CJ, Kieffer B, Sun X, Polakiewicz RD. Morphine induces desensitization of insulin receptor signaling.. Molecular and cellular biology, 2003.
51. Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, Hales TG. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory.. Molecular pharmacology, 2003.