David A Nathanson

Associate Professor, Molecular and Medical Pharmacology, University of California Los Angeles

Email: dnathanson@mednet.ucla.edu

Phone: 310 825-8813

10833 LeConte Avenue
Los Angeles, CA 90095

UC Profile

http://nathansonlab.com/

Affiliations

Member, I3T Theme, Molecular Pharmacology GPB Home Area, Neuroscience GPB Home Area

Biography

David Nathanson is an Associate Professor in the Ahmanson Translational Imaging Division (ATID) in the Department of Molecular and Medical Pharmacology at UCLA. Dr. Nathanson received his B.S. from Willamette University and his Ph.D in Molecular and Medical Pharmacology under Dr. Paul Mischel at UCLA. He was then a post-doctoral fellow in the lab of Dr. Caius Radu at UCLA. Dr. Nathanson’s lab focuses on the interplay between aberrant signal transduction and metabolism in glioblastoma (GBM), the most lethal brain tumor in adults, and developing new therapeutic strategies to treat this deadly disease.

Publications

A selected list of publications:

Wen Patrick Y, Weller Michael, Lee Eudocia Quant, Alexander Brian M, Barnholtz-Sloan Jill S, Barthel Floris P, Batchelor Tracy T, Bindra Ranjit S, Chang Susan M, Chiocca E Antonio, Cloughesy Timothy F, DeGroot John F, Galanis Evanthia, Gilbert Mark R, Hegi Monika E, Horbinski Craig, Huang Raymond Y, Lassman Andrew B, Le Rhun Emilie, Lim Michael, Mehta Minesh P, Mellinghoff Ingo K, Minniti Giuseppe, Nathanson David, Platten Michael, Preusser Matthias, Roth Patrick, Sanson Marc, Schiff David, Short Susan C, Taphoorn Martin J B, Tonn Joerg-Christian, Tsang Jonathan, Verhaak Roel G W, von Deimling Andreas, Wick Wolfgang, Zadeh Gelareh, Reardon David A, Aldape Kenneth D, van den Bent Martin J Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions Neuro-oncology, 2020; 22(8): 1073-1113.
Ellingson Benjamin M, Yao Jingwen, Raymond Catalina, Nathanson David A, Chakhoyan Ararat, Simpson Jeremy, Garner James S, Olivero Alan G, Mueller Lars U, Rodon Jordi, Gerstner Elizabeth, Cloughesy Timothy F, Wen Patrick Y Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma Clinical cancer research : an official journal of the American Association for Cancer Research, 2020; 26(13): 3135-3144.
Xiao Weikun, Wang Shanshan, Zhang Rongyu, Sohrabi Alireza, Yu Qi, Liu Sihan, Ehsanipour Arshia, Liang Jesse, Bierman Rebecca D, Nathanson David A, Seidlits Stephanie K Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma Matrix biology : journal of the International Society for Matrix Biology, 2020; 85-86(13): 128-146.
Zhang Le, Bailleul Justine, Yazal Taha, Dong Kevin, Sung David, Dao Amy, Gosa Laura, Nathanson David, Bhat Kruttika, Duhachek-Muggy Sara, Alli Claudia, Dratver Milana Bochkur, Pajonk Frank, Vlashi Erina PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation Breast cancer research and treatment, 2019; 178(1): 75-86.
Hu Xuchen, Matsumoto Ken, Jung Rachel S, Weston Thomas A, Heizer Patrick J, He Cuiwen, Sandoval Norma P, Allan Christopher M, Tu Yiping, Vinters Harry V, Liau Linda M, Ellison Rochelle M, Morales Jazmin E, Baufeld Lynn J, Bayley Nicholas A, He Liqun, Betsholtz Christer, Beigneux Anne P, Nathanson David A, Gerhardt Holger, Young Stephen G, Fong Loren G, Jiang Haibo GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients eLife, 2019; 8(4): 667-671.
Yao Jingwen, Chakhoyan Ararat, Nathanson David A, Yong William H, Salamon Noriko, Raymond Catalina, Mareninov Sergey, Lai Albert, Nghiemphu Phioanh L, Prins Robert M, Pope Whitney B, Everson Richard G, Liau Linda M, Cloughesy Timothy F, Ellingson Benjamin M Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI Neuro-oncology, 2019; 8(4): 667-671.
Davidson Tom B, Lee Alexander, Hsu Melody, Sedighim Shaina, Orpilla Joey, Treger Janet, Mastall Max, Roesch Saskia, Rapp Carmen, Galvez Mildred, Mochizuki Aaron, Antonios Joseph, Garcia Alejandro, Kotecha Nikesh, Bayless Nicholas, Nathanson David, Wang Anthony, Everson Richard, Yong William H, Cloughesy Timothy F, Liau Linda M, Herold-Mende Christel, Prins Robert M Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation Clinical cancer research : an official journal of the American Association for Cancer Research, 2019; 25(6): 1913-1922.
Chakhoyan Ararat, Yao Jingwen, Leu Kevin, Pope Whitney B, Salamon Noriko, Yong William, Lai Albert, Nghiemphu Phioanh L, Everson Richard G, Prins Robert M, Liau Linda M, Nathanson David A, Cloughesy Timothy F, Ellingson Benjamin M Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry Scientific reports, 2019; 9(1): 2846.
Ta Lisa, Gosa Laura, Nathanson David A Biosafety and Biohazards: Understanding Biosafety Levels and Meeting Safety Requirements of a Biobank Methods in molecular biology (Clifton, N.J.), 2019; 1897(1): 213-225.
Gosa Laura, Ta Lisa, Nathanson David A Processing of Primary Patient Tumors and Subsequent Generation of Primary Cell Lines Methods in molecular biology (Clifton, N.J.), 2019; 1897(1): 425-431.
Li Zhonghan, Cheng Hanjun, Shao Shiqun, Lu Xiang, Mo Li, Tsang Jonathan, Zeng Pu, Guo Zhili, Wang Siwen, Nathanson David A, Heath James R, Wei Wei, Xue Min Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities Angewandte Chemie (International ed. in English), 2018; 57(36): 11554-11558.
Xiao Weikun, Zhang Rongyu, Sohrabi Alireza, Ehsanipour Arshia, Sun Songping, Liang Jesse, Walthers Christopher M, Ta Lisa, Nathanson David A, Seidlits Stephanie K Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma Cancer research, 2018; 78(5): 1358-1370.
Mai Wilson X, Gosa Laura, Daniels Veerle W, Ta Lisa, Tsang Jonathan E, Higgins Brian, Gilmore W Blake, Bayley Nicholas A, Harati Mitra Dehghan, Lee Jason T, Yong William H, Kornblum Harley I, Bensinger Steven J, Mischel Paul S, Rao P Nagesh, Clark Peter M, Cloughesy Timothy F, Letai Anthony, Nathanson David A Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma Nature medicine, 2017; 23(11): 1342-1351.
Clark Peter M, Ebiana Victoria A, Gosa Laura, Cloughesy Timothy F, Nathanson David A Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017; 58(5): 689-696.
Turner Kristen M, Deshpande Viraj, Beyter Doruk, Koga Tomoyuki, Rusert Jessica, Lee Catherine, Li Bin, Arden Karen, Ren Bing, Nathanson David A, Kornblum Harley I, Taylor Michael D, Kaushal Sharmeela, Cavenee Webster K, Wechsler-Reya Robert, Furnari Frank B, Vandenberg Scott R, Rao P Nagesh, Wahl Geoffrey M, Bafna Vineet, Mischel Paul S Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity Nature, 2017; 543(7643): 122-125.
Laks Dan R, Ta Lisa, Crisman Thomas J, Gao Fuying, Coppola Giovanni, Radu Caius G, Nathanson David A, Kornblum Harley I Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma Molecular cancer therapeutics, 2016; 15(6): 1271-8.
Clark Peter M, Mai Wilson X, Cloughesy Timothy F, Nathanson David A Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma Current neurology and neuroscience reports, 2016; 16(2): 17.
Fu Xudong, Chin Randall M, Vergnes Laurent, Hwang Heejun, Deng Gang, Xing Yanpeng, Pai Melody Y, Li Sichen, Ta Lisa, Fazlollahi Farbod, Chen Chuo, Prins Robert M, Teitell Michael A, Nathanson David A, Lai Albert, Faull Kym F, Jiang Meisheng, Clarke Steven G, Cloughesy Timothy F, Graeber Thomas G, Braas Daniel, Christofk Heather R, Jung Michael E, Reue Karen, Huang Jing 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling Cell metabolism, 2015; 22(3): 508-15.
Shin Young Shik, Kim Jungwoo, Johnson Dazy, Dooraghi Alex A, Mai Wilson X, Ta Lisa, Chatziioannou Arion F, Phelps Michael E, Nathanson David A, Heath James R Quantitative assessments of glycolysis from single cells Technology, 2015; 3(4): 172-178.
Xue Min, Wei Wei, Su Yapeng, Kim Jungwoo, Shin Young Shik, Mai Wilson X, Nathanson David A, Heath James R Chemical methods for the simultaneous quantitation of metabolites and proteins from single cells Journal of the American Chemical Society, 2015; 137(12): 4066-9.
Lazari Mark, Collins Jeffrey, Shen Bin, Farhoud Mohammed, Yeh Daniel, Maraglia Brandon, Chin Frederick T, Nathanson David A, Moore Melissa, van Dam R Michael Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification Journal of nuclear medicine technology, 2014; 42(3): 203-10.
Danilova Nadia, Bibikova Elena, Covey Todd M, Nathanson David, Dimitrova Elizabeth, Konto Yoan, Lindgren Anne, Glader Bertil, Radu Caius G, Sakamoto Kathleen M, Lin Shuo The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia Disease models & mechanisms, 2014; 7(7): 895-905.
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication The Journal of experimental medicine, 2014; 211(3): 473-86.
Nathanson David A, Gini Beatrice, Mottahedeh Jack, Visnyei Koppany, Koga Tomoyuki, Gomez German, Eskin Ascia, Hwang Kiwook, Wang Jun, Masui Kenta, Paucar Andres, Yang Huijin, Ohashi Minori, Zhu Shaojun, Wykosky Jill, Reed Rachel, Nelson Stanley F, Cloughesy Timothy F, James C David, Rao P Nagesh, Kornblum Harley I, Heath James R, Cavenee Webster K, Furnari Frank B, Mischel Paul S Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA Science (New York, N.Y.), 2013; .
Wang Jun, Hwang Kiwook, Braas Daniel, Dooraghi Alex, Nathanson David, Campbell Dean O, Gu Yuchao, Sandberg Troy, Mischel Paul, Radu Caius, Chatziioannou Arion F, Phelps Michael E, Christofk Heather, Heath James R Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013; 54(10): 1820-4.
Gini Beatrice, Zanca Ciro, Guo Deliang, Matsutani Tomoo, Masui Kenta, Ikegami Shiro, Yang Huijun, Nathanson David, Villa Genaro R, Shackelford David, Zhu Shaojun, Tanaka Kazuhiro, Babic Ivan, Akhavan David, Lin Kelly, Assuncao Alvaro, Gu Yuchao, Bonetti Bruno, Mortensen Deborah S, Xu Shuichan, Raymon Heather K, Cavenee Webster K, Furnari Frank B, James C David, Kroemer Guido, Heath James R, Hege Kristen, Chopra Rajesh, Cloughesy Timothy F, Mischel Paul S The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas Clinical cancer research : an official journal of the American Association for Cancer Research, 2013; 19(20): 5722-32.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography Journal of medicinal chemistry, 2013; 56(17): 6696-708.
Herrmann Ken, Dahlbom Magnus, Nathanson David, Wei Liu, Radu Caius, Chatziioannou Arion, Czernin Johannes Evaluation of the Genisys4, a bench-top preclinical PET scanner Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013; 54(7): 1162-7.
Babic Ivan, Anderson Erik S, Tanaka Kazuhiro, Guo Deliang, Masui Kenta, Li Bing, Zhu Shaojun, Gu Yuchao, Villa Genaro R, Akhavan David, Nathanson David, Gini Beatrice, Mareninov Sergey, Li Rui, Camacho Carolina Espindola, Kurdistani Siavash K, Eskin Ascia, Nelson Stanley F, Yong William H, Cavenee Webster K, Cloughesy Timothy F, Christofk Heather R, Black Douglas L, Mischel Paul S EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer Cell metabolism, 2013; 17(6): 1000-8.
Akhavan David, Pourzia Alexandra L, Nourian Alex A, Williams Kevin J, Nathanson David, Babic Ivan, Villa Genaro R, Tanaka Kazuhiro, Nael Ali, Yang Huijun, Dang Julie, Vinters Harry V, Yong William H, Flagg Mitchell, Tamanoi Fuyuhiko, Sasayama Takashi, James C David, Kornblum Harley I, Cloughesy Tim F, Cavenee Webster K, Bensinger Steven J, Mischel Paul S De-repression of PDGFRÎ² transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients Cancer discovery, 2013; 3(5): 534-47.
Czernin Johannes, Allen-Auerbach Martin, Nathanson David, Herrmann Ken PET/CT in Oncology: Current Status and Perspectives Current radiology reports, 2013; 1(1): 177-190.
Braas Daniel, Ahler Ethan, Tam Brenna, Nathanson David, Riedinger Mirielle, Benz Matthias R, Smith Kathleen B, Eilber Fritz C, Witte Owen N, Tap William D, Wu Hong, Christofk Heather R Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment Cancer discovery, 2012; 2(12): 1109-17.
Austin Wayne R, Armijo Amanda L, Campbell Dean O, Singh Arun S, Hsieh Terry, Nathanson David, Herschman Harvey R, Phelps Michael E, Witte Owen N, Czernin Johannes, Radu Caius G Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress The Journal of experimental medicine, 2012; 209(12): 2215-28.
Fenton Tim R, Nathanson David, Ponte de Albuquerque Claudio, Kuga Daisuke, Iwanami Akio, Dang Julie, Yang Huijun, Tanaka Kazuhiro, Oba-Shinjo Sueli Mieko, Uno Miyuki, Inda Maria del Mar, Wykosky Jill, Bachoo Robert M, James C David, DePinho Ronald A, Vandenberg Scott R, Zhou Huilin, Marie Suely K N, Mischel Paul S, Cavenee Webster K, Furnari Frank B Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240 Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(35): 14164-9.
Tanaka Kazuhiro, Babic Ivan, Nathanson David, Akhavan David, Guo Deliang, Gini Beatrice, Dang Julie, Zhu Shaojun, Yang Huijun, De Jesus Jason, Amzajerdi Ali Nael, Zhang Yinan, Dibble Christian C, Dan Hancai, Rinkenbaugh Amanda, Yong William H, Vinters Harry V, Gera Joseph F, Cavenee Webster K, Cloughesy Timothy F, Manning Brendan D, Baldwin Albert S, Mischel Paul S Oncogenic EGFR signaling activates an mTORC2-NF-ÎºB pathway that promotes chemotherapy resistance Cancer discovery, 2011; 1(6): 524-38.
Guo Deliang, Reinitz Felicia, Youssef Mary, Hong Cynthia, Nathanson David, Akhavan David, Kuga Daisuke, Amzajerdi Ali Nael, Soto Horacio, Zhu Shaojun, Babic Ivan, Tanaka Kazuhiro, Dang Julie, Iwanami Akio, Gini Beatrice, Dejesus Jason, Lisiero Dominique D, Huang Tiffany T, Prins Robert M, Wen Patrick Y, Robins H Ian, Prados Michael D, Deangelis Lisa M, Mellinghoff Ingo K, Mehta Minesh P, James C David, Chakravarti Arnab, Cloughesy Timothy F, Tontonoz Peter, Mischel Paul S An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway Cancer discovery, 2011; 1(5): 442-56.
Nathanson David, Mischel Paul S Charting the course across the blood-brain barrier The Journal of clinical investigation, 2011; 121(1): 31-3.
Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens Cancer research, 2010; 70(15): 6128-38.
Tarcic Gabi, Boguslavsky Shlomit K, Wakim Jean, Kiuchi Tai, Liu Angela, Reinitz Felicia, Nathanson David, Takahashi Takamune, Mischel Paul S, Ng Tony, Yarden Yosef An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis Current biology : CB, 2009; 19(21): 1788-98.
Yoshimoto Koji, Dang Julie, Zhu Shaojun, Nathanson David, Huang Tiffany, Dumont Rebecca, Seligson David B, Yong William H, Xiong Zhenggang, Rao Nagesh, Winther Henrik, Chakravarti Arnab, Bigner Darell D, Mellinghoff Ingo K, Horvath Steve, Cavenee Webster K, Cloughesy Timothy F, Mischel Paul S Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples Clinical cancer research : an official journal of the American Association for Cancer Research, 2008; 14(2): 488-93.

Publications

Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. EGFR, the Lazarus target for precision oncology in glioblastoma.. Neuro-oncology, 2022.
Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. Corrigendum to: EGFR, the Lazarus target for precision oncology in glioblastoma.. Neuro-oncology, 2022.
Armenta DA, Laqtom NN, Alchemy G, Dong W, Morrow D, Poltorack CD, Nathanson DA, Abu-Remalieh M, Dixon SJ. Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.. Cell chemical biology, 2022.
Alvarado AG, Tessema K, Muthukrishnan SD, Sober M, Kawaguchi R, Laks DR, Bhaduri A, Swarup V, Nathanson DA, Geschwind DH, Goldman SA, Kornblum HI. Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma.. Cancer research communications, 2022.
Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM. Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis.. Immunology, 2022.
Cho NS, Hagiwara A, Yao J, Nathanson DA, Prins RM, Wang C, Raymond C, Desousa BR, Divakaruni A, Morrow DH, Nghiemphu PL, Lai A, Liau LM, Everson RG, Salamon N, Pope WB, Cloughesy TF, Ellingson BM. Amine-weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors.. NMR in biomedicine, 2022.
Breznik B, Ko MW, Tse C, Chen PC, Senjor E, Majc B, Habic A, Angelillis N, Novak M, Župunski V, Mlakar J, Nathanson D, Jewett A. Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres.. Communications biology, 2022.
Riggan L, Ma F, Li JH, Fernandez E, Nathanson DA, Pellegrini M, O'Sullivan TE. The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection.. Nature immunology, 2022.
Lee AH, Sun L, Mochizuki AY, Reynoso JG, Orpilla J, Chow F, Kienzler JC, Everson RG, Nathanson DA, Bensinger SJ, Liau LM, Cloughesy T, Hugo W, Prins RM. Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma.. Nature communications, 2021.
Hagiwara A, Yao J, Raymond C, Cho NS, Everson R, Patel K, Morrow DH, Desousa BR, Mareninov S, Chun S, Nathanson DA, Yong WH, Andrei G, Divakaruni AS, Salamon N, Pope WB, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM. "Aerobic glycolytic imaging" of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging.. NeuroImage. Clinical, 2021.
Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma.. Journal of the National Cancer Institute, 2021.
Morrow D, Minami J, Nathanson DA. Metabolic Vulnerabilities in Brain Cancer.. Neurosurgery clinics of North America, 2021.
Yao J, Wang C, Raymond C, Bergstrom B, Chen X, Das K, Dinh H, Kim ZS, Le AN, Lim MWJ, Pham JAN, Prusan JD, Rao SS, Nathanson DA, Ellingson BM. A physical phantom for amine chemical exchange saturation transfer (CEST) MRI.. Magma (New York, N.Y.), 2021.
Oughourlian TC, Yao J, Hagiwara A, Nathanson DA, Raymond C, Pope WB, Salamon N, Lai A, Ji M, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM. Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas.. Neuroradiology, 2020.
Falhammar H, Skov J, Calissendorff J, Nathanson D, Lindh JD, Mannheimer B. Associations Between Antihypertensive Medications and Severe Hyponatremia: A Swedish Population-Based Case-Control Study.. The Journal of clinical endocrinology and metabolism, 2020.
Patel KS, Yao J, Raymond C, Yong W, Everson R, Liau LM, Nathanson D, Kornblum H, Wang C, Oughourlian T, Lai A, Nghiemphu PL, Pope WB, Cloughesy TF, Ellingson BM. Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma.. Scientific reports, 2020.
Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.. Neuro-oncology, 2020.
Tsang JE, Urner LM, Kim G, Chow K, Baufeld L, Faull K, Cloughesy TF, Clark PM, Jung ME, Nathanson DA. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors.. ACS medicinal chemistry letters, 2020.
Ellingson BM, Yao J, Raymond C, Nathanson DA, Chakhoyan A, Simpson J, Garner JS, Olivero AG, Mueller LU, Rodon J, Gerstner E, Cloughesy TF, Wen PY. Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2020.
Fahl?n Bergh C, Toivanen S, Johnell K, Calissendorff J, Skov J, Falhammar H, Nathanson D, Lindh JD, Mannheimer B. Factors of importance for discontinuation of thiazides associated with hyponatremia in Sweden: A population-based register study.. Pharmacoepidemiology and drug safety, 2019.
Yao J, Chakhoyan A, Nathanson DA, Yong WH, Salamon N, Raymond C, Mareninov S, Lai A, Nghiemphu PL, Prins RM, Pope WB, Everson RG, Liau LM, Cloughesy TF, Ellingson BM. Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.. Neuro-oncology, 2019.
Falhammar H, Calissendorff J, Skov J, Nathanson D, Lindh JD, Mannheimer B. Tramadol- and codeine-induced severe hyponatremia: A Swedish population-based case-control study.. European journal of internal medicine, 2019.
Zhang L, Bailleul J, Yazal T, Dong K, Sung D, Dao A, Gosa L, Nathanson D, Bhat K, Duhachek-Muggy S, Alli C, Dratver MB, Pajonk F, Vlashi E. PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.. Breast cancer research and treatment, 2019.
Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H. GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.. eLife, 2019.
Xiao W, Wang S, Zhang R, Sohrabi A, Yu Q, Liu S, Ehsanipour A, Liang J, Bierman RD, Nathanson DA, Seidlits SK. Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma.. Matrix biology : journal of the International Society for Matrix Biology, 2019.
Xiao W, Zhang R, Sohrabi A, Ehsanipour A, Sun S, Liang J, Walthers CM, Ta L, Nathanson DA, Seidlits SK. Correction: Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma.. Cancer research, 2019.
Chakhoyan A, Yao J, Leu K, Pope WB, Salamon N, Yong W, Lai A, Nghiemphu PL, Everson RG, Prins RM, Liau LM, Nathanson DA, Cloughesy TF, Ellingson BM. Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry.. Scientific reports, 2019.
Ta L, Gosa L, Nathanson DA. Biosafety and Biohazards: Understanding Biosafety Levels and Meeting Safety Requirements of a Biobank.. Methods in molecular biology (Clifton, N.J.), 2019.
Gosa L, Ta L, Nathanson DA. Processing of Primary Patient Tumors and Subsequent Generation of Primary Cell Lines.. Methods in molecular biology (Clifton, N.J.), 2019.
Falhammar H, Lindh JD, Calissendorff J, Skov J, Nathanson D, Mannheimer B. Antipsychotics and severe hyponatremia: A Swedish population-based case-control study.. European journal of internal medicine, 2018.
Davidson TB, Lee A, Hsu M, Sedighim S, Orpilla J, Treger J, Mastall M, Roesch S, Rapp C, Galvez M, Mochizuki A, Antonios J, Garcia A, Kotecha N, Bayless N, Nathanson D, Wang A, Everson R, Yong WH, Cloughesy TF, Liau LM, Herold-Mende C, Prins RM. Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2018.
Falhammar H, Lindh JD, Calissendorff J, Skov J, Nathanson D, Mannheimer B. Associations of proton pump inhibitors and hospitalization due to hyponatremia: A population-based case-control study.. European journal of internal medicine, 2018.
Li Z, Cheng H, Shao S, Lu X, Mo L, Tsang J, Zeng P, Guo Z, Wang S, Nathanson DA, Heath JR, Wei W, Xue M. Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities.. Angewandte Chemie (International ed. in English), 2018.
Xiao W, Zhang R, Sohrabi A, Ehsanipour A, Sun S, Liang J, Walthers CM, Ta L, Nathanson DA, Seidlits SK. Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma.. Cancer research, 2017.
Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.. Nature medicine, 2017.
Clark PM, Ebiana VA, Gosa L, Cloughesy TF, Nathanson DA. Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017.
Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.. Nature, 2017.
Simmons RM, Ballman KV, Cox C, Carp N, Sabol J, Hwang RF, Attai D, Sabel M, Nathanson D, Kenler A, Gold L, Kaufman C, Han L, Bleznak A, Stanley Smith J, Holmes D, Fornage B, Le-Petross C, Hoda S, McCall L, Hunt KK, ACOSOG investigators. A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072.. Annals of surgical oncology, 2016.
Laks DR, Ta L, Crisman TJ, Gao F, Coppola G, Radu CG, Nathanson DA, Kornblum HI. Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma.. Molecular cancer therapeutics, 2016.
Clark PM, Mai WX, Cloughesy TF, Nathanson DA. Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.. Current neurology and neuroscience reports, 2016.
Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.. Cell metabolism, 2015.
Shin YS, Kim J, Johnson D, Dooraghi AA, Mai WX, Ta L, Chatziioannou AF, Phelps ME, Nathanson DA, Heath JR. Quantitative assessments of glycolysis from single cells.. Technology, 2015.
Xue M, Wei W, Su Y, Kim J, Shin YS, Mai WX, Nathanson DA, Heath JR. Chemical methods for the simultaneous quantitation of metabolites and proteins from single cells.. Journal of the American Chemical Society, 2015.
Lazari M, Collins J, Shen B, Farhoud M, Yeh D, Maraglia B, Chin FT, Nathanson DA, Moore M, van Dam RM. Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification.. Journal of nuclear medicine technology, 2014.
Darsalia V, Olverling A, Larsson M, Mansouri S, Nathanson D, Nyström T, Klein T, Sjöholm Å, Patrone C. Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice.. Regulatory peptides, 2014.
Danilova N, Bibikova E, Covey TM, Nathanson D, Dimitrova E, Konto Y, Lindgren A, Glader B, Radu CG, Sakamoto KM, Lin S. The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia.. Disease models & mechanisms, 2014.
Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.. The Journal of experimental medicine, 2014.
Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.. Science (New York, N.Y.), 2013.
Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013.
Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013.
Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.. Journal of medicinal chemistry, 2013.
Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer.. Cell metabolism, 2013.
Czernin J, Allen-Auerbach M, Nathanson D, Herrmann K. PET/CT in Oncology: Current Status and Perspectives.. Current radiology reports, 2013.
Herrmann K, Dahlbom M, Nathanson D, Wei L, Radu C, Chatziioannou A, Czernin J. Evaluation of the Genisys4, a bench-top preclinical PET scanner.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013.
Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.. Cancer discovery, 2013.
Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment.. Cancer discovery, 2012.
Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.. The Journal of experimental medicine, 2012.
Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, Dejesus J, Lisiero DD, Huang TT, Prins RM, Wen PY, Robins HI, Prados MD, Deangelis LM, Mellinghoff IK, Mehta MP, James CD, Chakravarti A, Cloughesy TF, Tontonoz P, Mischel PS. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway.. Cancer discovery, 2011.
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance.. Cancer discovery, 2011.
Nathanson D, Mischel PS. Charting the course across the blood-brain barrier.. The Journal of clinical investigation, 2010.
Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens.. Cancer research, 2010.
Tarcic G, Boguslavsky SK, Wakim J, Kiuchi T, Liu A, Reinitz F, Nathanson D, Takahashi T, Mischel PS, Ng T, Yarden Y. An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.. Current biology : CB, 2009.
Yoshimoto K, Dang J, Zhu S, Nathanson D, Huang T, Dumont R, Seligson DB, Yong WH, Xiong Z, Rao N, Winther H, Chakravarti A, Bigner DD, Mellinghoff IK, Horvath S, Cavenee WK, Cloughesy TF, Mischel PS. Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008.
Buck DC, Simonian PT, Larson RV, Borrow J, Nathanson DA. Timeline of tibial tunnel expansion after single-incision hamstring anterior cruciate ligament reconstruction.. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2004.

Setting