David T Wong

Professor, Dentistry Dept., University of California Los Angeles

Professor, Head and Neck Surgery, University of California Los Angeles

UC Profile
W Lab

Education and Training

Harvard Medical SchoolDMSc06/1985Molecular Biology
Harvard School of Dental MedicineCertificate06/1985Oral Pathology
University of British ColumbiaDMD06/1981Dental Medicine
Simon Fraser UniversityBSc06/1977Biochemistry

Publications

  1. Kamounah S, Wei F, Park JK, Song YW, Chia D, Wong DTW, Pedersen AML. Seronegative patients with primary Sjögren's syndrome and non-pSS sicca test positive for anti-SSA/Ro52 and -Ro60 in saliva.. Biochimica et biophysica acta. Molecular basis of disease, 2024.
  2. Salfer B, Havo D, Kuppinger S, Wong DTW, Li F, Zhang L. Evaluating Pre-Analytical Variables for Saliva Cell-Free DNA Liquid Biopsy.. Diagnostics (Basel, Switzerland), 2023.
  3. Kaczor-Urbanowicz KE, Wong DTW. RNA Sequencing Analysis of Saliva exRNA.. Methods in molecular biology (Clifton, N.J.), 2023.
  4. Tavanasefat H, Li F, Koyano K, Gourtani BK, Marty V, Mulpuri Y, Lee SH, Shin KH, Wong DTW, Xiao X, Spigelman I, Kim Y. Molecular consequences of fetal alcohol exposure on amniotic exosomal miRNAs with functional implications for stem cell potency and differentiation.. PloS one, 2020.
  5. Tu M, Cheng J, Chen YL, Jea WC, Chen WL, Chen CJ, Ho CL, Huang WL, Lin CC, Su WC, Ye Q, Deignan J, Grody W, Li F, Chia D, Wei F, Liao W, Wong DTW, Strom CM. Electric Field-Induced Release and Measurement (EFIRM): Characterization and Technical Validation of a Novel Liquid Biopsy Platform in Plasma and Saliva.. The Journal of molecular diagnostics : JMD, 2020.
  6. Kaczor-Urbanowicz KE, Wei F, Rao SL, Kim J, Shin H, Cheng J, Tu M, Wong DTW, Kim Y. Clinical validity of saliva and novel technology for cancer detection.. Biochimica et biophysica acta. Reviews on cancer, 2019.
  7. Cheng J, Nonaka T, Wong DTW. Salivary Exosomes as Nanocarriers for Cancer Biomarker Delivery.. Materials (Basel, Switzerland), 2019.
  8. Kaczor-Urbanowicz KE, Trivedi HM, Lima PO, Camargo PM, Giannobile WV, Grogan TR, Gleber-Netto FO, Whiteman Y, Li F, Lee HJ, Dharia K, Aro K, Martin Carreras-Presas C, Amuthan S, Vartak M, Akin D, Al-Adbullah H, Bembey K, Klokkevold PR, Elashoff D, Barnes VM, Richter R, DeVizio W, Masters JG, Wong DTW. Salivary exRNA biomarkers to detect gingivitis and monitor disease regression.. Journal of clinical periodontology, 2018.
  9. Katsiougiannis S, Wong DT. The Proteomics of Saliva in Sjögren's Syndrome.. Rheumatic diseases clinics of North America, 2016.
  10. Chiang SH, Thomas GA, Liao W, Grogan T, Buck RL, Fuentes L, Yakob M, Laughlin MJ, Schafer C, Nazmul-Hossain A, Wei F, Elashoff D, Slowey PD, Wong DT. RNAPro•SAL: a device for rapid and standardized collection of saliva RNA and proteins.. BioTechniques, 2015.
  11. Yakob M, Fuentes L, Wang MB, Abemayor E, Wong DT. Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances.. Current oral health reports, 2014.
  12. Schafer CA, Schafer JJ, Yakob M, Lima P, Camargo P, Wong DT. Saliva diagnostics: utilizing oral fluids to determine health status.. Monographs in oral science, 2014.
  13. Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DT. Salivary biomarkers: toward future clinical and diagnostic utilities.. Clinical microbiology reviews, 2013.
  14. Lau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT. Role of pancreatic cancer-derived exosomes in salivary biomarker development.. The Journal of biological chemistry, 2013.
  15. Wei F, Yang J, Wong DT. Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM).. Biosensors & bioelectronics, 2013.
  16. Yoshizawa JM, Wong DT. Salivary microRNAs and oral cancer detection.. Methods in molecular biology (Clifton, N.J.), 2013.
  17. Bonne NJ, Wong DT. Salivary biomarker development using genomic, proteomic and metabolomic approaches.. Genome medicine, 2012.
  18. Wong DT. Salivaomics.. Journal of the American Dental Association (1939), 2012.
  19. Spielmann N, Ilsley D, Gu J, Lea K, Brockman J, Heater S, Setterquist R, Wong DT. The human salivary RNA transcriptome revealed by massively parallel sequencing.. Clinical chemistry, 2012.
  20. Deshpande AM, Khalid O, Kim JJ, Kim Y, Lindgren A, Clark AT, Wong DT. Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells.. Stem cells and development, 2012.
  21. Zhang L, Xiao H, Zhou H, Santiago S, Lee JM, Garon EB, Yang J, Brinkmann O, Yan X, Akin D, Chia D, Elashoff D, Park NH, Wong DTW. Development of transcriptomic biomarker signature in human saliva to detect lung cancer.. Cellular and molecular life sciences : CMLS, 2012.
  22. Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. Prevalidation of salivary biomarkers for oral cancer detection.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012.
  23. Farrell JJ, Zhang L, Zhou H, Chia D, Elashoff D, Akin D, Paster BJ, Joshipura K, Wong DT. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer.. Gut, 2011.
  24. Brinkmann O, Zhang L, Giannobile WV, Wong DT. Salivary biomarkers for periodontal disease diagnostics.. Expert opinion on medical diagnostics, 2011.
  25. Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population.. Oral oncology, 2010.
  26. Ai J, Smith B, Wong DT. Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base.. BMC bioinformatics, 2010.
  27. Wei F, Liao W, Xu Z, Yang Y, Wong DT, Ho CM. Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis.. Small (Weinheim an der Bergstrasse, Germany), 2009.
  28. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation.. The Journal of biological chemistry, 2009.
  29. Hu S, Wong DT. Lectin microarray.. Proteomics. Clinical applications, 2009.
  30. Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spijkervet FK, Bootsma H, Kallenberg CG, Vissink A, Horvath S, Wong DT. Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands.. Arthritis and rheumatism, 2009.
  31. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation.. The Journal of biological chemistry, 2008.
  32. Jiang J, Park NJ, Hu S, Wong DT. A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature.. Archives of oral biology, 2008.
  33. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, Elashoff D, Wei R, Loo JA, Wong DT. Salivary proteomics for oral cancer biomarker discovery.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008.
  34. Brooks MN, Wang J, Li Y, Zhang R, Elashoff D, Wong DT. Salivary protein factors are elevated in breast cancer patients.. Molecular medicine reports, 2008.
  35. Hu Z, Zimmermann BG, Zhou H, Wang J, Henson BS, Yu W, Elashoff D, Krupp G, Wong DT. Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids.. Clinical chemistry, 2008.
  36. Wong DT. Salivary Diagnostics: Amazing as it might seem, doctors can detect and monitor diseases using molecules found in a sample of spit.. American scientist, 2008.
  37. Zimmermann BG, Wong DT. Salivary mRNA targets for cancer diagnostics.. Oral oncology, 2007.
  38. Hu S, Yen Y, Ann D, Wong DT. Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery.. Drug discovery today, 2007.
  39. Hu S, Wong DT. Oral cancer proteomics.. Current opinion in molecular therapeutics, 2007.
  40. Zimmermann BG, Park NJ, Wong DT. Genomic targets in saliva.. Annals of the New York Academy of Sciences, 2007.
  41. Hu S, Loo JA, Wong DT. Human saliva proteome analysis.. Annals of the New York Academy of Sciences, 2007.
  42. Zhou X, Temam S, Oh M, Pungpravat N, Huang BL, Mao L, Wong DT. Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma.. Neoplasia (New York, N.Y.), 2006.
  43. Park NJ, Li Y, Yu T, Brinkman BM, Wong DT. Characterization of RNA in saliva.. Clinical chemistry, 2006.
  44. Gu F, Lux R, Du-Thumm L, Stokes I, Kreth J, Anderson MH, Wong DT, Wolinsky L, Sullivan R, Shi W. In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies.. Journal of microbiological methods, 2005.
  45. Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DT. Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays.. Cancer genetics and cytogenetics, 2005.
  46. Kim Y, Ohyama H, Patel V, Figueiredo M, Wong DT. Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect.. The Journal of biological chemistry, 2005.
  47. Hu S, Denny P, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT. Differentially expressed protein markers in human submandibular and sublingual secretions.. International journal of oncology, 2004.
  48. Zhou X, Mok SC, Chen Z, Li Y, Wong DT. Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array.. Human genetics, 2004.
  49. St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, Jordan R, Wolinsky L, Park NH, Liu H, Abemayor E, Wong DT. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma.. Archives of otolaryngology--head & neck surgery, 2004.
  50. Zhou X, Cole SW, Hu S, Wong DT. Detection of DNA copy number abnormality by microarray expression analysis.. Human genetics, 2004.