Douglas L. Black*

Douglas Lyne Black

Department Vice Chair, MIMG, MIMG, University of California Los Angeles

Professor, MIMG, University of California Los Angeles

(310) 794-7689

Laboratory Address:
MRL 6-567

Work Address:
MRL 6-780
CAMPUS - 951489
CA

Office Phone Number:
(310) 794-7644

Affiliations

Member, Gene Regulation GPB Home Area, Biochemistry, Biophysics & Structural Biology GPB Home Area, JCCC Gene Regulation Program Area, Brain Research Institute, Center for Duchenne Muscular Dystrophy
Affiliate Faculty, Bioengineering

Research Interests

Our lab is interested in the regulation of pre-mRNA splicing and the biochemical mechanisms that control changes in splice sites. The sequences of metazoan genomes, with their relatively low gene numbers, have highlighted the question of how protein number can be expanded beyond the gene number for a complex organism. Alternative splicing, which allows the production of multiple mRNAs and hence multiple proteins from a single gene, is a major contributor to protein diversity. However, despite its key role in gene expression, this process is poorly understood mechanistically.

Biography

Dr. Black is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles, and the David Geffen School of Medicine at UCLA. His B.A. degree is in chemistry from the University of California, Santa Cruz. He received his PhD in Molecular Biophysics and Biochemistry from Yale University working with Dr. Joan A. Steitz. Prior to coming to UCLA, he did postdoctoral work at the Whitehead Institute for Biomedical Research and MIT, working with Drs. David Baltimore, Don Rio, and Phillip Sharp.

Publications