Edward M De Robertis

Professor, Biological Chemistry, University of California Los Angeles

(310) 206-1463

UC Profile
Complete list of published works in MyBibliogaphy
De Robertis Laboratory
Pontifical Academy

Interests

Chordin/BMP/Tolloid pathway, Gastrulation, Colorectal cancer, Developmental Biology, Morphogen gradients in development, Cerberus head inducer, Bone Morphogenetic Proteins, Spemann organizer signaling, Wnt signaling

Education and Training

MRC Lab Mol Biol06/1980Embryology (J B Gurdon)
Universidad de la RepublicaMD03/1971Medicine
Instituto LeloirPhD06/74Chemistry

Awards and Honors

  • LASDB Prize, Latin American Society of Developmental Biology, 2024.
  • Honorary Member, Society of Developmental Biology Academy, 2023.
  • Lifetime Achievment Award, Society of Developmental Biology, 2021.
  • Kowalevsky Medal in Evo-Devo, Soc. of Naturalists, St. Petersburg, 2020.
  • Corresponding Member, Academia Nacional de Buenos Aires, 2019.
  • Corresponding Member, Academia Nacional del Uruguay, 2019.
  • Doctor Honoris Causa, Universidad de la Republica del Uruguay, 2016.
  • Member, National Academy of Sciences, 2013.
  • Doctor Honoris Causa, Universite Sorbonne, Paris, France, 2013.
  • Ross Harrison Prize in Developmental Biology, International Society of Developmental Biologists, 2009.
  • Academician, Pontifical Academy of Sciences, The Vatican, 2009.
  • Membre D'Honneur, Societe de Biologie, Paris, France, 2008.
  • Investigator, Howard Hughes Medical Institute, 1995-2019.
  • Norman Sprague Chair in Molecular Oncology, UCLA School of Medicine, 1985-pres.
  • EMBO member, European Molecular Biology Organization, 1982.
  • Gold Medal to top Medical Student, Universidad de la Republica, Uruguay, 1971.

Publications

  1. Azbazdar Y, De Robertis EM. Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos.. Proceedings of the National Academy of Sciences of the United States of America, 2025.
  2. Azbazdar Y, De Robertis EM. Molecular analysis of a self-organizing signaling pathway for Xenopus axial patterning from egg to tailbud.. Proceedings of the National Academy of Sciences of the United States of America, 2024.
  3. Tejeda-Muñoz N, Azbazdar Y, Sosa EA, Monka J, Wei PS, Binder G, Mei KC, Kurmangaliyev YZ, De Robertis EM. Na,K-ATPase activity promotes macropinocytosis in colon cancer via Wnt signaling.. Biology open, 2024.
  4. De Robertis EM, Driever W, Mayor R. Celebrating the centennial of the most famous experiment in embryology: Hilde Mangold, Hans Spemann and the organizer.. Cells & development, 2024.
  5. Ringborg U, von Braun J, Celis J, Baumann M, Berns A, Eggermont A, Heard E, Heitor M, Chandy M, Chen CJ, Costa A, De Lorenzo F, De Robertis EM, Dubee FC, Ernberg I, Gabriel M, Helland Å, Henrique R, Jönsson B, Kallioniemi O, Korbel J, Krause M, Lowy DR, Michielin O, Nagy P, Oberst S, Paglia V, Parker MI, Ryan K, Sawyers CL, Schüz J, Silkaitis K, Solary E, Thomas D, Turkson P, Weiderpass E, Yang H. Strategies to decrease inequalities in cancer therapeutics, care and prevention: Proceedings on a conference organized by the Pontifical Academy of Sciences and the European Academy of Cancer Sciences, Vatican City, February 23-24, 2023.. Molecular oncology, 2024.
  6. Azbazdar Y, Pera EM, De Robertis EM. Head organizer: Cerberus and IGF cooperate in brain induction in Xenopus embryos.. Cells & development, 2023.
  7. Azbazdar Y, De Robertis EM. The early dorsal signal in vertebrate embryos requires endolysosomal membrane trafficking.. BioEssays : news and reviews in molecular, cellular and developmental biology, 2023.
  8. Tejeda-Munoz N, Azbazdar Y, Monka J, Binder G, Dayrit A, Ayala R, O'Brien N, De Robertis EM. The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis.. eLife, 2023.
  9. Azbazdar Y, Tejeda-Munoz N, Monka JC, Dayrit A, Binder G, Ozhan G, De Robertis EM. Addition of exogenous diacylglycerol enhances Wnt/β-catenin signaling through stimulation of macropinocytosis.. iScience, 2023.
  10. Tejeda-Muñoz N, Azbazdar Y, Monka J, Binder G, Dayrit A, Ayala R, O'Brien N, De Robertis EM. The PMA Phorbol Ester Tumor Promoter Increases Canonical Wnt Signaling Via Macropinocytosis.. bioRxiv : the preprint server for biology, 2023.
  11. Sosa E, De Robertis EM. The developmental gene Chordin is amplified and expressed in human cancers.. Molecular & cellular oncology, 2023.
  12. Tejeda-Muñoz N, Monka J, De Robertis EM. Protocol for culturing and imaging of ectodermal cells from Xenopus.. STAR protocols, 2022.
  13. De Robertis EM. The impact of developmental biology in the last 100 years.. Developmental biology, 2022.
  14. Tejeda-Muñoz N, De Robertis EM. Lysosomes are required for early dorsal signaling in the Xenopus embryo.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
  15. De Robertis EM, Tejeda-Muñoz N. Evo-Devo of Urbilateria and its larval forms.. Developmental biology, 2022.
  16. Tejeda-Muñoz N, Morselli M, Moriyama Y, Sheladiya P, Pellegrini M, De Robertis EM. Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis.. iScience, 2022.
  17. Tejeda-Muñoz N, De Robertis EM. Wnt, GSK3, and Macropinocytosis.. Sub-cellular biochemistry, 2022.
  18. De Robertis EM, Gurdon JB. A Brief History of Xenopus in Biology.. Cold Spring Harbor protocols, 2021.
  19. Albrecht LV, Tejeda-Muñoz N, De Robertis EM. Cell Biology of Canonical Wnt Signaling.. Annual review of cell and developmental biology, 2021.
  20. Zhang F, Zhu X, Wang P, He Q, Huang H, Zheng T, Li Y, Jia H, Xu L, Zhao H, Colozza G, Tao Q, De Robertis EM, Ding Y. The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
  21. Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Muñoz N, Albrecht LV, Sosa EA, Wohlschlegel JA, De Robertis EM. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway.. Scientific reports, 2020.
  22. Colozza G, De Robertis EM. Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins.. Gene expression patterns : GEP, 2020.
  23. Albrecht LV, Tejeda-Muñoz N, De Robertis EM. Protocol for Probing Regulated Lysosomal Activity and Function in Living Cells.. STAR protocols, 2020.
  24. Albrecht LV, Tejeda-Muñoz N, Bui MH, Cicchetto AC, Di Biagio D, Colozza G, Schmid E, Piccolo S, Christofk HR, De Robertis EM. GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery.. Cell reports, 2020.
  25. Tejeda-Muñoz N, Albrecht LV, Bui MH, De Robertis EM. Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
  26. Albrecht LV, Bui MH, De Robertis EM. Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
  27. Sosa EA, Moriyama Y, Ding Y, Tejeda-Muñoz N, Colozza G, De Robertis EM. Transcriptome analysis of regeneration during Xenopus laevis experimental twinning.. The International journal of developmental biology, 2019.
  28. Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM. Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
  29. Albrecht LV, Ploper D, Tejeda-Muñoz N, De Robertis EM. Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
  30. Moriyama Y, De Robertis EM. Embryonic regeneration by relocalization of the Spemann organizer during twinning in Xenopus.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
  31. Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C. Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover.. Developmental cell, 2017.
  32. De Robertis EM, Moriyama Y, Colozza G. Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson.. Development, growth & differentiation, 2017.
  33. Ding Y, Ploper D, Sosa EA, Colozza G, Moriyama Y, Benitez MD, Zhang K, Merkurjev D, De Robertis EM. Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in Xenopus laevis.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
  34. Ding Y, Colozza G, Zhang K, Moriyama Y, Ploper D, Sosa EA, Benitez MDJ, De Robertis EM. Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula.. Developmental biology, 2016.
  35. De Robertis EM, Moriyama Y. The Chordin Morphogenetic Pathway.. Current topics in developmental biology, 2016.
  36. De Robertis EM, Ploper D. Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins.. Developmental cell, 2015.
  37. Blum M, De Robertis EM, Wallingford JB, Niehrs C. Morpholinos: Antisense and Sensibility.. Developmental cell, 2015.
  38. Bier E, De Robertis EM. EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning.. Science (New York, N.Y.), 2015.
  39. Kim H, Vick P, Hedtke J, Ploper D, De Robertis EM. Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway.. Cell reports, 2015.
  40. Ploper D, De Robertis EM. The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis.. Pharmacological research, 2015.
  41. Demagny H, De Robertis EM. Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling.. Molecular & cellular oncology, 2015.
  42. Demagny H, De Robertis EM. Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling.. Molecular & cellular oncology, 2015.
  43. Ploper D, Taelman VF, Robert L, Perez BS, Titz B, Chen HW, Graeber TG, von Euw E, Ribas A, De Robertis EM. MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
  44. De Robertis EM. Lessons from a great developmental biologist.. Differentiation; research in biological diversity, 2014.
  45. Demagny H, Araki T, De Robertis EM. The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling.. Cell reports, 2014.
  46. De Robertis EM. Yoshiki Sasai 1962-2014.. Cell, 2014.
  47. De Robertis EM. Yoshiki Sasai 1962–2014.. Developmental cell, 2014.
  48. Colozza G, De Robertis EM. Maternal syntabulin is required for dorsal axis formation and is a germ plasm component in Xenopus.. Differentiation; research in biological diversity, 2014.
  49. De Robertis EM, Niehrs C. Herbert Steinbeisser: a life with the Xenopus embryo.. The International journal of developmental biology, 2014.
  50. Plouhinec JL, Zakin L, Moriyama Y, De Robertis EM. Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
  51. De Robertis EM, Colozza G. Development: scaling to size by protease inhibition.. Current biology : CB, 2013.
  52. Dobrowolski R, Vick P, Ploper D, Gumper I, Snitkin H, Sabatini DD, De Robertis EM. Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.. Cell reports, 2012.
  53. Dobrowolski R, De Robertis EM. Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles.. Nature reviews. Molecular cell biology, 2011.
  54. Eivers E, Demagny H, Choi RH, De Robertis EM. Phosphorylation of Mad controls competition between wingless and BMP signaling.. Science signaling, 2011.
  55. Plouhinec JL, Zakin L, De Robertis EM. Systems control of BMP morphogen flow in vertebrate embryos.. Current opinion in genetics & development, 2011.
  56. Vorwald-Denholtz PP, De Robertis EM. Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm.. Gene expression patterns : GEP, 2011.
  57. Ploper D, Lee HX, De Robertis EM. Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.. Developmental biology, 2011.
  58. Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, Sabatini DD, De Robertis EM. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.. Cell, 2010.
  59. Zakin L, Chang EY, Plouhinec JL, De Robertis EM. Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.. Developmental biology, 2010.
  60. De Robertis EM. Wnt signaling in axial patterning and regeneration: lessons from planaria.. Science signaling, 2010.
  61. Sander V, Eivers E, Choi RH, De Robertis EM. Drosophila Smad2 opposes Mad signaling during wing vein development.. PloS one, 2010.
  62. Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O. The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.. Development (Cambridge, England), 2010.
  63. Zakin L, De Robertis EM. Extracellular regulation of BMP signaling.. Current biology : CB, 2010.
  64. Eivers E, Demagny H, De Robertis EM. Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad.. Cytokine & growth factor reviews, 2009.
  65. Lee HX, Mendes FA, Plouhinec JL, De Robertis EM. Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity.. Genes & development, 2009.
  66. De Robertis EM. Spemann's organizer and the self-regulation of embryonic fields.. Mechanisms of development, 2009.
  67. Eivers E, Fuentealba LC, Sander V, Clemens JC, Hartnett L, De Robertis EM. Mad is required for wingless signaling in wing development and segment patterning in Drosophila.. PloS one, 2009.
  68. Plouhinec JL, De Robertis EM. Systems biology of the self-regulating morphogenetic gradient of the Xenopus gastrula.. Cold Spring Harbor perspectives in biology, 2009.
  69. De Robertis EM. The molecular ancestry of segmentation mechanisms.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
  70. Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM. Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.. Developmental biology, 2008.
  71. Ambrosio AL, Taelman VF, Lee HX, Metzinger CA, Coffinier C, De Robertis EM. Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.. Developmental cell, 2008.
  72. Eivers E, Fuentealba LC, De Robertis EM. Integrating positional information at the level of Smad1/5/8.. Current opinion in genetics & development, 2008.
  73. Fuentealba LC, Eivers E, Geissert D, Taelman V, De Robertis EM. Asymmetric mitosis: Unequal segregation of proteins destined for degradation.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
  74. De Robertis EM. Eddy M. De Robertis.. Current biology : CB, 2008.
  75. De Robertis EM. Evo-devo: variations on ancestral themes.. Cell, 2008.
  76. Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM, De Robertis EM. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.. Cell, 2007.
  77. Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K. Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases.. Neuron, 2007.
  78. Ishibashi H, Matsumura N, Hanafusa H, Matsumoto K, De Robertis EM, Kuroda H. Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos.. Mechanisms of development, 2007.
  79. Sander V, Reversade B, De Robertis EM. The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning.. The EMBO journal, 2007.
  80. Hurtado C, De Robertis EM. Neural induction in the absence of organizer in salamanders is mediated by MAPK.. Developmental biology, 2007.
  81. Plouhinec JL, De Robertis EM. Systems biology of embryonic morphogens.. Molecular bioSystems, 2007.
  82. De Robertis EM. Spemann's organizer and self-regulation in amphibian embryos.. Nature reviews. Molecular cell biology, 2006.
  83. Lee HX, Ambrosio AL, Reversade B, De Robertis EM. Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases.. Cell, 2006.
  84. Reversade B, De Robertis EM. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field.. Cell, 2005.
  85. Wessely O, Kim JI, Tran U, Fuentealba L, De Robertis EM. xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development.. Developmental biology, 2005.
  86. Reversade B, Kuroda H, Lee H, Mays A, De Robertis EM. Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.. Development (Cambridge, England), 2005.
  87. Kuroda H, Fuentealba L, Ikeda A, Reversade B, De Robertis EM. Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation.. Genes & development, 2005.
  88. Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM. Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm.. Development (Cambridge, England), 2005.
  89. Pera EM, Hou S, Strate I, Wessely O, De Robertis EM. Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo.. The International journal of developmental biology, 2005.
  90. Unterseher F, Hefele JA, Giehl K, De Robertis EM, Wedlich D, Schambony A. Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.. The EMBO journal, 2004.
  91. Wessely O, Kim JI, Geissert D, Tran U, De Robertis EM. Analysis of Spemann organizer formation in Xenopus embryos by cDNA macroarrays.. Developmental biology, 2004.
  92. Kuroda H, Wessely O, De Robertis EM. Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus.. PLoS biology, 2004.
  93. Oelgeschläger M, Tran U, Grubisic K, De Robertis EM. Identification of a second Xenopus twisted gastrulation gene.. The International journal of developmental biology, 2004.
  94. De Robertis EM, Kuroda H. Dorsal-ventral patterning and neural induction in Xenopus embryos.. Annual review of cell and developmental biology, 2004.
  95. Zakin L, De Robertis EM. Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development.. Development (Cambridge, England), 2003.
  96. Pera EM, Ikeda A, Eivers E, De Robertis EM. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.. Genes & development, 2003.
  97. Oelgeschläger M, Reversade B, Larraín J, Little S, Mullins MC, De Robertis EM. The pro-BMP activity of Twisted gastrulation is independent of BMP binding.. Development (Cambridge, England), 2003.
  98. Bachiller D, Klingensmith J, Shneyder N, Tran U, Anderson R, Rossant J, De Robertis EM. The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.. Development (Cambridge, England), 2003.
  99. Larraín J, Brown C, De Robertis EM. Integrin-alpha3 mediates binding of Chordin to the cell surface and promotes its endocytosis.. EMBO reports, 2003.
  100. Pera EM, Martinez SL, Flanagan JJ, Brechner M, Wessely O, De Robertis EM. Darmin is a novel secreted protein expressed during endoderm development in Xenopus.. Gene expression patterns : GEP, 2003.
  101. Oelgeschläger M, Kuroda H, Reversade B, De Robertis EM. Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos.. Developmental cell, 2003.
  102. Coffinier C, Ketpura N, Tran U, Geissert D, De Robertis EM. Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling.. Gene expression patterns : GEP, 2002.
  103. Coffinier C, Ketpura N, Tran U, Geissert D, De Robertis EM. Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling.. Mechanisms of development, 2002.
  104. Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta.. Nature cell biology, 2002.
  105. Pera EM, Kim JI, Martinez SL, Brechner M, Li SY, Wessely O, De Robertis EM. Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer.. Mechanisms of development, 2002.
  106. Garcia Abreu J, Coffinier C, Larraín J, Oelgeschläger M, De Robertis EM. Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems.. Gene, 2002.
  107. Wessely O, De Robertis EM. Neural plate patterning by secreted signals.. Neuron, 2002.
  108. Pera EM, Wessely O, Li SY, De Robertis EM. Neural and head induction by insulin-like growth factor signals.. Developmental cell, 2001.
  109. Larraín J, Oelgeschläger M, Ketpura NI, Reversade B, Zakin L, De Robertis EM. Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling.. Development (Cambridge, England), 2001.
  110. De Robertis EM, Bouwmeester T. New twists on embryonic patterning. EMBO workshop: embryonic organizer signaling: the next frontiers.. EMBO reports, 2001.
  111. Wessely O, Agius E, Oelgeschläger M, Pera EM, De Robertis EM. Neural induction in the absence of mesoderm: beta-catenin-dependent expression of secreted BMP antagonists at the blastula stage in Xenopus.. Developmental biology, 2001.
  112. Wessely O, Tran U, Zakin L, De Robertis EM. Identification and expression of the mammalian homologue of Bicaudal-C.. Mechanisms of development, 2001.
  113. De Robertis EM, Wessely O, Oelgeschläger M, Brizuela B, Pera E, Larraín J, Abreu J, Bachiller D. Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer.. The International journal of developmental biology, 2001.
  114. De Robertis EM, Larraín J, Oelgeschläger M, Wessely O. The establishment of Spemann's organizer and patterning of the vertebrate embryo.. Nature reviews. Genetics, 2000.
  115. Piccolo S, Sasai Y, Lu B, De Robertis EM. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.. Cell, 1996.
  116. Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.. Nature, 1996.
  117. De Robertis EM, Sasai Y. A common plan for dorsoventral patterning in Bilateria.. Nature, 1996.
  118. Holley SA, Jackson PD, Sasai Y, Lu B, De Robertis EM, Hoffmann FM, Ferguson EL. A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.. Nature, 1995.