Publications

1. Cheng X, Li Z, Zhu J, Wang J, Huang R, Yu LW, Lin S, Forman S, Gromilina E, Puri S, Patel P, Bahramian M, Tan J, Hojaiji H, Jelinek D, Voisin L, Yu KB, Zhang A, Ho C, Lei L, Coller HA, Hsiao EY, Reyes BL, Matsumoto JH, Lu DC, Liu C, Milla C, Davis RW, Emaminejad S. Tandem metabolic reaction-based sensors unlock in vivo metabolomics.. Proceedings of the National Academy of Sciences of the United States of America, 2025.
2. Orchanian SB, Hsiao EY. The microbiome as a modulator of neurological health across the maternal-offspring interface.. The Journal of clinical investigation, 2025.
3. Özcan E, Yu KB, Dinh L, Lum GR, Lau K, Hsu J, Arino M, Paramo J, Lopez-Romero A, Hsiao EY. Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice.. Nature communications, 2025.
4. Ohara TE, Hsiao EY. Microbiota-neuroepithelial signalling across the gut-brain axis.. Nature reviews. Microbiology, 2025.
5. Jameson KG, Kazmi SA, Ohara TE, Son C, Yu KB, Mazdeyasnan D, Leshan E, Vuong HE, Paramo J, Lopez-Romero A, Yang L, Schweizer FE, Hsiao EY. Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling.. iScience, 2024.
6. Chandra F, Hsiao EY. FAAHcilitating recovery in malnourished kids.. Cell chemical biology, 2024.
7. Özcan E, Yu KB, Dinh L, Lum GR, Lau K, Hsu J, Arino M, Paramo J, Lopez-Romero A, Hsiao EY. Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice.. bioRxiv : the preprint server for biology, 2024.
8. Fang P, Yu LW, Espey H, Agirman G, Kazmi SA, Li K, Deng Y, Lee J, Hrncir H, Romero-Lopez A, Arnold AP, Hsiao EY. Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson's disease.. Communications biology, 2024.
9. Gur TL, Hsiao EY. The Microbiome at the Interface of the Exposome and Risk for Psychiatric Disorders.. Biological psychiatry, 2024.
10. Yu KB, Son C, Chandra A, Paramo J, Novoselov A, Özcan E, Kazmi SA, Lum GR, Lopez-Romero A, Lynch JB, Hsiao EY. Complex carbohydrate utilization by gut bacteria modulates host food preference.. bioRxiv : the preprint server for biology, 2024.
11. Jameson KG, Kazmi SA, Son C, Mazdeyasnan D, Leshan E, Vuong HE, Paramo J, Lopez-Romero A, Yang L, Schweizer FE, Hsiao EY. Vagal interoception of microbial metabolites from the small intestinal lumen.. bioRxiv : the preprint server for biology, 2023.
12. Lum GR, Ha SM, Olson CA, Blencowe M, Paramo J, Reyes B, Matsumoto JH, Yang X, Hsiao EY. Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice.. Cell reports, 2023.
13. Pronovost GN, Yu KB, Coley-O'Rourke EJL, Telang SS, Chen AS, Vuong HE, Williams DW, Chandra A, Rendon TK, Paramo J, Kim RH, Hsiao EY. The maternal microbiome promotes placental development in mice.. Science advances, 2023.
14. Coley-O'Rourke EJ, Hsiao EY. Microbiome alterations in autism spectrum disorder.. Nature microbiology, 2023.
15. Lynch JB, Gonzalez EL, Choy K, Faull KF, Jewell T, Arellano A, Liang J, Yu KB, Paramo J, Hsiao EY. Gut microbiota Turicibacter strains differentially modify bile acids and host lipids.. Nature communications, 2023.
16. Lynch JB, Hsiao EY. Toward understanding links between the microbiome and neurotransmitters.. Annals of the New York Academy of Sciences, 2023.
17. Pronovost GN, Telang SS, Chen AS, Coley EJL, Vuong HE, Williams DW, Yu KB, Rendon TK, Paramo J, Kim RH, Hsiao EY. The maternal microbiome promotes placental development in mice.. bioRxiv : the preprint server for biology, 2023.
18. Kazmi SA, Hsiao EY. Extending genetic risk for Alzheimer's disease from host to holobiont.. Cell, 2023.
19. Yu KB, Hsiao EY. Gut microbiota: A sweet tale of mice and microbes.. Current biology : CB, 2023.
20. Agirman G, Hsiao EY. Gut microbes shape athletic motivation.. Nature, 2022.
21. An U, Shenhav L, Olson CA, Hsiao EY, Halperin E, Sankararaman S. STENSL: Microbial Source Tracking with ENvironment SeLection.. mSystems, 2022.
22. Özcan E, Lum GR, Hsiao EY. Interactions between the gut microbiome and ketogenic diet in refractory epilepsy.. International review of neurobiology, 2022.
23. Özcan E, Hsiao EY. Are changes in the gut microbiome a contributor or consequence of autism-why not both?. Cell reports. Medicine, 2022.
24. Yu LW, Agirman G, Hsiao EY. The Gut Microbiome as a Regulator of the Neuroimmune Landscape.. Annual review of immunology, 2022.
25. Agirman G, Yu KB, Hsiao EY. Signaling inflammation across the gut-brain axis.. Science (New York, N.Y.), 2021.
26. Olson CA, Iñiguez AJ, Yang GE, Fang P, Pronovost GN, Jameson KG, Rendon TK, Paramo J, Barlow JT, Ismagilov RF, Hsiao EY. Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia.. Cell host & microbe, 2021.
27. Coley EJL, Hsiao EY. Malnutrition and the microbiome as modifiers of early neurodevelopment.. Trends in neurosciences, 2021.
28. Coley EJL, Mayer EA, Osadchiy V, Chen Z, Subramanyam V, Zhang Y, Hsiao EY, Gao K, Bhatt R, Dong T, Vora P, Naliboff B, Jacobs JP, Gupta A. Early life adversity predicts brain-gut alterations associated with increased stress and mood.. Neurobiology of stress, 2021.
29. Yu KB, Hsiao EY. Roles for the gut microbiota in regulating neuronal feeding circuits.. The Journal of clinical investigation, 2021.
30. Vuong HE, Coley EJL, Kazantsev M, Cooke ME, Rendon TK, Paramo J, Hsiao EY. Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice.. Behavioural brain research, 2021.
31. Agirman G, Hsiao EY. SnapShot: The microbiota-gut-brain axis.. Cell, 2021.
32. Noble EE, Olson CA, Davis E, Tsan L, Chen YW, Schade R, Liu C, Suarez A, Jones RB, de La Serre C, Yang X, Hsiao EY, Kanoski SE. Gut microbial taxa elevated by dietary sugar disrupt memory function.. Translational psychiatry, 2021.
33. Yu LW, Hsiao EY. IL-33 Changes Our "Gut Feelings" about Serotonin.. Immunity, 2021.
34. Osadchiy V, Mayer EA, Gao K, Labus JS, Naliboff B, Tillisch K, Chang L, Jacobs JP, Hsiao EY, Gupta A. Analysis of brain networks and fecal metabolites reveals brain-gut alterations in premenopausal females with irritable bowel syndrome.. Translational psychiatry, 2020.
35. Ahn IS, Lang JM, Olson CA, Diamante G, Zhang G, Ying Z, Byun HR, Cely I, Ding J, Cohn P, Kurtz I, Gomez-Pinilla F, Lusis AJ, Hsiao EY, Yang X. Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice.. The Journal of nutrition, 2020.
36. Vuong HE, Pronovost GN, Williams DW, Coley EJL, Siegler EL, Qiu A, Kazantsev M, Wilson CJ, Rendon T, Hsiao EY. The maternal microbiome modulates fetal neurodevelopment in mice.. Nature, 2020.
37. Fang P, Kazmi SA, Jameson KG, Hsiao EY. The Microbiome as a Modifier of Neurodegenerative Disease Risk.. Cell host & microbe, 2020.
38. Olson CA, Lum GR, Hsiao EY. Ketone Bodies Exert Ester-Ordinary Suppression of Bifidobacteria and Th17 Cells.. Cell metabolism, 2020.
39. Fang P, Hsiao EY. Gut microbes tune inflammation and lifespan in a mouse model of amyotrophic lateral sclerosis.. Nature, 2020.
40. Jameson KG, Olson CA, Kazmi SA, Hsiao EY. Toward Understanding Microbiome-Neuronal Signaling.. Molecular cell, 2020.
41. Williams DW, Vuong HE, Kim S, Lenon A, Ho K, Hsiao EY, Sung EC, Kim RH. Indigenous Microbiota Protects against Inflammation-Induced Osteonecrosis.. Journal of dental research, 2020.
42. Fang P, Hsiao EY. Mitochondrial and Purinergic Dysregulation Promote Abnormal Behavior in Mice.. Trends in immunology, 2020.
43. Lynch JB, Hsiao EY. Microbiomes as sources of emergent host phenotypes.. Science (New York, N.Y.), 2019.
44. Fung TC, Vuong HE, Luna CDG, Pronovost GN, Aleksandrova AA, Riley NG, Vavilina A, McGinn J, Rendon T, Forrest LR, Hsiao EY. Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut.. Nature microbiology, 2019.
45. Lum GR, Olson CA, Hsiao EY. Emerging roles for the intestinal microbiome in epilepsy.. Neurobiology of disease, 2019.
46. Jameson KG, Hsiao EY. A novel pathway for microbial metabolism of levodopa.. Nature medicine, 2019.
47. Labus JS, Osadchiy V, Hsiao EY, Tap J, Derrien M, Gupta A, Tillisch K, Le Nevé B, Grinsvall C, Ljungberg M, Öhman L, Törnblom H, Simren M, Mayer EA. Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis.. Microbiome, 2019.
48. Vuong HE, Hsiao EY. Gut Microbes Join the Social Network.. Neuron, 2019.
49. Pronovost GN, Hsiao EY. Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment.. Immunity, 2019.
50. Fields CT, Sampson TR, Bruce-Keller AJ, Kiraly DD, Hsiao EY, de Vries GJ. Defining Dysbiosis in Disorders of Movement and Motivation.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018.
51. Lee K, Vuong HE, Nusbaum DJ, Hsiao EY, Evans CJ, Taylor AMW. The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018.
52. Kentner AC, Bilbo SD, Brown AS, Hsiao EY, McAllister AK, Meyer U, Pearce BD, Pletnikov MV, Yolken RH, Bauman MD. Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018.
53. Osadchiy V, Labus JS, Gupta A, Jacobs J, Ashe-McNalley C, Hsiao EY, Mayer EA. Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects.. PloS one, 2018.
54. Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.. Cell, 2018.
55. Jameson KG, Hsiao EY. Linking the Gut Microbiota to a Brain Neurotransmitter.. Trends in neurosciences, 2018.
56. Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.. Cell, 2018.
57. Pronovost GN, Hsiao EY. Microbes REV up Host Metabolism around the Clock.. Immunity, 2017.
58. Mayer EA, Hsiao EY. The Gut and Its Microbiome as Related to Central Nervous System Functioning and Psychological Well-being: Introduction to the Special Issue of Psychosomatic Medicine.. Psychosomatic medicine, 2017.
59. Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome.. Microbiome, 2017.
60. Vuong HE, Yano JM, Fung TC, Hsiao EY. The Microbiome and Host Behavior.. Annual review of neuroscience, 2017.
61. Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease.. Nature neuroscience, 2017.
62. Wu WL, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH. The placental interleukin-6 signaling controls fetal brain development and behavior.. Brain, behavior, and immunity, 2016.
63. Vuong HE, Hsiao EY. Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder.. Biological psychiatry, 2016.
64. Nelson MB, Chase AB, Martiny JB, Stocker R, Nguyen J, Lloyd K, Oshiro RT, Kearns DB, Schneider JP, Ringel PD, Basler M, Olson CA, Vuong HE, Hsiao EY, Roller BR, Ackermann M, Smillie C, Chien D, Alm E, Jermy AJ. The Microbial Olympics 2016.. Nature microbiology, 2016.
65. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.. Cell, 2015.
66. Hsiao EY. Gastrointestinal issues in autism spectrum disorder.. Harvard review of psychiatry, 2014.
67. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.. Cell, 2013.
68. Hsiao EY. Immune dysregulation in autism spectrum disorder.. International review of neurobiology, 2013.
69. Hsiao EY, Patterson PH. Placental regulation of maternal-fetal interactions and brain development.. Developmental neurobiology, 2012.
70. Garay PA, Hsiao EY, Patterson PH, McAllister AK. Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development.. Brain, behavior, and immunity, 2012.
71. Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH. Modeling an autism risk factor in mice leads to permanent immune dysregulation.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
72. Garbett KA, Hsiao EY, Kálmán S, Patterson PH, Mirnics K. Effects of maternal immune activation on gene expression patterns in the fetal brain.. Translational psychiatry, 2012.
73. Malkova NV, Yu CZ, Hsiao EY, Moore MJ, Patterson PH. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism.. Brain, behavior, and immunity, 2012.
74. Hsiao EY, Patterson PH. Activation of the maternal immune system induces endocrine changes in the placenta via IL-6.. Brain, behavior, and immunity, 2010.
75. Ito HT, Smith SE, Hsiao E, Patterson PH. Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring.. Brain, behavior, and immunity, 2010.