Elizabeta Nemeth is a Professor of Medicine at the David Geffen School of Medicine at UCLA, and Director of the UCLA Center for Iron Disorders. Dr. Nemeth received her BS in Molecular Biology at the University of Belgrade, Yugoslavia, and a PhD in Cell, Molecular and Neurosciences at the University of Hawaii. Since joining UCLA in 2002, Dr. Nemeth has been studying iron homeostasis and its disorders, with specific focus on the function of the hepatic peptide hormone hepcidin and its receptor/iron transporter ferroportin. Her work helped define the regulation of hepcidin production by iron, inflammation and erythropoiesis, described the role of hepcidin in different iron disorders including hereditary hemochromatosis, ß-thalassemia and anemia of inflammation, elucidated the mechanism of action of hepcidin as the ligand of ferroportin, described a novel hepcidin-regulating hormone erythroferrone, and developed novel hepcidin-targeted candidates for the treatment of iron disorders. Dr. Nemeth is also dedicated to translation of basic research and to this end has co-founded three biotechnology companies focused on hepcidin-targeted diagnostics and therapeutics. In 2007, Dr. Nemeth received the Grace Goldsmith Award from the American College of Nutrition for "significant achievements in the field of nutrition by a scientist under the age of 50 years". In 2019, she received the Presidential Award of the International BioIron Society, for “seminal work on the mode of action of hepcidin and the molecular basis of systemic iron homeostasis”. In 2021, Dr. Nemeth received William Dameshek Prize from the American Society of Hematology, for recent outstanding contribution to the field of hematology. Dr. Nemeth had served as a regular member of the NIH Molecular and Cellular Hematology Study Section and was elected President of the International Bioiron Society in 2019. She is also an associate editor of the American Journal of Hematology and a co-director of the UCLA K program for young faculty career development.

Interests

Anemia, Iron in pregnancy, Iron overload, Hepcidin peptide, Iron metabolism, Iron and inflammation

Education and Training

University of HawaiiPh.D.1998Cell, Molecular and Neurosciences
University of BelgradeB.S.1993Molecular Biology and Physiology

Awards and Honors

  • Kotobuki Scholarship, University of Hawaii at Manoa, 1994-1995.
  • 100 in 100 Recognition of Trailblazing Women in Honor of Women's Equality Day, UCLA Health, 2020.
  • Annual Biomedical Science Symposium Award for the Overall Best Presentation, John A. Burns School of Medicine, University of Hawaii at Manoa, 1998.
  • Tester Memorial Symposium, First Place Prize for the Best Research Paper Presented, University of Hawaii at Manoa, 1998.
  • Olympus Microscope Award for the Best Poster, European Placenta Group/International Federation of Placenta Associations (Denmark), 1997.
  • Junior Faculty Award, UCLA Department of Medicine Research Day, 2005.
  • Grace Goldsmith Award, American College of Nutrition, 2007.
  • Presidential Award, International BioIron Society, 2019.
  • Outstanding Tutor Award, UCLA David Geffen School of Medicine, 2010-2019.
  • Women Leaders in the Field of Metabolism, Cell Metabolism Series, 2016.
  • William Dameshek Prize, American Society of Hematology, 2021.
  • Plenary Presentation, European Hematology Association Meeting (Amsterdam), 2019.
  • Junior Faculty Award, UCLA Department of Medicine Research Day, 2007.

Publications

  1. Sardo U, Perrier P, Cormier K, Sotin M, Personnaz J, Medjbeur T, Desquesnes A, Cannizzo L, Ruiz-Martinez M, Thevenin J, Billoré B, Jung G, Abboud E, Peyssonnaux C, Nemeth E, Ginzburg YZ, Ganz T, Kautz L. The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling.. Blood, 2023.
  2. Banerjee S, Lu S, Jain A, Wang I, Tao H, Srinivasan S, Nemeth E, He P. Targeting PKC alleviates iron overload in diabetes and hemochromatosis.. bioRxiv : the preprint server for biology, 2023.
  3. Barad A, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O'Brien KO. Placental ferroportin protein abundance is associated with neonatal erythropoietic activity and iron status in newborns at high risk for iron deficiency and anemia.. The American journal of clinical nutrition, 2023.
  4. Srole DN, Jung G, Waring AJ, Nemeth E, Ganz T. Characterization of erythroferrone structural domains relevant to its iron-regulatory function.. The Journal of biological chemistry, 2023.
  5. Nair M, Choudhury SS, Rani A, Solomi C, Kakoty SD, Medhi R, Rao S, Mahanta P, Zahir F, Roy I, Chhabra S, Deka G, Minz B, Deka R, Opondo C, Churchill D, Lakhal-Littleton S, Nemeth E, MaatHRI collaboration. The complex relationship between iron status and anemia in pregnant and postpartum women in India: Analysis of two Indian study cohorts of uncomplicated pregnancies.. American journal of hematology, 2023.
  6. Olivera J, Zhang V, Nemeth E, Ganz T. Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia.. Blood advances, 2023.
  7. Yu Y, Woloshun RR, Lee JK, Ebea PO, Zhu S, Nemeth E, Garrick LM, Garrick MD, Collins JF. Fetal factors disrupt placental and maternal iron homeostasis in murine β-thalassemia.. Blood, 2023.
  8. Ganz T, Nemeth E. Hypoferremia of inflammation: Innate host defense against infections.. Blood cells, molecules & diseases, 2023.
  9. Sangkhae V, Fisher AL, Ganz T, Nemeth E. Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms.. Annual review of nutrition, 2023.
  10. Delaney KM, Barad A, Castillo LF, Hasund CM, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O'Brien KO. Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples.. The Journal of nutrition, 2023.
  11. Stetka J, Usart M, Kubovcakova L, Rai S, Rao TN, Sutter J, Hao-Shen H, Dirnhofer S, Geier F, Bader MS, Passweg JR, Manolova V, Dürrenberger F, Ahmed N, Schroeder T, Ganz T, Nemeth E, Silvestri L, Nai A, Camaschella C, Skoda RC. Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms.. Blood, 2023.
  12. Zhang V, Jenkitkasemwong S, Liu Q, Ganz T, Nemeth E, Knutson MD, Kim A. A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection.. Blood advances, 2023.
  13. Sardo U, Perrier P, Cormier K, Sotin M, Desquesnes A, Cannizzo L, Ruiz-Martinez M, Thevenin J, Billoré B, Jung G, Abboud E, Peyssonnaux C, Nemeth E, Ginzburg YZ, Ganz T, Kautz L. The hepatokine FGL1 regulates hepcidin and iron metabolism during the recovery from hemorrhage-induced anemia in mice.. bioRxiv : the preprint server for biology, 2023.
  14. Ganz T, Nemeth E. Pathogenic Mechanisms in Thalassemia II: Iron Overload.. Hematology/oncology clinics of North America, 2023.
  15. Azucenas CR, Ruwe TA, Bonamer JP, Qiao B, Ganz T, Jormakka M, Nemeth E, Mackenzie B. Comparative analysis of the functional properties of human and mouse ferroportin.. American journal of physiology. Cell physiology, 2023.
  16. Ganz T, Nemeth E, Rivella S, Goldberg P, Dibble AR, McCaleb ML, Guo S, Monia BP, Barrett TD. TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis.. Advances in therapy, 2023.
  17. Zhang V, Ganz T, Nemeth E, Umar S, Kim A. Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension.. Pulmonary circulation, 2022.
  18. González-Fernández D, Nemeth E, Pons EDC, Sinisterra OT, Rueda D, Starr L, Sangkhae V, Murillo E, Scott ME, Koski KG. Multiple Indicators of Undernutrition, Infection, and Inflammation in Lactating Women Are Associated with Maternal Iron Status and Infant Anthropometry in Panama: The MINDI Cohort.. Nutrients, 2022.
  19. Sangkhae V, Yu V, Coffey R, O'Brien KO, Ganz T, Nemeth E. Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron-deficient mouse pregnancies.. American journal of hematology, 2022.
  20. Nemeth E, Ganz T. Hepcidin and Iron in Health and Disease.. Annual review of medicine, 2022.
  21. Sangkhae V, Nemeth E. Quantitating Iron Transport across the Mouse Placenta In Vivo using Nonradioactive Iron Isotopes.. Journal of visualized experiments : JoVE, 2022.
  22. Breenfeldt Andersen A, Bejder J, Bonne TC, Sørensen H, Sørensen H, Jung G, Ganz T, Nemeth E, Secher NH, Johansson PI, Nordsborg NB. Hepcidin and Erythroferrone Complement the Athlete Biological Passport in the Detection of Autologous Blood Transfusion.. Medicine and science in sports and exercise, 2022.
  23. Luo G, Zhang J, Wang H, Sun Y, Cheng B, Xu Z, Zhang Y, Li H, Lu W, Nemeth E, Ganz T, Fang X. Human defensin-inspired discovery of peptidomimetic antibiotics.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
  24. Zhou A, Kong T, Fowles JS, Jung CL, Allen MJ, Fisher DAC, Fulbright M, Nemeth E, Ganz T, Oh ST. Hepcidin is elevated in primary and secondary myelofibrosis and remains elevated in patients treated with ruxolitinib.. British journal of haematology, 2022.
  25. Coffey R, Jung G, Olivera JD, Karin G, Pereira RC, Nemeth E, Ganz T. Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice.. Blood, 2022.
  26. Hanudel MR, Czaya B, Wong S, Rappaport M, Namjoshi S, Chua K, Jung G, Gabayan V, Qiao B, Nemeth E, Ganz T. Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin.. Kidney international, 2021.
  27. Tussing-Humphreys L, LaBomascus B, O'Brien K, Nemeth E, Sangkhae V, Steffen AD, Castellanos K, DeMartelly V, Ruchob R, Welke L, Hemphill NO, Pezley L, McLeod A, Hirsch B, Elam G, Ferrans CE, Koenig MD. Prepregnancy Obesity Does Not Impact Placental Iron Trafficking.. The Journal of nutrition, 2021.
  28. Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples.. The Journal of nutrition, 2021.
  29. Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E. Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis.. The Journal of biological chemistry, 2021.
  30. Drakesmith H, Pasricha SR, Cabantchik I, Hershko C, Weiss G, Girelli D, Stoffel N, Muckenthaler MU, Nemeth E, Camaschella C, Klenerman P, Zimmermann MB. Vaccine efficacy and iron deficiency: an intertwined pair?. The Lancet. Haematology, 2021.
  31. Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia.. The Journal of nutrition, 2021.
  32. Fisher AL, Sangkhae V, Balušíková K, Palaskas NJ, Ganz T, Nemeth E. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.. Nature communications, 2021.
  33. Breenfeldt Andersen A, Bonne TC, Bejder J, Jung G, Ganz T, Nemeth E, Olsen NV, Huertas JR, Nordsborg NB. Effects of altitude and recombinant human erythropoietin on iron metabolism: a randomized controlled trial.. American journal of physiology. Regulatory, integrative and comparative physiology, 2021.
  34. Nemeth E, Ganz T. Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.. International journal of molecular sciences, 2021.
  35. Castro-Mollo M, Gera S, Ruiz-Martinez M, Feola M, Gumerova A, Planoutene M, Clementelli C, Sangkhae V, Casu C, Kim SM, Ostland V, Han H, Nemeth E, Fleming R, Rivella S, Lizneva D, Yuen T, Zaidi M, Ginzburg Y. The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.. eLife, 2021.
  36. González-Fernández D, Nemeth E, Pons EDC, Rueda D, Sinisterra OT, Murillo E, Sangkhae V, Starr LM, Scott ME, Koski KG. INTERGROWTH-21 Identifies High Prevalence of Low Symphysis-Fundal Height in Indigenous Pregnant Women Experiencing Multiple Infections, Nutrient Deficiencies, and Inflammation: The Maternal Infections, Nutrient Deficiencies, and Inflammation (MINDI) Cohort.. Current developments in nutrition, 2021.
  37. Goncalves Monteiro D, van Dijk JWA, Aliyanto R, Fung E, Nemeth E, Ganz T, Rosengren J, Clark RJ. Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins.. Biomedicines, 2021.
  38. Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Isolation and thermal stabilization of mouse ferroportin.. FEBS open bio, 2020.
  39. Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E. Maternal hepcidin determines embryo iron homeostasis in mice.. Blood, 2020.
  40. Zhang V, Nemeth E, Kim A. Lung Iron Overload Does Not Exacerbate the Fibrotic Response to Bleomycin in a Mouse Model of Pulmonary Fibrosis.. American journal of respiratory cell and molecular biology, 2020.
  41. Jerzak KJ, Lohmann AE, Ennis M, Nemeth E, Ganz T, Goodwin PJ. Prognostic associations of plasma hepcidin in women with early breast cancer.. Breast cancer research and treatment, 2020.
  42. Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors.. The journal of applied laboratory medicine, 2020.
  43. Zhang V, Ganz T, Nemeth E, Kim A. Iron overload causes a mild and transient increase in acute lung injury.. Physiological reports, 2020.
  44. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism.. Nature genetics, 2020.
  45. Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH, Kallapur SG, Tabbah S, Buhimschi CS, Buhimschi IA, Ganz T, Nemeth E. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy.. JCI insight, 2020.
  46. Mangaonkar AA, Thawer F, Son J, Ajebo G, Xu H, Barrett NJ, Wells LG, Bowman L, Clair B, Patel N, Bora P, Jung G, Nemeth E, Kutlar A. Regulation of iron homeostasis through the erythroferrone-hepcidin axis in sickle cell disease.. British journal of haematology, 2020.
  47. Sangkhae V, Fisher AL, Wong S, Koenig MD, Tussing-Humphreys L, Chu A, Lelic M, Ganz T, Nemeth E. Effects of maternal iron status on placental and fetal iron homeostasis.. The Journal of clinical investigation, 2020.
  48. Hanudel MR, Eisenga MF, Rappaport M, Chua K, Qiao B, Jung G, Gabayan V, Gales B, Ramos G, de Jong MA, van Zanden JJ, de Borst MH, Bakker SJL, Nemeth E, Salusky IB, Gaillard CAJM, Ganz T. Effects of erythropoietin on fibroblast growth factor 23 in mice and humans.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019.
  49. Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.. Science translational medicine, 2019.
  50. Sangkhae V, Nemeth E. To induce or not to induce: the fight over hepcidin regulation.. Haematologica, 2019.
  51. Hall R, Peeling P, Nemeth E, Bergland D, McCluskey WTP, Stellingwerff T. Single versus Split Dose of Iron Optimizes Hemoglobin Mass Gains at 2106 m Altitude.. Medicine and science in sports and exercise, 2019.
  52. Delaney KM, Guillet R, Fleming RE, Ru Y, Pressman EK, Vermeylen F, Nemeth E, O'Brien KO. Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples.. The Journal of nutrition, 2019.
  53. Zhang V, Nemeth E, Kim A. Iron in Lung Pathology.. Pharmaceuticals (Basel, Switzerland), 2019.
  54. Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.. Radiation research, 2019.
  55. Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
  56. Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic MT, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.. The Journal of clinical investigation, 2018.
  57. Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S, Nemeth E. Iron homeostasis in pregnancy and spontaneous abortion.. American journal of hematology, 2018.
  58. Gagliano-Jucá T, Pencina KM, Ganz T, Travison TG, Kantoff PW, Nguyen PL, Taplin ME, Kibel AS, Li Z, Huang G, Edwards RR, Nemeth E, Basaria S. Mechanisms responsible for reduced erythropoiesis during androgen deprivation therapy in men with prostate cancer.. American journal of physiology. Endocrinology and metabolism, 2018.
  59. Coffey R, Sardo U, Kautz L, Gabayan V, Nemeth E, Ganz T. Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice.. Physiological reports, 2018.
  60. Deshpande CN, Ruwe TA, Shawki A, Xin V, Vieth KR, Valore EV, Qiao B, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Calcium is an essential cofactor for metal efflux by the ferroportin transporter family.. Nature communications, 2018.
  61. Garvican-Lewis LA, Vuong VL, Govus AD, Peeling P, Jung G, Nemeth E, Hughes D, Lovell G, Eichner D, Gore CJ. Intravenous Iron Does Not Augment the Hemoglobin Mass Response to Simulated Hypoxia.. Medicine and science in sports and exercise, 2018.
  62. Sangkhae V, Nemeth E. Placental iron transport: The mechanism and regulatory circuits.. Free radical biology & medicine, 2018.
  63. Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y. Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients.. Infection and immunity, 2018.
  64. Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, Nemeth E, Nielsen P, Pineau B, Piperno A, Porto G, Prince D, Ryan J, Sanchez M, Santos P, Swinkels D, Teixeira E, Toska K, Vanclooster A, White D, Contributors and Hemochromatosis International Taskforce. Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype.. Hepatology international, 2018.
  65. Meznarich JA, Draper L, Christensen RD, Yaish HM, Luem ND, Pysher TJ, Jung G, Nemeth E, Ganz T, Ward DM. Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations.. Blood cells, molecules & diseases, 2018.
  66. Casu C, Nemeth E, Rivella S. Hepcidin agonists as therapeutic tools.. Blood, 2018.
  67. Hanudel MR, Rappaport M, Chua K, Gabayan V, Qiao B, Jung G, Salusky IB, Ganz T, Nemeth E. Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease.. Haematologica, 2018.
  68. Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR, Jung G, Casu C, Rivella S, Jormakka M, Mackenzie B, Ganz T, Nemeth E. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin.. Blood, 2017.
  69. Fisher AL, Nemeth E. Iron homeostasis during pregnancy.. The American journal of clinical nutrition, 2017.
  70. Khorramian E, Fung E, Chua K, Gabayan V, Ganz T, Nemeth E, Kim A. In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment.. Shock (Augusta, Ga.), 2017.
  71. Clinkenbeard EL, Hanudel MR, Stayrook KR, Appaiah HN, Farrow EG, Cass TA, Summers LJ, Ip CS, Hum JM, Thomas JC, Ivan M, Richine BM, Chan RJ, Clemens TL, Schipani E, Sabbagh Y, Xu L, Srour EF, Alvarez MB, Kacena MA, Salusky IB, Ganz T, Nemeth E, White KE. Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow.. Haematologica, 2017.
  72. McLachlan S, Page KE, Lee SM, Loguinov A, Valore E, Hui ST, Jung G, Zhou J, Lusis AJ, Fuqua B, Ganz T, Nemeth E, Vulpe CD. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.. American journal of physiology. Gastrointestinal and liver physiology, 2017.
  73. Ganz T, Jung G, Naeim A, Ginzburg Y, Pakbaz Z, Walter PB, Kautz L, Nemeth E. Immunoassay for human serum erythroferrone.. Blood, 2017.
  74. Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.. Blood, 2017.
  75. Michels KR, Zhang Z, Bettina AM, Cagnina RE, Stefanova D, Burdick MD, Vaulont S, Nemeth E, Ganz T, Mehrad B. Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia.. JCI insight, 2017.
  76. Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L. Erythroferrone and matriptase-2 independently regulate hepcidin expression.. American journal of hematology, 2017.
  77. Sangkhae V, Nemeth E. Regulation of the Iron Homeostatic Hormone Hepcidin.. Advances in nutrition (Bethesda, Md.), 2017.
  78. Hanudel MR, Rappaport M, Gabayan V, Jung G, Salusky IB, Nemeth E, Ganz T, Zaritsky J. Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model.. Haematologica, 2016.
  79. Welke L, Koenig MD, Thomson JL, Nemeth E, White-Traut R, McFarlin BL, Giurgescu C, Engeland CG, Kominiarek MA, Tussing-Humphreys L. Iron Metabolism in African American Women in the Second and Third Trimesters of High-Risk Pregnancies.. Journal of obstetric, gynecologic, and neonatal nursing : JOGNN, 2016.
  80. Hanudel MR, Chua K, Rappaport M, Gabayan V, Valore E, Goltzman D, Ganz T, Nemeth E, Salusky IB. Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice.. American journal of physiology. Renal physiology, 2016.
  81. Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.. Blood, 2016.
  82. Girelli D, Nemeth E, Swinkels DW. Hepcidin in the diagnosis of iron disorders.. Blood, 2016.
  83. Ganz T, Nemeth E. Iron Balance and the Role of Hepcidin in Chronic Kidney Disease.. Seminars in nephrology, 2016.
  84. Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin.. Cell metabolism, 2015.
  85. Kim A, Fung E, Parikh SG, Gabayan V, Nemeth E, Ganz T. Isocitrate treatment of acute anemia of inflammation in a mouse model.. Blood cells, molecules & diseases, 2015.
  86. Michels K, Nemeth E, Ganz T, Mehrad B. Hepcidin and Host Defense against Infectious Diseases.. PLoS pathogens, 2015.
  87. Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, Nemeth E, Ganz T. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.. Blood, 2015.
  88. Ganz T, Nemeth E. Iron homeostasis in host defence and inflammation.. Nature reviews. Immunology, 2015.
  89. Kim A, Nemeth E. New insights into iron regulation and erythropoiesis.. Current opinion in hematology, 2015.
  90. Keel SB, Doty R, Liu L, Nemeth E, Cherian S, Ganz T, Abkowitz JL. Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver.. Experimental hematology, 2015.
  91. Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P. Small cyclic agonists of iron regulatory hormone hepcidin.. Bioorganic & medicinal chemistry letters, 2015.
  92. Arezes J, Jung G, Gabayan V, Valore E, Ruchala P, Gulig PA, Ganz T, Nemeth E, Bulut Y. Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus.. Cell host & microbe, 2015.
  93. Fung E, Chua K, Ganz T, Nemeth E, Ruchala P. Thiol-derivatized minihepcidins retain biological activity.. Bioorganic & medicinal chemistry letters, 2015.
  94. Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis.. Haematologica, 2014.
  95. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation.. Blood, 2014.
  96. Koenig MD, Tussing-Humphreys L, Day J, Cadwell B, Nemeth E. Hepcidin and iron homeostasis during pregnancy.. Nutrients, 2014.
  97. Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, Nemeth E, Ganz T, Liu S. Disordered hepcidin-ferroportin signaling promotes breast cancer growth.. Cellular signalling, 2014.
  98. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism.. Nature genetics, 2014.
  99. Kautz L, Nemeth E. Molecular liaisons between erythropoiesis and iron metabolism.. Blood, 2014.
  100. Nemeth E, Ganz T. Anemia of inflammation.. Hematology/oncology clinics of North America, 2014.
  101. Pusatcioglu CK, Nemeth E, Fantuzzi G, Llor X, Freels S, Tussing-Humphreys L, Cabay RJ, Linzmeier R, Ng D, Clark J, Braunschweig C. Systemic and tumor level iron regulation in men with colorectal cancer: a case control study.. Nutrition & metabolism, 2014.
  102. Kim A, Rivera S, Shprung D, Limbrick D, Gabayan V, Nemeth E, Ganz T. Mouse models of anemia of cancer.. PloS one, 2014.
  103. Ruchala P, Nemeth E. The pathophysiology and pharmacology of hepcidin.. Trends in pharmacological sciences, 2014.
  104. Dekan Z, Mobli M, Pennington MW, Fung E, Nemeth E, Alewood PF. Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl.. Angewandte Chemie (International ed. in English), 2014.
  105. Kim A, Fung E, Parikh SG, Valore EV, Gabayan V, Nemeth E, Ganz T. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin.. Blood, 2013.
  106. Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis AJ, Ganz T, Nemeth E. Testing the iron hypothesis in a mouse model of atherosclerosis.. Cell reports, 2013.
  107. Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc.. American journal of physiology. Cell physiology, 2013.
  108. Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6.. Infection and immunity, 2013.
  109. Fung E, Nemeth E. Manipulation of the hepcidin pathway for therapeutic purposes.. Haematologica, 2013.
  110. Nemeth E. Anti-hepcidin therapy for iron-restricted anemias.. Blood, 2013.
  111. Clark RJ, Preza GC, Tan CC, van Dijk JW, Fung E, Nemeth E, Ganz T, Craik DJ. Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin.. Biopolymers, 2013.
  112. Nemeth E. Hepcidin and β-thalassemia major.. Blood, 2013.
  113. Preza GC, Pinon R, Ganz T, Nemeth E. Cellular catabolism of the iron-regulatory peptide hormone hepcidin.. PloS one, 2013.
  114. Guo W, Bachman E, Li M, Roy CN, Blusztajn J, Wong S, Chan SY, Serra C, Jasuja R, Travison TG, Muckenthaler MU, Nemeth E, Bhasin S. Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells.. Aging cell, 2013.
  115. Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, Busch MP, Olbina G, Westerman M, Nemeth E, Ganz T, NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II). Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy.. Haematologica, 2013.
  116. Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. High-throughput screening of small molecules identifies hepcidin antagonists.. Molecular pharmacology, 2013.
  117. Basseri RJ, Nemeth E, Vassilaki ME, Basseri B, Enayati P, Shaye O, Bourikas LA, Ganz T, Papadakis KA. Hepcidin is a key mediator of anemia of inflammation in Crohn's disease.. Journal of Crohn's & colitis, 2012.
  118. Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis.. Blood, 2012.
  119. Ganz T, Goff J, Klasing K, Nemeth E, Roth T. IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011).. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2012.
  120. Ganz T, Nemeth E. Iron homeostasis and its disorders in mice and men: potential lessons for rhinos.. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2012.
  121. Goodnough JB, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors.. Hepatology (Baltimore, Md.), 2012.
  122. Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.. Cell metabolism, 2012.
  123. Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.. Cell metabolism, 2012.
  124. Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis.. Cold Spring Harbor perspectives in medicine, 2012.
  125. Tussing-Humphreys L, Pusatcioglu C, Pustacioglu C, Nemeth E, Braunschweig C. Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin.. Journal of the Academy of Nutrition and Dietetics, 2012.
  126. Ganz T, Nemeth E. Hepcidin and iron homeostasis.. Biochimica et biophysica acta, 2012.
  127. Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, Nemeth E. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload.. The Journal of clinical investigation, 2011.
  128. Tussing-Humphreys L, Frayn KN, Smith SR, Westerman M, Dennis AL, Nemeth E, Thomson J, Pusatcioglu C. Subcutaneous adipose tissue from obese and lean adults does not release hepcidin in vivo.. TheScientificWorldJournal, 2011.
  129. Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors.. Haematologica, 2011.
  130. Trombini P, Paolini V, Pelucchi S, Mariani R, Nemeth E, Ganz T, Piperno A. Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome.. Liver international : official journal of the International Association for the Study of the Liver, 2011.
  131. Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.. Hepatology (Baltimore, Md.), 2011.
  132. Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin.. Chemistry & biology, 2011.
  133. Burpee T, Mitchell P, Fishman D, Islam S, Nemeth E, Westerman M, Wessling-Resnick M, Grand RJ. Intestinal ferroportin expression in pediatric Crohn's disease.. Inflammatory bowel diseases, 2011.
  134. Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism.. Annual review of medicine, 2011.
  135. Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders.. Hematology. American Society of Hematology. Education Program, 2011.
  136. Girelli D, Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Westerman M, Ganz T, Nemeth E, Piperno A, Camaschella C. A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.. Haematologica, 2010.
  137. Kautz L, Nemeth E. Novel tools for the evaluation of iron metabolism.. Haematologica, 2010.
  138. Gardenghi S, Ramos P, Marongiu MF, Melchiori L, Breda L, Guy E, Muirhead K, Rao N, Roy CN, Andrews NC, Nemeth E, Follenzi A, An X, Mohandas N, Ginzburg Y, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.. The Journal of clinical investigation, 2010.
  139. Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis.. Blood, 2010.
  140. Rivella S, Nemeth E, Miller JL. Crosstalk between Erythropoiesis and Iron Metabolism.. Advances in hematology, 2010.
  141. Maes K, Nemeth E, Roodman GD, Huston A, Esteve F, Freytes C, Callander N, Katodritou E, Tussing-Humphreys L, Rivera S, Vanderkerken K, Lichtenstein A, Ganz T. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.. Blood, 2010.
  142. Nemeth E. Hepcidin in beta-thalassemia.. Annals of the New York Academy of Sciences, 2010.
  143. Ayoya MA, Spiekermann-Brouwer GM, Stoltzfus RJ, Nemeth E, Habicht JP, Ganz T, Rawat R, Traoré AK, Garza C. Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium.. The American journal of clinical nutrition, 2010.
  144. Nemeth E. Hepcidin biology and therapeutic applications.. Expert review of hematology, 2010.
  145. Zaritsky J, Young B, Gales B, Wang HJ, Rastogi A, Westerman M, Nemeth E, Ganz T, Salusky IB. Reduction of serum hepcidin by hemodialysis in pediatric and adult patients.. Clinical journal of the American Society of Nephrology : CJASN, 2010.
  146. Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. Proinflammatory state, hepcidin, and anemia in older persons.. Blood, 2010.
  147. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Holterman AX, Galvani C, Ayloo S, Vitello J, Braunschweig C. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery.. Obesity (Silver Spring, Md.), 2010.
  148. Nemeth E. Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias.. Advances in hematology, 2009.
  149. Nemeth E, Ganz T. The role of hepcidin in iron metabolism.. Acta haematologica, 2009.
  150. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Guzman G, Holterman AX, Braunschweig C. Elevated systemic hepcidin and iron depletion in obese premenopausal females.. Obesity (Silver Spring, Md.), 2009.
  151. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation.. Seminars in hematology, 2009.
  152. Girelli D, Pasino M, Goodnough JB, Nemeth E, Guido M, Castagna A, Busti F, Campostrini N, Martinelli N, Vantini I, Corrocher R, Ganz T, Fattovich G. Reduced serum hepcidin levels in patients with chronic hepatitis C.. Journal of hepatology, 2009.
  153. Sham RL, Phatak PD, Nemeth E, Ganz T. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation.. Blood, 2009.
  154. Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB. Hepcidin--a potential novel biomarker for iron status in chronic kidney disease.. Clinical journal of the American Society of Nephrology : CJASN, 2009.
  155. Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E. The molecular basis of hepcidin-resistant hereditary hemochromatosis.. Blood, 2009.
  156. Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V, Abergel A, Philippe P, Deugnier Y, Coudray C. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin.. Journal of hepatology, 2009.
  157. Troadec MB, Lainé F, Daniel V, Rochcongar P, Ropert M, Cabillic F, Perrin M, Morcet J, Loréal O, Olbina G, Westerman M, Nemeth E, Ganz T, Brissot P. Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism.. European journal of applied physiology, 2009.
  158. Tussing-Humphreys LM, Liang H, Nemeth E, Freels S, Braunschweig CA. Excess adiposity, inflammation, and iron-deficiency in female adolescents.. Journal of the American Dietetic Association, 2009.
  159. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin.. Blood, 2008.
  160. De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. The hepcidin-binding site on ferroportin is evolutionarily conserved.. Cell metabolism, 2008.
  161. Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, Roodman GD, Ganz T, Lichtenstein A. Involvement of hepcidin in the anemia of multiple myeloma.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008.
  162. Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz EA. Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis.. British journal of haematology, 2008.
  163. Nemeth E. Iron regulation and erythropoiesis.. Current opinion in hematology, 2008.
  164. Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T, Piperno A. Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload.. Journal of hepatology, 2008.
  165. Bozzini C, Campostrini N, Trombini P, Nemeth E, Castagna A, Tenuti I, Corrocher R, Camaschella C, Ganz T, Olivieri O, Piperno A, Girelli D. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis.. Blood cells, molecules & diseases, 2007.
  166. Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, Piperno A. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia.. Haematologica, 2007.
  167. Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site.. Blood cells, molecules & diseases, 2007.
  168. Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis.. Blood, 2007.
  169. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.. Blood, 2007.
  170. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation.. Molecular biology of the cell, 2007.
  171. Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E. Liver iron concentrations and urinary hepcidin in beta-thalassemia.. Haematologica, 2007.
  172. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ. Urinary hepcidin in congenital chronic anemias.. Pediatric blood & cancer, 2007.
  173. Semrin G, Fishman DS, Bousvaros A, Zholudev A, Saunders AC, Correia CE, Nemeth E, Grand RJ, Weinstein DA. Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation.. Inflammatory bowel diseases, 2006.
  174. De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. Molecular and clinical correlates in iron overload associated with mutations in ferroportin.. Haematologica, 2006.
  175. Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT. DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis.. Blood, 2006.
  176. Nemeth E, Ganz T. Hepcidin and iron-loading anemias.. Haematologica, 2006.
  177. Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals.. Biochimica et biophysica acta, 2006.
  178. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism.. American journal of physiology. Gastrointestinal and liver physiology, 2006.
  179. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin.. Annual review of nutrition, 2006.
  180. Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.. Blood, 2005.
  181. Zoller H, McFarlane I, Theurl I, Stadlmann S, Nemeth E, Oxley D, Ganz T, Halsall DJ, Cox TM, Vogel W. Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease.. Hepatology (Baltimore, Md.), 2005.
  182. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Novel urine hepcidin assay by mass spectrometry.. Blood, 2005.
  183. De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  184. Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.. Blood, 2005.
  185. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS.. Blood, 2005.
  186. Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function.. Blood, 2005.
  187. Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E. Hepcidin in iron overload disorders.. Blood, 2005.
  188. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.. Science (New York, N.Y.), 2004.
  189. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis.. Blood, 2004.
  190. Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia.. Blood, 2004.
  191. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.. The Journal of clinical investigation, 2004.
  192. Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.. Nature genetics, 2003.
  193. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.. Blood, 2002.