Affiliations
Associate Professor, Cardiology
Member, Gene Regulation GPB Home Area, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area
Member, Gene Regulation GPB Home Area, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area
Research Interests
Lipids (particularly cholesterol and phospholipids) are essential components of cell membranes and are precursors to many signaling molecules, including steroid hormones, bile acids and oxysterols. As such, lipid synthesis pathways are among the most intensely regulated processes in biology. We are interested in understanding molecular mechanisms that control celular, tissue and whole-body lipid homeostasis in healthy and disease states.
Biography:
I am an Associate Professor in the Department of Medicine-Cardiology at UCLA. I did my undergraduate and graduate training at the University of Nottingham, in the UK, and my postdoctoral training in the laboratory of Dr. Peter Edwards at UCLA. My research interests are understanding and identifying molecular mechanisms that control cellular and whole body cholesterol homeostasis, with a focus on pulmonary lipid homeostasis, inflammation and disease.
Publications
A selected list of publications:
- Tumurkhuu Gantsetseg, Dagvadorj Jargalsaikhan, Porritt Rebecca A, Crother Timothy R, Shimada Kenichi, Tarling Elizabeth J, Erbay Ebru, Arditi Moshe, Chen Shuang Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis Cell metabolism, 2018; 28(3): 432-448.e4.
- McCarthy Cormac, Lee Elinor, Bridges James P, Sallese Anthony, Suzuki Takuji, Woods Jason C, Bartholmai Brian J, Wang Tisha, Chalk Claudia, Carey Brenna C, Arumugam Paritha, Shima Kenjiro, Tarling Elizabeth J, Trapnell Bruce C Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis Nature communications, 2018; 9(1): 3127.
- Mack Julia J, Mosqueiro Thiago S, Archer Brian J, Jones William M, Sunshine Hannah, Faas Guido C, Briot Anais, Aragón Raquel L, Su Trent, Romay Milagros C, McDonald Austin I, Kuo Cheng-Hsiang, Lizama Carlos O, Lane Timothy F, Zovein Ann C, Fang Yun, Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Navab Mohamad, Fogelman Alan M, Bouchard Louis S, Iruela-Arispe M Luisa NOTCH1 is a mechanosensor in adult arteries Nature communications, 2017; 8(1): 1620.
- Tarling Elizabeth J, Clifford Bethan L, Cheng Joan, Morand Pauline, Cheng Angela, Lester Ellen, Sallam Tamer, Turner Martin, de Aguiar Vallim Thomas Q RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism The Journal of clinical investigation, 2017; 127(10): 3741-3754.
- de Aguiar Vallim Thomas Q, Lee Elinor, Merriott David J, Goulbourne Christopher N, Cheng Joan, Cheng Angela, Gonen Ayelet, Allen Ryan M, Palladino Elisa N D, Ford David A, Wang Tisha, Baldán Ángel, Tarling Elizabeth J ABCG1 regulates pulmonary surfactant metabolism in mice and men Journal of lipid research, 2017; 58(5): 941-954.
- Tarling Elizabeth J, Edwards Peter A Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report Arteriosclerosis, thrombosis, and vascular biology, 2016; 36(7): 1323-7.
- Wei Hao, Tarling Elizabeth J, McMillen Timothy S, Tang Chongren, LeBoeuf Renée C ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction Journal of lipid research, 2015; 56(12): 2337-47.
- York Autumn G, Williams Kevin J, Argus Joseph P, Zhou Quan D, Brar Gurpreet, Vergnes Laurent, Gray Elizabeth E, Zhen Anjie, Wu Nicholas C, Yamada Douglas H, Cunningham Cameron R, Tarling Elizabeth J, Wilks Moses Q, Casero David, Gray David H, Yu Amy K, Wang Eric S, Brooks David G, Sun Ren, Kitchen Scott G, Wu Ting-Ting, Reue Karen, Stetson Daniel B, Bensinger Steven J Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling Cell, 2015; 163(7): 1716-29.
- Tarling Elizabeth J, Ahn Hannah, de Aguiar Vallim Thomas Q The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2 Arteriosclerosis, thrombosis, and vascular biology, 2015; 35(4): 787-95.
- de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Ahn Hannah, Hagey Lee R, Romanoski Casey E, Lee Richard G, Graham Mark J, Motohashi Hozumi, Yamamoto Masayuki, Edwards Peter A MAFG is a transcriptional repressor of bile acid synthesis and metabolism Cell metabolism, 2015; 21(2): 298-310.
- Baldan Angel, Gonen Ayelet, Choung Christina, Que Xuchu, Marquart Tyler J, Hernandez Irene, Bjorkhem Ingemar, Ford David A, Witztum Joseph L, Tarling Elizabeth J ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis Journal of immunology (Baltimore, Md. : 1950), 2014; 193(11): 5637-48.
- Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Edwards Peter A Role of ABC transporters in lipid transport and human disease Trends in endocrinology and metabolism: TEM, 2013; 24(7): 342-50.
- de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Kim Tammy, Civelek Mete, Baldán Ãngel, Esau Christine, Edwards Peter A MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor Circulation research, 2013; 112(12): 1602-12.
- de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Edwards Peter A Pleiotropic roles of bile acids in metabolism Cell metabolism, 2013; 17(5): 657-69.
- Tarling Elizabeth J, Edwards Peter A ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(49): 19719-24.
- Jiang Yan J, Lu Biao, Tarling Elizabeth J, Kim Peggy, Man M-Q, Crumrine Debbie, Edwards Peter A, Elias Peter M, Feingold Kenneth R Regulation of ABCG1 expression in human keratinocytes and murine epidermis Journal of lipid research, 2010; 51(11): 3185-95.
- Tarling Elizabeth J, Bojanic Dragana D, Tangirala Rajendra K, Wang Xuping, Lovgren-Sandblom Anita, Lusis Aldons J, Bjorkhem Ingemar, Edwards Peter A Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(6): 1174-80.