Eric Sobel*

Eric Martin Sobel

Adjunct Professor, Human Genetics, University of California Los Angeles

Adjunct Professor, Computational Medicine, University of California Los Angeles


  1. Jung SY, Papp JC, Sobel EM, Pellegrini M, Yu H. Genetic variants of glucose metabolism and exposure to smoking in African American breast cancer.. Endocrine-related cancer, 2023.
  2. Ko S, Chu BB, Peterson D, Okenwa C, Papp JC, Alexander DH, Sobel EM, Zhou H, Lange KL. Unsupervised discovery of ancestry-informative markers and genetic admixture proportions in biobank-scale datasets.. American journal of human genetics, 2023.
  3. Chu BB, Sobel EM, Wasiolek R, Ko S, Sinsheimer JS, Zhou H, Lange K. A fast data-driven method for genotype imputation, phasing and local ancestry inference: MendelImpute.jl.. Bioinformatics (Oxford, England), 2021.
  4. Jung SY, Sobel EM, Pellegrini M, Yu H, Papp JC. Synergistic Effects of Genetic Variants of Glucose Homeostasis and Lifelong Exposures to Cigarette Smoking, Female Hormones, and Dietary Fat Intake on Primary Colorectal Cancer Development in African and Hispanic/Latino American Women.. Frontiers in oncology, 2021.
  5. Jung SY, Papp JC, Pellegrini M, Yu H, Sobel EM. Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis.. Biomolecules, 2021.
  6. Ji SS, German CA, Lange K, Sinsheimer JS, Zhou H, Zhou J, Sobel EM. Modern simulation utilities for genetic analysis.. BMC bioinformatics, 2021.
  7. Jung SY, Yu H, Pellegrini M, Papp JC, Sobel EM, Zhang ZF. Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk: Mendelian randomization with lifestyle interactions.. American journal of cancer research, 2021.
  8. Jung SY, Papp JC, Sobel EM, Pellegrini M, Yu H, Zhang ZF. Genetically Predicted C-Reactive Protein Associated With Postmenopausal Breast Cancer Risk: Interrelation With Estrogen and Cancer Molecular Subtypes Using Mendelian Randomization.. Frontiers in oncology, 2021.
  9. Jung SY, Papp JC, Sobel EM, Pellegrini M, Yu H, Zhang ZF. Pro-inflammatory cytokine polymorphisms and interactions with dietary alcohol and estrogen, risk factors for invasive breast cancer using a post genome-wide analysis for gene-gene and gene-lifestyle interaction.. Scientific reports, 2021.
  10. Jung SY, Scott PA, Papp JC, Sobel EM, Pellegrini M, Yu H, Han S, Zhang ZF. Genome-wide Association Analysis of Proinflammatory Cytokines and Gene-lifestyle Interaction for Invasive Breast Cancer Risk: The WHI dbGaP Study.. Cancer prevention research (Philadelphia, Pa.), 2020.
  11. Jung SY, Papp JC, Sobel EM, Pellegrini M, Yu H, Zhang ZF. Pro-inflammatory cytokine polymorphisms in ONECUT2 and HNF4A and primary colorectal carcinoma: a post genome-wide gene-lifestyle interaction study.. American journal of cancer research, 2020.
  12. Jung SY, Papp JC, Sobel EM, Zhang ZF. Mendelian Randomization Study: The Association Between Metabolic Pathways and Colorectal Cancer Risk.. Frontiers in oncology, 2020.
  13. Chu BB, Keys KL, German CA, Zhou H, Zhou JJ, Sobel EM, Sinsheimer JS, Lange K. Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity.. GigaScience, 2020.
  14. Jung SY, Papp JC, Sobel EM, Zhang ZF. Post Genome-Wide Gene-Environment Interaction Study Using Random Survival Forest: Insulin Resistance, Lifestyle Factors, and Colorectal Cancer Risk.. Cancer prevention research (Philadelphia, Pa.), 2019.
  15. Jung SY, Mancuso N, Papp J, Sobel E, Zhang ZF. Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization.. PloS one, 2019.
  16. Jung SY, Papp JC, Sobel EM, Yu H, Zhang ZF. Breast Cancer Risk and Insulin Resistance: Post Genome-Wide Gene-Environment Interaction Study Using a Random Survival Forest.. Cancer research, 2019.
  17. Zhou H, Sinsheimer JS, Bates DM, Chu BB, German CA, Ji SS, Keys KL, Kim J, Ko S, Mosher GD, Papp JC, Sobel EM, Zhai J, Zhou JJ, Lange K. OPENMENDEL: a cooperative programming project for statistical genetics.. Human genetics, 2019.
  18. Jung SY, Mancuso N, Yu H, Papp J, Sobel E, Zhang ZF. Genome-Wide Meta-analysis of Gene-Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women.. Cancer prevention research (Philadelphia, Pa.), 2018.
  19. Jung SY, Papp JC, Sobel EM, Zhang ZF. Genetic Variants in Metabolic Signaling Pathways and Their Interaction with Lifestyle Factors on Breast Cancer Risk: A Random Survival Forest Analysis.. Cancer prevention research (Philadelphia, Pa.), 2017.
  20. Jung SY, Ho G, Rohan T, Strickler H, Bea J, Papp J, Sobel E, Zhang ZF, Crandall C. Interaction of insulin-like growth factor-I and insulin resistance-related genetic variants with lifestyle factors on postmenopausal breast cancer risk.. Breast cancer research and treatment, 2017.
  21. Jung SY, Sobel EM, Papp JC, Zhang ZF. Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women.. BMC cancer, 2017.
  22. Clark MM, Chazara O, Sobel EM, Gjessing HK, Magnus P, Moffett A, Sinsheimer JS. Human Birth Weight and Reproductive Immunology: Testing for Interactions between Maternal and Offspring KIR and HLA-C Genes.. Human heredity, 2017.
  23. Zhou H, Blangero J, Dyer TD, Chan KK, Lange K, Sobel EM. Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data.. Genetic epidemiology, 2016.
  24. Zhou H, Zhou J, Hu T, Sobel EM, Lange K. Genome-wide QTL and eQTL analyses using Mendel.. BMC proceedings, 2016.
  25. Jung SY, Sobel EM, Papp JC, Crandall CJ, Fu AN, Zhang ZF. Obesity and associated lifestyles modify the effect of glucose metabolism-related genetic variants on impaired glucose homeostasis among postmenopausal women.. Genetic epidemiology, 2016.
  26. Clark MM, Blangero J, Dyer TD, Sobel EM, Sinsheimer JS. The Quantitative-MFG Test: A Linear Mixed Effect Model to Detect Maternal-Offspring Gene Interactions.. Annals of human genetics, 2015.
  27. Gilbert PS, Chang J, Pan C, Sobel EM, Sinsheimer JS, Faircloth BC, Alfaro ME. Genome-wide ultraconserved elements exhibit higher phylogenetic informativeness than traditional gene markers in percomorph fishes.. Molecular phylogenetics and evolution, 2015.
  28. Chan KH, Huang YT, Meng Q, Wu C, Reiner A, Sobel EM, Tinker L, Lusis AJ, Yang X, Liu S. Shared molecular pathways and gene networks for cardiovascular disease and type 2 diabetes mellitus in women across diverse ethnicities.. Circulation. Cardiovascular genetics, 2014.
  29. Zhou H, Zhou J, Sobel EM, Lange K. Fast genome-wide pedigree quantitative trait loci analysis using MENDEL.. BMC proceedings, 2014.
  30. Lange K, Papp JC, Sinsheimer JS, Sobel EM. Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data.. Annual review of statistics and its application, 2014.
  31. van Nas A, Pan C, Ingram-Drake LA, Ghazalpour A, Drake TA, Sobel EM, Papp JC, Lusis AJ. The systems genetics resource: a web application to mine global data for complex disease traits.. Frontiers in genetics, 2013.
  32. Lange K, Papp JC, Sinsheimer JS, Sripracha R, Zhou H, Sobel EM. Mendel: the Swiss army knife of genetic analysis programs.. Bioinformatics (Oxford, England), 2013.
  33. Chan KH, Niu T, Ma Y, You NC, Song Y, Sobel EM, Hsu YH, Balasubramanian R, Qiao Y, Tinker L, Liu S. Common genetic variants in peroxisome proliferator-activated receptor-γ (PPARG) and type 2 diabetes risk among Women's Health Initiative postmenopausal women.. The Journal of clinical endocrinology and metabolism, 2013.
  34. Iribarren C, Tolstykh IV, Miller MK, Sobel E, Eisner MD. Adult asthma and risk of coronary heart disease, cerebrovascular disease, and heart failure: a prospective study of 2 matched cohorts.. American journal of epidemiology, 2012.
  35. Sobel EM, Ettinger B, Lo JC, Pressman AR. Application of new method for evaluating performance of fracture risk tool.. The American journal of managed care, 2012.
  36. Chen GK, Wang K, Stram AH, Sobel EM, Lange K. Mendel-GPU: haplotyping and genotype imputation on graphics processing units.. Bioinformatics (Oxford, England), 2012.
  37. Zhou JJ, Ghazalpour A, Sobel EM, Sinsheimer JS, Lange K. Quantitative trait Loci association mapping by imputation of strain origins in multifounder crosses.. Genetics, 2011.
  38. Childs EJ, Sobel EM, Palmer CG, Sinsheimer JS. Detection of intergenerational genetic effects with application to HLA-B matching as a risk factor for schizophrenia.. Human heredity, 2011.
  39. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. Unifying ideas for non-parametric linkage analysis.. Human heredity, 2011.
  40. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. Linkage analysis without defined pedigrees.. Genetic epidemiology, 2011.
  41. Gao MC, Bellugi U, Dai L, Mills DL, Sobel EM, Lange K, Korenberg JR. Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex.. PloS one, 2010.
  42. Aldave AJ, Rosenwasser GO, Yellore VS, Papp JC, Sobel EM, Pham MN, Chen MC, Dandekar S, Sripracha R, Rayner SA, Sassani JW, Gorin MB. Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC.. Investigative ophthalmology & visual science, 2010.
  43. Aldave AJ, Yellore VS, Vo RC, Kamal KM, Rayner SA, Plaisier CL, Chen MC, Damani MR, Pham MN, Gorin MB, Sobel E, Papp J. Exclusion of positional candidate gene coding region mutations in the common posterior polymorphous corneal dystrophy 1 candidate gene interval.. Cornea, 2009.
  44. Korbel JO, Tirosh-Wagner T, Urban AE, Chen XN, Kasowski M, Dai L, Grubert F, Erdman C, Gao MC, Lange K, Sobel EM, Barlow GM, Aylsworth AS, Carpenter NJ, Clark RD, Cohen MY, Doran E, Falik-Zaccai T, Lewin SO, Lott IT, McGillivray BC, Moeschler JB, Pettenati MJ, Pueschel SM, Rao KW, Shaffer LG, Shohat M, Van Riper AJ, Warburton D, Weissman S, Gerstein MB, Snyder M, Korenberg JR. The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
  45. Wu TT, Chen YF, Hastie T, Sobel E, Lange K. Genome-wide association analysis by lasso penalized logistic regression.. Bioinformatics (Oxford, England), 2009.
  46. Presson AP, Sobel EM, Papp JC, Suarez CJ, Whistler T, Rajeevan MS, Vernon SD, Horvath S. Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome.. BMC systems biology, 2008.
  47. Bauman LE, Sinsheimer JS, Sobel EM, Lange K. Mixed effects models for quantitative trait loci mapping with inbred strains.. Genetics, 2008.
  48. Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P. WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.. American journal of human genetics, 2008.
  49. Presson AP, Sobel EM, Pajukanta P, Plaisier C, Weeks DE, Aberg K, Papp JC. Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis.. BMC bioinformatics, 2008.
  50. Jasinska AJ, Service S, Levinson M, Slaten E, Lee O, Sobel E, Fairbanks LA, Bailey JN, Jorgensen MJ, Breidenthal SE, Dewar K, Hudson TJ, Palmour R, Freimer NB, Ophoff RA. A genetic linkage map of the vervet monkey (Chlorocebus aethiops sabaeus).. Mammalian genome : official journal of the International Mammalian Genome Society, 2007.
  51. Brock GN, Weeks DE, Sobel E, Feingold E. A hierarchical model for estimating significance levels of non-parametric linkage statistics for large pedigrees.. Genetic epidemiology, 2007.
  52. Yellore VS, Papp JC, Sobel E, Khan MA, Rayner SA, Farber DB, Aldave AJ. Replication and refinement of linkage of posterior polymorphous corneal dystrophy to the posterior polymorphous corneal dystrophy 1 locus on chromosome 20.. Genetics in medicine : official journal of the American College of Medical Genetics, 2007.
  53. Lesueur F, Lefèvre C, Has C, Guilloud-Bataille M, Oudot T, Mahé E, Lahfa M, Mansouri S, Mosharraf-Olmolk H, Sobel E, Heath S, Lathrop M, Dizier MH, Prud'Homme JF, Fischer J. Confirmation of psoriasis susceptibility loci on chromosome 6p21 and 20p13 in French families.. The Journal of investigative dermatology, 2007.
  54. Presson AP, Sobel E, Lange K, Papp JC. Merging microsatellite data.. Journal of computational biology : a journal of computational molecular cell biology, 2006.
  55. Lange K, Sobel E. Variance component models for X-linked QTLs.. Genetic epidemiology, 2006.
  56. Riise Stensland HM, Saarela J, Bronnikov DO, Parkkonen M, Jokiaho AJ, Palotie A, Tienari PJ, Sumelahti ML, Elovaara I, Koivisto K, Pirttilä T, Reunanen M, Sobel E, Peltonen L. Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.. Journal of neuroimmunology, 2005.
  57. Lange K, Sinsheimer JS, Sobel E. Association testing with Mendel.. Genetic epidemiology, 2005.
  58. Narain S, Richards HB, Satoh M, Sarmiento M, Davidson R, Shuster J, Sobel E, Hahn P, Reeves WH. Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting.. Archives of internal medicine, 2004.
  59. Lilja HE, Suviolahti E, Soro-Paavonen A, Hiekkalinna T, Day A, Lange K, Sobel E, Taskinen MR, Peltonen L, Perola M, Pajukanta P. Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia.. Journal of lipid research, 2004.
  60. Song KK, Weeks DE, Sobel E, Feingold E. Efficient simulation of P values for linkage analysis.. Genetic epidemiology, 2004.
  61. Saarela J, Schoenberg Fejzo M, Chen D, Finnilä S, Parkkonen M, Kuokkanen S, Sobel E, Tienari PJ, Sumelahti ML, Wikström J, Elovaara I, Koivisto K, Pirttilä T, Reunanen M, Palotie A, Peltonen L. Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24.. Human molecular genetics, 2002.
  62. Wessman M, Kallela M, Kaunisto MA, Marttila P, Sobel E, Hartiala J, Oswell G, Leal SM, Papp JC, Hämäläinen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor RM, Zwart JA, Ilmavirta M, Havanka H, Färkkilä M, Peltonen L, Palotie A. A susceptibility locus for migraine with aura, on chromosome 4q24.. American journal of human genetics, 2002.
  63. Sobel E, Papp JC, Lange K. Detection and integration of genotyping errors in statistical genetics.. American journal of human genetics, 2002.