Eric Sobel*

Eric Martin Sobel

Adjunct Professor, Human Genetics, University of California Los Angeles

Adjunct Professor, Computational Medicine, University of California Los Angeles


Member, Bioinformatics GPB Home Area, Genetics & Genomics GPB Home Area


Eric Sobel received his PhD from the UCLA Department of Biomathematics in 1996. However, having grown up in much colder climates, he does not take Califormia’s beautiful and varied environments for granted. So, after a few years in Oxford and Paris, he and his fellow bioinformatician wife, Jeanette Papp, were glad to return and join the faculty at the newly-minted Department of Human Genetics.


A selected list of publications:
  • Lange, K Sinsheimer, JS Sobel, E   Association testing with Mendel Genetic epidemiology. , 2005; 29(1): 36-50.
  • Lilja, HE Suviolahti, E Soro-Paavonen, A Hiekkalinna, T Day, A Lange, K Sobel, E Taskinen, MR Peltonen, L Perola, M Pajukanta, P   Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia Journal of lipid research. , 2004; 45(10): 1876-84.
  • Song, KK Weeks, DE Sobel, E Feingold, E   Efficient simulation of P values for linkage analysis Genetic epidemiology. , 2004; 26(2): 88-96.
  • Wessman M, Kallela M, Kaunisto MA, Marttila P, Sobel E, Hartiala J, Oswell G, Leal SM, Papp JC, Hamalainen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor R, Zwart J-A, Ilmavirta M, Havanka H, Farkkila M, Peltonen L, Palotie A   A susceptibility locus for migraine with aura on chromosome 4q24, American Journal of Human Genetics, 2002; 70: 652-662.
  • Saarela J, Schoenberg Fejzo M, Chen D, Finnila S, Parkkonen M, Kuokkanen S, Sobel E, Tienari PJ, Sumelahti M-L, Wikstrom J, Elovaara I, Koivisto K, Pirttila T, Reunanen M, Palotie A, Peltonen L   Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24, Human Molecular Genetics, 2002; 11: 2257-2267.
  • Sobel, E Papp, JC Lange, K   Detection and integration of genotyping errors in statistical genetics American journal of human genetics. , 2002; 70(2): 496-508.
  • Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, Suhonen J, Ellonen P, Chan G, Sinsheimer JS, Sobel E, Juvonen H, Arajarvi R, Partonen T, Suvisaari J, Lonnqvist J, Meyer J, Peltonen L   Chromosome 1 loci in Finnish schizophrenia families, Human Molecular Genetics, 2001; 10: 1611-1617.
  • Sobel, E Sengul, H Weeks, DE   Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees Human heredity. , 2001; 52(3): 121-31.
  • Magre J, Delpine M, Khallouf E, Gedde-Dahl T, Van Maldergem L, Sobel E, Papp J, Meier M, Mgarban A, BSCL Working Group, Lathrop M, Capeau J   Mutations in the human homologue of GNG3LG cause Berardinelli-Seip congenital lipodystrophy linked to chromosome 11q13, Nature Genetics, 2001; 28: 365-370.
  • Keavney, B McKenzie, CA Connell, JM Julier, C Ratcliffe, PJ Sobel, E Lathrop, M Farrall, M   Measured haplotype analysis of the angiotensin-I converting enzyme gene Human molecular genetics. , 1998; 7(11): 1745-51.
  • Sobel E, Weeks DE   Haplotype analysis, Encyclopedia of Biostatistics, 1998; 3: 1804-1812.
  • Davis S, Sobel E, Marinov M, Weeks DE   Analysis of bipolar disorder using affected relatives (Genetic Analysis Workshop 10: Detection of genes for complex traits), Genetic Epidemiology, 1997; 14: 605-610.
  • Sobel E, Lange K, O’Connell JR, Weeks DE   Haplotyping algorithms, Genetic mapping and DNA sequencing (IMA Volumes in Mathematics and its Applications), 1996; 81: 89-110.
  • Sobel, E Lange, K   Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics American journal of human genetics. , 1996; 58(6): 1323-37.
  • Lange, E Borresen, AL Chen, X Chessa, L Chiplunkar, S Concannon, P Dandekar, S Gerken, S Lange, K Liang, T   Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium American journal of human genetics. , 1995; 57(1): 112-9.
  • Weeks, DE Sobel, E O’Connell, JR Lange, K   Computer programs for multilocus haplotyping of general pedigrees American journal of human genetics. , 1995; 56(6): 1506-7.
  • Lange E, Gatti RA, Sobel E, Concannon P, Lange K   How many ataxia-telangiectasia genes, Ataxia-Telangiectasia (NATO ASI Series), 1993; H77: 37-54.
  • Sobel, E Lange, K   Metropolis sampling in pedigree analysis Statistical methods in medical research. , 1993; 2(3): 263-82.
  • Sanal, O Lange, E Telatar, M Sobel, E Salazar-Novak, J Ersoy, F Morrison, A Concannon, P Tolun, A Gatti, RA   Ataxia-telangiectasia: linkage analysis of chromosome 11q22-23 markers in Turkish families The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. , 1992; 6(10): 2848-52.
  • Sobel E, Lange E, Jaspers NGJ, Chessa L, Sanal O, Shiloh Y, Taylor AMR, Weemaes CMA, Lange K, Gatti RA   Ataxia-telangiectasia: linkage evidence for genetic heterogeneity, American Journal of Human Genetics, 1992; 50: 1343-1348.
  • Lange, K Sobel, E   A random walk method for computing genetic location scores American journal of human genetics. , 1991; 49(6): 1320-34.
  • Foroud T, Wei S, Ziv Y, Sobel E, Lange E, Chao A, Goradia T, Huo Y, Tolun A, Chessa L, Charmley P, Sanal O, Salman N, Julier C, Concannon P, McConville C, Taylor AMR, Shiloh Y, Lange K, Gatti RA   Localization of an ataxia-telangiectasia locus to a 3 cM interval on chromosome 11q23: linkage analyses of 111 families by an international consortium, American Journal of Human Genetics, 1991; 49: 1263-1279.
  • Gatti RA, Lange E, Sobel E, Lange K   Localization of the ataxia-telangiectasia gene(s) to a 3 cM interval on chromosome 11q23 by linkage analysis, Cytogenetics and Cell Genetics, 1991; 58: 1959-1960.
  • Barstow T, Cooper D, Sobel E, Landaw E, Epstein S   Influence of increased metabolic rate on [13C] bicarbonate washout kinetics, American Journal of Physiology, 1990; 259: R163-R171.
  • Sobel E, Martinez H   A multiple sequence alignment program, Nucleic Acids Research, 1986; 14: 363-374.