Erina Vlashi

Associate Adjunct Professor, Radiation Oncology, University of California Los Angeles


Tumor metabolism and radiation therapy

Education and Training

UCLAPost-doc2010Cancer stem cell radiobiology
Purdue UniversityPhD2007Chemistry


  1. Bailleul J, Ruan Y, Abdulrahman L, Scott AJ, Yazal T, Sung D, Park K, Hoang H, Nathaniel J, Chu FI, Palomera D, Sehgal A, Tsang JE, Nathanson DA, Xu S, Park JO, Ten Hoeve J, Bhat K, Qi N, Kornblum HI, Schaue D, McBride WH, Lyssiotis CA, Wahl DR, Vlashi E. M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.. Neuro-oncology, 2023.
  2. Ludwig K, Le Belle JE, Muthukrishnan SD, Sperry J, Condro M, Vlashi E, Pajonk F, Kornblum HI. Nicotinamide Adenine Dinucleotide Phosphate Oxidase Promotes Glioblastoma Radiation Resistance in a Phosphate and Tensin Homolog-Dependent Manner.. Antioxidants & redox signaling, 2023.
  3. Bailleul J, Vlashi E. Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy Resistance.. Antioxidants & redox signaling, 2023.
  4. Schaue D, Micewicz ED, Ratikan JA, Iwamoto KS, Vlashi E, McDonald JT, McBride WH. NRF2 Mediates Cellular Resistance to Transformation, Radiation, and Inflammation in Mice.. Antioxidants (Basel, Switzerland), 2022.
  5. Read GH, Bailleul J, Vlashi E, Kesarwala AH. Metabolic response to radiation therapy in cancer.. Molecular carcinogenesis, 2021.
  6. Yazal T, Bailleul J, Ruan Y, Sung D, Chu FI, Palomera D, Dao A, Sehgal A, Gurunathan V, Aryan L, Eghbali M, Vlashi E. Radiosensitizing Pancreatic Cancer via Effective Autophagy Inhibition.. Molecular cancer therapeutics, 2021.
  7. Ahmad A, Santanam L, Solanki AA, Padilla L, Vlashi E, Guerrieri P, Dominello MM, Burmeister J, Joiner MC. Three discipline collaborative radiation therapy (3DCRT) special debate: Peer review in radiation oncology is more effective today than 20 years ago.. Journal of applied clinical medical physics, 2020.
  8. Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
  9. Duhachek-Muggy S, Bhat K, Medina P, Cheng F, He L, Alli C, Saki M, Muthukrishnan SD, Ruffenach G, Eghbali M, Vlashi E, Pajonk F. Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine.. Stem cells translational medicine, 2019.
  10. Zhang L, Bailleul J, Yazal T, Dong K, Sung D, Dao A, Gosa L, Nathanson D, Bhat K, Duhachek-Muggy S, Alli C, Dratver MB, Pajonk F, Vlashi E. PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.. Breast cancer research and treatment, 2019.
  11. Jung SY, Malhotra P, Nguyen KC, Salzman D, Qi Y, Pak EH, King J, Vlashi E, Ann D, Weidhaas JB. The KRAS-variant and its impact on normal breast epithelial cell biology.. Cell death and differentiation, 2019.
  12. Mohindra P, Sawant A, Griffin RJ, Lamichhane N, Vlashi E, Xu-Welliver M, Dominello M, Joiner MC, Burmeister J. Three discipline collaborative radiation therapy (3DCRT) special debate: I would treat all early-stage NSCLC patients with SBRT.. Journal of applied clinical medical physics, 2019.
  13. Steinberg ML, McBride WH, Vlashi E, Pajonk F. If It Seems Too Good to Be True….. International journal of radiation oncology, biology, physics, 2019.
  14. Bhat K, Sandler K, Duhachek-Muggy S, Alli C, Cheng F, Moatamed NA, Magyar CE, Du L, Li G, McCloskey S, Vlashi E, Pajonk F. Serum erythropoietin levels, breast cancer and breast cancer-initiating cells.. Breast cancer research : BCR, 2019.
  15. Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. 1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018.
  16. Zhang L, Bochkur Dratver M, Yazal T, Dong K, Nguyen A, Yu G, Dao A, Bochkur Dratver M, Duhachek-Muggy S, Bhat K, Alli C, Pajonk F, Vlashi E. Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer.. International journal of radiation oncology, biology, physics, 2018.
  17. Duhachek-Muggy S, Bhat K, Vlashi E, Pajonk F. Growth Differentiation Factor 11 does not Mitigate the Lethal Effects of Total-Abdominal Irradiation.. Radiation research, 2017.
  18. Zhang L, Xu L, Zhang F, Vlashi E. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer.. Cell cycle (Georgetown, Tex.), 2016.
  19. Vlashi E, Chen AM, Boyrie S, Yu G, Nguyen A, Brower PA, Hess CB, Pajonk F. Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells Into Cancer Stem Cells Depends on Human Papillomavirus Status.. International journal of radiation oncology, biology, physics, 2016.
  20. Vlashi E, Pajonk F. The metabolic state of cancer stem cells-a valid target for cancer therapy?. Free radical biology & medicine, 2014.
  21. Varghese B, Vlashi E, Xia W, Ayala Lopez W, Paulos CM, Reddy J, Xu LC, Low PS. Folate receptor-β in activated macrophages: ligand binding and receptor recycling kinetics.. Molecular pharmaceutics, 2014.
  22. Vlashi E, Pajonk F. Cancer stem cells, cancer cell plasticity and radiation therapy.. Seminars in cancer biology, 2014.
  23. Vlashi E, Lagadec C, Vergnes L, Reue K, Frohnen P, Chan M, Alhiyari Y, Dratver MB, Pajonk F. Metabolic differences in breast cancer stem cells and differentiated progeny.. Breast cancer research and treatment, 2014.
  24. Lagadec C, Vlashi E, Bhuta S, Lai C, Mischel P, Werner M, Henke M, Pajonk F. Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients.. BMC cancer, 2014.
  25. Lagadec C, Vlashi E, Frohnen P, Alhiyari Y, Chan M, Pajonk F. The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells.. Stem cells (Dayton, Ohio), 2014.
  26. Pajonk F, Vlashi E. Characterization of the stem cell niche and its importance in radiobiological response.. Seminars in radiation oncology, 2013.
  27. Vlashi E, Kelderhouse LE, Sturgis JE, Low PS. Effect of folate-targeted nanoparticle size on their rates of penetration into solid tumors.. ACS nano, 2013.
  28. Vlashi E, Lagadec C, Chan M, Frohnen P, McDonald AJ, Pajonk F. Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression.. Breast cancer research and treatment, 2013.
  29. Lagadec C, Vlashi E, Alhiyari Y, Phillips TM, Bochkur Dratver M, Pajonk F. Radiation-induced Notch signaling in breast cancer stem cells.. International journal of radiation oncology, biology, physics, 2013.
  30. Steinberg M, McBride WH, Vlashi E, Pajonk F. National Institutes of Health funding in radiation oncology: a snapshot.. International journal of radiation oncology, biology, physics, 2013.
  31. Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Pajonk F. Radiation-induced reprogramming of breast cancer cells.. Stem cells (Dayton, Ohio), 2012.
  32. Yang J, Vlashi E, Low P. Folate-linked drugs for the treatment of cancer and inflammatory diseases.. Sub-cellular biochemistry, 2012.
  33. Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Metabolic state of glioma stem cells and nontumorigenic cells.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
  34. McDonald JT, Kim K, Norris AJ, Vlashi E, Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky L, McBride WH. Ionizing radiation activates the Nrf2 antioxidant response.. Cancer research, 2010.
  35. Pajonk F, Vlashi E, McBride WH. Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited.. Stem cells (Dayton, Ohio), 2010.
  36. Lagadec C, Vlashi E, Della Donna L, Meng Y, Dekmezian C, Kim K, Pajonk F. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment.. Breast cancer research : BCR, 2010.
  37. Vlashi E, Pajonk F. Targeted cancer stem cell therapies start with proper identification of the target.. Molecular cancer research : MCR, 2010.
  38. Vlashi E, Mattes M, Lagadec C, Donna LD, Phillips TM, Nikolay P, McBride WH, Pajonk F. Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells.. Translational oncology, 2010.
  39. Vlashi E, Sturgis JE, Thomas M, Low PS. Real time, noninvasive imaging and quantitation of the accumulation of ligand-targeted drugs into receptor-expressing solid tumors.. Molecular pharmaceutics, 2009.
  40. Vlashi E, McBride WH, Pajonk F. Radiation responses of cancer stem cells.. Journal of cellular biochemistry, 2009.
  41. Vlashi E, Kim K, Lagadec C, Donna LD, McDonald JT, Eghbali M, Sayre JW, Stefani E, McBride W, Pajonk F. In vivo imaging, tracking, and targeting of cancer stem cells.. Journal of the National Cancer Institute, 2009.
  42. Phillips TM, Kim K, Vlashi E, McBride WH, Pajonk F. Effects of recombinant erythropoietin on breast cancer-initiating cells.. Neoplasia (New York, N.Y.), 2007.
  43. Acharya G, Chang CL, Doorneweerd DD, Vlashi E, Henne WA, Hartmann LC, Low PS, Savran CA. Immunomagnetic diffractometry for detection of diagnostic serum markers.. Journal of the American Chemical Society, 2007.
  44. Paulos CM, Varghese B, Widmer WR, Breur GJ, Vlashi E, Low PS. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis.. Arthritis research & therapy, 2006.