Frank Pajonk
Professor, Radiation Oncology, University of California Los Angeles
Professor, Neurosurgery, University of California Los Angeles
fpajonk@mednet.ucla.edu
310-206-8733
UCLA Rad Onc
BOX 951714
B3-109 CHS
Los Angeles, CA 90095
Fax Number:
310-206-1260
Affiliations
Member, Cell & Developmental Biology GPB Home Area, JCCC Signal Transduction and Therapeutics Program Area
Publications
A selected list of publications:
- Vlashi Erina, Lagadec Chann, Vergnes Laurent, Matsutani Tomoo, Masui Kenta, Poulou Maria, Popescu Ruxandra, Della Donna Lorenza, Evers Patrick, Dekmezian Carmen, Reue Karen, Christofk Heather, Mischel Paul S, Pajonk Frank Metabolic state of glioma stem cells and nontumorigenic cells Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(38): 16062-7.
- Donna Lorenza Della, Lagadec Chann, Pajonk Frank Radioresistance of prostate cancer cells with low proteasome activity The Prostate, 2011; 108(38): .
- Vlashi Erina, Mattes Malcom, Lagadec Chann, Donna Lorenza Della, Phillips Tiffany M, Nikolay Polin, McBride William H, Pajonk Frank Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells Translational oncology, 2010; 3(1): 50-5.
- Evers Patrick, Lee Percy P, DeMarco John, Agazaryan Nzhde, Sayre James W, Selch Michael, Pajonk Frank Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma BMC cancer, 2010; 10(38): 384.
- Pajonk Frank, Vlashi Erina, McBride William H Radiation resistance of cancer stem cells: the 4 R’s of radiobiology revisited Stem cells (Dayton, Ohio), 2010; 28(4): 639-48.
- Lagadec Chann, Vlashi Erina, Della Donna Lorenza, Meng Yonghong, Dekmezian Carmen, Kim Kwanghee, Pajonk Frank Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment Breast cancer research : BCR, 2010; 12(1): R13.
- Vlashi Erina, Pajonk Frank Targeted cancer stem cell therapies start with proper identification of the target Molecular cancer research : MCR, 2010; 8(2): 291; author reply 291.
- Vlashi, E. Kim, K. Dealla Donna, L. Lagadec, C. McDonald, T Eghbali, M. Sayre, JW. Stefani, E. McBride, WH. Pajonk, F. In-vivo imaging, tracking, and targeting of cancer stem cells J Natl Cancer Inst, 2009; 101(5): 350-359.
- Woodward, W. A. Bristow, R. G. Clarke, M. F. Coppes, R. P. Cristofanilli, M. Duda, D. G. Fike, J. R. Hambardzumyan, D. Hill, R. P. Jordan, C. T. Milas, L. Pajonk, F. Curran, W. J. Dicker, A. P. Chen, Y. Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials Int J Radiat Oncol Biol Phys, 2009; volume(number): pages.
- Vlashi Erina, McBride William H, Pajonk Frank Radiation responses of cancer stem cells Journal of cellular biochemistry, 2009; 108(2): 339-42.
- Phillips, T. M. Kim, K. Vlashi, E. McBride, W. H. Pajonk, F. Effects of recombinant erythropoietin on breast cancer-initiating cells Neoplasia, 2007; 9(12): 1122-9.
- Henke, M. Mattern, D. Pepe, M. Bezay, C. Weissenberger, C. Werner, M. Pajonk, F. Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol, 2006; 24(29): 4708-13.
- Henke, M. Mattern, D. Pepe, M. Bezay, C. Weissenberger, C. Werner, M. Pajonk, F. Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol, 2006; 24(29): 4708-13.
- Pajonk, F. Riedisser, A. Henke, M. McBride, W.H. Fiebich, B. The Effects Of Tea Extracts On Proinflammatory Signaling BMC Medicine, 2006; 4(28): pages.
- Pajonk, F. Grumann, T. McBride, W. H. The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation Neoplasia, 2006; 8(12): 1037-41.
- Phillips, T. M. McBride, W. H. Pajonk, F. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation J Natl Cancer Inst, 2006; 98(24): 1777-85.
- Fekete, M. R. McBride, W. H. Pajonk, F. Anthracyclines, proteasome activity and mult-drug-resistance BMC Cancer, 2005; 5(1): 114.
- Pajonk, F. Scholber, J. Fiebich, B. Hypericin-an inhibitor of proteasome function Cancer Chemother Pharmacol, 2005; 55(5): 439-46.
- Pajonk, F. van Ophoven, A. McBride, W. H. Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells Cancer Res, 2005; 65(11): 4836-43.
- Pajonk, F. van Ophoven, A. Weissenberger, C. McBride, W. H. The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism BMC Cancer, 2005; 5(1): 76.
- McBride, W. H. Chiang, C. S. Olson, J. L. Wang, C. C. Hong, J. H. Pajonk, F. Dougherty, G. J. Iwamoto, K. S. Pervan, M. Liao, Y. P. A sense of danger from radiation Radiat Res, 2004; 162(1): 1-19.
- Henke, M. Pajonk, F. Erythropoietin to treat anaemia in patients with head and neck cancer. The Lancet, 2004; 363(9413): 993.
- Pajonk, F. Weil, A. Sommer, A. Suwinski, R. Henke, M. The erythropoietin-receptor pathway modulates survival of cancer cells Oncogene, 2004; 23(55): 8987-91.
- McBride, W. H. Iwamoto, K. S. Syljuasen, R. Pervan, M. Pajonk, F. The role of the ubiquitin/proteasome system in cellular responses to radiation Oncogene, 2003; 22(37): 5755-73.
- Pajonk, F. Riess, K. Sommer, A. McBride, W. H. N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation Free Radic Biol Med, 2002; 32(6): 536-43.
- McBride, W. H. Pajonk, F. Chiang, C. S. Sun, J. R. NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure Mil Med, 2002; 167(2 Suppl): 66-7.
- Pajonk, F. McBride, W. H. Survival of AIDS patients with primary central nervous system lymphoma may be improved by the radiosensitizing effects of highly active antiretroviral therapy Aids, 2002; 16(8): 1195-6.
- Pajonk, F. Himmelsbach, J. Riess, K. Sommer, A. McBride, W. H. The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells Cancer Res, 2002; 62(18): 5230-5.
- Pajonk, F. Weissenberger, C. Witucki, G. Henke, M. Vitiligo at the sites of irradiation in a patient with Hodgkin’s disease Strahlenther Onkol, 2002; 178(3): 159-62.
- Pajonk, F. Schlessmann, S. Guttenberger, R. Henke, M. Epithelial cells in the peripheral blood of patients with cancer of the head and neck: incidence, detection and possible clinical significance Radiother Oncol, 2001; 59(2): 213-7..
- Pajonk, F. McBride, W. H. Ionizing radiation affects 26s proteasome function and associated molecular responses, even at low doses Radiother Oncol, 2001; 59(2): 203-12..
- Pervan, M. Pajonk, F. Sun, J. R. Withers, H. R. McBride, W. H. Molecular pathways that modify tumor radiation response Am J Clin Oncol, 2001; 24(5): 481-5.
- Pajonk, F. McBride, W. H. The Proteasome in Cancer Biology and Treatment Radiat Res, 2001; 156(5): 447-459.
- Pervan, Milena Pajonk, Frank Sun, Ji-Rong Withers, Rodney H. McBride, William H. The proteasome inhibitor PS-341 is a potential radiosensitizer Proceedings of the American Association for Cancer Research Annual Meeting, 2001; 42(number): 666-667.
- Pajonk, F. Pajonk, K. McBride, W. H. Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition International Journal of Radiation Oncology, Biology, Physics, 2000; 47(4): 1025-32.
- Pajonk, F. McBride, W. H. Comment on double-strand break repair and rapamycin treatment Int J Radiat Biol, 2000; 76(12): 1691-3..
- Henke, M. Guttenberger, R. Barke, A. Pajonk, F. Potter, R. Frommhold, H. Erythropoietin for patients undergoing radiotherapy: a pilot study Radiother Oncol, 1999; 50(2): 185-90..
- Pajonk, F. Pajonk, K. McBride, W. H. Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cells Journal of the National Cancer Institute, 1999; 91(22): 1956-60.
- Pajonk, F. Flick, H. Mittelviefhaus, H. Slanina, J. Postoperative pterygium prevention by radiotherapy with strontium-90 beta-rays Frontiers of Radiation Therapy and Oncology, 1997; 30(7): 259-64.
- Henke Michael, Mattern Dominik, Pepe Margaret, Bézay Christina, Weissenberger Christian, Werner Martin, Pajonk Frank Do erythropoietin receptors on cancer cells explain unexpected clinical findings? Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006; 24(29): 4708-13.
- Lagadec Chann, Vlashi Erina, Bhuta Sunita, Lai Chi, Mischel Paul, Werner Martin, Henke Michael, Pajonk Frank Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients BMC cancer, 2014; 14: 152.
- Fekete Mirela R, McBride William H, Pajonk Frank Anthracyclines, proteasome activity and multi-drug-resistance BMC cancer, 2005; 5(4 Pt 1): 114.
- van Ophoven Arndt, Rossbach Gordon, Pajonk Frank, Hertle Lothar Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial The Journal of urology, 2006; 176(4 Pt 1): 1442-6.
- Lagadec Chann, Vlashi Erina, Frohnen Patricia, Alhiyari Yazeed, Chan Mabel, Pajonk Frank The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells Stem cells (Dayton, Ohio), 2014; 32(1): 135-44.
- Pajonk Frank, van Ophoven Arndt, Weissenberger Christian, McBride William H The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism BMC cancer, 2005; 5(4 Pt 1): 76.
- Lagadec Chann, Vlashi Erina, Alhiyari Yazeed, Phillips Tiffany M, Bochkur Dratver Milana, Pajonk Frank Radiation-induced Notch signaling in breast cancer stem cells International journal of radiation oncology, biology, physics, 2013; 87(3): 609-18.
- Pajonk Frank, van Ophoven Arndt, McBride William H Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells Cancer research, 2005; 65(11): 4836-43.
- Pajonk Frank, Vlashi Erina Characterization of the stem cell niche and its importance in radiobiological response Seminars in radiation oncology, 2013; 23(4): 237-41.
- Pajonk Frank, Weil Antonia, Sommer Alfred, Suwinski Rafal, Henke Michael The erythropoietin-receptor pathway modulates survival of cancer cells Oncogene, 2004; 23(55): 8987-91.
- Vlashi Erina, Lagadec Chann, Chan Mabel, Frohnen Patricia, McDonald Alexandra Jean, Pajonk Frank Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression Breast cancer research and treatment, 2013; 141(2): 197-203.
- McBride William H, Chiang Chi-Shiun, Olson Jennifer L, Wang Chun-Chieh, Hong Ji-Hong, Pajonk Frank, Dougherty Graeme J, Iwamoto Keisuke S, Pervan Milena, Liao Yu-Pei A sense of danger from radiation Radiation research, 2004; 162(1): 1-19.
- Steinberg Michael, McBride William H, Vlashi Erina, Pajonk Frank National Institutes of Health funding in radiation oncology: a snapshot International journal of radiation oncology, biology, physics, 2013; 86(2): 234-40.
- McBride William H, Iwamoto Keisuke S, Syljuasen Randi, Pervan Milena, Pajonk Frank The role of the ubiquitin/proteasome system in cellular responses to radiation Oncogene, 2003; 22(37): 5755-73.
- Lagadec Chann, Pajonk Frank Catch-22: does breast cancer radiotherapy have negative impacts too? Future oncology (London, England), 2012; 8(6): 643-5.
- Pajonk Frank, Himmelsbach Judith, Riess Katrin, Sommer Alfred, McBride William H The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells Cancer research, 2002; 62(18): 5230-5.
- Lagadec Chann, Vlashi Erina, Della Donna Lorenza, Dekmezian Carmen, Pajonk Frank Radiation-induced reprogramming of breast cancer cells Stem cells (Dayton, Ohio), 2012; 30(5): 833-44.
- Pajonk Frank, McBride William H Survival of AIDS patients with primary central nervous system lymphoma may be improved by the radiosensitizing effects of highly active antiretroviral therapy AIDS (London, England), 2002; 16(8): 1195-6.
- Lagadec Chann, Dekmezian Carmen, Bauché Lucile, Pajonk Frank Oxygen levels do not determine radiation survival of breast cancer stem cells PloS one, 2012; 7(3): e34545.
- Woodward Wendy A, Bristow Robert G, Clarke Michael F, Coppes Robert P, Cristofanilli Massimo, Duda Dan G, Fike John R, Hambardzumyan Dolores, Hill Richard P, Jordan Craig T, Milas Luka, Pajonk Frank, Curran Walter J, Dicker Adam P, Chen Yuhchyau Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials International journal of radiation oncology, biology, physics, 2009; 74(5): 1580-91.
- Pajonk Frank, Riess Katrin, Sommer Alfred, McBride William H N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation Free radical biology & medicine, 2002; 32(6): 536-43.
- Vlashi Erina, Kim Kwanghee, Lagadec Chann, Donna Lorenza Della, McDonald John Tyson, Eghbali Mansoureh, Sayre James W, Stefani Encrico, McBride William, Pajonk Frank In vivo imaging, tracking, and targeting of cancer stem cells Journal of the National Cancer Institute, 2009; 101(5): 350-9.
- McBride William H, Pajonk Frank, Chiang Chi-Shuin, Sun Ji-Rong NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure Military medicine, 2002; 167(2 Suppl): 66-7.
- Pajonk Frank, Weissenberger Christian, Witucki Gerlo, Henke Michael Vitiligo at the sites of irradiation in a patient with Hodgkin’s disease Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft … [et al], 2002; 178(3): 159-62.
- Phillips Tiffany M, Kim Kwanghee, Vlashi Erina, McBride William H, Pajonk Frank Effects of recombinant erythropoietin on breast cancer-initiating cells Neoplasia (New York, N.Y.), 2007; 9(12): 1122-9.
- Phillips Tiffany M, McBride William H, Pajonk Frank The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation Journal of the National Cancer Institute, 2006; 98(24): 1777-85.
- Pajonk Frank, Riedisser Anja, Henke Michael, McBride William H, Fiebich Bernd The effects of tea extracts on proinflammatory signaling BMC medicine, 2006; 4(24): 28.
- Pajonk Frank, Grumann Thorsten, McBride William H The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation Neoplasia (New York, N.Y.), 2006; 8(12): 1037-41.
- Vlashi Erina, Lagadec Chann, Vergnes Laurent, Reue Karen, Frohnen Patricia, Chan Mabel, Alhiyari Yazeed, Dratver Milana Bochkur, Pajonk Frank Metabolic differences in breast cancer stem cells and differentiated progeny Breast cancer research and treatment, 2014; 146(3): 525-34.
- Vlashi Erina, Pajonk Frank Cancer stem cells, cancer cell plasticity and radiation therapy Seminars in cancer biology, 2015; 31: 28-35.
- Yu Victoria Y, Nguyen Dan, Pajonk Frank, Kupelian Patrick, Kaprealian Tania, Selch Michael, Low Daniel A, Sheng Ke Incorporating cancer stem cells in radiation therapy treatment response modeling and the implication in glioblastoma multiforme treatment resistance International journal of radiation oncology, biology, physics, 2015; 91(4): 866-75.
- Vlashi Erina, Pajonk Frank The metabolic state of cancer stem cells-a valid target for cancer therapy? Free radical biology & medicine, 2015; 79(4): 264-8.
Publications
- He L, Bhat K, Ioannidis A, Pajonk F. Effects of Dopamine Receptor Antagonists and Radiation on Mouse Neural Stem/Progenitor Cells.. bioRxiv : the preprint server for biology, 2023.
- Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.. Nature communications, 2022.
- Hölzle P, Frank A, Hörmann S, Pajonk FG, Förstl H. [Excited Delirium Syndrome (ExDS): emergence and emergency management].. Deutsche medizinische Wochenschrift (1946), 2021.
- Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma.. Journal of the National Cancer Institute, 2021.
- He L, Bhat K, Ioannidis A, Zhang L, Nguyen NT, Allen JE, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021.
- Muftuoglu Y, Pajonk F. Targeting Glioma Stem Cells.. Neurosurgery clinics of North America, 2021.
- He L, Bhat K, Duhacheck-Muggy S, Ioannidis A, Zhang L, Nguyen NT, Moatamed NA, Pajonk F. Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer.. Neoplasia (New York, N.Y.), 2020.
- Bhat K, Medina P, He L, Zhang L, Saki M, Ioannidis A, Nguyen NT, Sodhi SS, Sung D, Magyar CE, Liau LM, Kornblum HI, Pajonk F. 1-[(4-Nitrophenyl)sulfonyl]-4-phenylpiperazine treatment after brain irradiation preserves cognitive function in mice.. Neuro-oncology, 2020.
- Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
- Saki M, Bhat K, Sodhi SS, Nguyen NT, Kornblum HI, Pajonk F. Effects of Brain Irradiation in Immune-Competent and Immune-Compromised Mouse Models.. Radiation research, 2019.
- Duhachek-Muggy S, Bhat K, Medina P, Cheng F, He L, Alli C, Saki M, Muthukrishnan SD, Ruffenach G, Eghbali M, Vlashi E, Pajonk F. Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine.. Stem cells translational medicine, 2019.
- Zhang L, Bailleul J, Yazal T, Dong K, Sung D, Dao A, Gosa L, Nathanson D, Bhat K, Duhachek-Muggy S, Alli C, Dratver MB, Pajonk F, Vlashi E. PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.. Breast cancer research and treatment, 2019.
- Steinberg ML, McBride WH, Vlashi E, Pajonk F. If It Seems Too Good to Be True�.. International journal of radiation oncology, biology, physics, 2019.
- Bhat K, Sandler K, Duhachek-Muggy S, Alli C, Cheng F, Moatamed NA, Magyar CE, Du L, Li G, McCloskey S, Vlashi E, Pajonk F. Serum erythropoietin levels, breast cancer and breast cancer-initiating cells.. Breast cancer research : BCR, 2019.
- Messer T, Pajonk FB, Schmauß M. Untitled Publication. Fortschritte der Neurologie-Psychiatrie, 2019.
- Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. 1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018.
- Zhang L, Bochkur Dratver M, Yazal T, Dong K, Nguyen A, Yu G, Dao A, Bochkur Dratver M, Duhachek-Muggy S, Bhat K, Alli C, Pajonk F, Vlashi E. Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer.. International journal of radiation oncology, biology, physics, 2018.
- Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.. Cancer & metabolism, 2018.
- Kirsch DG, Diehn M, Kesarwala AH, Maity A, Morgan MA, Schwarz JK, Bristow R, Demaria S, Eke I, Griffin RJ, Haas-Kogan D, Higgins GS, Kimmelman AC, Kimple RJ, Lombaert IM, Ma L, Marples B, Pajonk F, Park CC, Schaue D, Tran PT, Bernhard EJ. The Future of Radiobiology.. Journal of the National Cancer Institute, 2018.
- Qi XS, Pajonk F, McCloskey S, Low DA, Kupelian P, Steinberg M, Sheng K. Radioresistance of the breast tumor is highly correlated to its level of cancer stem cell and its clinical implication for breast irradiation.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017.
- Duhachek-Muggy S, Bhat K, Vlashi E, Pajonk F. Growth Differentiation Factor 11 does not Mitigate the Lethal Effects of Total-Abdominal Irradiation.. Radiation research, 2017.
- Vlashi E, Chen AM, Boyrie S, Yu G, Nguyen A, Brower PA, Hess CB, Pajonk F. Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells Into Cancer Stem Cells Depends on Human Papillomavirus Status.. International journal of radiation oncology, biology, physics, 2016.
- Yu VY, Nguyen D, Pajonk F, Kupelian P, Kaprealian T, Selch M, Low DA, Sheng K. Incorporating cancer stem cells in radiation therapy treatment response modeling and the implication in glioblastoma multiforme treatment resistance.. International journal of radiation oncology, biology, physics, 2015.
- Vlashi E, Pajonk F. The metabolic state of cancer stem cells-a valid target for cancer therapy?. Free radical biology & medicine, 2014.
- Vlashi E, Pajonk F. Cancer stem cells, cancer cell plasticity and radiation therapy.. Seminars in cancer biology, 2014.
- Vlashi E, Lagadec C, Vergnes L, Reue K, Frohnen P, Chan M, Alhiyari Y, Dratver MB, Pajonk F. Metabolic differences in breast cancer stem cells and differentiated progeny.. Breast cancer research and treatment, 2014.
- Lagadec C, Vlashi E, Bhuta S, Lai C, Mischel P, Werner M, Henke M, Pajonk F. Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients.. BMC cancer, 2014.
- Lagadec C, Vlashi E, Frohnen P, Alhiyari Y, Chan M, Pajonk F. The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells.. Stem cells (Dayton, Ohio), 2014.
- Pajonk F, Vlashi E. Characterization of the stem cell niche and its importance in radiobiological response.. Seminars in radiation oncology, 2013.
- Vlashi E, Lagadec C, Chan M, Frohnen P, McDonald AJ, Pajonk F. Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression.. Breast cancer research and treatment, 2013.
- Lagadec C, Vlashi E, Alhiyari Y, Phillips TM, Bochkur Dratver M, Pajonk F. Radiation-induced Notch signaling in breast cancer stem cells.. International journal of radiation oncology, biology, physics, 2013.
- Steinberg M, McBride WH, Vlashi E, Pajonk F. National Institutes of Health funding in radiation oncology: a snapshot.. International journal of radiation oncology, biology, physics, 2013.
- Falkai P, Malchow B, Wobrock T, Gruber O, Schmitt A, Honer WG, Pajonk FG, Sun F, Cannon TD. The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study.. European archives of psychiatry and clinical neuroscience, 2012.
- Lagadec C, Pajonk F. Catch-22: does breast cancer radiotherapy have negative impacts too?. Future oncology (London, England), 2012.
- Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Pajonk F. Radiation-induced reprogramming of breast cancer cells.. Stem cells (Dayton, Ohio), 2012.
- Lagadec C, Dekmezian C, Bauch? L, Pajonk F. Oxygen levels do not determine radiation survival of breast cancer stem cells.. PloS one, 2012.
- Pajonk FG, Cransac P, M?ller V, Teichmann A, Meyer W. Trauma and stress-related disorders in German emergency physicians: the predictive role of personality factors.. International journal of emergency mental health, 2012.
- Della Donna L, Lagadec C, Pajonk F. Radioresistance of prostate cancer cells with low proteasome activity.. The Prostate, 2011.
- Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Metabolic state of glioma stem cells and nontumorigenic cells.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
- Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan D, Cusack JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, McBride W, McConkey DJ, Miller CP, Neuteboom ST, Oki Y, Ovaa H, Pajonk F, Richardson PG, Roccaro AM, Sloss CM, Spear MA, Valashi E, Younes A, Palladino MA. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials.. Current cancer drug targets, 2011.
- Evers P, Lee PP, DeMarco J, Agazaryan N, Sayre JW, Selch M, Pajonk F. Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma.. BMC cancer, 2010.
- Pajonk F, Vlashi E, McBride WH. Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited.. Stem cells (Dayton, Ohio), 2010.
- Lagadec C, Vlashi E, Della Donna L, Meng Y, Dekmezian C, Kim K, Pajonk F. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment.. Breast cancer research : BCR, 2010.
- Vlashi E, Pajonk F. Targeted cancer stem cell therapies start with proper identification of the target.. Molecular cancer research : MCR, 2010.
- Vlashi E, Mattes M, Lagadec C, Donna LD, Phillips TM, Nikolay P, McBride WH, Pajonk F. Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells.. Translational oncology, 2010.
- Vlashi E, McBride WH, Pajonk F. Radiation responses of cancer stem cells.. Journal of cellular biochemistry, 2009.
- Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y. Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.. International journal of radiation oncology, biology, physics, 2009.
- Vlashi E, Kim K, Lagadec C, Donna LD, McDonald JT, Eghbali M, Sayre JW, Stefani E, McBride W, Pajonk F. In vivo imaging, tracking, and targeting of cancer stem cells.. Journal of the National Cancer Institute, 2009.
- Kinn M, Holzbach R, Pajonk FG. [Substance-abuse related emergencies--illegal drugs, part II].. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2008.
- Kinn M, Holzbach R, Pajonk FG. [Substance-abuse related emergencies--illegal drugs, part I].. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2008.
- Kessler H, Pajonk FG, Bach D, Schneider-Axmann T, Falkai P, Herrmann W, Multhaup G, Wiltfang J, Schäfer S, Wirths O, Bayer TA. Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.. Journal of neural transmission (Vienna, Austria : 1996), 2008.
- Kinn M, Holzbach R, Pajonk FG. [Alcohol-related disorders in the preclinical medicine].. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2008.
- Heres S, Hamann J, Mendel R, Wickelmaier F, Pajonk FG, Leucht S, Kissling W. Identifying the profile of optimal candidates for antipsychotic depot therapy A cluster analysis.. Progress in neuro-psychopharmacology & biological psychiatry, 2008.
- Pajonk FG, Schmitt P, Biedler A, Richter JC, Meyer W, Luiz T, Madler C. Psychiatric emergencies in prehospital emergency medical systems: a prospective comparison of two urban settings.. General hospital psychiatry, 2008.
- Pajonk FG, D'Amelio R. [Psychosocial emergencies--Agitation, aggression and violence in emergency and search and rescue services].. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2008.
- Kessler H, Bayer TA, Bach D, Schneider-Axmann T, Supprian T, Herrmann W, Haber M, Multhaup G, Falkai P, Pajonk FG. Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.. Journal of neural transmission (Vienna, Austria : 1996), 2008.
- Karow A, Pajonk FG, Reimer J, Hirdes F, Osterwald C, Naber D, Moritz S. The dilemma of insight into illness in schizophrenia: self- and expert-rated insight and quality of life.. European archives of psychiatry and clinical neuroscience, 2008.
- Schmitt TK, Pajonk FG. [Postoperative delirium in the critically ill].. Der Anaesthesist, 2008.
- Phillips TM, Kim K, Vlashi E, McBride WH, Pajonk F. Effects of recombinant erythropoietin on breast cancer-initiating cells.. Neoplasia (New York, N.Y.), 2007.
- Heres S, Schmitz FS, Leucht S, Pajonk FG. The attitude of patients towards antipsychotic depot treatment.. International clinical psychopharmacology, 2007.
- Schäfer S, Pajonk FG, Multhaup G, Bayer TA. Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels.. Journal of molecular medicine (Berlin, Germany), 2007.
- Scherk H, Pajonk FG, Leucht S. Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials.. Archives of general psychiatry, 2007.
- Schäfer S, Pajonk FG, Multhaup G, Bayer TA. Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels.. Journal of molecular medicine (Berlin, Germany), 2007.
- Phillips TM, McBride WH, Pajonk F. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation.. Journal of the National Cancer Institute, 2006.
- Pajonk F, Riedisser A, Henke M, McBride WH, Fiebich B. The effects of tea extracts on proinflammatory signaling.. BMC medicine, 2006.
- Pajonk F, Grumann T, McBride WH. The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation.. Neoplasia (New York, N.Y.), 2006.
- Karow A, Pajonk FG. Insight and quality of life in schizophrenia: recent findings and treatment implications.. Current opinion in psychiatry, 2006.
- Henke M, Mattern D, Pepe M, Bézay C, Weissenberger C, Werner M, Pajonk F. Do erythropoietin receptors on cancer cells explain unexpected clinical findings?. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006.
- van Ophoven A, Rossbach G, Pajonk F, Hertle L. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial.. The Journal of urology, 2006.
- Kessler H, Pajonk FG, Meisser P, Schneider-Axmann T, Hoffmann KH, Supprian T, Herrmann W, Obeid R, Multhaup G, Falkai P, Bayer TA. Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease.. Journal of neural transmission (Vienna, Austria : 1996), 2006.
- Richter JC, Waydhas C, Pajonk FG. Incidence of posttraumatic stress disorder after prolonged surgical intensive care unit treatment.. Psychosomatics, 2006.
- Pajonk FG. [Not Available].. MMW Fortschritte der Medizin, 2006.
- Pajonk FG. Clinical trial design in schizophrenia: implications for clinical decisions.. Current opinion in psychiatry, 2005.
- Pajonk FG, Schwertner AK, Seelig MA. Rapid dose titration of quetiapine for the treatment of acute schizophrenia and acute mania: a case series.. Journal of psychopharmacology (Oxford, England), 2005.
- Fekete MR, McBride WH, Pajonk F. Anthracyclines, proteasome activity and multi-drug-resistance.. BMC cancer, 2005.
- Pajonk FG, Kessler H, Supprian T, Hamzei P, Bach D, Schweickhardt J, Herrmann W, Obeid R, Simons A, Falkai P, Multhaup G, Bayer TA. Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease.. Journal of Alzheimer's disease : JAD, 2005.
- Pajonk FG, Schreiner A, Peters S, Rettig K, Degner D, Rüther E. Risperidone: an open-label, observational study of the efficacy, tolerability, and prescribing behavior in acutely exacerbated patients with schizophrenia.. Journal of clinical psychopharmacology, 2005.
- Pajonk F, van Ophoven A, Weissenberger C, McBride WH. The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.. BMC cancer, 2005.
- Pajonk F, van Ophoven A, McBride WH. Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells.. Cancer research, 2005.
- Kessler H, Pajonk FG, Supprian T, Falkai P, Multhaup G, Bayer TA. [The role of copper in the pathophysiology of Alzheimer's disease].. Der Nervenarzt, 2005.
- Pajonk FG, Wobrock T, Falkai P. [Longterm therapy of schizophrenia].. Fortschritte der Neurologie-Psychiatrie, 2005.
- Pajonk FG, Ruchholtz S, Waydhas C, Schneider-Axmann T. Long-term follow-up after severe suicide attempt by multiple blunt trauma.. European psychiatry : the journal of the Association of European Psychiatrists, 2005.
- Pajonk FG, Wobrock T, Falkai P. [Longterm therapy of schizophrenia].. Fortschritte der Neurologie-Psychiatrie, 2005.
- Pajonk F, Scholber J, Fiebich B. Hypericin-an inhibitor of proteasome function.. Cancer chemotherapy and pharmacology, 2005.
- Wobrock T, Falkai P, Pajonk FG. [Acute treatment of schizophrenia].. Fortschritte der Neurologie-Psychiatrie, 2004.
- Pajonk F, Weil A, Sommer A, Suwinski R, Henke M. The erythropoietin-receptor pathway modulates survival of cancer cells.. Oncogene, 2004.
- Retz W, Retz-Junginger P, Hengesch G, Schneider M, Thome J, Pajonk FG, Salahi-Disfan A, Rees O, Wender PH, Rösler M. Psychometric and psychopathological characterization of young male prison inmates with and without attention deficit/hyperactivity disorder.. European archives of psychiatry and clinical neuroscience, 2004.
- Pajonk FG, Lubda J, Sittinger H, Moecke H, Andresen B, Von Knobelsdorff G. [Assessment of psychiatric emergencies by physicians in the pre-hospital emergency medical system. A re-evaluation after 7 years].. Der Anaesthesist, 2004.
- McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, Dougherty GJ, Iwamoto KS, Pervan M, Liao YP. A sense of danger from radiation.. Radiation research, 2004.
- Köllner V, Lautenschläger KA, Pajonk FG. [Psychooncology. New aspects for urology].. Der Urologe. Ausg. A, 2004.
- Wobrock T, Pajonk FG, Falkai P. [Schizophrenia].. Fortschritte der Neurologie-Psychiatrie, 2004.
- Wobrock T, Pajonk FG, Falkai P. [Schizophrenia].. Fortschritte der Neurologie-Psychiatrie, 2004.
- Pajonk FG. Risperidone in acute and long-term therapy of schizophrenia--a clinical profile.. Progress in neuro-psychopharmacology & biological psychiatry, 2004.
- McBride WH, Iwamoto KS, Syljuasen R, Pervan M, Pajonk F. The role of the ubiquitin/proteasome system in cellular responses to radiation.. Oncogene, 2003.
- Pajonk FG, Fleiter B. [Psychopharmacological treatment in the pre-clinical emergency medicine].. Der Anaesthesist, 2003.
- Lean ME, Pajonk FG. Patients on atypical antipsychotic drugs: another high-risk group for type 2 diabetes.. Diabetes care, 2003.
- Pajonk FG, Schreiner A, Peters S, Rettig K, Degner D, Rüther E. [Initial use of risperidone in the treatment of acutely exacerbated schizophrenic patients--an interim analysis].. Fortschritte der Neurologie-Psychiatrie, 2003.
- Pajonk F, Himmelsbach J, Riess K, Sommer A, McBride WH. The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells.. Cancer research, 2002.
- Pajonk F, McBride WH. Survival of AIDS patients with primary central nervous system lymphoma may be improved by the radiosensitizing effects of highly active antiretroviral therapy.. AIDS (London, England), 2002.
- Pajonk FG, Fischer A, Waydhas C, Bregenzer T, Schweiberer L. [Outcome of long-term intensive therapy of surgery patients].. Der Unfallchirurg, 2002.
- Pajonk FG, Holzbach R, Naber D. Comparing the efficacy of atypical antipsychotics in open uncontrolled versus double-blind controlled trials in schizophrenia.. Psychopharmacology, 2002.
- Pajonk F, Riess K, Sommer A, McBride WH. N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation.. Free radical biology & medicine, 2002.
- Pajonk F, Weissenberger C, Witucki G, Henke M. Vitiligo at the sites of irradiation in a patient with Hodgkin's disease.. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2002.
- McBride WH, Pajonk F, Chiang CS, Sun JR. NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure.. Military medicine, 2002.
- Pajonk FG, Gruenberg KA, Moecke H, Naber D. Suicides and suicide attempts in emergency medicine.. Crisis, 2002.
- Pajonk F, McBride WH. The proteasome in cancer biology and treatment.. Radiation research, 2001.
- Pervan M, Pajonk F, Sun JR, Withers HR, McBride WH. Molecular pathways that modify tumor radiation response.. American journal of clinical oncology, 2001.
- Pajonk FG, Bartels HH, Biberthaler P, Bregenzer T, Moecke H. [Psychiatric emergencies in preclinical emergency service; incidence, treatment and evaluation by emergency physicians and staff].. Der Nervenarzt, 2001.
- Naber D, Moritz S, Lambert M, Pajonk FG, Holzbach R, Mass R, Andresen B, Rajonk F. Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs.. Schizophrenia research, 2001.
- Pajonk F, Schlessmann S, Guttenberger R, Henke M. Epithelial cells in the peripheral blood of patients with cancer of the head and neck: incidence, detection and possible clinical significance.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2001.
- Pajonk F, McBride WH. Ionizing radiation affects 26s proteasome function and associated molecular responses, even at low doses.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2001.
- Pajonk FG, Grünberg KA, Paschen HR, Moecke H, Arbeitsgruppe Psychiatrie und Rettungswesen. [Psychiatric emergencies in the physician-based system of a German city].. Fortschritte der Neurologie-Psychiatrie, 2001.
- Pajonk FG, Riemenschneider O, Moecke H, Arbeitsgruppe Psychiatrie und Rettungswesen. [Evaluation of a training program "Psychiatry for EmergencyPhysicians"].. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2001.
- Pajonk F, McBride WH. Comment on double-strand break repair and rapamycin treatment.. International journal of radiation biology, 2000.
- Richter JC, Pajonk FG, Waydhas C, Bregenzer T. [Quality of life after long-term surgical intensive care treatment].. Der Anaesthesist, 2000.
- Pajonk F, Pajonk K, McBride WH. Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition.. International journal of radiation oncology, biology, physics, 2000.
- Pajonk FG, Holzbach R, Naber D. [Open studies in comparison to controlled studies in testing of neuroleptics].. Fortschritte der Neurologie-Psychiatrie, 2000.
- Moecke H, Dirks B, Friedrich HJ, Hennes HJ, Lackner CK, Messelken M, Neumann C, Pajonk FG, Reng M, Schächinger U, Violka T. [DIVI emergency medicine protocol, version 4.0].. Der Anaesthesist, 2000.
- Pajonk F, Pajonk K, McBride WH. Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cells.. Journal of the National Cancer Institute, 1999.
- Ruchholtz S, Pajonk FG, Waydhas C, Lewan U, Nast-Kolb D, Schweiberer L. Long-term results and quality of life after parasuicidal multiple blunt trauma.. Critical care medicine, 1999.
- Henke M, Guttenberger R, Barke A, Pajonk F, Pötter R, Frommhold H. Erythropoietin for patients undergoing radiotherapy: a pilot study.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1999.
- Holzbach R, Jahn H, Pajonk FG, Mähne C. Suicide attempts with mirtazapine overdose without complications.. Biological psychiatry, 1998.
- Pajonk FG, Biberthaler P, Cordes O, Moecke HP. [Psychiatric emergencies from the viewpoint of the emergency physician].. Der Anaesthesist, 1998.
- Naber D, Pajonk FG, Perro C, Löhmer B. Human immunodeficiency virus antibody test and seroprevalence in psychiatric patients.. Acta psychiatrica Scandinavica, 1994.