Genhong Cheng

Genhong Cheng

Professor, MIMG, University of California Los Angeles

(310) 825-8896

Los Angeles, CA 90095 BSRB 210A
CAMPUS - 736422
CA Factor
Los Angeles, CA 90095

Department Email Address:


Member, California NanoSystems InstituteGene Regulation GPB Home AreaImmunity, Microbes & Molecular Pathogenesis GPB Home AreaJCCC Gene Regulation Program AreaMolecular Pharmacology GPB Home AreaTumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)

Research Interests

Research in Dr. Cheng’s laboratory is aimed at the process of innate and adaptive immune responses in host defense against bacterial and viral infections as well as tumor challenges. Upon recognizing pathogen infections, host cellular receptors such as Toll-like and Nod family receptors can trigger a series of signal transduction and gene expression networks (gene programs) to initiate innate immune responses. These innate immune responses can directly control the replication or spread of bacteria and viruses through induction of phagocytosis or antimicrobial products. In addition, innate immune response can also instruct the activation of adaptive immune response through induction of antigen presentation and co-stimulatory molecules. Defects in any steps in the process of innate and adaptive immune responses can increase susceptible of hosts to pathogen infections, whereas over-reactive immune responses can also lead to many inflammatory diseases and metabolic syndromes. We hope to understand the similarity and difference in host immune responses to different types of bacterial and viral infections, the balance between immune and inflammatory responses, the crosstalk between host immune and metabolic systems. Our goal is to develop novel strategies to enhance our immune system against pathogen infections and tumor challenges while to prevent or inhibit inflammatory and metabolic diseases.


Dr. Cheng is a Professor in Microbiology, Immunology and Molecular Genetics at UCLA. He had his PhD training in Molecular Biology with Dr. Arthur Skoultchi at Albert Einstein College of Medicine, and had his postdoctoral training in Molecular Immunology with Dr. David Baltimore at Rockefeller University and Massachusetts Institute of Technology (MIT). Dr. Cheng is an expert on immune responses in host defense against infections and cancers as well as their associations with inflammatory and metabolic diseases. He has authored close to 100 peer-reviewed articles, many of which are published in top journals like Nature and Science. He has been the principal investigator in many research grants from government and private sources. Dr. Cheng has received many awards, including Stop Cancer Award, Leukemia & Lymphoma Society Scholar Award, Leukemia & Lymphoma Society Stohlman Scholar Award and NIH Merit Award.