Gerard Wong
gclwong@seas.ucla.edu
(310) 794-7684
Engineering IV, Room 5121
420 Westwood Plaza
Los Angeles, CA 90025
Affiliations
Professor, Bioengineering, Chemistry and Biochemistry
Member, California NanoSystems Institute, Immunity, Microbes & Molecular Pathogenesis GPB Home Area
Member, California NanoSystems Institute, Immunity, Microbes & Molecular Pathogenesis GPB Home Area
Biography:
Gerard Wong’s research program is centered on studying self-organization in biological and biomedical systems using state-of-the-art techniques from physics and chemistry. Current interests include antimicrobials, sociomicrobiology of bacterial communities, and high-resolution diffractive imaging techniques using synchrotron x-ray and electron scattering
Publications
A selected list of publications:
- Nathan W. Schmidt, Abhijit Mishra, Ghee Hwee Lai, Matthew Davis, Lori K. Sanders, Dat Tran, Angie Garcia, Kenneth P. Tai, Paul B. McCray, Jr., Andr J. Ouellette, Michael E. Selsted, and Gerard C. L. Wong Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization J. Am. Chem. Soc, 2011; 133(17): 6720-7.
- Mishra A, Tai KP, Schmidt NW, Ouellette AJ, Wong GC Small-Angle X-ray Scattering Studies of Peptide-Lipid Interactions Using the Mouse Paneth Cell ?-Defensin Cryptdin-4 Methods Enzymol, 2011; 492: 127-49.
- Colvin KM, Gordon VD, Murakami K, Borlee BR, Wozniak DJ, Wong GC, Parsek MR The pel polysaccharide can serve a structural and protective role in the biofilm matrix of Pseudomonas aeruginosa PLoS Pathog, 2011; 7(1): e1001264.
- Schmidt N, Mishra A, Lai GH, Wong GC. Arginine-rich cell-penetrating peptides FEBS Lett, 2010; 584(9): 1806-13.
- Maxsim L. Gibiansky, Jacinta C. Conrad, Fan Jin, Vernita D. Gordon, Dominick A. Motto, Margie A. Mathewson, Wiktor G. Stopka, Daria C. Zelasko, Joshua D. Shrout, Gerard C. L. Wong Bacteria Use Type IV Pili to Walk Upright and Detach from Surfaces Science, 2010; 330(6001): 197.
- Wong GC, Pollack L. Electrostatics of strongly charged biological polymers: ion-mediated interactions and self-organization in nucleic acids and proteins Annu Rev Phys Chem. , 2010; 61: 171-89.
- Peter Abbamonte, Gerard C L Wong, David G Cahill, James P Reed, Robert H Coridan, Nathan W Schmidt, Ghee Hwee Lai, Young Il Joe, Diego Casa Ultrafast imaging and the phase problem for inelastic X-ray scattering Adv Mater. , 2010; 22(10): 1141-7.
- Purdy Drew KR, Sanders LK, Culumber ZW, Zribi O, Wong GC Cationic amphiphiles increase activity of aminoglycoside antibiotic tobramycin in the presence of airway polyelectrolytes J Am Chem Soc. , 2009; 131(2): 486-93.
- Robert H Coridan, Nathan W Schmidt, Ghee Hwee Lai, Rahul Godawat, Michael Krisch, Shekhar Garde, Peter Abbamonte, Gerard C L Wong Hydration dynamics of femtosecond time scales and angstrom length scales from inelastic x-ray scattering Phys Rev Lett. , 2009; 103(23): 237402.
- Yigit MV, Mishra A, Tong R, Cheng J, Wong GC, Lu Y. Inorganic mercury detection and controlled release of chelating agents from ion-responsive liposomes Chem Biol. , 2009; 16(9): 937-42.
- Cao Z, Tong R, Mishra A, Xu W, Wong GC, Cheng J, Lu Y. Reversible cell-specific drug delivery with aptamer-functionalized liposomes Angew Chem Int Ed Engl. , 2009; 48(35): 6494-8.
- Mishra A, Gordon VD, Yang L, Coridan R, Wong GC. HIV TAT forms pores in membranes by inducing saddle-splay curvature: potential role of bidentate hydrogen bonding Angew Chem Int Ed Engl. , 2008; 47(16): 2986-9.
- Yang L, Gordon VD, Trinkle DR, Schmidt NW, Davis MA, DeVries C, Som A, Cronan JE Jr, Tew GN, Wong GC. Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids Proc Natl Acad Sci U S A. , 2008; 105(52): 20595-600.
- Lai GH, Butler JC, Zribi OV, Smalyukh II, Angelini TE, Purdy KR, Golestanian R, Wong GC. Self-organized gels in DNA/F-actin mixtures without crosslinkers: networks of induced nematic domains with tunable density Phys Rev Lett, 2008; 101(21): 218303.
- Smalyukh II, Butler J, Shrout JD, Parsek MR, Wong GC. ity-mediated nematiclike bacterial organization in model extracellular DNA matrix Phys Rev E Stat Nonlin Soft Matter Phys. , 2008; 78(3 Pt 1): 030701.
- Sanders Lori K, Xian Wujing, Guáqueta Camilo, Strohman Michael J, Vrasich Chuck R, Luijten Erik, Wong Gerard C L Control of electrostatic interactions between F-actin and genetically modified lysozyme in aqueous media Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(41): 15994-9.
- Yang Lihua, Gordon Vernita D, Mishra Abhijit, Som Abhigyan, Purdy Kirstin R, Davis Matthew A, Tew Gregory N, Wong Gerard C L Synthetic antimicrobial oligomers induce a composition-dependent topological transition in membranes Journal of the American Chemical Society, 2007; 129(40): 12141-7.
- Putnam SA, Cahill DG, Wong GC Temperature dependence of thermodiffusion in aqueous suspensions of charged nanoparticles Langmuir, 2007; 23(18): 9221-8.
- Lai Ghee Hwee, Coridan Rob, Zribi Olena V, Golestanian Ramin, Wong Gerard C L Evolution of growth modes for polyelectrolyte bundles Physical review letters, 2007; 98(18): 187802.
- Purdy Kirstin R, Bartles James R, Wong Gerard C L Structural polymorphism of the actin-espin system: a prototypical system of filaments and linkers in stereocilia Physical review letters, 2007; 98(5): 058105.
- Guáqueta Camilo, Sanders Lori K, Wong Gerard C L, Luijten Erik The effect of salt on self-assembled actin-lysozyme complexes Biophysical journal, 2006; 90(12): 4630-8.
- Angelini Thomas E, Golestanian Ramin, Coridan Robert H, Butler John C, Beraud Alexandre, Krisch Michael, Sinn Harald, Schweizer Kenneth S, Wong Gerard C L Counterions between charged polymers exhibit liquid-like organization and dynamics Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(21): 7962-7.
- Smalyukh Ivan I, Zribi Olena V, Butler John C, Lavrentovich Oleg D, Wong Gerard C L Structure and dynamics of liquid crystalline pattern formation in drying droplets of DNA Physical review letters, 2006; 96(17): 177801.
- Zribi Olena V, Kyung Hee, Golestanian Ramin, Liverpool Tanniemola B, Wong Gerard C L Condensation of DNA-actin polyelectrolyte mixtures driven by ions of different valences Physical review. E, Statistical, nonlinear, and soft matter physics, 2006; 73(3 Pt 1): 031911.
- Sanders Lori K, Guáqueta Camilo, Angelini Thomas E, Lee Jae-Wook, Slimmer Scott C, Luijten Erik, Wong Gerard C L Structure and stability of self-assembled actin-lysozyme complexes in salty water Physical review letters, 2005; 95(10): 108302.
- Liang Hongjun, Harries Daniel, Wong Gerard C L Polymorphism of DNA-anionic liposome complexes reveals hierarchy of ion-mediated interactions Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(32): 11173-8.
- Liang Hongjun, Angelini Thomas E, Braun Paul V, Wong Gerard C L Roles of anionic and cationic template components in biomineralization of CdS nanorods using self-assembled DNA-membrane complexes Journal of the American Chemical Society, 2004; 126(43): 14157-65.
- Yang Lihua, Liang Hongjun, Angelini Thomas E, Butler John, Coridan Robert, Tang Jay X, Wong Gerard C L Self-assembled virus-membrane complexes Nature materials, 2004; 3(9): 615-9.
- Liang Hongjun, Angelini Thomas E, Ho James, Braun Paul V, Wong Gerard C L Molecular imprinting of biomineralized CdS nanostructures: crystallographic control using self-assembled DNA-membrane templates Journal of the American Chemical Society, 2003; 125(39): 11786-7.
- Butler John C, Angelini Thomas, Tang Jay X, Wong Gerard C L Ion multivalence and like-charge polyelectrolyte attraction Physical review letters, 2003; 91(2): 028301.
- Wong Gerard C L, Lin Alison, Tang Jay X, Li Youli, Janmey Paul A, Safinya Cyrus R Lamellar phase of stacked two-dimensional rafts of actin filaments Physical review letters, 2003; 91(1): 018103.
- Angelini Thomas E, Liang Hongjun, Wriggers Willy, Wong Gerard C L Like-charge attraction between polyelectrolytes induced by counterion charge density waves Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(15): 8634-7.