Guillaume Chanfreau*

Guillaume Chanfreau

Professor, Chemistry and Biochemistry, University of California Los Angeles



  1. DeMario S, Xu K, He K, Chanfreau GF. Nanoblot: an R-package for visualization of RNA isoforms from long-read RNA-sequencing data.. RNA (New York, N.Y.), 2023.
  2. Roy KR, Gabunilas J, Neutel D, Ai M, Samson J, Lyu G, Chanfreau GF. Spliceosomal mutations decouple 3' splice site fidelity from cellular fitness.. bioRxiv : the preprint server for biology, 2023.
  3. Liu Y, DeMario S, He K, Gibbs MR, Barr KW, Chanfreau GF. Splicing inactivation generates hybrid mRNA-snoRNA transcripts targeted by cytoplasmic RNA decay.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
  4. Gibbs MR, Chanfreau GF. UPF1 adds an m6A feather to its (de)cap.. Cell reports, 2022.
  5. Wang C, Barr K, Neutel D, Roy K, Liu Y, Chanfreau GF. Stress-induced inhibition of mRNA export triggers RNase III-mediated decay of the BDF2 mRNA.. RNA (New York, N.Y.), 2021.
  6. Weathers I, Gabunilas J, Samson J, Roy K, Chanfreau GF. Protocol for High-Resolution Mapping of Splicing Products and Isoforms by RT-PCR Using Fluorescently Labeled Primers.. STAR protocols, 2020.
  7. Wang C, Liu Y, DeMario SM, Mandric I, Gonzalez-Figueroa C, Chanfreau GF. Rrp6 Moonlights in an RNA Exosome-Independent Manner to Promote Cell Survival and Gene Expression during Stress.. Cell reports, 2020.
  8. White JT, Cato T, Deramchi N, Gabunilas J, Roy KR, Wang C, Chanfreau GF, Clarke SG. Protein Methylation and Translation: Role of Lysine Modification on the Function of Yeast Elongation Factor 1A.. Biochemistry, 2019.
  9. Roy KR, Chanfreau GF. Robust mapping of polyadenylated and non-polyadenylated RNA 3' ends at nucleotide resolution by 3'-end sequencing.. Methods (San Diego, Calif.), 2019.
  10. Roy K, Chanfreau GF. A global function for transcription factors in assisting RNA polymerase II termination.. Transcription, 2017.
  11. Chanfreau GF. Impact of RNA Modifications and RNA-Modifying Enzymes on Eukaryotic Ribonucleases.. The Enzymes, 2017.
  12. Gillespie A, Gabunilas J, Jen JC, Chanfreau GF. Mutations of EXOSC3/Rrp40p associated with neurological diseases impact ribosomal RNA processing functions of the exosome in S. cerevisiae.. RNA (New York, N.Y.), 2017.
  13. Chanfreau GF. Preface.. The Enzymes, 2017.
  14. Roy K, Gabunilas J, Gillespie A, Ngo D, Chanfreau GF. Common genomic elements promote transcriptional and DNA replication roadblocks.. Genome research, 2016.
  15. Gabunilas J, Chanfreau G. Splicing-Mediated Autoregulation Modulates Rpl22p Expression in Saccharomyces cerevisiae.. PLoS genetics, 2016.
  16. Hodko D, Ward T, Chanfreau G. The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases.. RNA (New York, N.Y.), 2016.
  17. Al-Hadid Q, Roy K, Chanfreau G, Clarke SG. Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity.. RNA (New York, N.Y.), 2016.
  18. Kaweeteerawat C, Chang CH, Roy KR, Liu R, Li R, Toso D, Fischer H, Ivask A, Ji Z, Zink JI, Zhou ZH, Chanfreau GF, Telesca D, Cohen Y, Holden PA, Nel AE, Godwin HA. Cu Nanoparticles Have Different Impacts in Escherichia coli and Lactobacillus brevis than Their Microsized and Ionic Analogues.. ACS nano, 2015.
  19. Chanfreau G. Two degrading decades for RNA.. RNA (New York, N.Y.), 2015.
  20. Roy K, Chanfreau G. Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival.. PLoS genetics, 2014.
  21. Dzialo MC, Travaglini KJ, Shen S, Roy K, Chanfreau GF, Loo JA, Clarke SG. Translational roles of elongation factor 2 protein lysine methylation.. The Journal of biological chemistry, 2014.
  22. Al-Hadid Q, Roy K, Munroe W, Dzialo MC, Chanfreau GF, Clarke SG. Histidine methylation of yeast ribosomal protein Rpl3p is required for proper 60S subunit assembly.. Molecular and cellular biology, 2014.
  23. Kawashima T, Douglass S, Gabunilas J, Pellegrini M, Chanfreau GF. Widespread use of non-productive alternative splice sites in Saccharomyces cerevisiae.. PLoS genetics, 2014.
  24. Chanfreau GF. Zinc’ing down RNA polymerase I.. Transcription, 2013.
  25. Lee YJ, Lee CY, Grzechnik A, Gonzales-Zubiate F, Vashisht AA, Lee A, Wohlschlegel J, Chanfreau GF. RNA polymerase I stability couples cellular growth to metal availability.. Molecular cell, 2013.
  26. Hartman E, Wang Z, Zhang Q, Roy K, Chanfreau G, Feigon J. Intrinsic dynamics of an extended hydrophobic core in the S. cerevisiae RNase III dsRBD contributes to recognition of specific RNA binding sites.. Journal of molecular biology, 2012.
  27. Chanfreau G, Tamanoi F. Preface.. The Enzymes, 2012.
  28. Roy K, Chanfreau GF. The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism.. The Enzymes, 2012.
  29. Lee YJ, Huang X, Kropat J, Henras A, Merchant SS, Dickson RC, Chanfreau GF. Sphingolipid signaling mediates iron toxicity.. Cell metabolism, 2012.
  30. Sayani S, Chanfreau GF. Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae.. RNA (New York, N.Y.), 2012.
  31. Egecioglu DE, Kawashima TR, Chanfreau GF. Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation.. Nucleic acids research, 2011.
  32. Wang Z, Hartman E, Roy K, Chanfreau G, Feigon J. Structure of a yeast RNase III dsRBD complex with a noncanonical RNA substrate provides new insights into binding specificity of dsRBDs.. Structure (London, England : 1993), 2011.
  33. Toesca I, Nery CR, Fernandez CF, Sayani S, Chanfreau GF. Cryptic transcription mediates repression of subtelomeric metal homeostasis genes.. PLoS genetics, 2011.
  34. Koo BK, Park CJ, Fernandez CF, Chim N, Ding Y, Chanfreau G, Feigon J. Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface.. Journal of molecular biology, 2011.
  35. Egecioglu DE, Chanfreau G. Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control.. RNA (New York, N.Y.), 2011.
  36. Chanfreau GF. A dual role for RNA splicing signals.. EMBO reports, 2010.
  37. Chanfreau G. InvIGOrating mRNAs during Quiescence.. Molecular cell, 2010.
  38. Kawashima T, Pellegrini M, Chanfreau GF. Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations.. RNA (New York, N.Y.), 2009.
  39. Singh M, Gonzales FA, Cascio D, Heckmann N, Chanfreau G, Feigon J. Structure and functional studies of the CS domain of the essential H/ACA ribonucleoparticle assembly protein SHQ1.. The Journal of biological chemistry, 2008.
  40. Sayani S, Janis M, Lee CY, Toesca I, Chanfreau GF. Widespread impact of nonsense-mediated mRNA decay on the yeast intronome.. Molecular cell, 2008.
  41. Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernández E, Fukuzawa H, González-Ballester D, González-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riaño-Pachón DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martínez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR. The Chlamydomonas genome reveals the evolution of key animal and plant functions.. Science (New York, N.Y.), 2007.
  42. Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH. Shape-specific recognition in the structure of the Vts1p SAM domain with RNA.. Nature structural & molecular biology, 2006.
  43. Egecioglu DE, Henras AK, Chanfreau GF. Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome.. RNA (New York, N.Y.), 2006.
  44. Chanfreau GF. CUTting genetic noise by polyadenylation-induced RNA degradation.. Trends in cell biology, 2005.
  45. Lee A, Henras AK, Chanfreau G. Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.. Molecular cell, 2005.
  46. Henras AK, Sam M, Hiley SL, Wu H, Hughes TR, Feigon J, Chanfreau GF. Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III.. RNA (New York, N.Y.), 2005.
  47. Zer C, Chanfreau G. Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation.. The Journal of biological chemistry, 2005.
  48. Yang PK, Hoareau C, Froment C, Monsarrat B, Henry Y, Chanfreau G. Cotranscriptional recruitment of the pseudouridylsynthetase Cbf5p and of the RNA binding protein Naf1p during H/ACA snoRNP assembly.. Molecular and cellular biology, 2005.
  49. Sam M, Henras AK, Chanfreau G. A conserved major groove antideterminant for Saccharomyces cerevisiae RNase III recognition.. Biochemistry, 2005.
  50. Sam M, Hwang JH, Chanfreau G, Abu-Omar MM. Hydroxyl radical is the active species in photochemical DNA strand scission by bis(peroxo)vanadium(V) phenanthroline.. Inorganic chemistry, 2004.
  51. Henras AK, Bertrand E, Chanfreau G. A cotranscriptional model for 3'-end processing of the Saccharomyces cerevisiae pre-ribosomal RNA precursor.. RNA (New York, N.Y.), 2004.
  52. Wu H, Henras A, Chanfreau G, Feigon J. Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III.. Proceedings of the National Academy of Sciences of the United States of America, 2004.
  53. Lee CY, Lee A, Chanfreau G. The roles of endonucleolytic cleavage and exonucleolytic digestion in the 5'-end processing of S. cerevisiae box C/D snoRNAs.. RNA (New York, N.Y.), 2003.
  54. Chanfreau G. Conservation of RNase III processing pathways and specificity in hemiascomycetes.. Eukaryotic cell, 2003.
  55. Danin-Kreiselman M, Lee CY, Chanfreau G. RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns.. Molecular cell, 2003.
  56. Yang PK, Rotondo G, Porras T, Legrain P, Chanfreau G. The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis.. The Journal of biological chemistry, 2002.
  57. Wu H, Yang PK, Butcher SE, Kang S, Chanfreau G, Feigon J. A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III.. The EMBO journal, 2001.
  58. Kufel J, Allmang C, Chanfreau G, Petfalski E, Lafontaine DL, Tollervey D. Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding.. Molecular and cellular biology, 2000.
  59. Chanfreau G, Buckle M, Jacquier A. Recognition of a conserved class of RNA tetraloops by Saccharomyces cerevisiae RNase III.. Proceedings of the National Academy of Sciences of the United States of America, 2000.
  60. Allmang C, Kufel J, Chanfreau G, Mitchell P, Petfalski E, Tollervey D. Functions of the exosome in rRNA, snoRNA and snRNA synthesis.. The EMBO journal, 1999.
  61. Chanfreau G, Gouyette C, Schwer B, Jacquier A. Trans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons.. RNA (New York, N.Y.), 1999.
  62. Chanfreau G, Legrain P, Jacquier A. Yeast RNase III as a key processing enzyme in small nucleolar RNAs metabolism.. Journal of molecular biology, 1998.
  63. Chanfreau G, Rotondo G, Legrain P, Jacquier A. Processing of a dicistronic small nucleolar RNA precursor by the RNA endonuclease Rnt1.. The EMBO journal, 1998.
  64. Nolte A, Chanfreau G, Jacquier A. Influence of substrate structure on in vitro ribozyme activity of a group II intron.. RNA (New York, N.Y.), 1998.
  65. Chanfreau G, Elela SA, Ares M, Guthrie C. Alternative 3'-end processing of U5 snRNA by RNase III.. Genes & development, 1997.
  66. Chanfreau G, Noble SM, Guthrie C. Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF).. Science (New York, N.Y.), 1996.
  67. Chanfreau G, Jacquier A. An RNA conformational change between the two chemical steps of group II self-splicing.. The EMBO journal, 1996.
  68. Chanfreau G, Jacquier A. Catalytic site components common to both splicing steps of a group II intron.. Science (New York, N.Y.), 1994.
  69. Chanfreau G, Legrain P, Dujon B, Jacquier A. Interaction between the first and last nucleotides of pre-mRNA introns is a determinant of 3' splice site selection in S. cerevisiae.. Nucleic acids research, 1994.
  70. Chanfreau G, Jacquier A. Interaction of intronic boundaries is required for the second splicing step efficiency of a group II intron.. The EMBO journal, 1993.