A selected list of publications:

• Magnusson Mattias, Sierra Maria I, Sasidharan Rajkumar, Prashad Sacha L, Romero Melissa, Saarikoski Pamela, Van Handel Ben, Huang Andy, Li Xinmin, Mikkola Hanna K A   Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability PloS one, 2013; 8(1): e53912.
• Nakano Haruko, Liu Xiaoqian, Arshi Armin, Nakashima Yasuhiro, van Handel Ben, Sasidharan Rajkumar, Harmon Andrew W, Shin Jae-Ho, Schwartz Robert J, Conway Simon J, Harvey Richard P, Pashmforoush Mohammad, Mikkola Hanna K A, Nakano Atsushi   Haemogenic endocardium contributes to transient definitive haematopoiesis Nature communications, 2013; 4(4): 1564.
• Oh Philmo, Lobry Camille, Gao Jie, Tikhonova Anastasia, Loizou Evangelia, Manent Jan, van Handel Ben, Ibrahim Sherif, Greve Jeffrey, Mikkola Hanna, Artavanis-Tsakonas Spyros, Aifantis Iannis   In Vivo mapping of notch pathway activity in normal and stress hematopoiesis Cell stem cell, 2013; 13(2): 190-204.
• Palomares Karina, Vigant Frederic, Van Handel Ben, Pernet Olivier, Chikere Kelechi, Hong Patrick, Sherman Sean P, Patterson Michaela, An Dong Sung, Lowry William E, Mikkola Hanna K A, Morizono Kouki, Pyle April D, Lee Benhur   Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo Journal of virology, 2013; 87(4): 2094-108.
• Goddard Lauren M, Ton Amy N, Org Tõnis, Mikkola Hanna K A, Iruela-Arispe M Luisa   Selective suppression of endothelial cytokine production by progesterone receptor Vascular pharmacology, 2013; 59(1-2): 36-43.
• Montel-Hagen Amélie, Van Handel Ben, Mikkola Hanna   [An unexpected repressive role for Scl in the embryonic endothelium] Médecine sciences : M/S, 2013; 29(3): 257-9.
• Hall-Glenn Faith, De Young R Andrea, Huang Bau-Lin, van Handel Ben, Hofmann Jennifer J, Chen Tom T, Choi Aaron, Ong Jessica R, Benya Paul D, Mikkola Hanna, Iruela-Arispe M Luisa, Lyons Karen M   CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis PloS one, 2012; 7(2): e30562.
• Nsair Ali, Schenke-Layland Katja, Van Handel Ben, Evseenko Denis, Kahn Michael, Zhao Peng, Mendelis Joseph, Heydarkhan Sanaz, Awaji Obina, Vottler Miriam, Geist Susanne, Chyu Jennifer, Gago-Lopez Nuria, Crooks Gay M, Plath Kathrin, Goldhaber Josh, Mikkola Hanna K A, MacLellan W Robb   Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells PloS one, 2012; 7(10): e45603.
• Xu Jian, Shao Zhen, Glass Kimberly, Bauer Daniel E, Pinello Luca, Van Handel Ben, Hou Serena, Stamatoyannopoulos John A, Mikkola Hanna K A, Yuan Guo-Cheng, Orkin Stuart H   Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis Developmental cell, 2012; 23(4): 796-811.
• Hong Cynthia, Kidani Yoko, A-Gonzalez Noelia, Phung Tram, Ito Ayaka, Rong Xin, Ericson Katrin, Mikkola Hanna, Beaven Simon W, Miller Lloyd S, Shao Wen-Hai, Cohen Philip L, Castrillo Antonio, Tontonoz Peter, Bensinger Steven J   Coordinate regulation of neutrophil homeostasis by liver X receptors in mice The Journal of clinical investigation, 2012; 122(1): 337-47.
• Patterson Michaela, Chan David N, Ha Iris, Case Dana, Cui Yongyan, Van Handel Ben, Mikkola Hanna Ka, Lowry William E   Defining the nature of human pluripotent stem cell progeny Cell research, 2012; 22(1): 178-93.
• Li Jing-Yu, Patterson Michaela, Mikkola Hanna K A, Lowry William E, Kurdistani Siavash K   Dynamic distribution of linker histone H1.5 in cellular differentiation PLoS genetics, 2012; 8(8): e1002879.
• Kohn Lisa A, Hao Qian-Lin, Sasidharan Rajkumar, Parekh Chintan, Ge Shundi, Zhu Yuhua, Mikkola Hanna K A, Crooks Gay M   Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin Nature immunology, 2012; 13(10): 963-71.
• Van Handel Ben, Montel-Hagen Amélie, Sasidharan Rajkumar, Nakano Haruko, Ferrari Roberto, Boogerd Cornelis J, Schredelseker Johann, Wang Yanling, Hunter Sean, Org Tõnis, Zhou Jian, Li Xinmin, Pellegrini Matteo, Chen Jau-Nian, Orkin Stuart H, Kurdistani Siavash K, Evans Sylvia M, Nakano Atsushi, Mikkola Hanna K A   Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium Cell, 2012; 150(3): 590-605.
• Chhabra Akanksha, Lechner Andrew J, Ueno Masaya, Acharya Asha, Van Handel Ben, Wang Yanling, Iruela-Arispe M Luisa, Tallquist Michelle D, Mikkola Hanna K A   Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling Developmental cell, 2012; 22(3): 651-9.
• Schenke-Layland Katja, Nsair Ali, Van Handel Ben, Angelis Ekaterini, Gluck Jessica M, Votteler Miriam, Goldhaber Joshua I, Mikkola Hanna K, Kahn Michael, Maclellan William R   Recapitulation of the embryonic cardiovascular progenitor cell niche Biomaterials, 2011; 32(11): 2748-56.
• Chhabra Akanksha, Mikkola Hanna K A   Return to youth with Sox17 Genes & development, 2011; 25(15): 1557-62.
• Gekas Christos, Rhodes Katrin E, Van Handel Ben, Chhabra Akanksha, Ueno Masaya, Mikkola Hanna K A   Hematopoietic stem cell development in the placenta The International journal of developmental biology, 2010; 54(6-7): 1089-98.
• Lee Lydia K, Ueno Masaya, Van Handel Ben, Mikkola Hanna K A   Placenta as a newly identified source of hematopoietic stem cells Current opinion in hematology, 2010; 17(4): 313-8.
• Huang Xinqiang, Gschweng Eric, Van Handel Ben, Cheng Donghui, Mikkola Hanna K A, Witte Owen N   Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells Blood, 2010; .
• Mikkola Hanna K A, Radu Caius G, Witte Owen N   Targeting leukemia stem cells Nature biotechnology, 2010; 28(3): 237-8.
• Van Handel Ben, Prashad Sacha L, Hassanzadeh-Kiabi Nargess, Huang Andy, Magnusson Mattias, Atanassova Boriana, Chen Angela, Hamalainen Eija I, Mikkola Hanna K A   The first trimester human placenta is a site for terminal maturation of primitive erythroid cells Blood, 2010; 116(17): 3321-30.
• Gereige Laurraine-Marcelle, Mikkola Hanna K A   DNA methylation is a guardian of stem cell self-renewal and multipotency Nature genetics, 2009; 41(11): 1164-6.
• Park Tae Sub, Galic Zoran, Conway Anne E, Lindgren Anne, van Handel Benjamin J, Magnusson Mattias, Richter Laura, Teitell Michael A, Mikkola Hanna K A, Lowry William E, Plath Kathrin, Clark Amander T   Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells Stem cells (Dayton, Ohio), 2009; 27(4): 783-95.
• Mikkola Hanna   ESAM: adding to the hematopoietic toolbox Blood, 2009; 113(13): 2871-2.
• Gekas Christos, Rhodes Katrin E, Gereige Laurraine M, Helgadottir Hildur, Ferrari Roberto, Kurdistani Siavash K, Montecino-Rodriguez Encarnación, Bassel-Duby Rhonda, Olson Eric, Krivtsov Andrei V, Armstrong Scott, Orkin Stuart H, Pellegrini Matteo, Mikkola Hanna K A   Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis Blood, 2009; 113(15): 3461-71.
• Magnusson Mattias, Mikkola Hanna K A   Hematopoietic stem cells in transit–where’s the niche? Cell stem cell, 2008; 2(4): 302-4.
• Sankaran Vijay G, Menne Tobias F, Xu Jian, Akie Thomas E, Lettre Guillaume, Van Handel Ben, Mikkola Hanna K A, Hirschhorn Joel N, Cantor Alan B, Orkin Stuart H   Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A Science (New York, N.Y.), 2008; 322(5909): 1839-42.
• Gekas Christos, Rhodes Katrin E, Mikkola Hanna K A   Isolation and visualization of mouse placental hematopoietic stem cells Current protocols in stem cell biology, 2008; Chapter 2(5909): Unit 2A.8.1-2A.8.14.
• Schenke-Layland Katja, Rhodes Katrin E, Angelis Ekaterini, Butylkova Yekaterina, Heydarkhan-Hagvall Sepideh, Gekas Christos, Zhang Rui, Goldhaber Joshua I, Mikkola Hanna K, Plath Kathrin, MacLellan W Robb   Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages Stem cells (Dayton, Ohio), 2008; 26(6): 1537-46.
• Rhodes Katrin E, Gekas Christos, Wang Yanling, Lux Christopher T, Francis Cameron S, Chan David N, Conway Simon, Orkin Stuart H, Yoder Mervin C, Mikkola Hanna K A   The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation Cell stem cell, 2008; 2(3): 252-63.
• Elorza Alvaro, Hyde Brigham, Mikkola Hanna K, Collins Sheila, Shirihai Orian S   UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis The Journal of biological chemistry, 2008; 283(45): 30461-70.
• Schenke-Layland Katja, Angelis Ekaterini, Rhodes Katrin E, Heydarkhan-Hagvall Sepideh, Mikkola Hanna K, Maclellan W Robb   Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells Stem cells (Dayton, Ohio), 2007; 25(6): 1529-38.
• Martinez-Agosto Julian A, Mikkola Hanna K A, Hartenstein Volker, Banerjee Utpal   The hematopoietic stem cell and its niche: a comparative view Genes & development, 2007; 21(23): 3044-60.
• Mikkola Hanna K A, Orkin Stuart H   The journey of developing hematopoietic stem cells Development (Cambridge, England), 2006; 133(19): 3733-44.
• Teitell Michael A, Mikkola Hanna K A   Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development Pediatric research, 2006; 59(4 Pt 2): 33R-9R.
• Mikkola HK, Orkin SH   Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse Methods in molecular medicine. , 2005; 105: 3-22.
• Mikkola Hanna K A, Orkin Stuart H   Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse Methods in molecular medicine, 2005; 105(3): 3-22.
• Mikkola HKA, Gekas C, Orkin SH, Dieterlen-Lievre F   Placenta as a site for hematopoietic stem cell development, Experimental Hematology, 2005; 33: 1048-1054.
• Mikkola Hanna K A, Gekas Christos, Orkin Stuart H, Dieterlen-Lievre Francoise   Placenta as a site for hematopoietic stem cell development Experimental hematology, 2005; 33(9): 1048-54.
• Gekas C, Dieterlen-Lievre F, Orkin SH, Mikkola HK   The placenta is a niche for hematopoietic stem cells Dev Cell, 2005; 8(3): 365-75.
• Gekas Christos, Dieterlen-Lièvre Francoise, Orkin Stuart H, Mikkola Hanna K A   The placenta is a niche for hematopoietic stem cells Developmental cell, 2005; 8(3): 365-75.
• Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH   Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development Blood. , 2005; 105(10): 3871-4.
• Schlaeger Thorsten M, Mikkola Hanna K A, Gekas Christos, Helgadottir Hildur B, Orkin Stuart H   Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development Blood, 2005; 105(10): 3871-4.
• Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C   Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1 Mol Cell Biol, 2004; 24(17): 7491-502.
• Schlaeger Thorsten M, Schuh Anna, Flitter Simon, Fisher Andreas, Mikkola Hanna, Orkin Stuart H, Vyas Paresh, Porcher Catherine   Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1 Molecular and cellular biology, 2004; 24(17): 7491-502.
• Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH   Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo Blood. , 2003; 101(2): 508-16.
• Mikkola Hanna K A, Fujiwara Yuko, Schlaeger Thorsten M, Traver David, Orkin Stuart H   Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo Blood, 2003; 101(2): 508-16.
• Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH   Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene Nature, 2003; 421(6922): 547-51.
• Mikkola Hanna K A, Klintman Jenny, Yang Haidi, Hock Hanno, Schlaeger Thorsten M, Fujiwara Yuko, Orkin Stuart H   Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene Nature, 2003; 421(6922): 547-51.
• Mikkola Hanna K A, Orkin Stuart H   The search for the hemangioblast Journal of hematotherapy & stem cell research, 2002; 11(1): 9-17.
• Mikkola HK, Orkin SH   The search for the hemangioblast Journal of hematotherapy & stem cell research. , 2002; 11(1): 9-17.
• Woods NB, Mikkola H, Nilsson E, Olsson K, Trono D, Karlsson S   Lentiviral-mediated gene transfer into haematopoietic stem cells Journal of internal medicine. , 2001; 249(4): 339-43.
• Wartiovaara U, Mikkola H, Szoke G, Haramura G, Karpati L, Balogh I, Lassila R, Muszbek L, Palotie A   Effect of Val34Leu polymorphism on the activation of the coagulation factor XIII-A Thromb Haemost, 2000; 84(4): 595-600.
• Woods NB, Fahlman C, Mikkola H, Hamaguchi I, Olsson K, Zufferey R, Jacobsen SE, Trono D, Karlsson S   Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells Blood. , 2000; 96(12): 3725-33.
• Mikkola H, Woods NB, Sjogren M, Helgadottir H, Hamaguchi I, Jacobsen SE, Trono D, Karlsson S   Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells J Virol, 2000; 74(24): 11911-8.
• Hamaguchi I, Woods NB, Panagopoulos I, Andersson E, Mikkola H, Fahlman C, Zufferey R, Carlsson L, Trono D, Karlsson S   Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro Journal of virology. , 2000; 74(22): 10778-84.
• Loewy A, McDonagh J, Mikkola H, Teller DC, Yee VC   Structure and Function of Factor XIII , Hemostasis and Thrombosis: Basic Principles and Clinical Practise, 2000; 233-247.
• Balogh I, Szoke G, Karpati L, Wartiovaara U, Katona E, Komaromi I, Haramura G, Pfliegler G, Mikkola H, Muszbek L   Val34Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia Blood, 2000; 96(7): 2479-86.
• Helio T, Wartiovaara U, Halme L, Turunen U, Mikkola H, Palotie A, Farkkila M, Kontula K   Arg506Gln factor V mutation and Val34Leu factor XIII polymorphism in Finnish patients with inflammatory bowel disease Scand J Gastroenterol, 1999; 34(2): 170-4.
• Wartiovaara U, Perola M, Mikkola H, Totterman K, Savolainen V, Penttila A, Grant PJ, Tikkanen MJ, Vartiainen E, Karhunen PJ, Peltonen L, Palotie A   Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males Atherosclerosis, 1999; 142(2): 295-300.
• Kohler HP, Stickland MH, Ossei-Gerning N, Carter A, Mikkola H, Grant PJ   Association of a common polymorphism in the factor XIII gene with myocardial infarction Thrombosis and haemostasis. , 1998; 79(1): 8-13.
• Wartiovaara U, Salven P, Mikkola H, Lassila R, Kaukonen J, Joukov V, Orpana A, Ristimki A, Heikinheimo M, Joensuu H, Alitalo K, Palotie A   Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation Thrombosis and haemostasis. , 1998; 80(1): 171-5.
• Mikkola H, Muszbek L, Laiho E, Syrjala M, Hamalainen E, Haramura G, Salmi T, Peltonen L, Palotie A   Molecular mechanism of a mild phenotype in coagulation factor XIII (FXIII) deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA Blood, 1997; 89(4): 1279-87.
• Mikkola H, Muszbek L, Haramura G, Hmlinen E, Jalanko A, Palotie A   Molecular mechanisms of mutations in factor XIII A-subunit deficiency: in vitro expression in COS-cells demonstrates intracellular degradation of the mutant proteins Thrombosis and haemostasis. , 1997; 77(6): 1068-72.
• Laiho E, Ignatius J, Mikkola H, Yee VC, Teller DC, Niemi KM, Saarialho-Kere U, Kere J, Palotie A   Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population American journal of human genetics. , 1997; 61(3): 529-38.
• Mikkola H, Yee VC, Syrjala M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L, Palotie A   Four novel mutations in deficiency of coagulation factor XIII: consequences to expression and structure of the A-subunit Blood, 1996; 87(1): 141-51.
• Mikkola H, Palotie A   Gene defects in congenital factor XIII deficiency Seminars in thrombosis and hemostasis. , 1996; 22(5): 393-8.
• Muszbek L, Adany R, Mikkola H   Novel aspects of blood coagulation factor XIII. I. Structure, distribution, activation, and function Crit Rev Clin Lab Sci, 1996; 33(5): 357-421.
• Mikkola H, Syrjala M, Rasi V, Vahtera E, Hamalainen E, Peltonen L, Palotie A   Deficiency in the A-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels Blood, 1994; 84(2): 517-25.