Holden H Wu
Associate Professor-in-Residence, Radiological Sciences, University of California Los Angeles
hhwu@mednet.ucla.edu
Affiliations
Member, Center for Duchenne Muscular Dystrophy, Physics & Biology in Medicine GPB Home Area
Biography
I am interested in developing rapid and robust magnetic resonance imaging (MRI) techniques for improving diagnosis and treatment in oncologic and cardiovascular applications. My group focuses on technical developments in MRI pulse sequence design, accelerated data acquisition, new image reconstruction algorithms, and quantitative data analysis. These advanced techniques are used to improve early detection of disease, characterize the disease state, facilitate treatment planning, guide interventions, assess treatment efficacy, and perform monitoring.
Publications
- Lee B, Janzen C, Wu H, Vangala SS, Devaskar SU, Sung K. Utility of In Vivo Magnetic Resonance Imaging Is Predictive of Gestational Diabetes Mellitus During Early Pregnancy.. The Journal of clinical endocrinology and metabolism, 2023.
- Shih SF, Kafali SG, Calkins KL, Wu HH. Uncertainty-aware physics-driven deep learning network for free-breathing liver fat and R2 * quantification using self-gated stack-of-radial MRI.. Magnetic resonance in medicine, 2022.
- Strobel KM, Kafali SG, Shih SF, Artura AM, Masamed R, Elashoff D, Wu HH, Calkins KL. Pregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.. Journal of perinatology : official journal of the California Perinatal Association, 2022.
- Gao C, Ghodrati V, Shih SF, Wu HH, Liu Y, Nickel MD, Vahle T, Dale B, Sai V, Felker E, Surawech C, Miao Q, Finn JP, Zhong X, Hu P. Undersampling artifact reduction for free-breathing 3D stack-of-radial MRI based on a deep adversarial learning network.. Magnetic resonance imaging, 2022.
- Geoghegan R, Zhang L, Priester A, Wu HH, Marks L, Natarajan S. Interstitial Optical Monitoring of Focal Laser Ablation.. IEEE transactions on bio-medical engineering, 2022.
- Story JD, Ghahremani S, Kafali SG, Shih SF, Kuwahara KJ, Calkins KL, Wu HH. Using Free-Breathing MRI to Quantify Pancreatic Fat and Investigate Spatial Heterogeneity in Children.. Journal of magnetic resonance imaging : JMRI, 2022.
- Kafali SG, Armstrong T, Shih SF, Kim GJ, Holtrop JL, Venick RS, Ghahremani S, Bolster BD, Hillenbrand CM, Calkins KL, Wu HH. Free-breathing radial magnetic resonance elastography of the liver in children at 3�T: a pilot study.. Pediatric radiology, 2022.
- Li X, Lee Y, Lu DS, Tsao TC, Wu HH. Physics-Driven Mask R-CNN for Physical Needle Localization in MRI-Guided Percutaneous Interventions. IEEE Access, 2021.
- Kafali SG, Shih SF, Li X, Chowdhury S, Loong S, Barnes S, Li Z, Wu HH. 3D Neural Networks for Visceral and Subcutaneous Adipose Tissue Segmentation using Volumetric Multi-Contrast MRI.. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2021.
- Armstrong T, Zhong X, Shih SF, Felker E, Lu DS, Dale BM, Wu HH. Free-breathing 3D stack-of-radial MRI quantification of liver fat and R2* in adults with fatty liver disease.. Magnetic resonance imaging, 2021.
- Chang CC, Huang ZY, Shih SF, Luo Y, Ko A, Cui Q, Sumner J, Cavallero S, Das S, Gao W, Sinsheimer J, Bui A, Jacobs JP, Pajukanta P, Wu H, Tai YC, Li Z, Hsiai TK. Electrical impedance tomography for non-invasive identification of fatty liver infiltrate in overweight individuals.. Scientific reports, 2021.
- Deng T, Zhang L, Li X, Zink JI, Wu HH. Responsive Nanoparticles to Enable a Focused Ultrasound-Stimulated Magnetic Resonance Imaging Spotlight.. ACS nano, 2021.
- Zhong X, Armstrong T, Gao C, Nickel MD, Han F, Dale BM, Li X, Kafali SG, Hu P, Wu HH, Deshpande V. Accelerated k-space shift calibration for free-breathing stack-of-radial MRI quantification of liver fat and R2*.. Magnetic resonance in medicine, 2021.
- Dual SA, Maforo NG, McElhinney DB, Prosper A, Wu HH, Maskatia S, Renella P, Halnon N, Ennis DB. Right Ventricular Function and T1-Mapping in Boys With Duchenne Muscular Dystrophy.. Journal of magnetic resonance imaging : JMRI, 2021.
- Shih SF, Kafali SG, Armstrong T, Zhong X, Calkins KL, Wu HH. Deep Learning-Based Parameter Mapping with Uncertainty Estimation for Fat Quantification using Accelerated Free-Breathing Radial MRI.. Proceedings. IEEE International Symposium on Biomedical Imaging, 2021.
- Maforo NG, Magrath P, Moulin K, Shao J, Kim GH, Prosper A, Renella P, Wu HH, Halnon N, Ennis DB. T1-Mapping and extracellular volume estimates in pediatric subjects with Duchenne muscular dystrophy and healthy controls at 3T.. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2020.
- Martin T, Janzen C, Li X, Del Rosario I, Chanlaw T, Choi S, Armstrong T, Masamed R, Wu HH, Devaskar SU, Sung K. Characterization of Uterine Motion in Early Gestation Using MRI-Based Motion Tracking.. Diagnostics (Basel, Switzerland), 2020.
- Cheng CA, Chen W, Zhang L, Wu HH, Zink JI. Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform.. Chemical communications (Cambridge, England), 2020.
- Lee Y, Li X, Simonelli J, Lu D, Wu HH, Tsao TC. Adaptive Tracking Control of One-Dimensional Respiration Induced Moving Targets by Real-Time Magnetic Resonance Imaging Feedback. IEEE/ASME Transactions on Mechatronics, 2020.
- Singhrao K, Fu J, Gao Y, Wu HH, Yang Y, Hu P, Lewis JH. A generalized system of tissue-mimicking materials for computed tomography and magnetic resonance imaging.. Physics in medicine and biology, 2020.
- Li X, Young AS, Raman SS, Lu DS, Lee YH, Tsao TC, Wu HH. Automatic needle tracking using Mask R-CNN for MRI-guided percutaneous interventions.. International journal of computer assisted radiology and surgery, 2020.
- Zhang Z, Wu HH, Priester A, Magyar C, Afshari Mirak S, Shakeri S, Mohammadian Bajgiran A, Hosseiny M, Azadikhah A, Sung K, Reiter RE, Sisk AE, Raman S, Enzmann DR. Prostate Microstructure in Prostate Cancer Using 3-T MRI with Diffusion-Relaxation Correlation Spectrum Imaging: Validation with Whole-Mount Digital Histopathology.. Radiology, 2020.
- Zhong X, Hu HH, Armstrong T, Li X, Lee YH, Tsao TC, Nickel MD, Kannengiesser SAR, Dale BM, Deshpande V, Kiefer B, Wu HH. Free-Breathing Volumetric Liver R2* and Proton Density Fat Fraction Quantification in Pediatric Patients Using Stack-of-Radial MRI With Self-Gating Motion Compensation.. Journal of magnetic resonance imaging : JMRI, 2020.
- Simonelli J, Lee Y, Chen C, Li X, Mikaiel S, Lu D, Wu HH, Tsao TC. Hydrostatic Actuation for Remote Operations in MR Environment. IEEE/ASME Transactions on Mechatronics, 2020.
- Singhrao K, Fu J, Wu HH, Hu P, Kishan AU, Chin RK, Lewis JH. A novel anthropomorphic multimodality phantom for MRI-based radiotherapy quality assurance testing.. Medical physics, 2020.
- Li X, Perotti LE, Martinez JA, Duarte-Vogel SM, Ennis DB, Wu HH. Real-time 3T MRI-guided cardiovascular catheterization in a porcine model using a glass-fiber epoxy-based guidewire.. PloS one, 2020.
- Koulakis JP, Rouch J, Huynh N, Wu HH, Dunn JCY, Putterman S. Tumescent Injections in Subcutaneous Pig Tissue Disperse Fluids Volumetrically and Maintain Elevated Local Concentrations of Additives for Several Hours, Suggesting a Treatment for Drug Resistant Wounds.. Pharmaceutical research, 2020.
- Mikaiel S, Simonelli J, Li X, Lee YH, Lee YS, Sung K, Lu DS, Tsao TC, Wu HH. MRI-guided targeted needle placement during motion using hydrostatic actuators.. The international journal of medical robotics + computer assisted surgery : MRCAS, 2020.
- Hu HH, Branca RT, Hernando D, Karampinos DC, Machann J, McKenzie CA, Wu HH, Yokoo T, Velan SS. Magnetic resonance imaging of obesity and metabolic disorders: Summary from the 2019 ISMRM Workshop.. Magnetic resonance in medicine, 2019.
- Zhong X, Armstrong T, Nickel MD, Kannengiesser SAR, Pan L, Dale BM, Deshpande V, Kiefer B, Wu HH. Effect of respiratory motion on free-breathing 3D stack-of-radial liver R2* relaxometry and improved quantification accuracy using self-gating.. Magnetic resonance in medicine, 2019.
- Cheng CA, Chen W, Zhang L, Wu HH, Zink JI. A Responsive Mesoporous Silica Nanoparticle Platform for Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound-Stimulated Cargo Delivery with Controllable Location, Time, and Dose.. Journal of the American Chemical Society, 2019.
- Zhang Z, Moulin K, Aliotta E, Shakeri S, Afshari Mirak S, Hosseiny M, Raman S, Ennis DB, Wu HH. Prostate diffusion MRI with minimal echo time using eddy current nulled convex optimized diffusion encoding.. Journal of magnetic resonance imaging : JMRI, 2019.
- Li X, Lee YH, Mikaiel S, Simonelli J, Tsao TC, Wu HH. Respiratory Motion Prediction Using Fusion-Based Multi-Rate Kalman Filtering and Real-Time Golden-Angle Radial MRI.. IEEE transactions on bio-medical engineering, 2019.
- Deng T, Zhang L, Wu HH, Zink JI. A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight.. Chemical communications (Cambridge, England), 2019.
- Zhang L, Armstrong T, Li X, Wu HH. A variable flip angle golden-angle-ordered 3D stack-of-radial MRI technique for simultaneous proton resonant frequency shift and T1 -based thermometry.. Magnetic resonance in medicine, 2019.
- Zhong X, Cao R, Shakeri S, Scalzo F, Lee Y, Enzmann DR, Wu HH, Raman SS, Sung K. Deep transfer learning-based prostate cancer classification using 3 Tesla multi-parametric MRI.. Abdominal radiology (New York), 2019.
- Ly KV, Armstrong T, Yeh J, Ghahremani S, Kim GH, Wu HH, Calkins KL. Free-breathing Magnetic Resonance Imaging Assessment of Body Composition in Healthy and Overweight Children: An Observational Study.. Journal of pediatric gastroenterology and nutrition, 2019.
- Armstrong T, Ly KV, Ghahremani S, Calkins KL, Wu HH. Free-breathing 3-D quantification of infant body composition and hepatic fat using a stack-of-radial magnetic resonance imaging technique.. Pediatric radiology, 2019.
- Keenan KE, Biller JR, Delfino JG, Boss MA, Does MD, Evelhoch JL, Griswold MA, Gunter JL, Hinks RS, Hoffman SW, Kim G, Lattanzi R, Li X, Marinelli L, Metzger GJ, Mukherjee P, Nordstrom RJ, Peskin AP, Perez E, Russek SE, Sahiner B, Serkova N, Shukla-Dave A, Steckner M, Stupic KF, Wilmes LJ, Wu HH, Zhang H, Jackson EF, Sullivan DC. Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs.. Journal of magnetic resonance imaging : JMRI, 2019.
- Geoghegan R, Santamaria A, Priester A, Zhang L, Wu H, Grundfest W, Marks L, Natarajan S. A tissue-mimicking prostate phantom for 980?nm laser interstitial thermal therapy.. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2019.
- Zhong X, Shakeri S, Liu D, Sayre J, Raman SS, Wu HH, Sung K. Repeatability and reproducibility of variable flip angle T1 quantification in the prostate at 3 T.. Journal of magnetic resonance imaging : JMRI, 2018.
- Armstrong T, Liu D, Martin T, Masamed R, Janzen C, Wong C, Chanlaw T, Devaskar SU, Sung K, Wu HH. 3D R2* mapping of the placenta during early gestation using free-breathing multiecho stack-of-radial MRI at 3T.. Journal of magnetic resonance imaging : JMRI, 2018.
- Wu HH, Priester A, Khoshnoodi P, Zhang Z, Shakeri S, Afshari Mirak S, Asvadi NH, Ahuja P, Sung K, Natarajan S, Sisk A, Reiter R, Raman S, Enzmann D. A system using patient-specific 3D-printed molds to spatially align in vivo MRI with ex vivo MRI and whole-mount histopathology for prostate cancer research.. Journal of magnetic resonance imaging : JMRI, 2018.
- Felker ER, Choi KS, Sung K, Wu HH, Raman SS, Bolster BD, Kannengiesser S, Sorge K, Lu DSK. Liver MR Elastography at 3 T: Agreement Across Pulse Sequences and Effect of Liver R2* on Image Quality.. AJR. American journal of roentgenology, 2018.
- Zhong X, Martin T, Wu HH, Nayak KS, Sung K. Prostate DCE-MRI with
- Armstrong T, Ly KV, Murthy S, Ghahremani S, Kim GHJ, Calkins KL, Wu HH. Free-breathing quantification of hepatic fat in healthy children and children with nonalcoholic fatty liver disease using a multi-echo 3-D stack-of-radial MRI technique.. Pediatric radiology, 2018.
- Priester A, Wu H, Khoshnoodi P, Schneider D, Zhang Z, Asvadi NH, Sisk A, Raman S, Reiter R, Grundfest W, Marks LS, Natarajan S. Registration Accuracy of Patient-Specific, Three-Dimensional-Printed Prostate Molds for Correlating Pathology With Magnetic Resonance Imaging.. IEEE transactions on bio-medical engineering, 2018.
- Simonelli J, Lee Y, Mikaiel S, Chen C, Li X, Sung K, Lu D, Wu HH, Tsao TC. An MR-Compatible Stage for Respiratory Motion Emulation. International Federation of Automatic Control (IFAC) PapersOnLine, 2017.
- Armstrong T, Dregely I, Stemmer A, Han F, Natsuaki Y, Sung K, Wu HH. Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique.. Magnetic resonance in medicine, 2017.
- Felker ER, Dregely I, Chung DJ, Sung K, Osuagwu FC, Lassman C, Sayre J, Wu H, Lu DS. Irreversible Electroporation: Defining the MRI Appearance of the Ablation Zone With Histopathologic Correlation in a Porcine Liver Model.. AJR. American journal of roentgenology, 2017.
- Tan N, Lin WC, Khoshnoodi P, Asvadi NH, Yoshida J, Margolis DJ, Lu DS, Wu H, Sung KH, Lu DY, Huang J, Raman SS. In-Bore 3-T MR-guided Transrectal Targeted Prostate Biopsy: Prostate Imaging Reporting and Data System Version 2-based Diagnostic Performance for Detection of Prostate Cancer.. Radiology, 2016.
- Rangwala NA, Dregely I, Wu HH, Sung K. Optimization and evaluation of reference region variable flip angle (RR-VFA) B1+ and T1 Mapping in the Prostate at 3T.. Journal of magnetic resonance imaging : JMRI, 2016.
- Aliotta E, Wu HH, Ennis DB. Convex optimized diffusion encoding (CODE) gradient waveforms for minimum echo time and bulk motion-compensated diffusion-weighted MRI.. Magnetic resonance in medicine, 2016.
- Dregely I, Margolis DA, Sung K, Zhou Z, Rangwala N, Raman SS, Wu HH. Rapid quantitative T2 mapping of the prostate using three-dimensional dual echo steady state MRI at 3T.. Magnetic resonance in medicine, 2016.
- Chung DJ, Sung K, Osuagwu FC, Wu HH, Lassman C, Lu DS. Contrast Enhancement Patterns after Irreversible Electroporation: Experimental Study of CT Perfusion Correlated to Histopathology in Normal Porcine Liver.. Journal of vascular and interventional radiology : JVIR, 2015.
- Addy NO, Ingle RR, Wu HH, Hu BS, Nishimura DG. High-resolution variable-density 3D cones coronary MRA.. Magnetic resonance in medicine, 2015.
- Kwon KT, Kerr AB, Wu HH, Hu BS, Brittain JH, Nishimura DG. Non-contrast-enhanced peripheral angiography using a sliding interleaved cylinder acquisition.. Magnetic resonance in medicine, 2014.
- Srinivasan S, Wu HH, Sung K, Margolis DJ, Ennis DB. Fast 3D T2 -weighted imaging using variable flip angle transition into driven equilibrium (3D T2 -TIDE) balanced SSFP for prostate imaging at 3T.. Magnetic resonance in medicine, 2014.
- Middione MJ, Wu HH, Ennis DB. Convex gradient optimization for increased spatiotemporal resolution and improved accuracy in phase contrast MRI.. Magnetic resonance in medicine, 2013.
- Ingle RR, Wu HH, Addy NO, Cheng JY, Yang PC, Hu BS, Nishimura DG. Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory.. Magnetic resonance in medicine, 2013.
- Kwon KT, Wu HH, Shin T, Cukur T, Lustig M, Nishimura DG. Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory.. Magnetic resonance in medicine, 2013.
- McConnell MV, Wu HH. Respiratory-mode display of echocardiographic images highlights effects of pericardial disease.. JACC. Cardiovascular imaging, 2013.
- Dong HZ, Worters PW, Wu HH, Ingle RR, Vasanawala SS, Nishimura DG. Noncontrast-enhanced renal angiography using multiple inversion recovery and alternating TR balanced steady-state free precession.. Magnetic resonance in medicine, 2012.
- Wu HH, Gurney PT, Hu BS, Nishimura DG, McConnell MV. Free-breathing multiphase whole-heart coronary MR angiography using image-based navigators and three-dimensional cones imaging.. Magnetic resonance in medicine, 2012.
- Addy NO, Wu HH, Nishimura DG. Simple method for MR gradient system characterization and k-space trajectory estimation.. Magnetic resonance in medicine, 2011.
- Wu HH, Nishimura DG. 3D magnetization-prepared imaging using a stack-of-rings trajectory.. Magnetic resonance in medicine, 2010.
- Wu HH, Lee JH, Nishimura DG. Fat/water separation using a concentric rings trajectory.. Magnetic resonance in medicine, 2009.
- Wu HH, Lee JH, Nishimura DG. MRI using a concentric rings trajectory.. Magnetic resonance in medicine, 2008.