Holden H Wu
Associate Professor-in-Residence, Radiological Sciences, University of California Los Angeles
Member, Center for Duchenne Muscular Dystrophy, Physics & Biology in Medicine GPB Home Area
I am interested in developing rapid and robust magnetic resonance imaging (MRI) techniques for improving diagnosis and treatment in oncologic and cardiovascular applications. My group focuses on technical developments in MRI pulse sequence design, accelerated data acquisition, new image reconstruction algorithms, and quantitative data analysis. These advanced techniques are used to improve early detection of disease, characterize the disease state, facilitate treatment planning, guide interventions, assess treatment efficacy, and perform monitoring.
- Story JD, Ghahremani S, Kafali SG, Shih SF, Kuwahara KJ, Calkins KL, Wu HH. Using Free-Breathing MRI to Quantify Pancreatic Fat and Investigate Spatial Heterogeneity in Children.. Journal of magnetic resonance imaging : JMRI, 2022.
- Kafali SG, Armstrong T, Shih SF, Kim GJ, Holtrop JL, Venick RS, Ghahremani S, Bolster BD, Hillenbrand CM, Calkins KL, Wu HH. Free-breathing radial magnetic resonance elastography of the liver in children at 3 T: a pilot study.. Pediatric radiology, 2022.
- Armstrong T, Zhong X, Shih SF, Felker E, Lu DS, Dale BM, Wu HH. Free-breathing 3D stack-of-radial MRI quantification of liver fat and R2* in adults with fatty liver disease.. Magnetic resonance imaging, 2021.
- Deng T, Zhang L, Li X, Zink JI, Wu HH. Responsive Nanoparticles to Enable a Focused Ultrasound-Stimulated Magnetic Resonance Imaging Spotlight.. ACS nano, 2021.
- Shih SF, Kafali SG, Armstrong T, Zhong X, Calkins KL, Wu HH. Deep Learning-Based Parameter Mapping with Uncertainty Estimation for Fat Quantification using Accelerated Free-Breathing Radial MRI.. Proceedings. IEEE International Symposium on Biomedical Imaging, 2021.
- Maforo NG, Magrath P, Moulin K, Shao J, Kim GH, Prosper A, Renella P, Wu HH, Halnon N, Ennis DB. T1-Mapping and extracellular volume estimates in pediatric subjects with Duchenne muscular dystrophy and healthy controls at 3T.. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2020.
- Martin T, Janzen C, Li X, Del Rosario I, Chanlaw T, Choi S, Armstrong T, Masamed R, Wu HH, Devaskar SU, Sung K. Characterization of Uterine Motion in Early Gestation Using MRI-Based Motion Tracking.. Diagnostics (Basel, Switzerland), 2020.
- Cheng CA, Chen W, Zhang L, Wu HH, Zink JI. Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform.. Chemical communications (Cambridge, England), 2020.
- Singhrao K, Fu J, Gao Y, Wu HH, Yang Y, Hu P, Lewis JH. A generalized system of tissue-mimicking materials for computed tomography and magnetic resonance imaging.. Physics in medicine and biology, 2020.
- Li X, Young AS, Raman SS, Lu DS, Lee YH, Tsao TC, Wu HH. Automatic needle tracking using Mask R-CNN for MRI-guided percutaneous interventions.. International journal of computer assisted radiology and surgery, 2020.
- Zhang Z, Wu HH, Priester A, Magyar C, Afshari Mirak S, Shakeri S, Mohammadian Bajgiran A, Hosseiny M, Azadikhah A, Sung K, Reiter RE, Sisk AE, Raman S, Enzmann DR. Prostate Microstructure in Prostate Cancer Using 3-T MRI with Diffusion-Relaxation Correlation Spectrum Imaging: Validation with Whole-Mount Digital Histopathology.. Radiology, 2020.
- Singhrao K, Fu J, Wu HH, Hu P, Kishan AU, Chin RK, Lewis JH. A novel anthropomorphic multimodality phantom for MRI-based radiotherapy quality assurance testing.. Medical physics, 2020.
- Li X, Perotti LE, Martinez JA, Duarte-Vogel SM, Ennis DB, Wu HH. Real-time 3T MRI-guided cardiovascular catheterization in a porcine model using a glass-fiber epoxy-based guidewire.. PloS one, 2020.
- Koulakis JP, Rouch J, Huynh N, Wu HH, Dunn JCY, Putterman S. Tumescent Injections in Subcutaneous Pig Tissue Disperse Fluids Volumetrically and Maintain Elevated Local Concentrations of Additives for Several Hours, Suggesting a Treatment for Drug Resistant Wounds.. Pharmaceutical research, 2020.
- Mikaiel S, Simonelli J, Li X, Lee YH, Lee YS, Sung K, Lu DS, Tsao TC, Wu HH. MRI-guided targeted needle placement during motion using hydrostatic actuators.. The international journal of medical robotics + computer assisted surgery : MRCAS, 2020.
- Cheng CA, Chen W, Zhang L, Wu HH, Zink JI. A Responsive Mesoporous Silica Nanoparticle Platform for Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound-Stimulated Cargo Delivery with Controllable Location, Time, and Dose.. Journal of the American Chemical Society, 2019.
- Zhang Z, Moulin K, Aliotta E, Shakeri S, Afshari Mirak S, Hosseiny M, Raman S, Ennis DB, Wu HH. Prostate diffusion MRI with minimal echo time using eddy current nulled convex optimized diffusion encoding.. Journal of magnetic resonance imaging : JMRI, 2019.
- Deng T, Zhang L, Wu HH, Zink JI. A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight.. Chemical communications (Cambridge, England), 2019.
- Zhang L, Armstrong T, Li X, Wu HH. A variable flip angle golden-angle-ordered 3D stack-of-radial MRI technique for simultaneous proton resonant frequency shift and T1 -based thermometry.. Magnetic resonance in medicine, 2019.
- Zhong X, Cao R, Shakeri S, Scalzo F, Lee Y, Enzmann DR, Wu HH, Raman SS, Sung K. Deep transfer learning-based prostate cancer classification using 3 Tesla multi-parametric MRI.. Abdominal radiology (New York), 2019.
- Armstrong T, Ly KV, Ghahremani S, Calkins KL, Wu HH. Free-breathing 3-D quantification of infant body composition and hepatic fat using a stack-of-radial magnetic resonance imaging technique.. Pediatric radiology, 2019.
- Zhong X, Shakeri S, Liu D, Sayre J, Raman SS, Wu HH, Sung K. Repeatability and reproducibility of variable flip angle T1 quantification in the prostate at 3 T.. Journal of magnetic resonance imaging : JMRI, 2018.
- Armstrong T, Liu D, Martin T, Masamed R, Janzen C, Wong C, Chanlaw T, Devaskar SU, Sung K, Wu HH. 3D R2* mapping of the placenta during early gestation using free-breathing multiecho stack-of-radial MRI at 3T.. Journal of magnetic resonance imaging : JMRI, 2018.
- Wu HH, Priester A, Khoshnoodi P, Zhang Z, Shakeri S, Afshari Mirak S, Asvadi NH, Ahuja P, Sung K, Natarajan S, Sisk A, Reiter R, Raman S, Enzmann D. A system using patient-specific 3D-printed molds to spatially align in vivo MRI with ex vivo MRI and whole-mount histopathology for prostate cancer research.. Journal of magnetic resonance imaging : JMRI, 2018.
- Felker ER, Choi KS, Sung K, Wu HH, Raman SS, Bolster BD, Kannengiesser S, Sorge K, Lu DSK. Liver MR Elastography at 3 T: Agreement Across Pulse Sequences and Effect of Liver R2* on Image Quality.. AJR. American journal of roentgenology, 2018.
- Zhong X, Martin T, Wu HH, Nayak KS, Sung K. Prostate DCE-MRI with correction using an approximated analytical approach.. Magnetic resonance in medicine, 2018.
- Armstrong T, Ly KV, Murthy S, Ghahremani S, Kim GHJ, Calkins KL, Wu HH. Free-breathing quantification of hepatic fat in healthy children and children with nonalcoholic fatty liver disease using a multi-echo 3-D stack-of-radial MRI technique.. Pediatric radiology, 2018.
- Armstrong T, Dregely I, Stemmer A, Han F, Natsuaki Y, Sung K, Wu HH. Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique.. Magnetic resonance in medicine, 2017.
- Rangwala NA, Dregely I, Wu HH, Sung K. Optimization and evaluation of reference region variable flip angle (RR-VFA) B1+ and T1 Mapping in the Prostate at 3T.. Journal of magnetic resonance imaging : JMRI, 2016.
- Aliotta E, Wu HH, Ennis DB. Convex optimized diffusion encoding (CODE) gradient waveforms for minimum echo time and bulk motion-compensated diffusion-weighted MRI.. Magnetic resonance in medicine, 2016.
- Dregely I, Margolis DA, Sung K, Zhou Z, Rangwala N, Raman SS, Wu HH. Rapid quantitative T2 mapping of the prostate using three-dimensional dual echo steady state MRI at 3T.. Magnetic resonance in medicine, 2016.
- Chung DJ, Sung K, Osuagwu FC, Wu HH, Lassman C, Lu DS. Contrast Enhancement Patterns after Irreversible Electroporation: Experimental Study of CT Perfusion Correlated to Histopathology in Normal Porcine Liver.. Journal of vascular and interventional radiology : JVIR, 2015.
- Srinivasan S, Wu HH, Sung K, Margolis DJ, Ennis DB. Fast 3D T2 -weighted imaging using variable flip angle transition into driven equilibrium (3D T2 -TIDE) balanced SSFP for prostate imaging at 3T.. Magnetic resonance in medicine, 2014.
- Middione MJ, Wu HH, Ennis DB. Convex gradient optimization for increased spatiotemporal resolution and improved accuracy in phase contrast MRI.. Magnetic resonance in medicine, 2013.