Jason Hinman

Jason D Hinman

Associate Professor-in-Residence, Neurology, University of California Los Angeles

Dr. Hinman is a physician-scientist, Associate Professor of Neurology, and Vice Chair of Research in the David Geffen School of Medicine at UCLA. He also Stroke Program Director at the West Los Angeles VA Medical Center. His NIH-funded laboratory at UCLA focuses on cellular and molecular pathways active in injury and repair in stroke and neurodegenerative disease.

Interests

neural repair, oligodendrocytes, white matter, astrocytes, neurovascular unit, biomarkers, stroke, dementia

Education and Training

University of California Los Angeles06/2014Neurorehabilitation
University of California Los Angeles06/2013Vascular Neurology
University of California Los Angeles06/2011Adult Neurology Residency
Cedars-Sinai Medical Center06/2008Internal Medicine
Boston University School of MedicineM.D./Ph.D.05/2007Medicine/Molecular Medicine
Case Western Reserve UniversityB.A.05/1999Psychology

Publications

  1. Prochilo G, Pfeffer A, Du S, Kaneko N, Liebeskind DS, Hinman JD. Recent Translational Research Models of Intracranial Atherosclerotic Disease.. Stroke, 2024.
  2. Martirosian RA, Wiedner CD, Sanchez J, Mun KT, Marla K, Teran C, Thirion M, Liebeskind DS, McGrath ER, Zucker JM, Bernal R, Beiser AS, DeCarli C, Himali JJ, Seshadri S, Hinman JD. Association of Incident Stroke Risk With an IL-18-Centered Inflammatory Network Biomarker Composite.. Stroke, 2024.
  3. Melnik M, Miyoshi E, Ma R, Corrada M, Kawas C, Bohannan R, Caraway C, Miller CA, Hinman JD, John V, Bilousova T, Gylys KH. Simultaneous isolation of intact brain cells and cell-specific extracellular vesicles from cryopreserved Alzheimer's disease cortex.. Journal of neuroscience methods, 2024.
  4. Lee JJ, Patel S, Hinman JD. Late-Onset COL4A1 Mutation with Recurrent Ischemic and Hemorrhagic Strokes.. The neurologist, 2024.
  5. Tommasini D, Fox R, Ngo KJ, Hinman JD, Fogel BL. Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease.. iScience, 2023.
  6. Hinman JD, Elahi F, Chong D, Radabaugh H, Ferguson A, Maillard P, Thompson JF, Rosenberg GA, Sagare A, Moghekar A, Lu H, Lee T, Wilcock D, Satizabal CL, Tracy R, Seshadri S, Schwab K, Helmer K, Singh H, Kivisäkk P, Greenberg S, DeCarli C, Kramer J. Placental growth factor as a sensitive biomarker for vascular cognitive impairment.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023.
  7. Xiao G, Kumar R, Komuro Y, Burguet J, Kakarla V, Azizkhanian I, Sheth SA, Williams CK, Zhang XR, Macknicki M, Brumm A, Kawaguchi R, Mai P, Kaneko N, Vinters HV, Carmichael ST, Havton LA, DeCarli C, Hinman JD. IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury.. Cell reports, 2022.
  8. Patel SD, Saber H, Desai N, Otite FO, Kaneko N, Mehta TV, Hinman J, Hassan AE, Jadhav A, Liebeskind DS, Saver JL. Impact of ARUBA trial on trends and outcomes in symptomatic non-ruptured brain AVMs: A national sample analysis.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022.
  9. Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.. Nature communications, 2022.
  10. Hazany S, Nguyen KL, Lee M, Zhang A, Mokhtar P, Crossley A, Luthra S, Butani P, Dergalust S, Ellingson B, Hinman JD. Regional Cerebral Small Vessel Disease (rCSVD) Score: A clinical MRI grading system validated in a stroke cohort.. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2022.
  11. Patel SD, Oliver FO, Elmashad A, Patel N, Mehta T, Hinman J, Liebeskind DS, Singhal AB, Ducros A, Saver JL. Outcomes among patients with primary angiitis of the CNS: A Nationwide United States analysis.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022.
  12. Patel SD, Otite FO, Topiwala K, Saber H, Kaneko N, Sussman E, Mehta TV, Tummala R, Hinman J, Nogueira R, Haussen DC, Liebeskind DS, Saver JL. Interventional compared with medical management of symptomatic carotid web: A systematic review.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022.
  13. Sanchez JD, Martirosian RA, Mun KT, Chong DS, Llorente IL, Uphaus T, Gröschel K, Wölfer TA, Tiedt S, Hinman JD, DEMDAS Study Group. Temporal Patterning of Neurofilament Light as a Blood-Based Biomarker for Stroke: A Systematic Review and Meta-Analysis.. Frontiers in neurology, 2022.
  14. Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M. Post-Stroke Cognitive Impairment and Dementia.. Circulation research, 2022.
  15. Elahi FM, Harvey D, Altendahl M, Brathaban N, Fernandes N, Casaletto KB, Staffaroni AM, Maillard P, Hinman JD, Miller BL, DeCarli C, Kramer JH, Goetzl EJ. Author Correction: Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans.. Scientific reports, 2022.
  16. Mun KT, Hinman JD. Inflammation and the Link to Vascular Brain Health: Timing Is Brain.. Stroke, 2022.
  17. Pajewski NM, Elahi FM, Tamura MK, Hinman JD, Nasrallah IM, Ix JH, Miller LM, Launer LJ, Wright CB, Supiano MA, Lerner AJ, Sudduth TL, Killeen AA, Cheung AK, Reboussin DM, Wilcock DM, Williamson JD. Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT).. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021.
  18. Hashimoto T, Kunieda T, Honda T, Scalzo F, Sharma LK, Hinman JD, Rao NM, Nour M, Bahr-Hosseini M, Saver JL, Raychev R, Liebeskind DS. Heterogeneity between proximal and distal aspects of occlusive thrombi on pretreatment imaging in acute ischemic stroke.. The neuroradiology journal, 2021.
  19. Elahi FM, Harvey D, Altendahl M, Brathaban N, Fernandes N, Casaletto KB, Staffaroni AM, Maillard P, Hinman JD, Miller BL, DeCarli C, Kramer JH, Goetzl EJ. Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans.. Scientific reports, 2021.
  20. Bahr-Hosseini M, Bikson M, Iacoboni M, Liebeskind DS, Hinman JD, Carmichael ST, Saver JL. PRIMED2 Preclinical Evidence Scoring Tool to Assess Readiness for Translation of Neuroprotection Therapies.. Translational stroke research, 2021.
  21. Wong GJ, Yoo B, Liebeskind D, Baharvahdat H, Gornbein J, Jahan R, Szeder V, Duckwiler G, Tateshima S, Colby G, Nour M, Sharma L, Rao N, Hinman J, Starkman S, Saver JL, UCLA Thrombectomy Investigators*. Frequency, Determinants, and Outcomes of Emboli to Distal and New Territories Related to Mechanical Thrombectomy for Acute Ischemic Stroke.. Stroke, 2021.
  22. Kim SJ, Morales JM, Yaghi S, Honda T, Scalzo F, Hinman JD, Raychev R, Sharma LK, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Intracranial atherosclerotic disease mechanistic subtypes drive hypoperfusion patterns.. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021.
  23. Hinman JD, Ngo KJ, Kim D, Chen C, Abraham CR, Ghanbari M, Ikram MA, Kushner SA, Kawaguchi R, Coppola G, Goth K, Bellusci S, Hernandez I, Kosik KS, Fogel BL. miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy.. Human molecular genetics, 2021.
  24. Liebeskind DS, Hinman JD, Kaneko N, Kitajima H, Honda T, De Havenon AH, Feldmann E, Nogueira RG, Prabhakaran S, Romano JG, Callas PW, Schneider DJ. Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease.. Frontiers in neurology, 2021.
  25. Yaghi S, Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis.. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021.
  26. Kakarla V, Kaneko N, Nour M, Khatibi K, Elahi F, Liebeskind DS, Hinman JD. Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021.
  27. Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, Rosenberg G, Sagare A, Satizabal CL, Schneider J, Seshadri S, Sur S, Tracy RP, Yasar S, Williams V, Singh H, Mazina L, Helmer KG, Corriveau RA, Schwab K, Kivisäkk P, Greenberg SM, MarkVCID Consortium. MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021.
  28. Raychev R, Saber H, Saver JL, Hinman JD, Brown S, Vinuela F, Duckwiler G, Jahan R, Tateshima S, Szeder V, Nour M, Colby GP, Restrepo L, Kim D, Bahr-Hosseini M, Ali L, Starkman S, Rao N, Nogueira RG, Liebeskind D. Impact of eloquent motor cortex-tissue reperfusion beyond the traditional thrombolysis in cerebral infarction (TICI) scoring after thrombectomy.. Journal of neurointerventional surgery, 2020.
  29. Kaneko N, Satta S, Komuro Y, Muthukrishnan SD, Kakarla V, Guo L, An J, Elahi F, Kornblum HI, Liebeskind DS, Hsiai T, Hinman JD. Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection.. Stroke, 2020.
  30. Gonzalez NR, Jiang H, Lyden P, Song S, Schlick K, Dumitrascu O, Quintero-Consuegra MD, Toscano JF, Liebeskind DS, Restrepo L, Rao N, Hinman J, Alexander MJ, Schievink W, Piantadosi S, Saver JL. Encephaloduroarteriosynangiosis (EDAS) revascularization for symptomatic intracranial atherosclerotic steno-occlusive (ERSIAS) Phase-II objective performance criterion trial.. International journal of stroke : official journal of the International Stroke Society, 2020.
  31. Atchaneeyasakul K, Liebeskind DS, Jahan R, Starkman S, Sharma L, Yoo B, Avelar J, Rao N, Hinman J, Duckwiler G, Nour M, Szeder V, Tateshima S, Colby G, Hosseini MB, Raychev R, Kim D, Saver JL, UCLA Reperfusion Therapy Investigators. Efficient Multimodal MRI Evaluation for Endovascular Thrombectomy of Anterior Circulation Large Vessel Occlusion.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020.
  32. Kaneko N, Ullman H, Ali F, Berg P, Ooi YC, Tateshima S, Colby GP, Komuro Y, Hu P, Khatibi K, Ponce Mejia LL, Szeder V, Nour M, Guo L, Chien A, Vinuela F, Nemoto S, Mashiko T, Sehara Y, Hinman JD, Duckwiler G, Jahan R. In Vitro Modeling of Human Brain Arteriovenous Malformation for Endovascular Simulation and Flow Analysis.. World neurosurgery, 2020.
  33. Hayden EY, Huang JM, Charreton M, Nunez SM, Putman JN, Teter B, Lee JT, Welch A, Frautschy S, Cole G, Teng E, Hinman JD. Modeling Mixed Vascular and Alzheimer's Dementia Using Focal Subcortical Ischemic Stroke in Human ApoE4-TR:5XFAD Transgenic Mice.. Translational stroke research, 2020.
  34. Altendahl M, Maillard P, Harvey D, Cotter D, Walters S, Wolf A, Singh B, Kakarla V, Azizkhanian I, Sheth SA, Xiao G, Fox E, You M, Leng M, Elashoff D, Kramer JH, Decarli C, Elahi F, Hinman JD. An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury.. PloS one, 2020.
  35. Sozmen EG, DiTullio DJ, Rosenzweig S, Hinman JD, Bridges SP, Marin MA, Kawaguchi R, Coppola G, Carmichael ST. White Matter Stroke Induces a Unique Oligo-Astrocyte Niche That Inhibits Recovery.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019.
  36. Hinman JD. The Power of Observation in Neurology Then and Now-Notes From Charcot's Library.. JAMA neurology, 2019.
  37. Azizkhanian I, Sheth SA, Iavarone AT, Lee S, Kakarla V, Hinman JD. Plasma Lipid Profiling Identifies Biomarkers of Cerebral Microvascular Disease.. Frontiers in neurology, 2019.
  38. Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation.. Acta neuropathologica communications, 2019.
  39. Kaneko N, Minhas A, Tateshima S, Colby GP, Szeder V, Hinman JD, Nour M, Jahan R, Duckwiler G. Pre-procedural simulation for precision stent-assisted coiling of cerebral aneurysm.. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2019.
  40. Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, Glymour MM, Miller BL, Hinman JD, DeCarli C, Goetzl EJ, Kramer JH. "Liquid Biopsy" of White Matter Hyperintensity in Functionally Normal Elders.. Frontiers in aging neuroscience, 2018.
  41. Bahr Hosseini M, Woolf G, Sharma LK, Hinman JD, Rao NM, Yoo B, Jahan R, Starkman S, Nour M, Raychev R, Liebeskind DS, Saver JL. The Frequency of Substantial Salvageable Penumbra in Thrombectomy-ineligible Patients with Acute Stroke.. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2018.
  42. Sheth SA, Verma A, Malhotra K, Tang X, Tateshima S, Jahan R, Hinman JD. Human Endothelial Cell Collection from the Middle Cerebral Artery in Acute Ischemic Stroke.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2017.
  43. Coban H, Tung S, Yoo B, Vinters HV, Hinman JD. Molecular Disorganization of Axons Adjacent to Human Cortical Microinfarcts.. Frontiers in neurology, 2017.
  44. Liebeskind DS, Malhotra K, Hinman JD. Crowdsourcing the Million Brains Initiative-Reply.. JAMA neurology, 2017.
  45. Yu S, Ma SJ, Liebeskind DS, Yu D, Li N, Qiao XJ, Shao X, Yan L, Yoo B, Scalzo F, Hinman JD, Sharma LK, Rao N, Jahan R, Tateshima S, Duckwiler GR, Saver JL, Salamon N, Wang DJ. ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017.
  46. Liebeskind DS, Malhotra K, Hinman JD. Imaging as the Nidus of Precision Cerebrovascular Health: A Million Brains Initiative.. JAMA neurology, 2017.
  47. Lou X, Yu S, Scalzo F, Starkman S, Ali LK, Kim D, Rao NM, Hinman JD, Vespa PM, Jahan R, Tateshima S, Gonzalez NR, Duckwiler GR, Saver JL, Yoo B, Salamon N, Lyu J, Ma L, Wang DJ, Liebeskind DS. Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke.. Oncotarget, 2017.
  48. Sozmen EG, Rosenzweig S, Llorente IL, DiTullio DJ, Machnicki M, Vinters HV, Havton LA, Giger RJ, Hinman JD, Carmichael ST. Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
  49. Hinman JD, Rost NS, Leung TW, Montaner J, Muir KW, Brown S, Arenillas JF, Feldmann E, Liebeskind DS. Principles of precision medicine in stroke.. Journal of neurology, neurosurgery, and psychiatry, 2016.
  50. Liu D, Scalzo F, Rao NM, Hinman JD, Kim D, Ali LK, Saver JL, Sun W, Dai Q, Liu X, Liebeskind DS. Fluid-Attenuated Inversion Recovery Vascular Hyperintensity Topography, Novel Imaging Marker for Revascularization in Middle Cerebral Artery Occlusion.. Stroke, 2016.
  51. Xiao G, Hinman JD. Concepts and opportunities for repair in cerebral microvascular disease and white matter stroke.. Neural regeneration research, 2016.
  52. Brumm AJ, Nunez S, Doroudchi MM, Kawaguchi R, Duan J, Pellegrini M, Lam L, Carmichael ST, Deb A, Hinman JD. Astrocytes Can Adopt Endothelial Cell Fates in a p53-Dependent Manner.. Molecular neurobiology, 2016.
  53. Nunez S, Doroudchi MM, Gleichman AJ, Ng KL, Llorente IL, Sozmen EG, Carmichael ST, Hinman JD. A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology.. Journal of visualized experiments : JoVE, 2016.
  54. Liu D, Scalzo F, Starkman S, Rao NM, Hinman JD, Kim D, Ali LK, Saver JL, Noorian AR, Ng K, Liang C, Sheth SA, Yoo B, Liu X, Liebeskind DS, UCLA-Jinling Neurovascular Imaging Research Collaborators. DWI Lesion Patterns Predict Outcome in Stroke Patients with Thrombolysis.. Cerebrovascular diseases (Basel, Switzerland), 2015.
  55. Tansy AP, Hinman JD, Ng KL, Calderon-Arnulphi M, Modir R, Chatfield F, Liebeskind DS. Image More to Save More.. Frontiers in neurology, 2015.
  56. Hinman JD, Lee MD, Tung S, Vinters HV, Carmichael ST. Molecular disorganization of axons adjacent to human lacunar infarcts.. Brain : a journal of neurology, 2015.
  57. Hinman JD. The back and forth of axonal injury and repair after stroke.. Current opinion in neurology, 2014.
  58. Takahashi C, Liang CW, Liebeskind DS, Hinman JD. To Tube or Not to Tube? The Role of Intubation during Stroke Thrombectomy.. Frontiers in neurology, 2014.
  59. Hinman JD, Rao NM, Yallapragada A, Capri J, Souda P, Whitelegge J, Yong WH, Jahan R, Quinones-Baldrich W, Saver JL. Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli.. Frontiers in neurology, 2013.
  60. Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013.
  61. Hinman JD, Rasband MN, Carmichael ST. Remodeling of the axon initial segment after focal cortical and white matter stroke.. Stroke, 2012.
  62. Sozmen EG, Hinman JD, Carmichael ST. Models that matter: white matter stroke models.. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2012.
  63. Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR. Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts.. Glia, 2008.
  64. Hinman JD, Abraham CR. What's behind the decline? The role of white matter in brain aging.. Neurochemical research, 2007.
  65. Hinman JD, Peters A, Cabral H, Rosene DL, Hollander W, Rasband MN, Abraham CR. Age-related molecular reorganization at the node of Ranvier.. The Journal of comparative neurology, 2006.
  66. Chen CD, Oh SY, Hinman JD, Abraham CR. Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation.. Journal of neurochemistry, 2006.
  67. Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. Amyloid precursor protein interacts with notch receptors.. Journal of neuroscience research, 2005.
  68. Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR. Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey.. Journal of neurochemistry, 2004.