Jau-Nian Chen

Jau-Nian Chen

Professor, Molecular, Cell and Developmental Biology, University of California Los Angeles

(310) 206-4513

Education and Training



  1. Shimizu H, Huber S, Langenbacher AD, Crisman L, Huang J, Wang K, Wilting F, Gudermann T, Schredelseker J, Chen JN. Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca2+ Uptake.. Frontiers in physiology, 2021.
  2. Langenbacher AD, Shimizu H, Hsu W, Zhao Y, Borges A, Koehler C, Chen JN. Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia.. Frontiers in physiology, 2020.
  3. Hilfenhaus G, Mompeón A, Freshman J, Prajapati DP, Hernandez G, Freitas VM, Ma F, Langenbacher AD, Mirkov S, Song D, Cho BK, Goo YA, Pellegrini M, Chen JN, Damoiseaux R, Iruela-Arispe ML. A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier.. Cancer research, 2020.
  4. Xu Q, Dupper NJ, Smaligo AJ, Fan YC, Cai L, Wang Z, Langenbacher AD, Chen JN, Kwon O. Catalytic Enantioselective Synthesis of Guvacine Derivatives through [4 + 2] Annulations of Imines with α-Methylallenoates.. Organic letters, 2018.
  5. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system.. JCI insight, 2018.
  6. Ziyad S, Riordan JD, Cavanaugh AM, Su T, Hernandez GE, Hilfenhaus G, Morselli M, Huynh K, Wang K, Chen JN, Dupuy AJ, Iruela-Arispe ML. A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.. Cell reports, 2018.
  7. Hua KT, Hong JB, Sheen YS, Huang HY, Huang YL, Chen JS, Liao YH. miR-519d Promotes Melanoma Progression by Downregulating EphA4.. Cancer research, 2017.
  8. Shimizu H, Langenbacher AD, Huang J, Wang K, Otto G, Geisler R, Wang Y, Chen JN. The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.. eLife, 2017.
  9. Lu F, Langenbacher A, Chen JN. Tbx20 drives cardiac progenitor formation and cardiomyocyte proliferation in zebrafish.. Developmental biology, 2016.
  10. Berchtold MW, Zacharias T, Kulej K, Wang K, Torggler R, Jespersen T, Chen JN, Larsen MR, la Cour JM. The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish.. The Journal of biological chemistry, 2016.
  11. Lu F, Langenbacher AD, Chen JN. Transcriptional Regulation of Heart Development in Zebrafish.. Journal of cardiovascular development and disease, 2016.
  12. Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, Xiao X, Fu XD, Chen JN, Wang Y. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure.. The Journal of clinical investigation, 2015.
  13. Cavanaugh AM, Huang J, Chen JN. Two developmentally distinct populations of neural crest cells contribute to the zebrafish heart.. Developmental biology, 2015.
  14. Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen JN. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity.. eLife, 2015.
  15. Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT. Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.. Genes & development, 2014.
  16. Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK. Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos.. Arteriosclerosis, thrombosis, and vascular biology, 2014.
  17. Zhang Y, Shimizu H, Siu KL, Mahajan A, Chen JN, Cai H. NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish.. The Journal of biological chemistry, 2014.
  18. Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J. High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population.. The Journal of biological chemistry, 2014.
  19. Monte E, Mouillesseaux K, Chen H, Kimball T, Ren S, Wang Y, Chen JN, Vondriska TM, Franklin S. Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes.. American journal of physiology. Heart and circulatory physiology, 2013.
  20. Foster WH, Langenbacher A, Gao C, Chen J, Wang Y. Nuclear phosphatase PPM1G in cellular survival and neural development.. Developmental dynamics : an official publication of the American Association of Anatomists, 2013.
  21. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.. Cell, 2012.
  22. Langenbacher AD, Huang J, Chen Y, Chen JN. Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis.. Developmental biology, 2011.
  23. Mouillesseaux K, Chen JN. Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryos.. PloS one, 2011.
  24. Langenbacher AD, Nguyen CT, Cavanaugh AM, Huang J, Lu F, Chen JN. The PAF1 complex differentially regulates cardiomyocyte specification.. Developmental biology, 2011.
  25. Choi J, Mouillesseaux K, Wang Z, Fiji HD, Kinderman SS, Otto GW, Geisler R, Kwon O, Chen JN. Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis.. Development (Cambridge, England), 2011.
  26. Sun H, Lu G, Ren S, Chen J, Wang Y. Catabolism of branched-chain amino acids in heart failure: insights from genetic models.. Pediatric cardiology, 2011.
  27. Yu F, Huang J, Adlerz K, Jadvar H, Hamdan MH, Chi N, Chen JN, Hsiai TK. Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity.. Zebrafish, 2010.
  28. Nguyen CT, Langenbacher A, Hsieh M, Chen JN. The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish.. Developmental biology, 2010.
  29. Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.. Nature, 2009.
  30. Langenbacher A, Chen JN. Calcium signaling: a common thread in vertebrate left-right axis development.. Developmental dynamics : an official publication of the American Association of Anatomists, 2008.
  31. Colantonio JR, Vermot J, Wu D, Langenbacher AD, Fraser S, Chen JN, Hill KL. The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear.. Nature, 2008.
  32. Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart.. American journal of physiology. Cell physiology, 2008.
  33. Nguyen CT, Lu Q, Wang Y, Chen JN. Zebrafish as a model for cardiovascular development and disease.. Drug discovery today. Disease models, 2008.
  34. Liu J, Fraser SD, Faloon PW, Rollins EL, Vom Berg J, Starovic-Subota O, Laliberte AL, Chen JN, Serluca FC, Childs SJ. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
  35. Shu X, Huang J, Dong Y, Choi J, Langenbacher A, Chen JN. Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterning.. Development (Cambridge, England), 2007.
  36. Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.. Genes & development, 2007.
  37. Choi J, Dong L, Ahn J, Dao D, Hammerschmidt M, Chen JN. FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish.. Developmental biology, 2007.
  38. Cibrián-Uhalte E, Langenbacher A, Shu X, Chen JN, Abdelilah-Seyfried S. Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance.. The Journal of cell biology, 2007.
  39. Mably JD, Chuang LP, Serluca FC, Mohideen MA, Chen JN, Fishman MC. santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish.. Development (Cambridge, England), 2006.
  40. Lin SJ, Lo W, Tan HY, Chan JY, Chen WL, Wang SH, Sun Y, Lin WC, Chen JS, Hsu CJ, Tjiu JW, Yu HS, Jee SH, Dong CY. Prediction of heat-induced collagen shrinkage by use of second harmonic generation microscopy.. Journal of biomedical optics, 2006.
  41. Langenbacher AD, Dong Y, Shu X, Choi J, Nicoll DA, Goldhaber JI, Philipson KD, Chen JN. Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  42. Jin SW, Beis D, Mitchell T, Chen JN, Stainier DY. Cellular and molecular analyses of vascular tube and lumen formation in zebrafish.. Development (Cambridge, England), 2005.
  43. Beis D, Bartman T, Jin SW, Scott IC, D'Amico LA, Ober EA, Verkade H, Frantsve J, Field HA, Wehman A, Baier H, Tallafuss A, Bally-Cuif L, Chen JN, Stainier DY, Jungblut B. Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development.. Development (Cambridge, England), 2005.
  44. Kim HJ, Sumanas S, Palencia-Desai S, Dong Y, Chen JN, Lin S. Genetic analysis of early endocrine pancreas formation in zebrafish.. Molecular endocrinology (Baltimore, Md.), 2005.
  45. Chen JN, Cowan DB, Mably JD. Cardiogenesis and the regulation of cardiac-specific gene expression.. Heart failure clinics, 2005.
  46. Huang H, Zhang B, Hartenstein PA, Chen JN, Lin S. NXT2 is required for embryonic heart development in zebrafish.. BMC developmental biology, 2005.
  47. Mably JD, Mohideen MA, Burns CG, Chen JN, Fishman MC. heart of glass regulates the concentric growth of the heart in zebrafish.. Current biology : CB, 2003.
  48. Chan HP, Goodsitt MM, Hadjiiski LM, Bailey JE, Klein K, Darner KL, Sahiner B. Effects of magnification and zooming on depth perception in digital stereomammography: an observer performance study.. Physics in medicine and biology, 2003.
  49. Shu X, Cheng K, Patel N, Chen F, Joseph E, Tsai HJ, Chen JN. Na,K-ATPase is essential for embryonic heart development in the zebrafish.. Development (Cambridge, England), 2003.
  50. Cross LM, Cook MA, Lin S, Chen JN, Rubinstein AL. Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay.. Arteriosclerosis, thrombosis, and vascular biology, 2003.
  51. Childs S, Chen JN, Garrity DM, Fishman MC. Patterning of angiogenesis in the zebrafish embryo.. Development (Cambridge, England), 2002.
  52. Peterson RT, Mably JD, Chen JN, Fishman MC. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul.. Current biology : CB, 2001.
  53. Chan J, Mably JD, Serluca FC, Chen JN, Goldstein NB, Thomas MC, Cleary JA, Brennan C, Fishman MC, Roberts TM. Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling.. Developmental biology, 2001.
  54. Chen JN, van Bebber F, Goldstein AM, Serluca FC, Jackson D, Childs S, Serbedzija G, Warren KS, Mably JD, Lindahl P, Mayer A, Haffter P, Fishman MC. Genetic steps to organ laterality in zebrafish.. Comparative and functional genomics, 2001.
  55. Chen JN, Fishman MC. Genetics of heart development.. Trends in genetics : TIG, 2000.
  56. Chen JN, Fishman MC. Genetic dissection of heart development.. Ernst Schering Research Foundation workshop, 2000.
  57. Park M, Lewis C, Turbay D, Chung A, Chen JN, Evans S, Breitbart RE, Fishman MC, Izumo S, Bodmer R. Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes.. Proceedings of the National Academy of Sciences of the United States of America, 1998.
  58. Serbedzija GN, Chen JN, Fishman MC. Regulation in the heart field of zebrafish.. Development (Cambridge, England), 1998.
  59. Chen JN, van Eeden FJ, Warren KS, Chin A, Nüsslein-Volhard C, Haffter P, Fishman MC. Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish.. Development (Cambridge, England), 1997.
  60. Chin AJ, Chen JN, Weinberg ES. Bone morphogenetic protein-4 expression characterizes inductive boundaries in organs of developing zebrafish.. Development genes and evolution, 1997.
  61. Chen JN, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA, Kelsh RN, Mullins MC, Nüsslein-Volhard C. Mutations affecting the cardiovascular system and other internal organs in zebrafish.. Development (Cambridge, England), 1996.
  62. Stainier DY, Fouquet B, Chen JN, Warren KS, Weinstein BM, Meiler SE, Mohideen MA, Neuhauss SC, Solnica-Krezel L, Schier AF, Zwartkruis F, Stemple DL, Malicki J, Driever W, Fishman MC. Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo.. Development (Cambridge, England), 1996.
  63. Chen JN, Fishman MC. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation.. Development (Cambridge, England), 1996.
  64. Murphy M, Chen JN, George DL. Establishment and characterization of a human leptomeningeal cell line.. Journal of neuroscience research, 1991.