Publications

1. Gonzalez-DeWhitt KR, Ermolova N, Wang HK, Hekstra DR, Althoff T, Abramson J. Insights into VDAC Gating: Room-Temperature X-ray Crystal Structure of mVDAC-1.. Biomolecules, 2024.
2. Khan F, Elgeti M, Grandfield S, Paz A, Naughton FB, Marcoline FV, Althoff T, Ermolova N, Wright EM, Hubbell WL, Grabe M, Abramson J. Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.. Nature communications, 2023.
3. Premageetha GTR, Dhanabalan K, Bose S, Manjunath L, Joseph D, Paz A, Grandfield S, Nayak V, Bredeston LM, Abramson J, Ramaswamy S. Biochemical characterization of a GDP-mannose transporter from Chaetomium thermophilum.. PloS one, 2023.
4. Ngo VA, Queralt-Martín M, Khan F, Bergdoll L, Abramson J, Bezrukov SM, Rostovtseva TK, Hoogerheide DP, Noskov SY. The Single Residue K12 Governs the Exceptional Voltage Sensitivity of Mitochondrial Voltage-Dependent Anion Channel Gating.. Journal of the American Chemical Society, 2022.
5. Besterman AD, Althoff T, Elfferich P, Gutierrez-Mejia I, Sadik J, Bernstein JA, van Ierland Y, Kattentidt-Mouravieva AA, Nellist M, Abramson J, Martinez-Agosto JA. Functional and structural analyses of novel Smith-Kingsmore Syndrome-Associated MTOR variants reveal potential new mechanisms and predictors of pathogenicity.. PLoS genetics, 2021.
6. Mannucci I, Dang NDP, Huber H, Murry JB, Abramson J, Althoff T, Banka S, Baynam G, Bearden D, Beleza-Meireles A, Benke PJ, Berland S, Bierhals T, Bilan F, Bindoff LA, Braathen GJ, Busk ØL, Chenbhanich J, Denecke J, Escobar LF, Estes C, Fleischer J, Groepper D, Haaxma CA, Hempel M, Holler-Managan Y, Houge G, Jackson A, Kellogg L, Keren B, Kiraly-Borri C, Kraus C, Kubisch C, Le Guyader G, Ljungblad UW, Brenman LM, Martinez-Agosto JA, Might M, Miller DT, Minks KQ, Moghaddam B, Nava C, Nelson SF, Parant JM, Prescott T, Rajabi F, Randrianaivo H, Reiter SF, Schuurs-Hoeijmakers J, Shieh PB, Slavotinek A, Smithson S, Stegmann APA, Tomczak K, Tveten K, Wang J, Whitlock JH, Zweier C, McWalter K, Juusola J, Quintero-Rivera F, Fischer U, Yeo NC, Kreienkamp HJ, Lessel D. Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders.. Genome medicine, 2021.
7. Shum M, Shintre CA, Althoff T, Gutierrez V, Segawa M, Saxberg AD, Martinez M, Adamson R, Young MR, Faust B, Gharakhanian R, Su S, Chella Krishnan K, Mahdaviani K, Veliova M, Wolf DM, Ngo J, Nocito L, Stiles L, Abramson J, Lusis AJ, Hevener AL, Zoghbi ME, Carpenter EP, Liesa M. ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.. Science translational medicine, 2021.
8. Abramson J, Wright EM. Function Trumps Form in Two Sugar Symporters, LacY and vSGLT.. International journal of molecular sciences, 2021.
9. Martynowycz MW, Khan F, Hattne J, Abramson J, Gonen T. MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
10. Petroff JT, Tong A, Chen LJ, Dekoster GT, Khan F, Abramson J, Frieden C, Cheng WWL. Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts.. Analytical chemistry, 2020.
11. Queralt-Martín M, Bergdoll L, Teijido O, Munshi N, Jacobs D, Kuszak AJ, Protchenko O, Reina S, Magrì A, De Pinto V, Bezrukov SM, Abramson J, Rostovtseva TK. A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology.. The Journal of general physiology, 2020.
12. Althoff T, Abramson J. Protein structure reveals how a malaria parasite imports a wide range of sugars.. Nature, 2020.
13. Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS. Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019.
14. Pantazis A, Westerberg K, Althoff T, Abramson J, Olcese R. Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances.. Nature communications, 2018.
15. Queralt-Martín M, Bergdoll L, Jacobs D, Bezrukov SM, Abramson J, Rostovtseva TK. Assessing the role of residue E73 and lipid headgroup charge in VDAC1 voltage gating.. Biochimica et biophysica acta. Bioenergetics, 2018.
16. Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.. Nature communications, 2018.
17. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. Conformational transitions of the sodium-dependent sugar transporter, vSGLT.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
18. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
19. Hoogerheide DP, Noskov SY, Jacobs D, Bergdoll L, Silin V, Worcester DL, Abramson J, Nanda H, Rostovtseva TK, Bezrukov SM. Structural features and lipid binding domain of tubulin on biomimetic mitochondrial membranes.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
20. Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.. The Journal of biological chemistry, 2017.
21. Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS. Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.. Analytical chemistry, 2017.
22. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. Stochastic steps in secondary active sugar transport.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
23. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.. Science signaling, 2016.
24. Ji J, Lee H, Argiropoulos B, Dorrani N, Mann J, Martinez-Agosto JA, Gomez-Ospina N, Gallant N, Bernstein JA, Hudgins L, Slattery L, Isidor B, Le Caignec C, David A, Obersztyn E, Wisniowiecka-Kowalnik B, Fox M, Deignan JL, Vilain E, Hendricks E, Horton Harr M, Noon SE, Jackson JR, Wilkens A, Mirzaa G, Salamon N, Abramson J, Zackai EH, Krantz I, Innes AM, Nelson SF, Grody WW, Quintero-Rivera F. DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies.. European journal of human genetics : EJHG, 2015.
25. Li Z, Lee ASE, Bracher S, Jung H, Paz A, Kumar JP, Abramson J, Quick M, Shi L. Identification of a second substrate-binding site in solute-sodium symporters.. The Journal of biological chemistry, 2015.
26. Li Z, Lee AS, Bracher S, Jung H, Paz A, Kumar JP, Abramson J, Quick M, Shi L. Identification of a second substrate-binding site in solute-sodium symporters.. The Journal of biological chemistry, 2014.
27. Choudhary OP, Paz A, Adelman JL, Colletier JP, Abramson J, Grabe M. Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1.. Nature structural & molecular biology, 2014.
28. Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. Structural determinants of water permeation through the sodium-galactose transporter vSGLT.. Biophysical journal, 2014.
29. Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J. High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population.. The Journal of biological chemistry, 2014.
30. Abramson J, Vartanian AS. Biochemistry. Watch water flow.. Science (New York, N.Y.), 2013.
31. Vartanian AS, Paz A, Fortgang EA, Abramson J, Dahlquist FW. Structure of flagellar motor proteins in complex allows for insights into motor structure and switching.. The Journal of biological chemistry, 2012.
32. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).. Proceedings of the National Academy of Sciences of the United States of America, 2012.
33. Abramson J, Paz A, Philipson KD. Structural biology. It's all in the symmetry.. Science (New York, N.Y.), 2012.
34. Besserer GM, Nicoll DA, Abramson J, Philipson KD. Characterization and purification of a Na+/Ca2+ exchanger from an archaebacterium.. The Journal of biological chemistry, 2012.
35. Teijido O, Ujwal R, Hillerdal CO, Kullman L, Rostovtseva TK, Abramson J. Affixing N-terminal α-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gating.. The Journal of biological chemistry, 2012.
36. Ujwal R, Abramson J. High-throughput crystallization of membrane proteins using the lipidic bicelle method.. Journal of visualized experiments : JoVE, 2012.
37. Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM. Bridging the gap between structure and kinetics of human SGLT1.. American journal of physiology. Cell physiology, 2011.
38. Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
39. Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. The mechanism of sodium and substrate release from the binding pocket of vSGLT.. Nature, 2010.
40. Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. Water permeation through the sodium-dependent galactose cotransporter vSGLT.. Biophysical journal, 2010.
41. Hsieh JM, Tsirulnikov K, Sawaya MR, Magilnick N, Abuladze N, Kurtz I, Abramson J, Pushkin A. Structures of aminoacylase 3 in complex with acetylated substrates.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
42. Westenhoff S, Malmerberg E, Arnlund D, Johansson L, Nazarenko E, Cammarata M, Davidsson J, Chaptal V, Abramson J, Katona G, Menzel A, Neutze R. Rapid readout detector captures protein time-resolved WAXS.. Nature methods, 2010.
43. Hiller S, Abramson J, Mannella C, Wagner G, Zeth K. The 3D structures of VDAC represent a native conformation.. Trends in biochemical sciences, 2010.
44. Lin MC, Abramson J, Papazian DM. Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening.. The Journal of general physiology, 2010.
45. Hsieh JM, Besserer GM, Madej MG, Bui HQ, Kwon S, Abramson J. Bridging the gap: a GFP-based strategy for overexpression and purification of membrane proteins with intra and extracellular C-termini.. Protein science : a publication of the Protein Society, 2010.
46. Chaptal V, Ujwal R, Nie Y, Watanabe A, Kwon S, Abramson J. Fluorescence Detection of Heavy Atom Labeling (FD-HAL): a rapid method for identifying covalently modified cysteine residues by phasing atoms.. Journal of structural biology, 2010.
47. Kracun S, Chaptal V, Abramson J, Khakh BS. Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.. The Journal of biological chemistry, 2010.
48. Ryan CM, Souda P, Bassilian S, Ujwal R, Zhang J, Abramson J, Ping P, Durazo A, Bowie JU, Hasan SS, Baniulis D, Cramer WA, Faull KF, Whitelegge JP. Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation.. Molecular & cellular proteomics : MCP, 2010.
49. Choudhary OP, Ujwal R, Kowallis W, Coalson R, Abramson J, Grabe M. The electrostatics of VDAC: implications for selectivity and gating.. Journal of molecular biology, 2009.
50. Abramson J, Chaptal V. Keeping an eye on membrane transport by TR-WAXS.. Structure (London, England : 1993), 2009.
51. Abramson J, Wright EM. Structure and function of Na(+)-symporters with inverted repeats.. Current opinion in structural biology, 2009.
52. Ujwal R, Cascio D, Chaptal V, Ping P, Abramson J. Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation.. Channels (Austin, Tex.), 2009.
53. Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger.. The Journal of biological chemistry, 2009.
54. Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, Abramson J. The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
55. Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport.. Science (New York, N.Y.), 2008.
56. Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger?. Channels (Austin, Tex.), 2008.
57. Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
58. Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. What we know about the structure of NCX1 and how it relates to its function.. Annals of the New York Academy of Sciences, 2007.
59. Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J. The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif.. The Journal of biological chemistry, 2006.
60. Abramson J, Kaback HR, Iwata S. Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily.. Current opinion in structural biology, 2004.
61. Abramson J, Iwata S, Kaback HR. Lactose permease as a paradigm for membrane transport proteins (Review).. Molecular membrane biology, 2004.
62. Abramson J, Smirnova I, Kasho V, Verner G, Iwata S, Kaback HR. The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport.. FEBS letters, 2003.
63. Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. Structure and mechanism of the lactose permease of Escherichia coli.. Science (New York, N.Y.), 2003.
64. Iwata M, Abramson J, Byrne B, Iwata S. Structure and function of quinone binding membrane proteins.. Advances in protein chemistry, 2003.
65. Svensson-Ek M, Abramson J, Larsson G, Törnroth S, Brzezinski P, Iwata S. The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides.. Journal of molecular biology, 2002.
66. Jormakka M, Törnroth S, Abramson J, Byrne B, Iwata S. Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli.. Acta crystallographica. Section D, Biological crystallography, 2001.