Jennifer M Murphy
Associate Professor, Molecular and Medical Pharmacology, University of California Los Angeles
jmmurphy@mednet.ucla.edu
(310) 825-7548
Laboratory Address:
CNSI 4310, Crump Institute for Molecular Imaging
Los Angeles, CA 90095
Office Address:
CNSI 4321, Crump Institute for Molecular Imaging
570 Westwood Plaza
Los Angeles, CA 90095
Affiliations
Member, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Faculty, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology
Faculty, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology
Biography:
Dr. Murphy’s lab is focused on developing new [18F]-fluorination methods for the synthesis of small-molecule imaging probes that are useful for performing in vivo assays of biochemical and biological processes using the molecular imaging technique of positron emission tomography (PET). In addition to small molecule PET probes, research includes developing novel approaches for the site-specific and rapid [18F]-radiolabeling of biologics like peptides, proteins and antibodies. The aim is to simplify and facilitate general access to promising PET imaging probes for examining the biology of disease, enhancing molecular diagnostic tools and advancing therapeutic developments.
Publications
- McDaniel JW, Stauber JM, Doud EA, Spokoyny AM, Murphy JM. An Organometallic Gold(III) Reagent for 18F Labeling of Unprotected Peptides and Sugars in Aqueous Media.. Organic letters, 2022.
- Narayanam MK, Lai BT, Loredo JM, Wilson JA, Eliasen AM, LaBerge NA, Nason M, Cantu AL, Luton BK, Xu S, Agnew HD, Murphy JM. Positron Emission Tomography Tracer Design of Targeted Synthetic Peptides via 18F-Sydnone Alkyne Cycloaddition.. Bioconjugate chemistry, 2021.
- Ma G, McDaniel JW, Murphy JM. One-Step Synthesis of [18F]Fluoro-4-(vinylsulfonyl)benzene: A Thiol Reactive Synthon for Selective Radiofluorination of Peptides.. Organic letters, 2020.
- Narayanam MK, Toutov AA, Murphy JM. Rapid One-Step 18F-Labeling of Peptides via Heteroaromatic Silicon-Fluoride Acceptors.. Organic letters, 2020.
- Gamache RF, Zettlitz KA, Tsai WK, Collins J, Wu AM, Murphy JM. Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging.. Chemical science, 2020.
- Zettlitz KA, Waldmann CM, Tsai WK, Tavaré R, Collins J, Murphy JM, Wu AM. A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence Imaging.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019.
- Chao PH, Lazari M, Hanet S, Narayanam MK, Murphy JM, van Dam RM. Automated concentration of [18F]fluoride into microliter volumes.. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2018.
- Tao H, Liu F, Zeng R, Shao Z, Zou L, Cao Y, Murphy JM, Houk KN, Liang Y. Origins of halogen effects in bioorthogonal sydnone cycloadditions.. Chemical communications (Cambridge, England), 2018.
- Levandowski BJ, Gamache RF, Murphy JM, Houk KN. Readily Accessible Ambiphilic Cyclopentadienes for Bioorthogonal Labeling.. Journal of the American Chemical Society, 2018.
- Collins J, Waldmann CM, Drake C, Slavik R, Ha NS, Sergeev M, Lazari M, Shen B, Chin FT, Moore M, Sadeghi S, Phelps ME, Murphy JM, van Dam RM. Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
- Narayanam MK, Ma G, Champagne PA, Houk KN, Murphy JM. Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.. Angewandte Chemie (International ed. in English), 2017.
- Gamache RF, Waldmann C, Murphy JM. Copper-Mediated Oxidative Fluorination of Aryl Stannanes with Fluoride.. Organic letters, 2016.
- Hoover AJ, Lazari M, Ren H, Narayanam MK, Murphy JM, van Dam RM, Hooker JM, Ritter T. A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging.. Organometallics, 2016.
- Narayanam MK, Liang Y, Houk KN, Murphy JM. Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening.. Chemical science, 2015.
- Lazari M, Lyashchenko SK, Burnazi EM, Lewis JS, van Dam RM, Murphy JM. Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2015.
- Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.. The Journal of experimental medicine, 2014.
- Nomme J, Murphy JM, Su Y, Sansone ND, Armijo AL, Olson ST, Radu C, Lavie A. Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.. Acta crystallographica. Section D, Biological crystallography, 2013.
- Mazzotti AR, Campbell MG, Tang P, Murphy JM, Ritter T. Palladium(III)-catalyzed fluorination of arylboronic acid derivatives.. Journal of the American Chemical Society, 2013.
- Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.. Journal of medicinal chemistry, 2013.