Publications

1. Wu MF, Thannickal T, Li S, McGregor R, Lai YY, Siegel JM. Effects of sodium oxybate on hypocretin/orexin and locus coeruleus neurons.. Sleep, 2023.
2. McGregor R, Matzeu A, Thannickal TC, Wu F, Cornford M, Martin-Fardon R, Siegel JM. Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study.. Neuroscience, 2023.
3. Siegel JM. Sleep function: an evolutionary perspective.. The Lancet. Neurology, 2022.
4. Salminen AV, Clemens S, García-Borreguero D, Ghorayeb I, Li Y, Manconi M, Ondo W, Rye D, Siegel JM, Silvani A, Winkelman JW, Allen RP, Ferré S, International Restless Legs Syndrome Study Group (IRLSSG). Consensus guidelines on the construct validity of rodent models of restless legs syndrome.. Disease models & mechanisms, 2022.
5. Lyamin OI, Siegel JM, Nazarenko EA, Rozhnov VV. Sleep in the lesser mouse-deer (Tragulus kanchil).. Sleep, 2022.
6. Lai YY, Hsieh KC, Chew KT, Nguyen D, Siegel JM. Striatal mechanism of the restless legs syndrome.. Sleep, 2022.
7. McGregor R, Wu MF, Holmes B, Lam HA, Maidment NT, Gera J, Yamanaka A, Siegel JM. Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021.
8. Williams VM, Bhagwandin A, Swiegers J, Bertelsen MF, Hård T, Thannickal TC, Siegel JM, Sherwood CC, Manger PR. Nuclear organization of orexinergic neurons in the hypothalamus of a lar gibbon and a chimpanzee.. Anatomical record (Hoboken, N.J. : 2007), 2021.
9. Coleman P, de Lecea L, Gotter A, Hagan J, Hoyer D, Kilduff T, Kukkonen JP, Porter R, Renger J, Siegel JM, Sutcliffe G, Upton N, Winrow CJ. Orexin receptors in GtoPdb v.2021.3.. IUPHAR/BPS guide to pharmacology CITE, 2021.
10. Lyamin OI, Kibalnikov AS, Siegel JM. Sleep in ostrich chicks (Struthio camelus).. Sleep, 2021.
11. Lai YY, Kodama T, Hsieh KC, Nguyen D, Siegel JM. Substantia nigra pars reticulata-mediated sleep and motor activity regulation.. Sleep, 2021.
12. Siegel JM. Memory Consolidation Is Similar in Waking and Sleep.. Current sleep medicine reports, 2021.
13. McGregor R, Thannickal TC, Siegel JM. Pleasure, addiction, and hypocretin (orexin).. Handbook of clinical neurology, 2021.
14. Salminen AV, Silvani A, Allen RP, Clemens S, Garcia-Borreguero D, Ghorayeb I, Ferré S, Li Y, Ondo W, Picchietti DL, Rye D, Siegel JM, Winkelman JW, Manconi M, International Restless Legs Syndrome Study Group (IRLSSG). Consensus Guidelines on Rodent Models of Restless Legs Syndrome.. Movement disorders : official journal of the Movement Disorder Society, 2020.
15. Lai YY, Hsieh KC, Cheng YH, Chew KT, Nguyen D, Ramanathan L, Siegel JM. Striatal histamine mechanism in the pathogenesis of restless legs syndrome.. Sleep, 2020.
16. Manger PR, Siegel JM. Do all mammals dream?. The Journal of comparative neurology, 2020.
17. Siegel JM. Sleep under evolutionarily relevant conditions.. Sleep medicine, 2020.
18. Kostin A, Alam MA, Siegel JM, McGinty D, Alam MN. Sex- and Age-dependent Differences in Sleep-wake Characteristics of Fisher-344 Rats.. Neuroscience, 2019.
19. Smit AN, Broesch T, Siegel JM, Mistlberger RE. Sleep timing and duration in indigenous villages with and without electric lighting on Tanna Island, Vanuatu.. Scientific reports, 2019.
20. Lyamin OI, Siegel JM. Sleep in Aquatic Mammals.. Handbook of behavioral neuroscience, 2019.
21. Kendall-Bar JM, Vyssotski AL, Mukhametov LM, Siegel JM, Lyamin OI. Eye state asymmetry during aquatic unihemispheric slow wave sleep in northern fur seals (Callorhinus ursinus).. PloS one, 2019.
22. Prall SP, Yetish G, Scelza BA, Siegel JM. The influence of age- and sex-specific labor demands on sleep in Namibian agropastoralists.. Sleep health, 2018.
23. Donjacour CEHM, Lammers GJ, Siegel JM. Striking cessation of cataplexy by opioids.. Journal of sleep research, 2018.
24. Alam MA, Kostin A, Siegel J, McGinty D, Szymusiak R, Alam MN. Characteristics of sleep-active neurons in the medullary parafacial zone in rats.. Sleep, 2018.
25. Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM. Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.. Science translational medicine, 2018.
26. Lyamin OI, Kosenko PO, Korneva SM, Vyssotski AL, Mukhametov LM, Siegel JM. Fur Seals Suppress REM Sleep for Very Long Periods without Subsequent Rebound.. Current biology : CB, 2018.
27. Lai YY, Cheng YH, Hsieh KC, Nguyen D, Chew KT, Ramanathan L, Siegel JM. Reply: The iron-deficient rat as a model of restless legs syndrome: Was anything lost in translation?. Movement disorders : official journal of the Movement Disorder Society, 2017.
28. Gravett N, Bhagwandin A, Lyamin OI, Siegel JM, Manger PR. Sociality Affects REM Sleep Episode Duration Under Controlled Laboratory Conditions in the Rock Hyrax, Procavia capensis.. Frontiers in neuroanatomy, 2017.
29. Lai YY, Cheng YH, Hsieh KC, Nguyen D, Chew KT, Ramanathan L, Siegel JM. Motor hyperactivity of the iron-deficient rat - an animal model of restless legs syndrome.. Movement disorders : official journal of the Movement Disorder Society, 2017.
30. McGregor R, Shan L, Wu MF, Siegel JM. Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss.. PloS one, 2017.
31. Lyamin OI, Mukhametov LM, Siegel JM. Sleep in the northern fur seal.. Current opinion in neurobiology, 2017.
32. Gravett N, Bhagwandin A, Sutcliffe R, Landen K, Chase MJ, Lyamin OI, Siegel JM, Manger PR. Inactivity/sleep in two wild free-roaming African elephant matriarchs - Does large body size make elephants the shortest mammalian sleepers?. PloS one, 2017.
33. Yetish G, Kaplan H, Gurven M, Wood B, Pontzer H, Manger PR, Wilson C, McGregor R, Siegel JM. Response to de la Iglesia et al.. Current biology : CB, 2016.
34. Lyamin OI, Lapierre JL, Kosenko PO, Kodama T, Bhagwandin A, Korneva SM, Peever JH, Mukhametov LM, Siegel JM. Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal.. Sleep, 2016.
35. Dell LA, Patzke N, Spocter MA, Siegel JM, Manger PR. Organization of the sleep-related neural systems in the brain of the harbour porpoise (Phocoena phocoena).. The Journal of comparative neurology, 2016.
36. Dell LA, Patzke N, Spocter MA, Bertelsen MF, Siegel JM, Manger PR. Organization of the sleep-related neural systems in the brain of the river hippopotamus (Hippopotamus amphibius): A most unusual cetartiodactyl species.. The Journal of comparative neurology, 2016.
37. Macey PM, Sarma MK, Nagarajan R, Aysola R, Siegel JM, Harper RM, Thomas MA. Obstructive sleep apnea is associated with low GABA and high glutamate in the insular cortex.. Journal of sleep research, 2016.
38. Dell LA, Karlsson KA, Patzke N, Spocter MA, Siegel JM, Manger PR. Organization of the sleep-related neural systems in the brain of the minke whale (Balaenoptera acutorostrata).. The Journal of comparative neurology, 2015.
39. Yetish G, Kaplan H, Gurven M, Wood B, Pontzer H, Manger PR, Wilson C, McGregor R, Siegel JM. Natural sleep and its seasonal variations in three pre-industrial societies.. Current biology : CB, 2015.
40. Dell LA, Spocter MA, Patzke N, Karlson KÆ, Alagaili AN, Bennett NC, Muhammed OB, Bertelsen MF, Siegel JM, Manger PR. Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls.. Journal of chemical neuroanatomy, 2015.
41. Shan L, Dauvilliers Y, Siegel JM. Interactions of the histamine and hypocretin systems in CNS disorders.. Nature reviews. Neurology, 2015.
42. Ramanathan L, Siegel JM. Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance.. Journal of neurochemistry, 2014.
43. John J, Kodama T, Siegel JM. Caffeine promotes glutamate and histamine release in the posterior hypothalamus.. American journal of physiology. Regulatory, integrative and comparative physiology, 2014.
44. Kostin A, Siegel JM, Alam MN. Lack of hypocretin attenuates behavioral changes produced by glutamatergic activation of the perifornical-lateral hypothalamic area.. Sleep, 2014.
45. Blouin AM, Siegel JM. Relation of melanin concentrating hormone levels to sleep, emotion and hypocretin levels.. Sleep, 2013.
46. John J, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N, Yamanaka A, Stone C, Cornford M, Siegel JM. Greatly increased numbers of histamine cells in human narcolepsy with cataplexy.. Annals of neurology, 2013.
47. Lapierre JL, Kosenko PO, Kodama T, Peever JH, Mukhametov LM, Lyamin OI, Siegel JM. Symmetrical serotonin release during asymmetrical slow-wave sleep: implications for the neurochemistry of sleep-waking states.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013.
48. Blouin AM, Fried I, Wilson CL, Staba RJ, Behnke EJ, Lam HA, Maidment NT, Karlsson KÆ, Lapierre JL, Siegel JM. Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.. Nature communications, 2013.
49. Hsieh KC, Nguyen D, Siegel JM, Lai YY. New pathways and data on rapid eye movement sleep behaviour disorder in a rat model.. Sleep medicine, 2012.
50. Siegel JM. Evolution. Suppression of sleep for mating.. Science (New York, N.Y.), 2012.
51. Dell LA, Patzke N, Bhagwandin A, Bux F, Fuxe K, Barber G, Siegel JM, Manger PR. Organization and number of orexinergic neurons in the hypothalamus of two species of Cetartiodactyla: a comparison of giraffe (Giraffa camelopardalis) and harbour porpoise (Phocoena phocoena).. Journal of chemical neuroanatomy, 2012.
52. Lyamin OI, Pavlova IF, Kosenko PO, Mukhametov LM, Siegel JM. Regional differences in cortical electroencephalogram (EEG) slow wave activity and interhemispheric EEG asymmetry in the fur seal.. Journal of sleep research, 2012.
53. Gravett N, Bhagwandin A, Lyamin OI, Siegel JM, Manger PR. Sleep in the rock hyrax, Procavia capensis.. Brain, behavior and evolution, 2012.
54. McGregor R, Wu MF, Barber G, Ramanathan L, Siegel JM. Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
55. Bhagwandin A, Gravett N, Lyamin OI, Oosthuizen MK, Bennett NC, Siegel JM, Manger PR. Sleep and wake in rhythmic versus arrhythmic chronotypes of a microphthalmic species of African mole rat (Fukomys mechowii).. Brain, behavior and evolution, 2011.
56. Ramanathan L, Siegel JM. Sleep deprivation under sustained hypoxia protects against oxidative stress.. Free radical biology & medicine, 2011.
57. Wu MF, Nienhuis R, Maidment N, Lam HA, Siegel JM. Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
58. Siegel JM. REM sleep: a biological and psychological paradox.. Sleep medicine reviews, 2011.
59. McGregor R, Siegel JM. Illuminating the locus coeruleus: control of posture and arousal.. Nature neuroscience, 2010.
60. Lai YY, Kodama T, Schenkel E, Siegel JM. Behavioral response and transmitter release during atonia elicited by medial medullary stimulation.. Journal of neurophysiology, 2010.
61. Ramanathan L, Hu S, Frautschy SA, Siegel JM. Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior.. Behavioural brain research, 2009.
62. Siegel JM. The neurobiology of sleep.. Seminars in neurology, 2009.
63. Siegel JM. Sleep viewed as a state of adaptive inactivity.. Nature reviews. Neuroscience, 2009.
64. Thannickal TC, Nienhuis R, Siegel JM. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy.. Sleep, 2009.
65. Siegel JM. Narcolepsy. Interview by Norman Sussman.. CNS spectrums, 2009.
66. Pryaslova JP, Lyamin OI, Siegel JM, Mukhametov LM. Behavioral sleep in the walrus.. Behavioural brain research, 2009.
67. Scammell TE, Willie JT, Guilleminault C, Siegel JM, International Working Group on Rodent Models of Narcolepsy. A consensus definition of cataplexy in mouse models of narcolepsy.. Sleep, 2009.
68. Siegel JM. Gaps that wake you up.. Sleep, 2008.
69. Lyamin OI, Kosenko PO, Lapierre JL, Mukhametov LM, Siegel JM. Fur seals display a strong drive for bilateral slow-wave sleep while on land.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
70. John J, Ramanathan L, Siegel JM. Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats.. American journal of physiology. Regulatory, integrative and comparative physiology, 2008.
71. Allada R, Siegel JM. Unearthing the phylogenetic roots of sleep.. Current biology : CB, 2008.
72. Lyamin OI, Lapierre JL, Kosenko PO, Mukhametov LM, Siegel JM. Electroencephalogram asymmetry and spectral power during sleep in the northern fur seal.. Journal of sleep research, 2008.
73. Lyamin OI, Manger PR, Ridgway SH, Mukhametov LM, Siegel JM. Cetacean sleep: an unusual form of mammalian sleep.. Neuroscience and biobehavioral reviews, 2008.
74. Burgess C, Lai D, Siegel J, Peever J. An endogenous glutamatergic drive onto somatic motoneurons contributes to the stereotypical pattern of muscle tone across the sleep-wake cycle.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
75. Siegel JM. Do all animals sleep?. Trends in neurosciences, 2008.
76. Deadwyler SA, Porrino L, Siegel JM, Hampson RE. Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
77. Lapierre JL, Kosenko PO, Lyamin OI, Kodama T, Mukhametov LM, Siegel JM. Cortical acetylcholine release is lateralized during asymmetrical slow-wave sleep in northern fur seals.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
78. Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) and melanin concentrating hormone loss and the symptoms of Parkinson's disease.. Brain : a journal of neurology, 2007.
79. Lyamin O, Pryaslova J, Kosenko P, Siegel J. Behavioral aspects of sleep in bottlenose dolphin mothers and their calves.. Physiology & behavior, 2007.
80. Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson's disease.. Brain : a journal of neurology, 2007.
81. Hu WP, Li JD, Zhang C, Boehmer L, Siegel JM, Zhou QY. Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice.. Sleep, 2007.
82. Li JD, Hu WP, Boehmer L, Cheng MY, Lee AG, Jilek A, Siegel JM, Zhou QY. Attenuated circadian rhythms in mice lacking the prokineticin 2 gene.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006.
83. Siegel JM, Boehmer LN. Narcolepsy and the hypocretin system--where motion meets emotion.. Nature clinical practice. Neurology, 2006.
84. Siegel JM. The stuff dreams are made of: anatomical substrates of REM sleep.. Nature neuroscience, 2006.
85. Siegel JM. Clues to the functions of mammalian sleep.. Nature, 2005.
86. Pisula W, Siegel J. Exploratory behavior as a function of environmental novelty and complexity in male and female rats.. Psychological reports, 2005.
87. Vertes RP, Siegel JM. Rebuttal.. Sleep, 2005.
88. Vertes RP, Siegel JM. Time for the sleep community to take a critical look at the purported role of sleep in memory processing.. Sleep, 2005.
89. Lyamin O, Pryaslova J, Lance V, Siegel J. Animal behaviour: continuous activity in cetaceans after birth.. Nature, 2005.
90. Mileykovskiy BY, Kiyashchenko LI, Siegel JM. Behavioral correlates of activity in identified hypocretin/orexin neurons.. Neuron, 2005.
91. Siegel JM. Functional implications of sleep development.. PLoS biology, 2005.
92. Ramanathan L, Gozal D, Siegel JM. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons.. Journal of neurochemistry, 2005.
93. John J, Wu MF, Maidment NT, Lam HA, Boehmer LN, Patton M, Siegel JM. Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers.. The Journal of physiology, 2004.
94. Siegel J. Brain mechanisms that control sleep and waking.. Die Naturwissenschaften, 2004.
95. John J, Wu MF, Boehmer LN, Siegel JM. Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior.. Neuron, 2004.
96. Manger PR, Fuxe K, Ridgway SH, Siegel JM. The distribution and morphological characteristics of catecholaminergic cells in the diencephalon and midbrain of the bottlenose dolphin (Tursiops truncatus).. Brain, behavior and evolution, 2004.
97. Siegel JM. Hypocretin (orexin): role in normal behavior and neuropathology.. Annual review of psychology, 2004.
98. Greene R, Siegel J. Sleep: a functional enigma.. Neuromolecular medicine, 2004.
99. Siegel JM. The neurotransmitters of sleep.. The Journal of clinical psychiatry, 2004.
100. Siegel JM. Why we sleep.. Scientific American, 2003.
101. Thannickal TC, Siegel JM, Nienhuis R, Moore RY. Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy.. Brain pathology (Zurich, Switzerland), 2003.
102. Manger PR, Ridgway SH, Siegel JM. The locus coeruleus complex of the bottlenose dolphin (Tursiops truncatus) as revealed by tyrosine hydroxylase immunohistochemistry.. Journal of sleep research, 2003.
103. Lai YY, Siegel JM. Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder.. Molecular neurobiology, 2003.
104. John J, Wu MF, Kodama T, Siegel JM. Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats.. The Journal of physiology, 2003.
105. Kodama T, Lai YY, Siegel JM. Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
106. Peever JH, Lai YY, Siegel JM. Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism.. Journal of neurophysiology, 2003.
107. Siegel JM. The narcoleptic borderland.. Sleep medicine, 2003.
108. Mileykovskiy BY, Kiyashchenko LI, Siegel JM. Cessation of activity in red nucleus neurons during stimulation of the medial medulla in decerebrate rats.. The Journal of physiology, 2002.
109. Ramanathan L, Gulyani S, Nienhuis R, Siegel JM. Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem.. Neuroreport, 2002.
110. Eiland MM, Ramanathan L, Gulyani S, Gilliland M, Bergmann BM, Rechtschaffen A, Siegel JM. Increases in amino-cupric-silver staining of the supraoptic nucleus after sleep deprivation.. Brain research, 2002.
111. Kiyashchenko LI, Mileykovskiy BY, Maidment N, Lam HA, Wu MF, John J, Peever J, Siegel JM. Release of hypocretin (orexin) during waking and sleep states.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002.