Jide Tian
Adjunct Professor, Molecular and Medical Pharmacology, University of California Los Angeles
jtian@mednet.ucla.edu
310-206-3350
10833 Le Conte Ave.
Los Angeles, CA 90095
Research Interests
My research focuses on the molecular mechanism(s), which establish peripheral T cell tolerance, the interaction between T cell and antigen presenting cells, and neuroimmune regulation. Using autoimmune disease murine models, my current investigations are 1) to characterize autoimmune processes; 2) to determine the impact of modulation of antigen presenting cells on T cell immunity; and 3) to develop antigen based immunotherapies to re-establish self tolerance. An additional area of my research is to characterize lymphocytic GABA receptors and the potential immuno-regulatory function of GABA.
These studies will aid future endeavors to design immunotherapies for autoimmune diseases and prevent immuno-rejection of transplanted grafts.
Publications
- Tian J, Middleton B, Kaufman DL. GABAA-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice.. Viruses, 2021.
- Tian J, Song M, Kaufman DL. Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis.. Scientific reports, 2021.
- Tian J, Middleton B, Lee VS, Park HW, Zhang Z, Kim B, Lowe C, Nguyen N, Liu H, Beyer RS, Chao HW, Chen R, Mai D, O'Laco KA, Song M, Kaufman DL. GABAB-Receptor Agonist-Based Immunotherapy for Type 1 Diabetes in NOD Mice.. Biomedicines, 2021.
- Tian J, Middleton B, Kaufman DL. GABA administration prevents severe illness and death following coronavirus infection in mice.. bioRxiv : the preprint server for biology, 2020.
- Tian J, Dang H, O'Laco KA, Song M, Tiu BC, Gilles S, Zakarian C, Kaufman DL. Homotaurine Treatment Enhances CD4+ and CD8+ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice.. ImmunoHorizons, 2019.
- Yong J, Tian J, Dang H, Wu TT, Atkinson MA, Sun R, Kaufman DL. Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene.. Scientific reports, 2019.
- Tian J, Dang H, Karashchuk N, Xu I, Kaufman DL. A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA's Ability to Inhibit Inflammatory T Cells.. Journal of diabetes research, 2019.
- Tian J, Dang H, Wallner M, Olsen R, Kaufman DL. Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis.. Scientific reports, 2018.
- Tian J, Dang H, Hu A, Xu W, Kaufman DL. Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication.. Journal of diabetes research, 2017.
- Tian J, Dang H, Middleton B, Kaufman DL. Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication.. Scientific reports, 2017.
- Tian J, Dang H, Nguyen AV, Chen Z, Kaufman DL. Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice.. Diabetes, 2014.
- Tian J, Dang H, Chen Z, Guan A, Jin Y, Atkinson MA, Kaufman DL. γ-Aminobutyric acid regulates both the survival and replication of human β-cells.. Diabetes, 2013.
- Lacan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL. Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.. Journal of neuroscience research, 2013.
- Bilousova T, Dang H, Xu W, Gustafson S, Jin Y, Wickramasinghe L, Won T, Bobarnac G, Middleton B, Tian J, Kaufman DL. Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.. Journal of neuroimmunology, 2012.
- Tian J, Dang H, Kaufman DL. Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice.. PloS one, 2011.
- Tian J, Dang HN, Yong J, Chui WS, Dizon MP, Yaw CK, Kaufman DL. Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice.. PloS one, 2011.
- Tian J, Yong J, Dang H, Kaufman DL. Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis.. Autoimmunity, 2011.
- Washburn LR, Zekzer D, Eitan S, Lu Y, Dang H, Middleton B, Evans CJ, Tian J, Kaufman DL. A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth.. PloS one, 2011.
- Yong J, Rasooly J, Dang H, Lu Y, Middleton B, Zhang Z, Hon L, Namavari M, Stout DB, Atkinson MA, Tian J, Gambhir SS, Kaufman DL. Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.. Diabetes, 2011.
- Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL. BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.. PloS one, 2011.
- Wu ZP, Bilousova T, Escande-Beillard N, Dang H, Hsieh T, Tian J, Kaufman DL. Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves.. Immunology letters, 2010.
- Wu ZP, Washburn L, Bilousova TV, Boudzinskaia M, Escande-Beillard N, Querubin J, Dang H, Xie CW, Tian J, Kaufman DL. Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair.. Journal of neuroimmunology, 2010.
- Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, Joyce S, Tian J, Kaufman DL. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented.. Journal of immunology (Baltimore, Md. : 1950), 2009.
- Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.. Diabetes, 2009.
- Tian J, Kaufman DL. Antigen-based therapy for the treatment of type 1 diabetes.. Diabetes, 2009.
- Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. Long-term monitoring of transplanted islets using positron emission tomography.. Molecular therapy : the journal of the American Society of Gene Therapy, 2006.
- Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL. Noninvasive imaging of islet grafts using positron-emission tomography.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
- Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.. Molecular and cellular biology, 2006.
- Tian J, Zekzer D, Lu Y, Dang H, Kaufman DL. B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice.. Journal of immunology (Baltimore, Md. : 1950), 2006.
- Olcott AP, Tian J, Walker V, Dang H, Middleton B, Adorini L, Washburn L, Kaufman DL. Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice.. Journal of immunology (Baltimore, Md. : 1950), 2005.
- Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL. Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model.. Journal of immunology (Baltimore, Md. : 1950), 2004.
- Olcott AP, Tocco G, Tian J, Zekzer D, Fukuto J, Ignarro L, Kaufman DL. A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.. Diabetes, 2004.
- Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. Bioluminescent monitoring of islet graft survival after transplantation.. Molecular therapy : the journal of the American Society of Gene Therapy, 2004.
- Tian J, Lu Y, Hanssen L, Dang H, Kaufman DL. Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens.. Cellular immunology, 2003.
- Tian J, Olcott AP, Kaufman DL. Antigen-based immunotherapy drives the precocious development of autoimmunity.. Journal of immunology (Baltimore, Md. : 1950), 2002.
- Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL. Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice.. Journal of immunology (Baltimore, Md. : 1950), 2001.