Jonathan Flint

Jonathan Frederic Rest Flint

Professor-in-Residence, Psychiatry and Biobehavioral Sciences, University of California Los Angeles

Professor-in-Residence, Human Genetics, University of California Los Angeles

UC Profile

Dr. Jonathan Flint holds the Billy and Audrey Wilder Endowed Chair in Psychiatry and Neuroscience.

Publications

  1. Balliu B, Douglas C, Seok D, Shenhav L, Wu Y, Chatzopoulou D, Kaiser W, Chen V, Kim J, Deverasetty S, Arnaudova I, Gibbons R, Congdon E, Craske MG, Freimer N, Halperin E, Sankararaman S, Flint J. Personalized mood prediction from patterns of behavior collected with smartphones.. NPJ digital medicine, 2024.
  2. Ravi V, Wang J, Flint J, Alwan A. Enhancing accuracy and privacy in speech-based depression detection through speaker disentanglement.. Computer speech & language, 2023.
  3. Flint J, Heffel MG, Chen Z, Mefford J, Marcus E, Chen PB, Ernst J, Luo C. Single-cell methylation analysis of brain tissue prioritizes mutations that alter transcription.. Cell genomics, 2023.
  4. An U, Pazokitoroudi A, Alvarez M, Huang L, Bacanu S, Schork AJ, Kendler K, Pajukanta P, Flint J, Zaitlen N, Cai N, Dahl A, Sankararaman S. Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries.. Nature genetics, 2023.
  5. Dahl A, Thompson M, An U, Krebs M, Appadurai V, Border R, Bacanu SA, Werge T, Flint J, Schork AJ, Sankararaman S, Kendler KS, Cai N. Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder.. Nature genetics, 2023.
  6. Cui L, Yang B, Xiao S, Gao J, Baud A, Graham D, McBride M, Dominiczak A, Schafer S, Aumatell RL, Mont C, Teruel AF, Hübner N, Flint J, Mott R, Huang L. Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.. Genome biology, 2023.
  7. Flint J. The genetic basis of major depressive disorder.. Molecular psychiatry, 2023.
  8. Gorla A, Sankararaman S, Burchard E, Flint J, Zaitlen N, Rahmani E. Phenotypic subtyping via contrastive learning.. bioRxiv : the preprint server for biology, 2023.
  9. Border R, Athanasiadis G, Buil A, Schork AJ, Cai N, Young AI, Werge T, Flint J, Kendler KS, Sankararaman S, Dahl AW, Zaitlen NA. Cross-trait assortative mating is widespread and inflates genetic correlation estimates.. Science (New York, N.Y.), 2022.
  10. Ravi V, Wang J, Flint J, Alwan A. A Step Towards Preserving Speakers' Identity While Detecting Depression Via Speaker Disentanglement.. Interspeech, 2022.
  11. Sarwal V, Niehus S, Ayyala R, Kim M, Sarkar A, Chang S, Lu A, Rajkumar N, Darfci-Maher N, Littman R, Chhugani K, Soylev A, Comarova Z, Wesel E, Castellanos J, Chikka R, Distler MG, Eskin E, Flint J, Mangul S. A comprehensive benchmarking of WGS-based deletion structural variant callers.. Briefings in bioinformatics, 2022.
  12. Ravi V, Wang J, Flint J, Alwan A. FRAUG: A FRAME RATE BASED DATA AUGMENTATION METHOD FOR DEPRESSION DETECTION FROM SPEECH SIGNALS.. Proceedings of the ... IEEE International Conference on Acoustics, Speech, and Signal Processing. ICASSP (Conference), 2022.
  13. Guo L, Boocock J, Hilt EE, Chandrasekaran S, Zhang Y, Munugala C, Sathe L, Alexander N, Arboleda VA, Flint J, Eskin E, Luo C, Yang S, Garner OB, Yin Y, Bloom JS, Kruglyak L. Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA.. BMC genomics, 2022.
  14. Zou J, Gopalakrishnan S, Parker CC, Nicod J, Mott R, Cai N, Lionikas A, Davies RW, Palmer AA, Flint J. Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility.. G3 (Bethesda, Md.), 2022.
  15. Wang J, Ravi V, Flint J, Alwan A. Unsupervised Instance Discriminative Learning for Depression Detection from Speech Signals.. Interspeech, 2022.
  16. Adamson PC, Pfeffer MA, Arboleda VA, Garner OB, de St Maurice A, von Bredow B, Flint J, Kruglyak L, Currier JS. Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California.. Open forum infectious diseases, 2021.
  17. Chen PB, Flint J. What connectomics can learn from genomics.. PLoS genetics, 2021.
  18. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples.. Nature biomedical engineering, 2021.
  19. Majumdar A, Giambartolomei C, Cai N, Haldar T, Schwarz T, Gandal M, Flint J, Pasaniuc B. Leveraging eQTLs to identify individual-level tissue of interest for a complex trait.. PLoS computational biology, 2021.
  20. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing.. medRxiv : the preprint server for health sciences, 2021.
  21. Chatzinakos C, Lee D, Cai N, Vladimirov VI, Webb BT, Riley BP, Flint J, Kendler KS, Ressler KJ, Daskalakis NP, Bacanu SA. Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel.. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2021.
  22. Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2020.
  23. Cai N, Bigdeli TB, Kretzschmar WW, Li Y, Liang J, Hu J, Peterson RE, Bacanu S, Webb BT, Riley B, Li Q, Marchini J, Mott R, Kendler KS, Flint J. Retraction Note: 11,670 whole-genome sequences representative of the Han Chinese population from the CONVERGE project.. Scientific data, 2020.
  24. Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke TK, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, Mors O, Müller-Myhsok B, Penninx BWJH, Perlis RH, Pistis G, Potash JB, Preisig M, Shi J, Smoller JW, Streit F, Tiemeier H, Uher R, Van der Auwera S, Viktorin A, Weissman MM, MDD Working Group of the Psychiatric Genomics Consortium, Kendler KS, Flint J. Minimal phenotyping yields genome-wide association signals of low specificity for major depression.. Nature genetics, 2020.
  25. Dahl A, Nguyen K, Cai N, Gandal MJ, Flint J, Zaitlen N. A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits.. American journal of human genetics, 2020.
  26. Flint J, Ideker T. The great hairball gambit.. PLoS genetics, 2019.
  27. Mangul S, Mosqueiro T, Abdill RJ, Duong D, Mitchell K, Sarwal V, Hill B, Brito J, Littman RJ, Statz B, Lam AK, Dayama G, Grieneisen L, Martin LS, Flint J, Eskin E, Blekhman R. Challenges and recommendations to improve the installability and archival stability of omics computational tools.. PLoS biology, 2019.
  28. Pan W, Flint J, Shenhav L, Liu T, Liu M, Hu B, Zhu T. Re-examining the robustness of voice features in predicting depression: Compared with baseline of confounders.. PloS one, 2019.
  29. Dahl A, Cai N, Ko A, Laakso M, Pajukanta P, Flint J, Zaitlen N. Reverse GWAS: Using genetics to identify and model phenotypic subtypes.. PLoS genetics, 2019.
  30. Docherty AR, Moscati A, Bigdeli TB, Edwards AC, Peterson RE, Adkins DE, Anderson JS, Flint J, Kendler KS, Bacanu SA. Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE.. Psychological medicine, 2019.
  31. Mangul S, Martin LS, Hill BL, Lam AK, Distler MG, Zelikovsky A, Eskin E, Flint J. Systematic benchmarking of omics computational tools.. Nature communications, 2019.
  32. Flint J. Outside in.. PLoS genetics, 2019.
  33. Mont C, Hernandez-Pliego P, Cañete T, Oliveras I, Río-Álamos C, Blázquez G, López-Aumatell R, Martínez-Membrives E, Tobeña A, Flint J, Fernández-Teruel A, Mott R. Coping-Style Behavior Identified by a Survey of Parent-of-Origin Effects in the Rat.. G3 (Bethesda, Md.), 2018.
  34. Lilue J, Doran AG, Fiddes IT, Abrudan M, Armstrong J, Bennett R, Chow W, Collins J, Collins S, Czechanski A, Danecek P, Diekhans M, Dolle DD, Dunn M, Durbin R, Earl D, Ferguson-Smith A, Flicek P, Flint J, Frankish A, Fu B, Gerstein M, Gilbert J, Goodstadt L, Harrow J, Howe K, Ibarra-Soria X, Kolmogorov M, Lelliott CJ, Logan DW, Loveland J, Mathews CE, Mott R, Muir P, Nachtweide S, Navarro FCP, Odom DT, Park N, Pelan S, Pham SK, Quail M, Reinholdt L, Romoth L, Shirley L, Sisu C, Sjoberg-Herrera M, Stanke M, Steward C, Thomas M, Threadgold G, Thybert D, Torrance J, Wong K, Wood J, Yalcin B, Yang F, Adams DJ, Paten B, Keane TM. Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.. Nature genetics, 2018.
  35. Gstrein T, Edwards A, Pristoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA. Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.. Nature neuroscience, 2018.
  36. Weissbrod O, Flint J, Rosset S. Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics.. American journal of human genetics, 2018.
  37. Peterson RE, Cai N, Dahl AW, Bigdeli TB, Edwards AC, Webb BT, Bacanu SA, Zaitlen N, Flint J, Kendler KS. Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.. The American journal of psychiatry, 2018.
  38. Gstrein T, Edwards A, Pristoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA. Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.. Nature neuroscience, 2018.
  39. Flint J. Deep Reads: How I learnt to love population genetics.. PLoS genetics, 2017.
  40. Kendler KS, Aggen SH, Flint J, Borsboom D, Fried EI. The centrality of DSM and non-DSM depressive symptoms in Han Chinese women with major depression.. Journal of affective disorders, 2017.
  41. Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A, WGS500 Consortium, Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC. A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.. Human molecular genetics, 2017.
  42. Baud A, Flint J. Identifying genes for neurobehavioural traits in rodents: progress and pitfalls.. Disease models & mechanisms, 2017.
  43. Cai N, Bigdeli TB, Kretzschmar WW, Li Y, Liang J, Hu J, Peterson RE, Bacanu S, Webb BT, Riley B, Li Q, Marchini J, Mott R, Kendler KS, Flint J. 11,670 whole-genome sequences representative of the Han Chinese population from the CONVERGE project.. Scientific data, 2017.
  44. Docherty AR, Edwards AC, Yang F, Peterson RE, Sawyers C, Adkins DE, Moore AA, Webb BT, Bacanu SA, Flint J, Kendler KS. Age of onset and family history as indicators of polygenic risk for major depression.. Depression and anxiety, 2017.
  45. Peterson RE, Cai N, Bigdeli TB, Li Y, Reimers M, Nikulova A, Webb BT, Bacanu SA, Riley BP, Flint J, Kendler KS. The Genetic Architecture of Major Depressive Disorder in Han Chinese Women.. JAMA psychiatry, 2017.
  46. McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ. A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.. G3 (Bethesda, Md.), 2016.
  47. Doran AG, Wong K, Flint J, Adams DJ, Hunter KW, Keane TM. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations.. Genome biology, 2016.
  48. Nicod J, Davies RW, Cai N, Hassett C, Goodstadt L, Cosgrove C, Yee BK, Lionikaite V, McIntyre RE, Remme CA, Lodder EM, Gregory JS, Hough T, Joynson R, Phelps H, Nell B, Rowe C, Wood J, Walling A, Bopp N, Bhomra A, Hernandez-Pliego P, Callebert J, Aspden RM, Talbot NP, Robbins PA, Harrison M, Fray M, Launay JM, Pinto YM, Blizard DA, Bezzina CR, Adams DJ, Franken P, Weaver T, Wells S, Brown SD, Potter PK, Klenerman P, Lionikas A, Mott R, Flint J. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.. Nature genetics, 2016.
  49. Davies RW, Flint J, Myers S, Mott R. Rapid genotype imputation from sequence without reference panels.. Nature genetics, 2016.
  50. Edwards AC, Aggen SH, Cai N, Bigdeli TB, Peterson RE, Docherty AR, Webb BT, Bacanu SA, Flint J, Kendler KS. CHRONICITY OF DEPRESSION AND MOLECULAR MARKERS IN A LARGE SAMPLE OF HAN CHINESE WOMEN.. Depression and anxiety, 2016.
  51. Flint J. Rare genetic variants and schizophrenia.. Nature neuroscience, 2016.
  52. Nicod J, Wagner S, Vonberg F, Bhomra A, Schlicht KF, Tadic A, Mott R, Lieb K, Flint J. The Amount of Mitochondrial DNA in Blood Reflects the Course of a Depressive Episode.. Biological psychiatry, 2015.
  53. Cai N, Li Y, Chang S, Liang J, Lin C, Zhang X, Liang L, Hu J, Chan W, Kendler KS, Malinauskas T, Huang GJ, Li Q, Mott R, Flint J. Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder.. Current biology : CB, 2015.
  54. Moscati A, Flint J, Kendler KS. CLASSIFICATION OF ANXIETY DISORDERS COMORBID WITH MAJOR DEPRESSION: COMMON OR DISTINCT INFLUENCES ON RISK?. Depression and anxiety, 2015.
  55. Geschwind DH, Flint J. Genetics and genomics of psychiatric disease.. Science (New York, N.Y.), 2015.
  56. Yang F, Gardner CO, Bigdeli T, Gao J, Zhang Z, Tao M, Liu Y, Li Y, Wang G, Shi J, Gao C, Zhang K, Li K, Wang X, Liu L, Sun J, Du B, Shi S, Zhang J, Wu W, Wang X, Shen J, Liu T, Gu D, Liang W, Deng H, Pan J, Yang L, Jian H, Jiang G, Meng H, Miao G, Li Y, Hu C, Huang G, Zhang Y, Chen Y, Ha B, Gao S, Fang X, Mei Q, Hong X, Yang D, Liu T, Fengyu Y, Zhong H, Sang H, Chen G, Cai M, Song Y, Dong J, Shen Z, Zhang W, Wang X, Pan R, Liu X, Li Y, Liu Z, Zhang Q, Li G, Flint J, Kendler KS. Clinical features of and risk factors for major depression with history of postpartum episodes in Han Chinese women: A retrospective study.. Journal of affective disorders, 2015.
  57. Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.. Nature genetics, 2015.
  58. Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G, Jiang G, Jiang T, Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H, Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J, Marchini J, Chen Y, Xu Q, Xu X, Mott R, Huang GJ, Kendler K, Flint J. Molecular signatures of major depression.. Current biology : CB, 2015.
  59. Munafò MR, Flint J. The genetic architecture of psychophysiological phenotypes.. Psychophysiology, 2014.
  60. Flint J, Timpson N, Munafò M. Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease.. Trends in neurosciences, 2014.
  61. He Q, Yang L, Shi S, Gao J, Tao M, Zhang K, Gao C, Yang L, Li K, Shi J, Wang G, Liu L, Zhang J, Du B, Jiang G, Shen J, Zhang Z, Liang W, Sun J, Hu J, Liu T, Wang X, Miao G, Meng H, Li Y, Hu C, Li Y, Huang G, Li G, Ha B, Deng H, Mei Q, Zhong H, Gao S, Sang H, Zhang Y, Fang X, Yu F, Yang D, Liu T, Chen Y, Hong X, Wu W, Chen G, Cai M, Song Y, Pan J, Dong J, Pan R, Zhang W, Shen Z, Liu Z, Gu D, Wang X, Liu Y, Liu X, Zhang Q, Li Y, Chen Y, Kendler KS, Wang X, Li Y, Flint J. Smoking and major depressive disorder in Chinese women.. PloS one, 2014.
  62. Flint J, Munafò MR. Genetics: finding genes for schizophrenia.. Current biology : CB, 2014.
  63. Flint J, Munafò M. Schizophrenia: genesis of a complex disease.. Nature, 2014.
  64. Baud A, Guryev V, Hummel O, Johannesson M, Rat Genome Sequencing and Mapping Consortium, Flint J. Erratum: Genomes and phenomes of a population of outbred rats and its progenitors.. Scientific data, 2014.
  65. Keane TM, Wong K, Adams DJ, Flint J, Reymond A, Yalcin B. Identification of structural variation in mouse genomes.. Frontiers in genetics, 2014.
  66. Baud A, Guryev V, Hummel O, Johannesson M, Rat Genome Sequencing and Mapping Consortium, Flint J. Genomes and phenomes of a population of outbred rats and its progenitors.. Scientific data, 2014.
  67. Krohn J, Speed D, Palme R, Touma C, Mott R, Flint J. Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.. PloS one, 2014.
  68. Flint J, Kendler KS. The Genetics of Major Depression.. Neuron, 2014.
  69. Tuncel J, Haag S, Yau AC, Norin U, Baud A, Lönnblom E, Maratou K, Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A, EURATRANS Consortium, Stridh P, Jagodic M, Olsson T, Fernández-Teruel A, Zubarev RA, Mott R, Aitman TJ, Flint J, Holmdahl R. Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat.. PLoS genetics, 2014.
  70. Flint J, Kendler KS. The genetics of major depression.. Neuron, 2014.
  71. Shi J, Zhang Y, Liu F, Li Y, Wang J, Flint J, Gao J, Li Y, Tao M, Zhang K, Wang X, Gao C, Yang L, Li K, Shi S, Wang G, Liu L, Zhang J, Du B, Jiang G, Shen J, Zhang Z, Liang W, Sun J, Hu J, Liu T, Wang X, Miao G, Meng H, Li Y, Hu C, Li Y, Huang G, Li G, Ha B, Deng H, Mei Q, Zhong H, Gao S, Sang H, Zhang Y, Fang X, Yu F, Yang D, Liu T, Chen Y, Hong X, Wu W, Chen G, Cai M, Song Y, Pan J, Dong J, Pan R, Zhang W, Shen Z, Liu Z, Gu D, Wang X, Liu X, Zhang Q, Li Y, Chen Y, Kendler KS. Associations of educational attainment, occupation, social class and major depressive disorder among Han Chinese women.. PloS one, 2014.
  72. Chen J, Cai Y, Cong E, Liu Y, Gao J, Li Y, Tao M, Zhang K, Wang X, Gao C, Yang L, Li K, Shi J, Wang G, Liu L, Zhang J, Du B, Jiang G, Shen J, Zhang Z, Liang W, Sun J, Hu J, Liu T, Wang X, Miao G, Meng H, Li Y, Hu C, Li Y, Huang G, Li G, Ha B, Deng H, Mei Q, Zhong H, Gao S, Sang H, Zhang Y, Fang X, Yu F, Yang D, Liu T, Chen Y, Hong X, Wu W, Chen G, Cai M, Song Y, Pan J, Dong J, Pan R, Zhang W, Shen Z, Liu Z, Gu D, Wang X, Liu X, Zhang Q, Li Y, Chen Y, Kendler KS, Shi S, Flint J. Childhood sexual abuse and the development of recurrent major depression in Chinese women.. PloS one, 2014.
  73. Yang F, Qiu J, Zhao H, Wang Z, Tao D, Xiao X, Niu Q, Wang Q, Li Y, Guo L, Li J, Li K, Xia J, Wang L, Shang X, Sang W, Gan Z, He K, Zhao X, Tian T, Xu D, Gu D, Weng X, Li H, Tian J, Yang L, Li Q, Yang Q, Wang H, Dang Y, Dai L, Cui Y, Ye D, Cao J, Guo L, Kang Z, Liu J, Chen B, Liu J, Zhang J, Yang D, Jiao B, Yu F, Geng F, Li L, Yang H, Dai H, Wang H, Liu C, Liu H, Peng L, Wang X, Wei S, Liu X, Li C, Liu Z, Zhang Q, Di D, Shi S, Flint J, Kendler KS. The prevalence, clinical correlates and structure of phobic fears in Han Chinese women with recurrent major depression.. Journal of affective disorders, 2014.
  74. Yang F, Zhao H, Wang Z, Tao D, Xiao X, Niu Q, Wang Q, Li Y, Guo L, Li J, Li K, Xia J, Wang L, Shang X, Sang W, Shao C, Gan Z, He K, Zhao X, Tian T, Xu D, Gu D, Weng X, Li H, Tian J, Yang L, Li Q, Yang Q, Wang H, Dang Y, Dai L, Cui Y, Ye D, Cao J, Guo L, Kang Z, Liu J, Chen B, Liu J, Zhang J, Yang D, Jiao B, Yu F, Geng F, Li L, Yang H, Dai H, Wang H, Liu C, Liu H, Peng L, Wang X, Wei S, Liu X, Li C, Liu Z, Zhang Q, Di D, Flint J, Shi S, Kendler KS. Age at onset of recurrent major depression in Han Chinese women - a replication study.. Journal of affective disorders, 2014.
  75. Mott R, Yuan W, Kaisaki P, Gan X, Cleak J, Edwards A, Baud A, Flint J. The architecture of parent-of-origin effects in mice.. Cell, 2014.
  76. Wu W, Wang Z, Wei Y, Zhang G, Shi S, Gao J, Li Y, Tao M, Zhang K, Wang X, Gao C, Yang L, Li K, Shi J, Wang G, Liu L, Zhang J, Du B, Jiang G, Shen J, Liu Y, Liang W, Sun J, Hu J, Liu T, Wang X, Miao G, Meng H, Li Y, Hu C, Li Y, Huang G, Li G, Ha B, Deng H, Mei Q, Zhong H, Gao S, Sang H, Zhang Y, Fang X, Yu F, Yang D, Liu T, Chen Y, Hong X, Wu W, Chen G, Cai M, Song Y, Pan J, Dong J, Pan R, Zhang W, Shen Z, Liu Z, Gu D, Wang X, Liu X, Zhang Q, Li Y, Chen Y, Kendler KS, Flint J, Zhang Z. Clinical features of patients with dysthymia in a large cohort of Han Chinese women with recurrent major depression.. PloS one, 2013.
  77. Zhu Y, Zhang H, Shi S, Gao J, Li Y, Tao M, Zhang K, Wang X, Gao C, Yang L, Li K, Shi J, Wang G, Liu L, Zhang J, Du B, Jiang G, Shen J, Zhang Z, Liang W, Sun J, Hu J, Liu T, Wang X, Miao G, Meng H, Li Y, Hu C, Li Y, Huang G, Li G, Ha B, Deng H, Mei Q, Zhong H, Gao S, Sang H, Zhang Y, Fang X, Yu F, Yang D, Liu T, Chen Y, Hong X, Wu W, Chen G, Cai M, Song Y, Pan J, Dong J, Pan R, Zhang W, Shen Z, Liu Z, Gu D, Wang X, Liu X, Zhang Q, Li Y, Chen Y, Kendler KS, Flint J, Liu Y. Suicidal risk factors of recurrent major depression in Han Chinese women.. PloS one, 2013.
  78. Groves JO, Leslie I, Huang GJ, McHugh SB, Taylor A, Mott R, Munafò M, Bannerman DM, Flint J. Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.. PLoS genetics, 2013.
  79. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.. Cell, 2013.
  80. Baud A, Calderari S, Mott R, Flint J, Gauguier D, Rat Genome Sequencing and Mapping Consortium. [Genome sequencing and genetic mapping to dissect the genetic basis of complex traits].. Medecine sciences : M/S, 2013.
  81. Mott R, Flint J. Dissecting quantitative traits in mice.. Annual review of genomics and human genetics, 2013.
  82. Hosseini M, Goodstadt L, Hughes JR, Kowalczyk MS, de Gobbi M, Otto GW, Copley RR, Mott R, Higgs DR, Flint J. Causes and consequences of chromatin variation between inbred mice.. PLoS genetics, 2013.
  83. Rat Genome Sequencing and Mapping Consortium, Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, Jagodic M, Tuncel J, Norin U, Beattie E, Huynh N, Miller WH, Koller DL, Alam I, Falak S, Osborne-Pellegrin M, Martinez-Membrives E, Canete T, Blazquez G, Vicens-Costa E, Mont-Cardona C, Diaz-Moran S, Tobena A, Hummel O, Zelenika D, Saar K, Patone G, Bauerfeind A, Bihoreau MT, Heinig M, Lee YA, Rintisch C, Schulz H, Wheeler DA, Worley KC, Muzny DM, Gibbs RA, Lathrop M, Lansu N, Toonen P, Ruzius FP, de Bruijn E, Hauser H, Adams DJ, Keane T, Atanur SS, Aitman TJ, Flicek P, Malinauskas T, Jones EY, Ekman D, Lopez-Aumatell R, Dominiczak AF, Johannesson M, Holmdahl R, Olsson T, Gauguier D, Hubner N, Fernandez-Teruel A, Cuppen E, Mott R, Flint J. Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.. Nature genetics, 2013.
  84. Flint J. GWAS.. Current biology : CB, 2013.
  85. Flint J, Eskin E. Genome-wide association studies in mice.. Nature reviews. Genetics, 2012.
  86. Goodson M, Rust MB, Witke W, Bannerman D, Mott R, Ponting CP, Flint J. Cofilin-1: a modulator of anxiety in mice.. PLoS genetics, 2012.
  87. Flint J, Munafò MR. Candidate and non-candidate genes in behavior genetics.. Current opinion in neurobiology, 2012.
  88. Karayiorgou M, Flint J, Gogos JA, Malenka RC, Genetic and Neural Complexity in Psychiatry 2011 Working Group. The best of times, the worst of times for psychiatric disease.. Nature neuroscience, 2012.
  89. Danecek P, Nellåker C, McIntyre RE, Buendia-Buendia JE, Bumpstead S, Ponting CP, Flint J, Durbin R, Keane TM, Adams DJ. High levels of RNA-editing site conservation amongst 15 laboratory mouse strains.. Genome biology, 2012.
  90. Webb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, de Geus EJ, Hottenga JJ, Boomsma DI, Slagboom EP, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J, Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM. Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.. European journal of human genetics : EJHG, 2012.
  91. Chen Y, Li H, Li Y, Xie D, Wang Z, Yang F, Shen Y, Ni S, Wei Y, Liu Y, Liu L, Gao C, Liu J, Yan L, Wang G, Li K, He Q, Liu T, Zhang J, Ren Y, Du Q, Tian J, Chen H, Luo Y, Zhang F, Sun G, Shan C, Wang X, Zhang Y, Weng X, Chen Y, Kang Z, Guan J, Chen Y, Shi S, Kendler KS, Flint J, Deng H. Resemblance of symptoms for major depression assessed at interview versus from hospital record review.. PloS one, 2012.
  92. Yalcin B, Wong K, Bhomra A, Goodson M, Keane TM, Adams DJ, Flint J. The fine-scale architecture of structural variants in 17 mouse genomes.. Genome biology, 2012.
  93. López-Aumatell R, Martínez-Membrives E, Vicens-Costa E, Cañete T, Blázquez G, Mont-Cardona C, Johannesson M, Flint J, Tobeña A, Fernández-Teruel A. Effects of environmental and physiological covariates on sex differences in unconditioned and conditioned anxiety and fear in a large sample of genetically heterogeneous (N/Nih-HS) rats.. Behavioral and brain functions : BBF, 2011.
  94. Sun N, Li Y, Cai Y, Chen J, Shen Y, Sun J, Zhang Z, Zhang J, Wang L, Guo L, Yang L, Qiang L, Yang Y, Wang G, Du B, Xia J, Rong H, Gan Z, Hu B, Pan J, Li C, Sun S, Han W, Xiao X, Dai L, Jin G, Zhang Y, Sun L, Chen Y, Zhao H, Dang Y, Shi S, Kendler KS, Flint J, Zhang K. A comparison of melancholic and nonmelancholic recurrent major depression in Han Chinese women.. Depression and anxiety, 2011.
  95. Wang L, Qiao D, Li Y, Wang L, Ren J, He K, Sun J, Wang Z, Tian T, Chen C, Yang L, Hu J, Deng H, Wang Q, Li K, Han J, Rong H, Gan Z, Yang H, Zhou P, Pan J, Zhou C, Cui Y, Song L, Zhu Y, Li Y, Wang X, Ye L, Liang W, Chen Y, Tang Q, Guan J, Shi S, Kendler KS, Flint J, Liu L. Clinical predictors of familial depression in Han Chinese women.. Depression and anxiety, 2011.
  96. Flint J, Chen Y, Shi S, Kendler KS, CONVERGE consortium. Epilogue: Lessons from the CONVERGE study of major depressive disorder in China.. Journal of affective disorders, 2011.
  97. Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assunção JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J, Adams DJ. Mouse genomic variation and its effect on phenotypes and gene regulation.. Nature, 2011.
  98. Yalcin B, Wong K, Agam A, Goodson M, Keane TM, Gan X, Nellåker C, Goodstadt L, Nicod J, Bhomra A, Hernandez-Pliego P, Whitley H, Cleak J, Dutton R, Janowitz D, Mott R, Adams DJ, Flint J. Sequence-based characterization of structural variation in the mouse genome.. Nature, 2011.
  99. Hettema JM, Webb BT, Guo AY, Zhao Z, Maher BS, Chen X, An SS, Sun C, Aggen SH, Kendler KS, Kuo PH, Otowa T, Flint J, van den Oord EJ. Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.. Biological psychiatry, 2011.
  100. Tian T, Li Y, Xie D, Shen Y, Ren J, Wu W, Guan C, Zhang Z, Zhang D, Gao C, Zhang X, Wu J, Deng H, Wang G, Zhang Y, Shao Y, Rong H, Gan Z, Sun Y, Hu B, Pan J, Li Y, Sun S, Song L, Fan X, Li Y, Zhao X, Yang B, Lv L, Chen Y, Wang X, Ning Y, Shi S, Chen Y, Kendler KS, Flint J, Tian H. Clinical features and risk factors for post-partum depression in a large cohort of Chinese women with recurrent major depressive disorder.. Journal of affective disorders, 2011.
  101. Sang W, Li Y, Su L, Yang F, Wu W, Shang X, Zhang G, Shen J, Sun M, Guo L, Li Z, Yan L, Zhang B, Wang G, Liu G, Liu T, Zhang J, Wang Y, Yu B, Pan J, Li Y, Hu C, Yang L, Huang Y, Xie S, Wang X, Liu J, Lv L, Chen Y, Zhang L, Dang Y, Shi S, Chen Y, Kendler KS, Flint J, Li K. A comparison of the clinical characteristics of Chinese patients with recurrent major depressive disorder with and without dysthymia.. Journal of affective disorders, 2011.
  102. Tao M, Li Y, Xie D, Wang Z, Qiu J, Wu W, Sun J, Wang Z, Tao D, Zhao H, Tian T, Zhang J, Gao C, Niu Q, Li Q, Liu S, Liu J, Zhang Y, He Q, Rong H, Gan Z, Li J, Chen X, Pan J, Li Y, Cui Y, Han W, Ma H, Xie S, Jin G, Li L, Zhang R, Tan Q, Zhang J, Guan J, Shi S, Chen Y, Kendler KS, Flint J, Gao J. Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women.. Journal of affective disorders, 2011.
  103. Gan Z, Li Y, Xie D, Shao C, Yang F, Shen Y, Zhang N, Zhang G, Tian T, Yin A, Chen C, Liu J, Tang C, Zhang Z, Liu J, Sang W, Wang X, Liu T, Wei Q, Xu Y, Sun L, Wang S, Li C, Hu C, Cui Y, Liu Y, Li Y, Zhao X, Zhang L, Sun L, Chen Y, Zhang Y, Ning Y, Shi S, Chen Y, Kendler KS, Flint J, Zhang J. The impact of educational status on the clinical features of major depressive disorder among Chinese women.. Journal of affective disorders, 2011.
  104. Xia J, He Q, Li Y, Xie D, Zhu S, Chen J, Shen Y, Zhang N, Wei Y, Chen C, Shen J, Zhang Y, Gao C, Li Y, Ding J, Shen W, Wang Q, Cao M, Liu T, Zhang J, Duan H, Bao C, Ma P, Zhou C, Luo Y, Zhang F, Liu Y, Li Y, Jin G, Zhang Y, Liang W, Chen Y, Zhao C, Li H, Chen Y, Shi S, Kendler KS, Flint J, Wang X. The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women.. Journal of affective disorders, 2011.
  105. Yang F, Li Y, Xie D, Shao C, Ren J, Wu W, Zhang N, Zhang Z, Zou Y, Zhang J, Qiao D, Gao C, Li Y, Hu J, Deng H, Wang G, Du B, Wang X, Liu T, Gan Z, Peng J, Wei B, Pan J, Chen H, Sun S, Jia H, Liu Y, Chen Q, Wang X, Cao J, Lv L, Chen Y, Ha B, Ning Y, Chen Y, Kendler KS, Flint J, Shi S. Age at onset of major depressive disorder in Han Chinese women: relationship with clinical features and family history.. Journal of affective disorders, 2011.
  106. Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Sim S, Parent JM, Johnsen A, Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus.. PLoS biology, 2010.
  107. Agam A, Yalcin B, Bhomra A, Cubin M, Webber C, Holmes C, Flint J, Mott R. Elusive copy number variation in the mouse genome.. PloS one, 2010.
  108. Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, Østerås M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, Adams DJ, Mott R, Flint J. Commercially available outbred mice for genome-wide association studies.. PLoS genetics, 2010.
  109. Flint J. Mapping quantitative traits and strategies to find quantitative trait genes.. Methods (San Diego, Calif.), 2010.
  110. Valdar W, Holmes CC, Mott R, Flint J. Mapping in structured populations by resample model averaging.. Genetics, 2009.
  111. Flint J, Mackay TF. Genetic architecture of quantitative traits in mice, flies, and humans.. Genome research, 2009.
  112. Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.. Genome research, 2009.
  113. Cotton CH, Flint J, Campbell TG. Is there an association between NPY and neuroticism?. Nature, 2009.
  114. Munafò MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, Järvelin MR, Taanila A, Flint J. 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data.. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009.
  115. Flint J, Mott R. Applying mouse complex-trait resources to behavioural genetics.. Nature, 2008.
  116. Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-Santamaría C, Gulko PS, Brenner M, Tobeña A, Guitart-Masip M, Giménez-Llort L, Dominiczak A, Holmdahl R, Gauguier D, Olsson T, Mott R, Valdar W, Redei EE, Fernández-Teruel A, Flint J. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.. Genome research, 2008.
  117. Flint J, Shifman S. Animal models of psychiatric disease.. Current opinion in genetics & development, 2008.
  118. Flint J, Munafò MR. Forum: Interactions between gene and environment.. Current opinion in psychiatry, 2008.
  119. Mott R, Flint J. Prospects for complex trait analysis in the mouse.. Mammalian genome : official journal of the International Mammalian Genome Society, 2008.
  120. Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, Miller SR, Bhomra A, Davidson S, Oliver PL, Mott R, Flint J. Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.. Biological psychiatry, 2008.
  121. Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, Kendler KS, Li T, O'Donovan M, O'Neill FA, Owen MJ, Walsh D, Weinberger DR, Sun C, Flint J, Darvasi A. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.. PLoS genetics, 2008.
  122. Flint J, Shifman S, Munafo M, Mott R. Genetic variants in major depression.. Novartis Foundation symposium, 2008.
  123. Taylor M, Valdar W, Kumar A, Flint J, Mott R. Management, presentation and interpretation of genome scans using GSCANDB.. Bioinformatics (Oxford, England), 2007.
  124. Keays DA, Tian G, Poirier K, Huang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnár Z, Piñon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, Flint J. Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.. Cell, 2007.
  125. Shifman S, Bell JT, Copley RR, Taylor MS, Williams RW, Mott R, Flint J. A high-resolution single nucleotide polymorphism genetic map of the mouse genome.. PLoS biology, 2006.
  126. Willis-Owen SA, Flint J. Identifying the genetic determinants of emotionality in humans; insights from rodents.. Neuroscience and biobehavioral reviews, 2006.
  127. Flint J, Munafò MR. The endophenotype concept in psychiatric genetics.. Psychological medicine, 2006.
  128. Valdar W, Solberg LC, Gauguier D, Cookson WO, Rawlins JN, Mott R, Flint J. Genetic and environmental effects on complex traits in mice.. Genetics, 2006.
  129. Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J. Genome-wide genetic association of complex traits in heterogeneous stock mice.. Nature genetics, 2006.
  130. Willis-Owen SA, Flint J. The genetic basis of emotional behaviour in mice.. European journal of human genetics : EJHG, 2006.
  131. Keays DA, Clark TG, Flint J. Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.. Mammalian genome : official journal of the International Mammalian Genome Society, 2006.
  132. Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, Burnett S, Arboledas-Hita C, Hernandez-Pliego P, Davidson S, Burns P, Bhattacharya S, Hough T, Higgs D, Klenerman P, Cookson WO, Zhang Y, Deacon RM, Rawlins JN, Mott R, Flint J. A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice.. Mammalian genome : official journal of the International Mammalian Genome Society, 2006.
  133. Valdar W, Flint J, Mott R. Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice.. Genetics, 2005.
  134. Willis-Owen SA, Fullerton J, Surtees PG, Wainwright NW, Miller S, Flint J. The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism.. Biological psychiatry, 2005.
  135. Willis-Owen SA, Turri MG, Munafò MR, Surtees PG, Wainwright NW, Brixey RD, Flint J. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association.. Biological psychiatry, 2005.
  136. Price TS, Regan R, Mott R, Hedman A, Honey B, Daniels RJ, Smith L, Greenfield A, Tiganescu A, Buckle V, Ventress N, Ayyub H, Salhan A, Pedraza-Diaz S, Broxholme J, Ragoussis J, Higgs DR, Flint J, Knight SJ. SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data.. Nucleic acids research, 2005.
  137. Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents.. Nature reviews. Genetics, 2005.
  138. Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.. Nature genetics, 2004.
  139. Flint J. The genetic basis of neuroticism.. Neuroscience and biobehavioral reviews, 2004.
  140. Flint J, DeFries JC, Henderson ND. Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice.. Mammalian genome : official journal of the International Mammalian Genome Society, 2004.
  141. Turri MG, DeFries JC, Henderson ND, Flint J. Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice.. Mammalian genome : official journal of the International Mammalian Genome Society, 2004.
  142. Knight SJ, Flint J. The use of subtelomeric probes to study mental retardation.. Methods in cell biology, 2004.
  143. Valdar WS, Flint J, Mott R. QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks.. Mammalian genome : official journal of the International Mammalian Genome Society, 2003.
  144. Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Gensler B, Burgers S, Williams RW, Manly K, Flint J, Talbot C. A strategy for the integration of QTL, gene expression, and sequence analyses.. Mammalian genome : official journal of the International Mammalian Genome Society, 2003.
  145. Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F, Complex Trait Consortium. The nature and identification of quantitative trait loci: a community's view.. Nature reviews. Genetics, 2003.
  146. Flint J, Knight S. The use of telomere probes to investigate submicroscopic rearrangements associated with mental retardation.. Current opinion in genetics & development, 2003.
  147. Steinberger D, Reynolds DS, Ferris P, Lincoln R, Datta S, Stanley J, Paterson A, Dawson GR, Flint J. Genetic mapping of variation in spatial learning in the mouse.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
  148. Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S, Miller S, Fairburn C, Goodwin G, Neale MC, Fiddy S, Mott R, Allison DB, Flint J. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.. American journal of human genetics, 2003.
  149. Flint J. Animal models of anxiety and their molecular dissection.. Seminars in cell & developmental biology, 2003.
  150. Flint J. Analysis of quantitative trait loci that influence animal behavior.. Journal of neurobiology, 2003.
  151. Fernández-Teruel A, Escorihuela RM, Gray JA, Aguilar R, Gil L, Giménez-Llort L, Tobeña A, Bhomra A, Nicod A, Mott R, Driscoll P, Dawson GR, Flint J. A quantitative trait locus influencing anxiety in the laboratory rat.. Genome research, 2002.