Publications

1. Sugrue VJ, Zoller JA, Narayan P, Lu AT, Ortega-Recalde OJ, Grant MJ, Bawden CS, Rudiger SR, Haghani A, Bond DM, Hore RR, Garratt M, Sears KE, Wang N, Yang XW, Snell RG, Hore TA, Horvath S. Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci.. eLife, 2023.
2. Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG, Zhang B, Zhang Z, Zhao P, Zhao Y, Zhou W, Zimmermann J, Ernst J, Raj K, Horvath S. Author Correction: Universal DNA methylation age across mammalian tissues.. Nature aging, 2023.
3. Sadier A, Anthwal N, Krause AL, Dessalles R, Lake M, Bentolila LA, Haase R, Nieves NA, Santana SE, Sears KE. Bat teeth illuminate the diversification of mammalian tooth classes.. Nature communications, 2023.
4. Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM, Alagaili AN, Almunia J, Aloysius A, Amor NMS, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter G, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chavez AS, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke S, Cook JA, Cooper LN, Cossette ML, Day J, DeYoung J, Dirocco S, Dold C, Dunnum JL, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Fei Z, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Goya RG, Grant MJ, Green CB, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaître JF, Levine AJ, Li X, Li C, Lim AR, Lin DTS, Lindemann DM, Liphardt SW, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Murphy WJ, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, Nyamsuren B, O'Brien JK, Ginn PO, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pedersen AB, Pellegrini M, Peters KJ, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Shafer ABA, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmohammadi E, Spangler ML, Spriggs M, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Vu H, Wallingford MC, Wang N, Wilkinson GS, Williams RW, Yan Q, Yao M, Young BG, Zhang B, Zhang Z, Zhao Y, Zhao P, Zhou W, Zoller JA, Ernst J, Seluanov A, Gorbunova V, Yang XW, Raj K, Horvath S. DNA methylation networks underlying mammalian traits.. Science (New York, N.Y.), 2023.
5. Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG, Zhang B, Zhang Z, Zhao P, Zhao Y, Zhou W, Zimmermann J, Ernst J, Raj K, Horvath S. Universal DNA methylation age across mammalian tissues.. Nature aging, 2023.
6. Mutumi GL, Hall RP, Hedrick BP, Yohe LR, Sadier A, Davies KTJ, Rossiter SJ, Sears KE, Dávalos LM, Dumont ER. Disentangling Mechanical and Sensory Modules in the Radiation of Noctilionoid Bats.. The American naturalist, 2023.
7. Anthwal N, Urban DJ, Sadier A, Takenaka R, Spiro S, Simmons N, Behringer RR, Cretekos CJ, Rasweiler JJ, Sears KE. Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development.. BMC biology, 2023.
8. White HE, Tucker AS, Fernandez V, Portela Miguez R, Hautier L, Herrel A, Urban DJ, Sears KE, Goswami A. Pedomorphosis in the ancestry of marsupial mammals.. Current biology : CB, 2023.
9. Gros J, Davey M, Sears KE. Limb development, evolution, and regeneration and repair: Part two.. Developmental dynamics : an official publication of the American Association of Anatomists, 2022.
10. Yohe LR, Fabbri M, Lee D, Davies KTJ, Yohe TP, Sánchez MKR, Rengifo EM, Hall RP, Mutumi G, Hedrick BP, Sadier A, Simmons NB, Sears KE, Dumont E, Rossiter SJ, Bhullar BS, Dávalos LM. Ecological constraints on highly evolvable olfactory receptor genes and morphology in neotropical bats.. Evolution; international journal of organic evolution, 2022.
11. Santana SE, Grossnickle DM, Sadier A, Patterson E, Sears KE. Bat Dentitions: A Model System for Studies at The Interface of Development, Biomechanics, and Evolution.. Integrative and comparative biology, 2022.
12. Horvath S, Haghani A, Zoller JA, Raj K, Sinha I, Robeck TR, Black P, Couzens A, Lau C, Manoyan M, Ruiz YA, Talbott A, Belov K, Hogg CJ, Sears KE. Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies.. GeroScience, 2022.
13. Feng S, Bai M, Rivas-González I, Li C, Liu S, Tong Y, Yang H, Chen G, Xie D, Sears KE, Franco LM, Gaitan-Espitia JD, Nespolo RF, Johnson WE, Yang H, Brandies PA, Hogg CJ, Belov K, Renfree MB, Helgen KM, Boomsma JJ, Schierup MH, Zhang G. Incomplete lineage sorting and phenotypic evolution in marsupials.. Cell, 2022.
14. Sears KE, Gros J, Davey M. Limb development, evolution, and regeneration & repair: Part 1.. Developmental dynamics : an official publication of the American Association of Anatomists, 2021.
15. Sugrue VJ, Zoller JA, Narayan P, Lu AT, Ortega-Recalde OJ, Grant MJ, Bawden CS, Rudiger SR, Haghani A, Bond DM, Hore RR, Garratt M, Sears KE, Wang N, Yang XW, Snell RG, Hore TA, Horvath S. Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci.. eLife, 2021.
16. Couzens AMC, Sears KE, Rücklin M. Developmental influence on evolutionary rates and the origin of placental mammal tooth complexity.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
17. Hall RP, Mutumi GL, Hedrick BP, Yohe LR, Sadier A, Davies KTJ, Rossiter SJ, Sears K, Dávalos LM, Dumont ER. Find the food first: An omnivorous sensory morphotype predates biomechanical specialization for plant based diets in phyllostomid bats.. Evolution; international journal of organic evolution, 2021.
18. Todorov OS, Blomberg SP, Goswami A, Sears K, Drhlík P, Peters J, Weisbecker V. Testing hypotheses of marsupial brain size variation using phylogenetic multiple imputations and a Bayesian comparative framework.. Proceedings. Biological sciences, 2021.
19. Howenstine AO, Sadier A, Anthwal N, Lau CL, Sears KE. Non-model systems in mammalian forelimb evo-devo.. Current opinion in genetics & development, 2021.
20. Nojiri T, Wilson LAB, López-Aguirre C, Tu VT, Kuratani S, Ito K, Higashiyama H, Son NT, Fukui D, Sadier A, Sears KE, Endo H, Kamihori S, Koyabu D. Embryonic evidence uncovers convergent origins of laryngeal echolocation in bats.. Current biology : CB, 2021.
21. Sadier A, Urban DJ, Anthwal N, Howenstine AO, Sinha I, Sears KE. Making a bat: The developmental basis of bat evolution.. Genetics and molecular biology, 2021.
22. Sadier A, Sears KE, Womack M. Unraveling the heritage of lost traits.. Journal of experimental zoology. Part B, Molecular and developmental evolution, 2021.
23. Patel BV, Yao F, Howenstine A, Takenaka R, Hyatt JA, Sears KE, Shewchuk BM. Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue.. Journal of molecular biology, 2020.
24. Sadier A, Santana SE, Sears KE. The role of core and variable Gene Regulatory Network modules in tooth development and evolution.. Integrative and comparative biology, 2020.
25. Davies KTJ, Yohe LR, Almonte J, Sánchez MKR, Rengifo EM, Dumont ER, Sears KE, Dávalos LM, Rossiter SJ. Foraging shifts and visual preadaptation in ecologically diverse bats.. Molecular ecology, 2020.
26. Kavanagh KD, Bailey CS, Sears KE. Evidence of five digits in embryonic horses and developmental stabilization of tetrapod digit number.. Proceedings. Biological sciences, 2020.
27. Yohe LR, Davies KTJ, Simmons NB, Sears KE, Dumont ER, Rossiter SJ, Dávalos LM. Evaluating the performance of targeted sequence capture, RNA-Seq, and degenerate-primer PCR cloning for sequencing the largest mammalian multigene family.. Molecular ecology resources, 2019.
28. Kelly EM, Marcot JD, Selwood L, Sears KE. The Development of Integration in Marsupial and Placental Limbs.. Integrative organismal biology (Oxford, England), 2019.
29. Sadier A, Davies KT, Yohe LR, Yun K, Donat P, Hedrick BP, Dumont ER, Dávalos LM, Rossiter SJ, Sears KE. Multifactorial processes underlie parallel opsin loss in neotropical bats.. eLife, 2018.
30. Sears K, Maier JA, Sadier A, Sorensen D, Urban DJ. Timing the developmental origins of mammalian limb diversity.. Genesis (New York, N.Y. : 2000), 2017.
31. Cooper LN, Sears KE, Armfield BA, Kala B, Hubler M, Thewissen JGM. Review and experimental evaluation of the embryonic development and evolutionary history of flipper development and hyperphalangy in dolphins (Cetacea: Mammalia).. Genesis (New York, N.Y. : 2000), 2017.
32. Maier JA, Rivas-Astroza M, Deng J, Dowling A, Oboikovitz P, Cao X, Behringer RR, Cretekos CJ, Rasweiler JJ, Zhong S, Sears KE. Transcriptomic insights into the genetic basis of mammalian limb diversity.. BMC evolutionary biology, 2017.
33. Yohe LR, Abubakar R, Giordano C, Dumont E, Sears KE, Rossiter SJ, Dávalos LM. Trpc2 pseudogenization dynamics in bats reveal ancestral vomeronasal signaling, then pervasive loss.. Evolution; international journal of organic evolution, 2017.
34. Anthwal N, Urban DJ, Luo ZX, Sears KE, Tucker AS. Meckel's cartilage breakdown offers clues to mammalian middle ear evolution.. Nature ecology & evolution, 2017.
35. Urban DJ, Anthwal N, Luo ZX, Maier JA, Sadier A, Tucker AS, Sears KE. A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw.. Proceedings. Biological sciences, 2017.
36. Petit F, Sears KE, Ahituv N. Limb development: a paradigm of gene regulation.. Nature reviews. Genetics, 2017.
37. Sorensen D, Sackett A, Urban DJ, Maier J, Vargesson N, Sears KE. A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica.. Reproductive toxicology (Elmsford, N.Y.), 2017.
38. Dowling A, Doroba C, Maier JA, Cohen L, VandeBerg J, Sears KE. Cellular and molecular drivers of differential organ growth: insights from the limbs of Monodelphis domestica.. Development genes and evolution, 2016.
39. Sears KE, Capellini TD, Diogo R. On the serial homology of the pectoral and pelvic girdles of tetrapods.. Evolution; international journal of organic evolution, 2015.
40. Sears KE, Maier JA, Rivas-Astroza M, Poe R, Zhong S, Kosog K, Marcot JD, Behringer RR, Cretekos CJ, Rasweiler JJ, Rapti Z. The Relationship between Gene Network Structure and Expression Variation among Individuals and Species.. PLoS genetics, 2015.
41. Moczek AP, Sears KE, Stollewerk A, Wittkopp PJ, Diggle P, Dworkin I, Ledon-Rettig C, Matus DQ, Roth S, Abouheif E, Brown FD, Chiu CH, Cohen CS, Tomaso AW, Gilbert SF, Hall B, Love AC, Lyons DC, Sanger TJ, Smith J, Specht C, Vallejo-Marin M, Extavour CG. The significance and scope of evolutionary developmental biology: a vision for the 21st century.. Evolution & development, 2015.
42. Molineaux AC, Maier JA, Schecker T, Sears KE. Exogenous retinoic acid induces digit reduction in opossums (Monodelphis domestica) by disrupting cell death and proliferation, and apical ectodermal ridge and zone of polarizing activity function.. Birth defects research. Part A, Clinical and molecular teratology, 2015.
43. Abouheif E, Sears K. It's time to get together: announcing the new society for evolutionary developmental biology in the Americas.. Evolution & development, 2015.
44. Sears KE. Quantifying the impact of development on phenotypic variation and evolution.. Journal of experimental zoology. Part B, Molecular and developmental evolution, 2014.
45. Cooper KL, Sears KE, Uygur A, Maier J, Baczkowski KS, Brosnahan M, Antczak D, Skidmore JA, Tabin CJ. Patterning and post-patterning modes of evolutionary digit loss in mammals.. Nature, 2014.
46. Beiriger A, Sears KE. Cellular basis of differential limb growth in postnatal gray short-tailed opossums (Monodelphis domestica).. Journal of experimental zoology. Part B, Molecular and developmental evolution, 2014.
47. Ross D, Marcot JD, Betteridge KJ, Nascone-Yoder N, Bailey CS, Sears KE. Constraints on Mammalian forelimb development: insights from developmental disparity.. Evolution; international journal of organic evolution, 2013.
48. Sears KE, Bianchi C, Powers L, Beck AL. Integration of the mammalian shoulder girdle within populations and over evolutionary time.. Journal of evolutionary biology, 2013.
49. Hübler M, Molineaux AC, Keyte A, Schecker T, Sears KE. Development of the marsupial shoulder girdle complex: a case study in Monodelphis domestica.. Evolution & development, 2013.
50. Sears KE, Patel A, Hübler M, Cao X, Vandeberg JL, Zhong S. Disparate Igf1 expression and growth in the fore- and hind limbs of a marsupial mammal (Monodelphis domestica).. Journal of experimental zoology. Part B, Molecular and developmental evolution, 2012.
51. Cooper LN, Cretekos CJ, Sears KE. The evolution and development of mammalian flight.. Wiley interdisciplinary reviews. Developmental biology, 2012.
52. Sears KE, Bormet AK, Rockwell A, Powers LE, Noelle Cooper L, Wheeler MB. Developmental basis of mammalian digit reduction: a case study in pigs.. Evolution & development, 2011.
53. Sears KE. Novel insights into the regulation of limb development from 'natural' mammalian mutants. Studies in 'non-traditional' mammalian models with very different limb morphologies and sizes can contribute to resolving general developmental mechanisms.. BioEssays : news and reviews in molecular, cellular and developmental biology, 2011.
54. Doroba CK, Sears KE. The divergent development of the apical ectodermal ridge in the marsupial Monodelphis domestica.. Anatomical record (Hoboken, N.J. : 2007), 2010.
55. Hubler M, Niswander LA, Peters J, Sears KE. The developmental reduction of the marsupial coracoid: a case study in Monodelphis domestica.. Journal of morphology, 2010.
56. de Guzman Strong C, Conlan S, Deming CB, Cheng J, Sears KE, Segre JA. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis.. Human molecular genetics, 2010.
57. Sears KE. Differences in the timing of prechondrogenic limb development in mammals: the marsupial-placental dichotomy resolved.. Evolution; international journal of organic evolution, 2009.
58. Sears KE. Molecular determinants of bat wing development.. Cells, tissues, organs, 2007.
59. Sears KE, Goswami A, Flynn JJ, Niswander LA. The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora.. Evolution & development, 2007.
60. Sears KE, Behringer RR, Rasweiler JJ, Niswander LA. The evolutionary and developmental basis of parallel reduction in mammalian zeugopod elements.. The American naturalist, 2006.
61. Sears KE, Behringer RR, Rasweiler JJ, Niswander LA. Development of bat flight: morphologic and molecular evolution of bat wing digits.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
62. Sears KE. Role of development in the evolution of the scapula of the giant sthenurine kangaroos (Macropodidae: Sthenurinae).. Journal of morphology, 2005.
63. Sears KE. Constraints on the morphological evolution of marsupial shoulder girdles.. Evolution; international journal of organic evolution, 2004.