Keisuke Steven Iwamoto
Adjunct Professor, Radiation Oncology, University of California Los Angeles
kiwamoto@mednet.ucla.edu
65595
UCLA Rad Onc
BOX 951714
B3-109 CHS
Los Angeles, CA 90095
Affiliations
Director, Defined Flora Mouse Facility
Member, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Member, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Biography:
Dr. Iwamoto was recruited as a professor at the UCLA Department of Radiation Oncology in 1999. He received his PH.D. at UCLA in 1990, and from 1992 until 1999 he worked for the U.S National Academy of Science, Department of Radiation Effects Research Foundation in Hiroshima, Japan. Dr. Iwamoto has a broad background in both the physical and biological sciences with special focus on the interaction of ionizing radiation and cells. He also has extensive experience in radiobiology and the use of animal models for study of radiation oncology.
Publications
- Nakamura Y, Fukutomi Y, Sekiya K, Kajiwara K, Kawasaki Y, Fujita N, Nagayama K, Iwata M, Iwamoto K, Yano K, Hamada Y, Watai K, Ryu K, Hayashi H, Kamide Y, Taniguchi M. Low-dose mepolizumab is effective as an add-on therapy for treating long-lasting peripheral neuropathy in patients with eosinophilic granulomatosis with polyangiitis.. Modern rheumatology, 2022.
- Micewicz ED, Damoiseaux RD, Deng G, Gomez A, Iwamoto KS, Jung ME, Nguyen C, Norris AJ, Ratikan JA, Ruchala P, Sayre JW, Schaue D, Whitelegge JP, McBride WH. Classes of Drugs that Mitigate Radiation Syndromes.. Frontiers in pharmacology, 2021.
- Iwamoto K, Saito T, Takemoto Y, Ueno K, Yanagihara M, Furuya-Kondo T, Kurazumi H, Tanaka Y, Taura Y, Harada E, Hamano K. Autologous transplantation of multilayered fibroblast sheets prevents postoperative pancreatic fistula by regulating fibrosis and angiogenesis.. American journal of translational research, 2021.
- Iwamoto KS, Sandstrom RE, Bryan M, Liu Y, Elgart SR, Sheng K, Steinberg ML, McBride WH, Low DA. Weak Magnetic Fields Enhance the Efficacy of Radiation Therapy.. Advances in radiation oncology, 2021.
- Rogers CJ, Lukaszewicz AI, Yamada-Hanff J, Micewicz ED, Ratikan JA, Starbird MA, Miller TA, Nguyen C, Lee JT, Olafsen T, Iwamoto KS, McBride WH, Schaue D, Menon N. Identification of miRNA signatures associated with radiation-induced late lung injury in mice.. PloS one, 2020.
- MacKenzie C, Iwamoto KS, Smith K. University of California Replacement of Cesium Irradiators with Alternative Technologies.. Health physics, 2020.
- Ito Y, Tanigawa M, Yaguchi T, Toyoshima H, Iwamoto K, Nigi A, Itani H, Kondo S, Tokui T, Sasano H. Pulmonary nocardiosis caused by Nocardia blacklokiae in an immunocompetent patient.. Respiratory medicine case reports, 2020.
- Mori T, Takamura T, Yamagishi H, Iwamoto K, Unno K, Seko T, Kasai A. Patent foramen ovale and the platypnea-orthodeoxia syndrome detected by transesophageal echocardiography.. Journal of echocardiography, 2019.
- Ito Y, Tanigawa M, Iwamoto K, Nigi A, Itani H, Kondo S, Tokui T, Usui E, Tamaki S. Interstitial pneumonitis associated with dasatinib: two case reports and literature review.. Respiratory investigation, 2019.
- Wang C, Kishan AU, Yu JB, Raldow A, King CR, Iwamoto KS, Chu FI, Steinberg ML, Kupelian PA. Association between Long-Term Second Malignancy Risk and Radiation: A Comprehensive Analysis of the Entire Surveillance, Epidemiology, and End Results Database (1973-2014).. Advances in radiation oncology, 2019.
- Ito Y, Tanigawa M, Takemura T, Iwamoto K, Nigi A, Sasano H, Itani H, Kondo S, Tokui T, Nakamura S, Miyazaki Y. Chronic Nodular Pulmonary Aspergillosis in a Patient with Rheumatoid Arthritis.. Internal medicine (Tokyo, Japan), 2019.
- Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.. Radiation research, 2019.
- Sasano H, Sekine A, Hirata T, Iwamoto K, Itou Y, Itani H, Kondou S, Tokui T, Tanigawa M. Ovarian Metastases from ALK-rearranged Lung Adenocarcinoma: A Case Report and Literature Review.. Internal medicine (Tokyo, Japan), 2018.
- Ito Y, Toyoshima H, Suzuki T, Iwamoto K, Sasano H, Itani H, Kondo S, Tanigawa M. Lung abscess caused by Streptococcus pneumoniae serotype 6B.. Respiratory medicine case reports, 2017.
- Purbey PK, Scumpia PO, Kim PJ, Tong AJ, Iwamoto KS, McBride WH, Smale ST. Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation.. Immunity, 2017.
- Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH. 4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.. PloS one, 2017.
- Valdes G, Lee C, Tenn S, Lee P, Robinson C, Iwamoto K, Low D, Lamb JM. The relative accuracy of 4D dose accumulation for lung radiotherapy using rigid dose projection versus dose recalculation on every breathing phase.. Medical physics, 2017.
- Wang C, King CR, Kamrava M, Iwamoto KS, Chen AM, Low D, Kupelian PA, Steinberg ML. Pattern of solid and hematopoietic second malignancy after local therapy for prostate cancer.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017.
- Brown RJ, Jun BJ, Cushman JD, Nguyen C, Beighley AH, Blanchard J, Iwamoto K, Schaue D, Harris NG, Jentsch JD, Bluml S, McBride WH. Changes in Imaging and Cognition in Juvenile Rats After Whole-Brain Irradiation.. International journal of radiation oncology, biology, physics, 2016.
- Elgart SR, Bostani M, Mok KC, Adibi A, Ruehm S, Enzmann D, McNitt-Gray M, Iwamoto KS. Investigation of DNA Damage Dose-Response Kinetics after Ionizing Radiation Schemes Similar to CT Protocols.. Radiation research, 2015.
- Valdes G, Robinson C, Lee P, Morel D, Low D, Iwamoto KS, Lamb JM. Tumor control probability and the utility of 4D vs 3D dose calculations for stereotactic body radiotherapy for lung cancer.. Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 2014.
- Clemenson GD, Lee SW, Deng W, Barrera VR, Iwamoto KS, Fanselow MS, Gage FH. Enrichment rescues contextual discrimination deficit associated with immediate shock.. Hippocampus, 2014.
- Takahashi M, Valdes G, Hiraoka K, Inagaki A, Kamijima S, Micewicz E, Gruber HE, Robbins JM, Jolly DJ, McBride WH, Iwamoto KS, Kasahara N. Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.. Cancer gene therapy, 2014.
- Valdes G, Schulte RW, Ostermeier M, Iwamoto KS. The high-affinity maltose switch MBP317-347 has low affinity for glucose: implications for targeting tumors with metabolically directed enzyme prodrug therapy.. Chemical biology & drug design, 2013.
- Sha W, Ye H, Iwamoto KS, Wong KP, Wilks MQ, Stout D, McBride W, Huang SC. Factors affecting tumor (18)?F-FDG uptake in longitudinal mouse PET studies.. EJNMMI research, 2013.
- Valdes G, Iwamoto KS. Re-evaluation of cellular radiosensitization by 5-fluorouracil: high-dose, pulsed administration is effective and preferable to conventional low-dose, chronic administration.. International journal of radiation biology, 2013.
- Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, Tonegawa S. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.. Cell, 2012.
- Schaue D, Ratikan JA, Iwamoto KS. Cellular autofluorescence following ionizing radiation.. PloS one, 2012.
- Schaue D, Ratikan JA, Iwamoto KS, McBride WH. Maximizing tumor immunity with fractionated radiation.. International journal of radiation oncology, biology, physics, 2011.
- Kachikwu EL, Iwamoto KS, Liao YP, DeMarco JJ, Agazaryan N, Economou JS, McBride WH, Schaue D. Radiation enhances regulatory T cell representation.. International journal of radiation oncology, biology, physics, 2010.
- Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA, McBride WH. High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009.
- Brush JM, Kim K, Sayre JW, McBride WH, Iwamoto KS. Imaging of radiation effects on cellular 26S proteasome function in situ.. International journal of radiation biology, 2009.
- Liao YP, Wang CC, Schaue D, Iwamoto KS, McBride WH. Local irradiation of murine melanoma affects the development of tumour-specific immunity.. Immunology, 2009.
- Hafer K, Iwamoto KS, Schiestl RH. Refinement of the dichlorofluorescein assay for flow cytometric measurement of reactive oxygen species in irradiated and bystander cell populations.. Radiation research, 2008.
- Kim K, Brush JM, Watson PA, Cacalano NA, Iwamoto KS, McBride WH. Epidermal growth factor receptor vIII expression in U87 glioblastoma cells alters their proteasome composition, function, and response to irradiation.. Molecular cancer research : MCR, 2008.
- Bassler N, Alsner J, Beyer G, DeMarco JJ, Doser M, Hajdukovic D, Hartley O, Iwamoto KS, Jäkel O, Knudsen HV, Kovacevic S, Møller SP, Overgaard J, Petersen JB, Solberg TD, Sørensen BS, Vranjes S, Wouters BG, Holzscheiter MH. Antiproton radiotherapy.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2007.
- Hafer K, Iwamoto KS, Iwamoto KK, Scuric Z, Schiestl RH. Adaptive response to gamma radiation in mammalian cells proficient and deficient in components of nucleotide excision repair.. Radiation research, 2007.
- Iwamoto KS, Barber CL. Radiation-induced posttranscriptional control of M6P/IGF2r expression in breast cancer cell lines.. Molecular carcinogenesis, 2007.
- Iwamoto KS, Yano S, Barber CL, MacPhee DG, Tokuoka S. A dose-dependent decrease in the fraction of cases harboring M6P/IGF2R mutations in hepatocellular carcinomas from the atomic bomb survivors.. Radiation research, 2006.
- Holzscheiter MH, Bassler N, Agazaryan N, Beyer G, Blackmore E, DeMarco JJ, Doser M, Durand RE, Hartley O, Iwamoto KS, Knudsen HV, Landua R, Maggiore C, McBride WH, Møller SP, Petersen J, Skarsgard LD, Smathers JB, Solberg TD, Uggerhøj UI, Vranjes S, Withers HR, Wong M, Wouters BG. The biological effectiveness of antiproton irradiation.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006.
- Wang CC, Liao YP, Mischel PS, Iwamoto KS, Cacalano NA, McBride WH. HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway.. Cancer research, 2006.
- Mizuno T, Tokuoka S, Kishikawa M, Nakashima E, Mabuchi K, Iwamoto KS. Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations.. Carcinogenesis, 2006.
- Hafer K, Scuric Z, Iwamoto KS, Schiestl RH. Point-source irradiation with eccentric rotation causes inhomogeneous dose distribution.. Radiation research, 2006.
- Pervan M, Iwamoto KS, McBride WH. Proteasome structures affected by ionizing radiation.. Molecular cancer research : MCR, 2005.
- Liao YP, Wang CC, Butterfield LH, Economou JS, Ribas A, Meng WS, Iwamoto KS, McBride WH. Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells.. Journal of immunology (Baltimore, Md. : 1950), 2004.
- McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, Dougherty GJ, Iwamoto KS, Pervan M, Liao YP. A sense of danger from radiation.. Radiation research, 2004.
- McBride WH, Iwamoto KS, Syljuasen R, Pervan M, Pajonk F. The role of the ubiquitin/proteasome system in cellular responses to radiation.. Oncogene, 2003.
- Iwamoto KS. Tracking the errant cell after the atomic bombings: what went wrong?. Health physics, 2003.
- Chen WC, McBride WH, Iwamoto KS, Barber CL, Wang CC, Oh YT, Liao YP, Hong JH, de Vellis J, Shau H. Induction of radioprotective peroxiredoxin-I by ionizing irradiation.. Journal of neuroscience research, 2002.