Publications

1. Landeros A, Xu J, Lange K. MM optimization: Proximal distance algorithms, path following, and trust regions.. Proceedings of the National Academy of Sciences of the United States of America, 2023.
2. Chu BB, Ko S, Zhou JJ, Jensen A, Zhou H, Sinsheimer JS, Lange K. Multivariate genome-wide association analysis by iterative hard thresholding.. Bioinformatics (Oxford, England), 2023.
3. Ko S, Chu BB, Peterson D, Okenwa C, Papp JC, Alexander DH, Sobel EM, Zhou H, Lange KL. Unsupervised discovery of ancestry-informative markers and genetic admixture proportions in biobank-scale datasets.. American journal of human genetics, 2023.
4. Lange K, Zhou H. A Legacy of EM Algorithms.. International statistical review = Revue internationale de statistique, 2022.
5. Mester R, Landeros A, Rackauckas C, Lange K. Differential methods for assessing sensitivity in biological models.. PLoS computational biology, 2022.
6. Landeros A, Padilla OHM, Zhou H, Lange K. Extensions to the Proximal Distance Method of Constrained Optimization.. Journal of machine learning research : JMLR, 2022.
7. Chu BB, Sobel EM, Wasiolek R, Ko S, Sinsheimer JS, Zhou H, Lange K. A fast data-driven method for genotype imputation, phasing and local ancestry inference: MendelImpute.jl.. Bioinformatics (Oxford, England), 2021.
8. Landeros A, Ji X, Lange K, Stutz TC, Xu J, Sehl ME, Sinsheimer JS. An examination of school reopening strategies during the SARS-CoV-2 pandemic.. PloS one, 2021.
9. Ji SS, German CA, Lange K, Sinsheimer JS, Zhou H, Zhou J, Sobel EM. Modern simulation utilities for genetic analysis.. BMC bioinformatics, 2021.
10. Landeros A, Ji X, Lange K, Stutz TC, Xu J, Sehl ME, Sinsheimer JS. An examination of school reopening strategies during the SARS-CoV-2 pandemic.. medRxiv : the preprint server for health sciences, 2021.
11. Stutz TC, Landeros A, Xu J, Sinsheimer JS, Sehl M, Lange K. Stochastic simulation algorithms for Interacting Particle Systems.. PloS one, 2021.
12. Khan AH, Lin A, Wang RT, Bloom JS, Lange K, Smith DJ. Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells.. Genome research, 2020.
13. Chu BB, Keys KL, German CA, Zhou H, Zhou JJ, Sobel EM, Sinsheimer JS, Lange K. Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity.. GigaScience, 2020.
14. Zhou H, Sinsheimer JS, Bates DM, Chu BB, German CA, Ji SS, Keys KL, Kim J, Ko S, Mosher GD, Papp JC, Sobel EM, Zhai J, Zhou JJ, Lange K. OPENMENDEL: a cooperative programming project for statistical genetics.. Human genetics, 2019.
15. Zhou H, Hu L, Zhou J, Lange K. MM Algorithms For Variance Components Models.. Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 2019.
16. Landeros A, Stutz T, Keys KL, Alekseyenko A, Sinsheimer JS, Lange K, Sehl ME. BioSimulator.jl: Stochastic simulation in Julia.. Computer methods and programs in biomedicine, 2018.
17. Zhou H, Blangero J, Dyer TD, Chan KK, Lange K, Sobel EM. Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data.. Genetic epidemiology, 2016.
18. Zhou H, Zhou J, Hu T, Sobel EM, Lange K. Genome-wide QTL and eQTL analyses using Mendel.. BMC proceedings, 2016.
19. Sehl ME, Shimada M, Landeros A, Lange K, Wicha MS. Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response.. PloS one, 2015.
20. Shi H, Pasaniuc B, Lange KL. A multivariate Bernoulli model to predict DNaseI hypersensitivity status from haplotype data.. Bioinformatics (Oxford, England), 2015.
21. Chi EC, Zhou H, Lange K. Distance majorization and its applications.. Mathematical programming, 2014.
22. Rañola JM, Novembre J, Lange K. Fast spatial ancestry via flexible allele frequency surfaces.. Bioinformatics (Oxford, England), 2014.
23. Lange K, Chi EC, Zhou H. A Brief Survey of Modern Optimization for Statisticians.. International statistical review = Revue internationale de statistique, 2014.
24. Lange K. Hadamard's Determinant Inequality.. The American mathematical monthly : the official journal of the Mathematical Association of America, 2014.
25. Chi EC, Lange K. A Look at the Generalized Heron Problem through the Lens of Majorization-Minimization.. The American mathematical monthly : the official journal of the Mathematical Association of America, 2014.
26. Lange K, Zhou H. MM Algorithms for Geometric and Signomial Programming.. Mathematical programming, 2014.
27. Lange K, Papp JC, Sinsheimer JS, Sobel EM. Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data.. Annual review of statistics and its application, 2014.
28. Chi EC, Allen GI, Zhou H, Kohannim O, Lange K, Thompson PM. IMAGING GENETICS VIA SPARSE CANONICAL CORRELATION ANALYSIS.. Proceedings. IEEE International Symposium on Biomedical Imaging, 2013.
29. Lange K, Papp JC, Sinsheimer JS, Sripracha R, Zhou H, Sobel EM. Mendel: the Swiss army knife of genetic analysis programs.. Bioinformatics (Oxford, England), 2013.
30. Ranola JM, Langfelder P, Lange K, Horvath S. Cluster and propensity based approximation of a network.. BMC systems biology, 2013.
31. Riley L, Zhou H, Lange K, Sinsheimer JS, Sehl ME. Determining duration of HER2-targeted therapy using stem cell extinction models.. PloS one, 2012.
32. Chi EC, Zhou H, Chen GK, Del Vecchyo DO, Lange K. Genotype imputation via matrix completion.. Genome research, 2012.
33. Zhang Z, Lange K, Sabatti C. Reconstructing DNA copy number by joint segmentation of multiple sequences.. BMC bioinformatics, 2012.
34. Wang RT, Ahn S, Park CC, Khan AH, Lange K, Smith DJ. Effects of genome-wide copy number variation on expression in mammalian cells.. BMC genomics, 2011.
35. Sehl M, Zhou H, Sinsheimer JS, Lange KL. Extinction models for cancer stem cell therapy.. Mathematical biosciences, 2011.
36. Alexander DH, Lange K. Stability selection for genome-wide association.. Genetic epidemiology, 2011.
37. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. Unifying ideas for non-parametric linkage analysis.. Human heredity, 2011.
38. Alexander DH, Lange K. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation.. BMC bioinformatics, 2011.
39. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. Linkage analysis without defined pedigrees.. Genetic epidemiology, 2011.
40. Zhou H, Alexander D, Lange K. A quasi-Newton acceleration for high-dimensional optimization algorithms.. Statistics and computing, 2011.
41. Zhou H, Lange K. A Fast Procedure for Calculating Importance Weights in Bootstrap Sampling.. Computational statistics & data analysis, 2011.
42. Zhou H, Lange KL. On the Bumpy Road to the Dominant Mode.. Scandinavian journal of statistics, theory and applications, 2010.
43. Zhang Z, Lange K, Ophoff R, Sabatti C. RECONSTRUCTING DNA COPY NUMBER BY PENALIZED ESTIMATION AND IMPUTATION.. The annals of applied statistics, 2010.
44. Zhou H, Lange K. MM Algorithms for Some Discrete Multivariate Distributions.. Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 2010.
45. Zhou H, Sehl ME, Sinsheimer JS, Lange K. Association screening of common and rare genetic variants by penalized regression.. Bioinformatics (Oxford, England), 2010.
46. Childs EJ, Palmer CG, Lange K, Sinsheimer JS. Modeling maternal-offspring gene-gene interactions: the extended-MFG test.. Genetic epidemiology, 2010.
47. Ranola JM, Ahn S, Sehl M, Smith DJ, Lange K. A Poisson model for random multigraphs.. Bioinformatics (Oxford, England), 2010.
48. Cantor RM, Lange K, Sinsheimer JS. Prioritizing GWAS results: A review of statistical methods and recommendations for their application.. American journal of human genetics, 2010.
49. Sehl ME, Sinsheimer JS, Zhou H, Lange KL. Differential destruction of stem cells: implications for targeted cancer stem cell therapy.. Cancer research, 2009.
50. Zhou H, Lange K. Rating Movies and Rating the Raters Who Rate Them.. The American statistician, 2009.
51. Sehl M, Alekseyenko AV, Lange KL. Accurate stochastic simulation via the step anticipation tau-leaping (SAL) algorithm.. Journal of computational biology : a journal of computational molecular cell biology, 2009.
52. Alexander DH, Novembre J, Lange K. Fast model-based estimation of ancestry in unrelated individuals.. Genome research, 2009.
53. de Leeuw J, Lange K. Sharp Quadratic Majorization in One Dimension.. Computational statistics & data analysis, 2009.
54. Zhou JJ, Lange K, Papp JC, Sinsheimer JS. A heterozygote-homozygote test of Hardy-Weinberg equilibrium.. European journal of human genetics : EJHG, 2009.
55. Ayers KL, Lange K. Penalized estimation of haplotype frequencies.. Bioinformatics (Oxford, England), 2008.
56. Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu T, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ. Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids.. Nature genetics, 2008.
57. Sabatti C, Lange K. Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays.. Journal of the American Statistical Association, 2008.
58. Sinsheimer JS, Plaisier CL, Huertas-Vazquez A, Aguilar-Salinas C, Tusie-Luna T, Pajukanta P, Lange K. Estimating ethnic admixture from pedigree data.. American journal of human genetics, 2008.
59. Ayers KL, Sabatti C, Lange K. A dictionary model for haplotyping, genotype calling, and association testing.. Genetic epidemiology, 2007.
60. Presson AP, Sobel E, Lange K, Papp JC. Merging microsatellite data.. Journal of computational biology : a journal of computational molecular cell biology, 2006.
61. Lange K, Sobel E. Variance component models for X-linked QTLs.. Genetic epidemiology, 2006.
62. Chen GK, Slaten E, Ophoff RA, Lange K. Accommodating chromosome inversions in linkage analysis.. American journal of human genetics, 2006.
63. Ayers KL, Sabatti C, Lange K. Reconstructing ancestral haplotypes with a dictionary model.. Journal of computational biology : a journal of computational molecular cell biology, 2006.
64. Lange K, Sinsheimer JS, Sobel E. Association testing with Mendel.. Genetic epidemiology, 2005.
65. Cantor RM, Chen GK, Pajukanta P, Lange K. Association testing in a linked region using large pedigrees.. American journal of human genetics, 2005.
66. Sabatti C, Rohlin L, Lange K, Liao JC. Vocabulon: a dictionary model approach for reconstruction and localization of transcription factor binding sites.. Bioinformatics (Oxford, England), 2004.
67. Lange K, Sinsheimer JS. The pedigree trimming problem.. Human heredity, 2004.
68. Ro KM, Cantor RM, Lange KL, Ahn SS. Palmar hyperhidrosis: evidence of genetic transmission.. Journal of vascular surgery, 2002.
69. Sobel E, Papp JC, Lange K. Detection and integration of genotyping errors in statistical genetics.. American journal of human genetics, 2002.
70. Berloff N, Perola M, Lange K. Spline methods for the comparison of physical and genetic maps.. Journal of computational biology : a journal of computational molecular cell biology, 2002.