
Lars Dreier
Assistant Adjunct Professor, Biological Chemistry, University of California Los Angeles
Laboratory Address:
Gonda Center, Room 3309
Lab Number:
(310) 206-1701
Mailing Address:
David Geffen School of Medicine at UCLA
Department of Neurobiology
695 Charles E. Young Dr. South
Gonda Center, Room 3309
Los Angeles, CA 90095
Office Address:
Gonda 3506C
Affiliations
Research Interests
Recent evidence indicates that regulated degradation of synaptic proteins is an important mechanism to control synapse formation and function. Ubiquitin-dependent degradation is a major pathway for regulated protein degradation. In this pathway, ubiquitin ligases conjugate the small protein ubiquitin to target proteins destined for degradation. We are currently characterizing the function of ubiquitin ligase mutants that affect synapse structure and synaptic transmission at various synapses. The activity of ubiquitin ligases is antagonized by deubiquitinating enzymes that remove ubiquitin from target proteins (in a similar way, protein kinases and phosphatases antagonize each other). Deubiquitinating enzymes are probably as important as ubiquitin ligases in regulating protein degradation, but very few have been characterized to date. The C. elegans genome encodes about 300 ubiquitin ligases and 50 deubiquitinating enzymes. In RNAi based screens, we are now identifying deubiquitinating enzymes that affect synaptic transmission and synapse structure.
Biography
Dr. Lars Dreier joined the Department of Neurobiology as an Assistant Professor in 2006. Lars did his Ph.D. work in the Department of Cell Biology, Harvard Medical School, Boston, in the lab of Tom Rapoport, reconstituting the transport of secretory proteins through the Endoplasmic Reticulum (ER) membrane and characterizing the formation of the ER in vitro. In 2000, he joined the lab of Josh Kaplan at the University of California, Berkeley, where he started to work on ubiquitin-dependent regulation of glutamate receptors in C. elegans. Lars moved with the Kaplan lab back to Boston in 2002.
Publications
A selected list of publications:
- Sun Yu, Vashisht Ajay A, Tchieu Jason, Wohlschlegel James A, Dreier Lars Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy The Journal of biological chemistry, 2012; 287(48): 40652-60.
- Wang, J, G.W. Farr, D.H. Hall, F. Li, K. Furtak, L. Dreier, A.L. Horwich An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans PLoS Genetics, 2009; 5(1): .
- Dreier, L.* Burbea, M.* Kaplan, J. M. LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans Neuron, 2005; 46: 51-64.
- Burbea, M.* Dreier, L.* Dittman, J. S. Grunwald, M. E. Kaplan, J. M. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans Neuron, 2002; 35: 107-20, * contributed equally.
- Felbor, U. Dreier, L. Bryant, R. A. Ploegh, H. L. Olsen, B. R. Mothes, W. Secreted cathepsin L generates endostatin from collagen XVIII Embo J, 2000; 19(6): 1187-94.
- Dreier, L. Rapoport, T. A. In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction J Cell Biol, 2000; 148(5): 883-98.
- Panzner, S. Dreier, L. Hartmann, E. Kostka, S. Rapoport, T. A. Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p Cell, 1995; 81(4): 561-70.