Linda L Demer

Professor, Medicine, University of California Los Angeles

Professor, Physiology, University of California Los Angeles

(310) 206-2677

UC Profile
http://www.uclahealth.org/LindaDemer
http://www.cardiology.med.ucla.edu/faculty/demercv.htm
Cardiovascular Calcification Research Laboratory

Dr. Demer pioneered the field of research in cardiovascular calcification, studying its mechanisms at the level of cellular, molecular and biomechanical regulation. Her research group overcame dogma by demonstrating that bone and marrow form in human arteries, often in association with atherosclerosis, and that the process is both regulated by bone differentiation factors and related to embryonic skeletal development. They developed the first tissue culture model of vascular calcification, isolated and cloned the cells responsible for producing calcium mineral, and identified the regulatory molecules controlling the re-differentiation of vascular cells into osteooblastic cells. Her group is currently addressing the conundrum that coronary calcification is associated with increased risk of cardiovascular events, while it also progresses most rapidly in patients using statin drugs (which are associated with reduced risk), and it is more prevalent in elite endurance athletes, which is also associated with reduced risk. Using microCT and microPET imaging, her group is exploring the possibility that structural differences in the calcium mineral deposits affect whether they prevent or promote cardiac events.

Education and Training

Johns HopkinsMD,PhD06/1983Medicine, Bioengineering

Awards and Honors

  • Steward Niewiarowski Award, Temple University, 2007.
  • Davidson Memorial Lectureship, Royal College of Physicians, 2001.
  • Jeffrey Hoeg Award, American Heart Association, 2003.
  • Franklin D. Murphy Research Prz, 2002.
  • Stein-Oppenheimer Award, 1993.
  • Chair, Gordon Research Conference, 2009.

Publications

  1. Hon A, Hsu JJ, Zambrano A, Xia Y, Lu M, Echeverri D, Kalanski S, Umar S, Demer LL, Tintut Y. Effects of activity levels on aortic calcification in hyperlipidemic mice as measured by microPETmicroCT.. Atherosclerosis, 2023.
  2. Zambrano A, Tintut Y, Demer LL, Hsu JJ. Potential mechanisms linking high-volume exercise with coronary artery calcification.. Heart (British Cardiac Society), 2023.
  3. Cai X, Tintut Y, Demer LL. A Potential New Link Between Inflammation and Vascular Calcification.. Journal of the American Heart Association, 2022.
  4. Hsu JJ, Tintut Y, Demer LL. Regulation of cardiovascular calcification by lipids and lipoproteins.. Current opinion in lipidology, 2022.
  5. Patel NR, Setya K, Pradhan S, Lu M, Demer LL, Tintut Y. Microarchitectural Changes of Cardiovascular Calcification in Response to In Vivo Interventions Using Deep-Learning Segmentation and Computed Tomography Radiomics.. Arteriosclerosis, thrombosis, and vascular biology, 2022.
  6. Tintut Y, Honda HM, Demer LL. Biomolecules Orchestrating Cardiovascular Calcification.. Biomolecules, 2021.
  7. Hsu JJ, Tintut Y, Demer LL. Lipids and cardiovascular calcification: contributions to plaque vulnerability.. Current opinion in lipidology, 2021.
  8. Hsu JJ, Tintut Y, Demer LL. A biomarker for vascular calcification: shedding light on an unfinished story?. Cardiovascular research, 2021.
  9. Demer LL, Tintut Y. Hearts of Stone: Calcific Aortic Stenosis and Antiresorptive Agents for Osteoporosis.. Circulation, 2021.
  10. Tintut Y, Demer LL. Potential impact of the steroid hormone, vitamin D, on the vasculature.. American heart journal, 2021.
  11. Xian JZ, Lu M, Fong F, Qiao R, Patel NR, Abeydeera D, Iriana S, Demer LL, Tintut Y. Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice.. Arteriosclerosis, thrombosis, and vascular biology, 2021.
  12. Fong F, Xian J, Demer LL, Tintut Y. Serotonin receptor type 2B activation augments TNF-α-induced matrix mineralization in murine valvular interstitial cells.. Journal of cellular biochemistry, 2020.
  13. Borén J, Chapman MJ, Krauss RM, Packard CJ, Bentzon JF, Binder CJ, Daemen MJ, Demer LL, Hegele RA, Nicholls SJ, Nordestgaard BG, Watts GF, Bruckert E, Fazio S, Ference BA, Graham I, Horton JD, Landmesser U, Laufs U, Masana L, Pasterkamp G, Raal FJ, Ray KK, Schunkert H, Taskinen MR, van de Sluis B, Wiklund O, Tokgozoglu L, Catapano AL, Ginsberg HN. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel.. European heart journal, 2020.
  14. Hsu JJ, Fong F, Patel R, Qiao R, Lo K, Soundia A, Chang CC, Le V, Tseng CH, Demer LL, Tintut Y. Changes in microarchitecture of atherosclerotic calcification assessed by 18F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020.
  15. Sallam T, Tintut Y, Demer LL. Regulation of calcific vascular and valvular disease by nuclear receptors.. Current opinion in lipidology, 2019.
  16. Demer LL, Tintut Y. Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease.. Trends in endocrinology and metabolism: TEM, 2019.
  17. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK. Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation.. JCI insight, 2019.
  18. Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M. Training the physician-scientist: views from program directors and aspiring young investigators.. JCI insight, 2018.
  19. Tintut Y, Hsu JJ, Demer LL. Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges.. Frontiers in cardiovascular medicine, 2018.
  20. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system.. JCI insight, 2018.
  21. Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation.. JCI insight, 2018.
  22. Demer LL, Hsu JJ, Tintut Y. Steroid Hormone Vitamin D: Implications for Cardiovascular Disease.. Circulation research, 2018.
  23. Demer LL. The Autism Spectrum: Human Rights Perspectives.. Pediatrics, 2018.
  24. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.. American journal of physiology. Heart and circulatory physiology, 2018.
  25. Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT. Rigor and Reproducibility in Analysis of Vascular Calcification.. Circulation research, 2017.
  26. Hsu JJ, Lim J, Tintut Y, Demer LL. Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification.. Heart (British Cardiac Society), 2016.
  27. Tintut Y, Demer LL. COMP-lex Mechanics: Matricrine Signaling.. Circulation research, 2016.
  28. Demer LL, Tintut Y. Reply: Evolutionary approach sheds light on the significance of vascular calcification.. Trends in cardiovascular medicine, 2016.
  29. Lim J, Ehsanipour A, Hsu JJ, Lu J, Pedego T, Wu A, Walthers CM, Demer LL, Seidlits SK, Tintut Y. Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis.. The American journal of pathology, 2016.
  30. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques.. Annals of biomedical engineering, 2016.
  31. Wong MD, Guerrero L, Sallam T, Frank JS, Fogelman AM, Demer LL. Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship.. Journal of graduate medical education, 2016.
  32. Li X, Lim J, Lu J, Pedego TM, Demer L, Tintut Y. Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification.. Journal of cellular biochemistry, 2015.
  33. Tintut Y, Demer LL. Exosomes: nanosized cellular messages.. Circulation research, 2015.
  34. Demer LL, Boström KI. Conflicting forces of warfarin and matrix gla protein in the artery wall.. Arteriosclerosis, thrombosis, and vascular biology, 2015.
  35. Demer LL, Tintut Y. The leading edge of vascular calcification.. Trends in cardiovascular medicine, 2014.
  36. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.. Arteriosclerosis, thrombosis, and vascular biology, 2014.
  37. Demer LL, Tintut Y. Inflammatory, metabolic, and genetic mechanisms of vascular calcification.. Arteriosclerosis, thrombosis, and vascular biology, 2014.
  38. van Venrooij NA, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K. FGF23 protein expression in coronary arteries is associated with impaired kidney function.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014.
  39. Li X, Garcia J, Lu J, Iriana S, Kalajzic I, Rowe D, Demer LL, Tintut Y. Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts.. Journal of cellular biochemistry, 2014.
  40. Tintut Y, Demer LL. Effects of bioactive lipids and lipoproteins on bone.. Trends in endocrinology and metabolism: TEM, 2013.
  41. Heistad DD, Shanahan C, Demer LL. Introduction to the Compendium on calcific aortic valve disease.. Circulation research, 2013.
  42. Lu J, Cheng H, Atti E, Shih DM, Demer LL, Tintut Y. Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice.. Biochemical and biophysical research communications, 2013.
  43. Sallam T, Cheng H, Demer LL, Tintut Y. Regulatory circuits controlling vascular cell calcification.. Cellular and molecular life sciences : CMLS, 2012.
  44. Wong MN, Nguyen TP, Chen TH, Hsu JJ, Zeng X, Saw A, Demer EM, Zhao X, Tintut Y, Demer LL. Preferred mitotic orientation in pattern formation by vascular mesenchymal cells.. American journal of physiology. Heart and circulatory physiology, 2012.
  45. Morony S, Sage AP, Corbin T, Lu J, Tintut Y, Demer LL. Enhanced mineralization potential of vascular cells from SM22α-Rankl (tg) mice.. Calcified tissue international, 2012.
  46. Chen TH, Zhu X, Pan L, Zeng X, Garfinkel A, Tintut Y, Demer LL, Zhao X, Ho CM. Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells.. Biomaterials, 2012.
  47. Cheng H, Reddy A, Sage A, Lu J, Garfinkel A, Tintut Y, Demer LL. Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells.. Journal of vascular research, 2012.
  48. Chen TH, Guo C, Zhao X, Yao Y, Boström KI, Wong MN, Tintut Y, Demer LL, Ho CM, Garfinkel A. Patterns of periodic holes created by increased cell motility.. Interface focus, 2012.
  49. Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, Tetradis S, Demer L, Aghaloo T, Tintut Y. Adverse effects of hyperlipidemia on bone regeneration and strength.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012.
  50. Chen TH, Hsu JJ, Zhao X, Guo C, Wong MN, Huang Y, Li Z, Garfinkel A, Ho CM, Tintut Y, Demer LL. Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics.. Circulation research, 2012.
  51. Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases.. American journal of physiology. Cell physiology, 2011.
  52. Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.. Circulation, 2011.
  53. Geng Y, Hsu JJ, Lu J, Ting TC, Miyazaki M, Demer LL, Tintut Y. Role of cellular cholesterol metabolism in vascular cell calcification.. The Journal of biological chemistry, 2011.
  54. Demer L, Tintut Y. The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification.. Circulation research, 2011.
  55. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011.
  56. Towler DA, Demer LL. Thematic series on the pathobiology of vascular calcification: an introduction.. Circulation research, 2011.
  57. Ting TC, Miyazaki-Anzai S, Masuda M, Levi M, Demer LL, Tintut Y, Miyazaki M. Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells.. The Journal of biological chemistry, 2011.
  58. Tintut Y, Demer L. The hemosteoblast: friend or foe?. Circulation research, 2011.
  59. Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y. Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages.. Arteriosclerosis, thrombosis, and vascular biology, 2011.
  60. Sage AP, Lu J, Tintut Y, Demer LL. Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro.. Kidney international, 2010.
  61. Tseng W, Graham LS, Geng Y, Reddy A, Lu J, Effros RB, Demer L, Tintut Y. PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.. The Journal of biological chemistry, 2010.
  62. Sage AP, Tintut Y, Demer LL. Regulatory mechanisms in vascular calcification.. Nature reviews. Cardiology, 2010.
  63. Demer L, Tintut Y. The bone-vascular axis in chronic kidney disease.. Current opinion in nephrology and hypertension, 2010.
  64. Tseng W, Lu J, Bishop GA, Watson AD, Sage AP, Demer L, Tintut Y. Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids.. Journal of lipid research, 2009.
  65. Graham LS, Parhami F, Tintut Y, Kitchen CM, Demer LL, Effros RB. Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.. Clinical immunology (Orlando, Fla.), 2009.
  66. Demer LL, Tintut Y. Mechanisms linking osteoporosis with cardiovascular calcification.. Current osteoporosis reports, 2009.
  67. Hoshino T, Chow LA, Hsu JJ, Perlowski AA, Abedin M, Tobis J, Tintut Y, Mal AK, Klug WS, Demer LL. Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability.. American journal of physiology. Heart and circulatory physiology, 2009.
  68. Sage A, Tintut Y, Garfinkel A, Demer L. Systems biology of vascular calcification.. Trends in cardiovascular medicine, 2009.
  69. Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. T0901317, an LXR agonist, augments PKA-induced vascular cell calcification.. FEBS letters, 2009.
  70. Demer LL, Sage AP, Tintut Y. Nanoscale architecture in atherosclerotic calcification.. Arteriosclerosis, thrombosis, and vascular biology, 2008.
  71. Huang MS, Lu J, Ivanov Y, Sage AP, Tseng W, Demer LL, Tintut Y. Hyperlipidemia impairs osteoanabolic effects of PTH.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008.
  72. Huang MS, Sage AP, Lu J, Demer LL, Tintut Y. Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification.. Biochemical and biophysical research communications, 2008.
  73. Hsu JJ, Tintut Y, Demer LL. Vitamin D and osteogenic differentiation in the artery wall.. Clinical journal of the American Society of Nephrology : CJASN, 2008.
  74. Demer LL, Tintut Y. Vascular calcification: pathobiology of a multifaceted disease.. Circulation, 2008.
  75. Hsu JJ, Tintut Y, Demer LL. Murine models of atherosclerotic calcification.. Current drug targets, 2008.
  76. Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.. Circulation, 2008.
  77. Demer LL, Tintut Y. A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells".. Free radical biology & medicine, 2007.
  78. Tintut Y, Huang M, Lu J, Tseng W, Garfinkel A, Demer LL. Vascular calcification.. Journal of musculoskeletal & neuronal interactions, 2007.
  79. Huang MS, Morony S, Lu J, Zhang Z, Bezouglaia O, Tseng W, Tetradis S, Demer LL, Tintut Y. Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts.. The Journal of biological chemistry, 2007.
  80. Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. Mineralocorticoid receptor activation promotes vascular cell calcification.. Arteriosclerosis, thrombosis, and vascular biology, 2007.
  81. Tintut Y, Demer L. Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification.. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2006.
  82. Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK. Mechanical response of a calcified plaque model to fluid shear force.. Annals of biomedical engineering, 2006.
  83. Demer LL, Tintut Y. Pitting phosphate transport inhibitors against vascular calcification.. Circulation research, 2006.
  84. Abedin M, Lim J, Tang TB, Park D, Demer LL, Tintut Y. N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways.. Circulation research, 2006.
  85. Tintut Y, Abedin M, Cho J, Choe A, Lim J, Demer LL. Regulation of RANKL-induced osteoclastic differentiation by vascular cells.. Journal of molecular and cellular cardiology, 2005.
  86. Demer LL, Tintut Y. Return to ectopia: stem cells in the artery wall.. Arteriosclerosis, thrombosis, and vascular biology, 2005.
  87. Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer LL, Tintut Y. Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways.. Circulation research, 2005.
  88. Demer LL, Abedin M. Skeleton key to vascular disease.. Journal of the American College of Cardiology, 2004.
  89. Abedin M, Tintut Y, Demer LL. Mesenchymal stem cells and the artery wall.. Circulation research, 2004.
  90. Garfinkel A, Tintut Y, Petrasek D, Boström K, Demer LL. Pattern formation by vascular mesenchymal cells.. Proceedings of the National Academy of Sciences of the United States of America, 2004.
  91. Abedin M, Tintut Y, Demer LL. Vascular calcification: mechanisms and clinical ramifications.. Arteriosclerosis, thrombosis, and vascular biology, 2004.
  92. Hsiai TK, Cho SK, Wong PK, Ing MH, Salazar A, Hama S, Navab M, Demer LL, Ho CM. Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses.. Annals of biomedical engineering, 2004.
  93. Tintut Y, Morony S, Demer LL. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo.. Arteriosclerosis, thrombosis, and vascular biology, 2003.
  94. Tintut Y, Alfonso Z, Saini T, Radcliff K, Watson K, Boström K, Demer LL. Multilineage potential of cells from the artery wall.. Circulation, 2003.
  95. Demer LL, Tintut Y. Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture.. Arteriosclerosis, thrombosis, and vascular biology, 2003.
  96. Hsiai TK, Cho SK, Wong PK, Ing M, Salazar A, Sevanian A, Navab M, Demer LL, Ho CM. Monocyte recruitment to endothelial cells in response to oscillatory shear stress.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003.
  97. Mody N, Tintut Y, Radcliff K, Demer LL. Vascular calcification and its relation to bone calcification: possible underlying mechanisms.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2003.
  98. Demer LL. Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids.. International journal of epidemiology, 2002.
  99. Demer LL, Tintut Y, Parhami F. Novel mechanisms in accelerated vascular calcification in renal disease patients.. Current opinion in nephrology and hypertension, 2002.
  100. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt).. Annals of biomedical engineering, 2002.
  101. Demer LL. Adipose rex: fat and fats that rule differentiation.. Circulation research, 2002.
  102. Hsiai TK, Cho SK, Reddy S, Hama S, Navab M, Demer LL, Honda HM, Ho CM. Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells.. Arteriosclerosis, thrombosis, and vascular biology, 2001.
  103. Demer LL. Cholesterol in vascular and valvular calcification.. Circulation, 2001.
  104. Tintut Y, Demer LL. Recent advances in multifactorial regulation of vascular calcification.. Current opinion in lipidology, 2001.
  105. Poggi SH, Bostrom KI, Demer LL, Skinner HC, Koos BJ. Placental calcification: a metastatic process?. Placenta, 2001.
  106. Parhami F, Tintut Y, Ballard A, Fogelman AM, Demer LL. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin.. Circulation research, 2001.
  107. Boström K, Tsao D, Shen S, Wang Y, Demer LL. Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells.. The Journal of biological chemistry, 2001.
  108. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL. Atherogenic high-fat diet reduces bone mineralization in mice.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001.
  109. Parhami F, Tintut Y, Patel JK, Mody N, Hemmat A, Demer LL. Regulation of vascular calcification in atherosclerosis.. Zeitschrift fur Kardiologie, 2001.
  110. Tintut Y, Patel J, Parhami F, Demer LL. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway.. Circulation, 2000.
  111. Parhami F, Garfinkel A, Demer LL. Role of lipids in osteoporosis.. Arteriosclerosis, thrombosis, and vascular biology, 2000.
  112. Boström K, Tintut Y, Kao SC, Stanford WP, Demer LL. HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells.. Journal of cellular biochemistry, 2000.
  113. Jackson SM, Demer LL. Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts.. FEBS letters, 2000.
  114. Boström K, Demer LL. Regulatory mechanisms in vascular calcification.. Critical reviews in eukaryotic gene expression, 2000.
  115. Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M, Demer LL. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1999.
  116. Tintut Y, Parhami F, Le V, Karsenty G, Demer LL. Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.. The Journal of biological chemistry, 1999.
  117. Jackson SM, Parhami F, Xi XP, Berliner JA, Hsueh WA, Law RE, Demer LL. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.. Arteriosclerosis, thrombosis, and vascular biology, 1999.
  118. Demer LL, Tintut Y. Osteopontin. Between a rock and a hard plaque.. Circulation research, 1999.
  119. Watson KE, Parhami F, Shin V, Demer LL. Fibronectin and collagen I matrixes promote calcification of vascular cells in vitro, whereas collagen IV matrix is inhibitory.. Arteriosclerosis, thrombosis, and vascular biology, 1998.
  120. Tintut Y, Parhami F, Boström K, Jackson SM, Demer LL. cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification.. The Journal of biological chemistry, 1998.
  121. Parhami F, Demer LL. Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids?. Current opinion in lipidology, 1997.
  122. Watson KE, Abrolat ML, Malone LL, Hoeg JM, Doherty T, Detrano R, Demer LL. Active serum vitamin D levels are inversely correlated with coronary calcification.. Circulation, 1997.
  123. Doherty TM, Tang W, Dascalos S, Watson KE, Demer LL, Shavelle RM, Detrano RC. Ethnic origin and serum levels of 1alpha,25-dihydroxyvitamin D3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography.. Circulation, 1997.
  124. Balica M, Boström K, Shin V, Tillisch K, Demer LL. Calcifying subpopulation of bovine aortic smooth muscle cells is responsive to 17 beta-estradiol.. Circulation, 1997.
  125. Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA, Demer LL. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients.. Arteriosclerosis, thrombosis, and vascular biology, 1997.
  126. Demer LL. Lipid hypothesis of cardiovascular calcification.. Circulation, 1997.
  127. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture.. Arteriosclerosis, thrombosis, and vascular biology, 1996.
  128. Uyemura K, Demer LL, Castle SC, Jullien D, Berliner JA, Gately MK, Warrier RR, Pham N, Fogelman AM, Modlin RL. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.. The Journal of clinical investigation, 1996.
  129. Watson KE, Demer LL. The atherosclerosis-calcification link?. Current opinion in lipidology, 1996.
  130. Honda HM, Goldhaber JI, Demer LL, Weiss JN. Endothelium-dependent vasodilators do not cause propagated intercellular Ca2+ waves in vascular endothelial monolayers.. Cell calcium, 1996.
  131. Parhami F, Boström K, Watson K, Demer LL. Role of molecular regulation in vascular calcification.. Journal of atherosclerosis and thrombosis, 1996.
  132. Qiao JH, Fishbein MC, Demer LL, Lusis AJ. Genetic determination of cartilaginous metaplasia in mouse aorta.. Arteriosclerosis, thrombosis, and vascular biology, 1995.
  133. Neilson EG, Ausiello D, Demer LL. Physician-scientists as missing persons. Association of Subspecialty Professors.. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 1995.
  134. Demer LL. A skeleton in the atherosclerosis closet.. Circulation, 1995.
  135. Navab M, Fogelman AM, Berliner JA, Territo MC, Demer LL, Frank JS, Watson AD, Edwards PA, Lusis AJ. Pathogenesis of atherosclerosis.. The American journal of cardiology, 1995.
  136. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics.. Circulation, 1995.
  137. Boström K, Watson KE, Stanford WP, Demer LL. Atherosclerotic calcification: relation to developmental osteogenesis.. The American journal of cardiology, 1995.
  138. Chang GJ, Woo P, Honda HM, Ignarro LJ, Young L, Berliner JA, Demer LL. Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen.. Arteriosclerosis and thrombosis : a journal of vascular biology, 1994.
  139. Qiao JH, Xie PZ, Fishbein MC, Kreuzer J, Drake TA, Demer LL, Lusis AJ. Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification.. Arteriosclerosis and thrombosis : a journal of vascular biology, 1994.
  140. Watson KE, Boström K, Ravindranath R, Lam T, Norton B, Demer LL. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.. The Journal of clinical investigation, 1994.
  141. Demer LL, Watson KE, Boström K. Mechanism of calcification in atherosclerosis.. Trends in cardiovascular medicine, 1994.
  142. Demer LL, Wortham CM, Dirksen ER, Sanderson MJ. Mechanical stimulation induces intercellular calcium signaling in bovine aortic endothelial cells.. The American journal of physiology, 1993.
  143. Boström K, Watson KE, Horn S, Wortham C, Herman IM, Demer LL. Bone morphogenetic protein expression in human atherosclerotic lesions.. The Journal of clinical investigation, 1993.
  144. Bennett RL, Navab M, Demer LL, Fogelman AM. A new anti-inflammatory leucine derivative, NPC-15669, inhibits growth of cultured human aortic smooth muscle cells.. Arteriosclerosis and thrombosis : a journal of vascular biology, 1993.
  145. Park JC, Siegel RJ, Demer LL. Effect of calcification and formalin fixation on in vitro distensibility of human femoral arteries.. American heart journal, 1993.
  146. Demer LL, Ariani M, Siegel RJ. High intensity ultrasound increases distensibility of calcific atherosclerotic arteries.. Journal of the American College of Cardiology, 1991.
  147. Nienaber CA, Brunken RC, Sherman CT, Yeatman LA, Gambhir SS, Krivokapich J, Demer LL, Ratib O, Child JS, Phelps ME. Metabolic and functional recovery of ischemic human myocardium after coronary angioplasty.. Journal of the American College of Cardiology, 1991.
  148. Mehrabian M, Demer LL, Lusis AJ. Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice.. Arteriosclerosis and thrombosis : a journal of vascular biology, 1991.
  149. Demer LL. Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation.. Circulation, 1991.
  150. Liao F, Berliner JA, Mehrabian M, Navab M, Demer LL, Lusis AJ, Fogelman AM. Minimally modified low density lipoprotein is biologically active in vivo in mice.. The Journal of clinical investigation, 1991.
  151. Demer LL, Gould KL, Goldstein RA, Kirkeeide RL, Mullani NA, Smalling RW, Nishikawa A, Merhige ME. Assessment of coronary artery disease severity by positron emission tomography. Comparison with quantitative arteriography in 193 patients.. Circulation, 1989.