Lindsay M De Biase

Assistant Professor, Physiology, University of California Los Angeles

Assistant Professor, Neurobiology, University of California Los Angeles

UC Profile
De Biase Lab Website
UCLA Department of Physiology

Interests

Lysosome and mitochondrial function in glial cells, Microglial-astrocyte interactions, Development and function of basal ganglia circuits, Glial-neuron interactions in health and disease

Education and Training

National Institutes on Drug Abuse07/2018Postdoctoral Training
Johns Hopkins University School of MedicinePh.D.10/2011Neuroscience
Yale UniversityB.S.05/2003Molecular Cellular and Developmental Biology

Awards and Honors

  • Fellows Award for Research Excellence, NIH, 2014.
  • Fellows Award for Research Excellence, NIH, 2016.
  • NARSAD Young Investigator Award, Brain and Behavior Research Foundation, 2018.
  • Stanley Fahn Junior Faculty Award, Parkinson's Foundation, 2021.
  • NIDA Postdoctoral Fellow Mentoring Award, NIDA, 2017.
  • Robert Goodman Scholars Award, Johns Hopkins School of Medicine, 2009.
  • First Place, Postdoctoral poster, Annual Meeting of Greater Baltimore Chapter, Society for Neuroscience, 2014.
  • Fellows Award for Research Excellence, NIH, 2015.
  • Excellence in Scientific Research Award, NIDA Women’s Science Advisory Committee, 2017.
  • Grant for Junior Faculty, Glen Foundation and American Foundation for Aging Research, 2019.
  • Second Place; Poster awards, Winter Conference on Brain Research, Breckenridge, CO, 2016.
  • Innovator Award in Cognitive Aging, McKnight Brain Research Foundation / AFAR, 2021.

Publications

  1. Blagburn-Blanco SV, Chappell MS, De Biase LM, DeNardo LA. Synapse-specific roles for microglia in development: New horizons in the prefrontal cortex.. Frontiers in molecular neuroscience, 2022.
  2. Moca EN, Lecca D, Hope KT, Etienne F, Schaler AW, Espinoza K, Chappell MS, Gray DT, Tweedie D, Sidhu S, Masukawa L, Sitoy H, Mathew R, Saban DR, Greig NH, De Biase LM. Microglia Drive Pockets of Neuroinflammation in Middle Age.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022.
  3. Gray DT, De Biase LM. AMPA Receptors Exist in Tunable Mobile and Immobile Synaptic Fractions In Vivo.. eNeuro, 2021.
  4. Hope KT, Hawes IA, Moca EN, Bonci A, De Biase LM. Maturation of the microglial population varies across mesolimbic nuclei.. The European journal of neuroscience, 2020.
  5. Shen H, Marino RAM, McDevitt RA, Bi GH, Chen K, Madeo G, Lee PT, Liang Y, De Biase LM, Su TP, Xi ZX, Bonci A. Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
  6. De Biase LM, Bonci A. Region-Specific Phenotypes of Microglia: The Role of Local Regulatory Cues.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2018.
  7. Xin W, Schuebel KE, Jair KW, Cimbro R, De Biase LM, Goldman D, Bonci A. Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018.
  8. De Biase LM, Schuebel KE, Fusfeld ZH, Jair K, Hawes IA, Cimbro R, Zhang HY, Liu QR, Shen H, Xi ZX, Goldman D, Bonci A. Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.. Neuron, 2017.
  9. Wallace VJ, Cimbro R, Rubio FJ, Fortuno LV, Necarsulmer JC, Koivula PP, Henderson MJ, DeBiase LM, Warren BL, Harvey BK, Hope BT. Neurons Internalize Functionalized Micron-Sized Silicon Dioxide Microspheres.. Cellular and molecular neurobiology, 2017.
  10. De Biase LM, Bergles DE. Same players, different game: AMPA receptor regulation in oligodendrocyte progenitors.. Nature neuroscience, 2011.
  11. De Biase LM, Kang SH, Baxi EG, Fukaya M, Pucak ML, Mishina M, Calabresi PA, Bergles DE. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
  12. Boersma MC, Dresselhaus EC, De Biase LM, Mihalas AB, Bergles DE, Meffert MK. A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
  13. De Biase LM, Nishiyama A, Bergles DE. Excitability and synaptic communication within the oligodendrocyte lineage.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010.
  14. Freishtat RJ, Natale J, Benton AS, Cohen J, Sharron M, Wiles AA, Ngor WM, Mojgani B, Bradbury M, Degnan A, Sachdeva R, Debiase LM, Ghimbovschi S, Chow M, Bunag C, Kristosturyan E, Hoffman EP. Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.. American journal of respiratory and critical care medicine, 2009.